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Liu, CT

Changdeng Liu, Storrs, CT US

Patent application numberDescriptionPublished
20080249245BLENDS OF AMORPHOUS AND SEMICRYSTALLINE POLYMERS HAVING SHAPE MEMORY PROPERTIES - A shape memory polymeric material has a glass transition temperature, T10-09-2008
20090253842SHAPE MEMORY POLYMERS BASED ON SEMICRYSTALLINE THERMOPLASTIC POLYURETHANES BEARING NANOSTRUCTURED HARD SEGMENTS - Thermoplastic polyurethanes having an alternating sequence of hard and soft segments in which a nanostructured polyhedral oligosilsesquioxane diol is used as a chain extender to form a crystalline hard segment constituting SMPs. The polyurethanes are formed by reacting a polyol, a chain extender dihydroxyl-terminated polyhedral oligosilsesquioxane and a diisocyanate. The polyurethanes have multiple applications including for example, implants for human health care, drug delivery matrices, superabsorbant hydrogels, coatings, adhesives, temperature and moisture sensors, etc.10-08-2009
20090275704CROSSLINKED POLYCYCLOOCTENE - Chemically crosslinked polycyclooctene having excellent shape recovery properties is prepared by ring-opening metathesis polymerization of cis-cyclooctene followed by chemical crosslinking. The crosslinked polycyclooctene can be shaped, the shape memorized, a new shape imparted with the original shape being recoverable by suitable temperature adjustment. The dependence of shape memory characteristics on degree of crosslinking was established. In addition to polycyclooctene, blends thereof with other materials such as SBR, EVA, polyurethane rubbers, and inorganic fillers can be utilized to provide chemically crosslinked products having excellent and tailored shape memory properties.11-05-2009
20100160522CROSSLINKED POLYCYCLOOCTENE - Chemically crosslinked polycyclooctene having excellent shape recovery properties is prepared by ring-opening metathesis polymerization of cis-cyclooctene followed by chemical crosslinking. The crosslinked polycyclooctene can be shaped, the shape memorized, a new shape imparted with the original shape being recoverable by suitable temperature adjustment. The dependence of shape memory characteristics on degree of crosslinking was established. In addition to polycyclooctene, blends thereof with other materials such as SBR, EVA, polyurethane rubbers, and inorganic fillers can be utilized to provide chemically crosslinked products having excellent and tailored shape memory properties.06-24-2010
20100331954IMPLANTABLE MEDICAL DEVICES - A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.12-30-2010
20110054591IMPLANTABLE MEDICAL DEVICES - A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.03-03-2011
20110071562MEDICAL DEVICES - A medical device, such as, for example, a catheter, includes a tubular member having a first portion having a shape memory polymer.03-24-2011
20110172753ENDOPROSTHESES - Endoprosthesis are disclosed.07-14-2011

Patent applications by Changdeng Liu, Storrs, CT US

Chuanju Liu, Orange, CT US

Patent application numberDescriptionPublished
20100298232Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof - The present invention provides modulators of TNF, particularly peptides and their derivatives, particularly GEP peptides, which antagonize TNF and TNF-mediated responses, activity or signaling. The invention provides methods of antagonizing TNF and the modulation of TNF-mediated diseases or responses, including inflammatory diseases and conditions. Compositions of GEP peptides, including in combination with other inflammatory mediators, are provided. Methods of treatment, alleviation, or prevention of TNF-mediated diseases and inflammatory conditions, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, inflammatory bowel diseases, Chrohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, are provided.11-25-2010

Cuixan Liu, Madison, CT US

Patent application numberDescriptionPublished
20090304605Substituted Aminothiazole Prodrugs of Compounds with Anti-HCV Activity - The invention provides amino-substituted aminothiazole compounds of Formula I and Formula II12-10-2009

Cuixian Liu, Madison, CT US

Patent application numberDescriptionPublished
20090041720HETEROARYL SUBSTITUTED THIAZOLES - The invention provides heteroaryl substituted thiazolo compounds of Formula I and II02-12-2009
201001521034-AMINO-4-OXOBUTANOYL PEPTIDE CYCLIC ANALOGUES, INHIBITORS OF VIRAL REPLICATION - The invention provides 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Formula I06-17-2010
20100216725 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION - The invention provides 4-amino-4-oxobutanoyl peptides of Formula I08-26-2010

Patent applications by Cuixian Liu, Madison, CT US

Cuixian Liu, Branford, CT US

Patent application numberDescriptionPublished
20090023730SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION - The invention provides compounds and pharmaceutically acceptable salts of Formula I01-22-2009

Patent applications by Cuixian Liu, Branford, CT US

Hai Paul Liu, New Haven, CT US

Patent application numberDescriptionPublished
20100034084Reliability as an Interdomain Service - A system and techniques are disclosed that increase the redundancy (i.e., physical diversity and bandwidth) available to an IP network, thereby increasing the failure processing capability of IP networks. The techniques include pooling the resources of multiple networks together for mutual backup purposes to improve network reliability and employing methods to efficiently utilize both the intradomain and the interdomain redundancies provided by networks at low cost.02-11-2010

Hongjie Liu, Shelton, CT US

Patent application numberDescriptionPublished
20100210500Personal Wash Compositions Comprising Specific Blends of Saturated (Hydrogenated) Oil to Unsaturated Triglyceride Oils - The present invention provides personal wash compositions where blends of triglyceride oils are specifically formulated to provide functional benefits. Specifically when formulated to have specific blend of saturated to unsaturated oils, perfect balance between, on the one hand, spreadability and deposition and, on the other hand, retention of excellent framing, is achieved.08-19-2010

Jianping Liu, S. Glastonbury, CT US

Patent application numberDescriptionPublished
20090232996METAL TREATMENT COATING COMPOSITIONS, METHODS OF TREATING METALS THEREWITH AND COATED METALS PREPARED USING THE SAME - Methods comprising: (a) providing a coating composition comprising a fluoroacid compound of the general formula (I):09-17-2009

Junjian Liu, Norwich, CT US

Patent application numberDescriptionPublished
20100076178Dual Variable Domain Immumoglobulins and Uses Thereof - The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.03-25-2010

Kevin K. Liu, East Lyme, CT US

Patent application numberDescriptionPublished
20110028452PYRIDO[4,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS - The present invention is directed to novel pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula I02-03-2011

Patent applications by Kevin K. Liu, East Lyme, CT US

Kitty P. Liu, Waterbury, CT US

Patent application numberDescriptionPublished
20110210564BI-STABLE ACTUATOR FOR ELECTRONIC LOCK - An actuator for an electronic door lock includes a stationary first magnet assembly, a beam, and a second magnet assembly. The first magnet includes at least one magnet stationarily positioned within the electronic door lock. The beam is movable relative to the first magnet assembly to a first position and a second position. The second magnet assembly is connected to the beam and is configured to be magnetically repulsed away from the first magnet assembly. The repulsion of the second magnet assembly maintains the beam in either the first or second position until the beam is selectively actuated therefrom.09-01-2011

Lance Y. Liu, Middlebury, CT US

Patent application numberDescriptionPublished
20090297926Use of large format prismatic lithium-ion cells in electric vehicles - This invention is directed to a battery pack with high energy density and a large format prismatic lithium-ion cell of at least 16 squre inches, comprising (1) at least one positive electrode, (2) at least one negative electrode, (3) a non-aqueous electrolyte, and (4) a homogeneous microporous membrane which comprises (a) a hot-melt adhesive, (b) an engineering plastics, (c) optionally a tackifier and (d) a filler having an average particle size of less than about 50 μm. The resulting battery pack can be used as power source for electric vehicles to extend its ranged up to 700 miles per charge.12-03-2009

Na Liu, Bloomfield, CT US

Patent application numberDescriptionPublished
20100014037Liquid crystal device and methods thereof - Provided is a liquid crystal (LC) device and method thereof. The device comprises (i) a body of liquid crystal, (ii) a first layer comprising a first material, and (iii) a second layer comprising a second material; wherein the first layer is located between the body of liquid crystal and the second layer; the first layer alone aligns the liquid crystal in a first orientation; the second layer alone aligns the liquid crystal in a second orientation; and the first orientation is different from the second orientation. With optimized first layer thickness, the invention can be used in sensor applications to improve detection sensitivity, and in LCD applications with enhanced control over LC pretilt transition.01-21-2010
20100029952Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems - Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.02-04-2010

Nian Liu, North Branford, CT US

Patent application numberDescriptionPublished
20100267698Benzimidazole and Pyridylimidazole Derivatives - This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I10-21-2010

Peiying Liu, Madison, CT US

Patent application numberDescriptionPublished
20090239838PYRROLOTRIAZINE KINASE INHIBITORS - The invention provides compounds of formula I09-24-2009
20100197654TRIAZINE KINASE INHIBITORS - The invention provides compounds of formula I08-05-2010
20110124623PYRROLOTRIAZINE KINASE INHIBITORS - The invention provides compounds of formula I05-26-2011

Patent applications by Peiying Liu, Madison, CT US

Pingrong Liu, Southbury, CT US

Patent application numberDescriptionPublished
20090325988Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof - Compounds of Formula (I)12-31-2009
20100093724Azaindazole Compounds As CCR1 Receptor Antagonists - Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.04-15-2010
20110086846Azaindazole Compounds As CCR1 Receptor Antagonists - Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis.04-14-2011
20110230521Pyrazole Compounds As CCR1 Antagonists - Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.09-22-2011

Patent applications by Pingrong Liu, Southbury, CT US

Qingjie Liu, Orange, CT US

Patent application numberDescriptionPublished
20080214545Substituted Pyrazolyl Urea Derivatives Useful in the Treatment of Cancer - The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).09-04-2008
20110136809Substituted Pyrazolyl Urea Derivatives Useful In The Treatment Of Cancer - The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).06-09-2011
20110172224NOVEL HETEROCYCLES - The invention relates to novel heterocycles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.07-14-2011

Patent applications by Qingjie Liu, Orange, CT US

Shwu-Huey Liu, Madison, CT US

Patent application numberDescriptionPublished
20100166892HERBAL COMPOSITION PHY906 AND ITS USE IN CHEMOTHERAPY - This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.07-01-2010
20100255129HERBAL COMPOSITION PHY906 AND ITS USE IN CHEMOTHERAPY - This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.10-07-2010
20110111070USE OF PHY906 AS TREATMENT FOR INFLAMMATORY BOWEL DISEASE AND/OR IRRITABLE BOWEL SYNDROME - The present invention includes a method of using PHY906 for treating a bowel disorder including inflammatory bowel disease and irritable bowel syndrome. Particularly, the present invention provides a multiple symptoms treatment for the bowel disorder.05-12-2011

Patent applications by Shwu-Huey Liu, Madison, CT US

Weimin Liu, Sandy Hook, CT US

Patent application numberDescriptionPublished
20080312185SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES - Disclosed are methods of treating cancer by administration of compounds according to formula (I):12-18-2008
20110224188DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES - Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.09-15-2011

Patent applications by Weimin Liu, Sandy Hook, CT US

Wu Liu, New London, CT US

Patent application numberDescriptionPublished
20110075807Intrafraction motion management using a rough to accurate monitoring strategy - An adaptive imaging method of monitoring intrafraction target motion during radiation therapy is provided that includes using a simultaneous Mega-Voltage (MV) imaging process and Kilo-Voltage (KV) imaging process to determine an initial 3D target position. 2D target position is monitored using the MV imaging process during a radiation therapy treatment delivery, and is in combination with an online-updated characterization of target motion that are disposed to estimate if the target has moved beyond a 3D threshold distance. The simultaneous MV imaging and KV imaging processes are for accurately determining a new 3D target position for intrafraction motion compensation and for further 2D imaging by the MV imaging process, where another simultaneous MV and KV imaging process is initiated when the target has potentially moved beyond the threshold distance as measured by the MV imaging process. The intrafraction target motion monitoring is achieved at the cost of ultralow patient imaging dose.03-31-2011

Xiao-Gao Liu, New Haven, CT US

Patent application numberDescriptionPublished
20100125139PROCESS FOR PREPARING QUINAZOLINE RHO-KINASE INHIBITORS AND INTERMEDIATES THEREOF - A process for the preparation of various quinazoline compounds which are useful as Rho-Kinase inhibitors, and thus having utility in the treatment of hypertension and other indications.05-20-2010
20100137324RHO-KINASE INHIBITORS - Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.06-03-2010
20100216789RHO-KINASE INHIBITORS - Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.08-26-2010

Patent applications by Xiao-Gao Liu, New Haven, CT US

Xiaohong Liu, Wallingford, CT US

Xingrong Liu, East Lyme, CT US

Patent application numberDescriptionPublished
20100173333METHOD OF SCREENING CANDIDATE COMPOUNDS FOR SUSCEPTIBILITY TO BILIARY EXCRETION - A method of screening a candidate compound for susceptibility to biliary excretion. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile canaliculus; exposing a candidate compound to the culture; and determining an amount of candidate compound in the at least one bile canaliculus, the amount of candidate compound in the at least one bile canaliculus indicating the susceptibility of the candidate compound to biliary excretion. Optionally, the culture of hepatocytes is a long-term culture in a sandwich configuration. The method is particularly applicable to the screening of multiple candidate compounds in a single effort.07-08-2010

Yanbin Liu, New Haven, CT US

Patent application numberDescriptionPublished
20110247005Methods and Apparatus for Resource Capacity Evaluation in a System of Virtual Containers - Methods and apparatus are provided for evaluating potential resource capacity in a system where there is elasticity and competition between a plurality of containers. A dynamic potential capacity is determined for at least one container in a plurality of containers competing for a total capacity of a larger container. A current utilization by each of the plurality of competing containers is obtained, and an equilibrium capacity is determined for each of the competing containers. The equilibrium capacity indicates a capacity that the corresponding container is entitled to. The dynamic potential capacity is determined based on the total capacity, a comparison of one or more of the current utilizations to one or more of the corresponding equilibrium capacities and a relative resource weight of each of the plurality of competing containers. The dynamic potential capacity is optionally recalculated when the set of plurality of containers is changed or after the assignment of each work element.10-06-2011

Yongxing Liu, New Britain, CT US

Patent application numberDescriptionPublished
20080226893Methods for increasing the strength and controlling the architecture and composition of ceramic articles - Ceramic porous and non-porous articles are made by a process that includes a hardening step in which a fluid-containing ceramic composition is exposed to a solvent in which the fluid in the composition is soluble before the ceramic composition is solidified into the final ceramic article.09-18-2008