Liu, CO
Bolin Liu, Centennial, CO US
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20110182888 | Administration of an Inhibitor of HDAC, an Inhibitor of HER-2, and a Selective Estrogen Receptor Modulator - Methods of treating patients with an HDAC inhibitor and a HER-2 inhibitor are provided herein. In some embodiments, a SERM is also administered. | 07-28-2011 |
20140051744 | Markers For Assessing the Susceptibility of Cancer to Survivin-Targeting miRNA Treatment - The present invention relates to the use of miRNA treatment of survivin-positive cancer cells to increase sensitivity of cells to chemotherapy. | 02-20-2014 |
Chuan-Fa Liu, Longmont, CO US
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20090186822 | Thrombopoietic Compounds - The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal. | 07-23-2009 |
Dajiang Liu, Fort Collins, CO US
Hengsheng Liu, Colorado Springs, CO US
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20130271216 | High Side Current Sense Amplifier - A single stage current sense amplifier is described that generates a differential output that is proportional to a current through a sense resistor. The voltage across the sense resistor is Vsense. The current sense amplifier includes a differential transconductance amplifier having high impedance input terminals. An on-chip RC filter filters transients in the Vsense signal. A feedback circuit for each leg of the amplifier causes a pair of input transistors to conduct a fixed constant current irrespective of Vsense, which stabilizes the transconductance. A gain control resistor (Re) is coupled across terminals of the pair of input transistors and has Vsense across it. The current through the gain control resistor is therefore Vsensex1/Re. A level shifting circuit coupled to each of the input transistors lowers a common mode voltage at an output of the amplifier. Chopper circuits at the input and output cancel any offset voltages. | 10-17-2013 |
Jian-Yu Liu, Boulder, CO US
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20100322269 | TUNABLE LASER - A tunable laser has a gain material and a mirror defining an external resonant cavity. A tunable Fabry-Perot etalon disposed along the optical path between the mirror and the gain material includes a liquid crystal layer having a variable refractive index to tune the transmission peaks of the etalon and the resonant frequency of the laser resonant cavity. A second etalon having a fixed set of transmission peaks can also be included in the laser resonant cavity. The tunable etalon is then tuned to select a resonant frequency corresponding to one of the transmission peaks of the fixed etalon. | 12-23-2010 |
Jinfeng Liu, Longmont, CO US
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20120324307 | Systems and Methods for Retimed Virtual Data Processing - Various embodiments of the present invention provide systems and methods for data processing system. As one example, a data processing circuit is described that includes an analog to digital converter, an online timing loop, and an offline timing loop. The analog to digital converter receives an analog input and provides a first series of data samples Each bit of the first series of data samples corresponds to the analog input at a time controlled by an updated sampling clock. The online timing loop modifies the updated sampling clock based at least in part upon a processed version of the first series of data samples. | 12-20-2012 |
Lujiang Liu, Highlands Ranch, CO US
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20090055445 | ON DEMAND DATA CONVERSION - Novel tools for updating data structures in a database. In an aspect, the tools are used to update a database's structures in response to the update of an application (such as an enterprise application) that uses the database. In another aspect, the tools may convert a data set to a new format when the updated application attempts to access the data set; in some cases, other data sets within the database might remain unconverted until their use. Advantageously, this allows for a database (and/or a table within a database) to be updated incrementally and/or on demand. This feature can mitigate the impact of the update on users, for example, by avoiding the need to take the database (and/or application) offline to perform a batch process to update the database. | 02-26-2009 |
20120117493 | CONFIGURABLE METRIC GROUPS FOR PRESENTING DATA TO A USER - A dashboard application can enable a user to quickly view data (and, in a particular aspect, data from one or more business applications) in an efficient manner. The dashboard application can be used to view data about one or more metrics that reflect the performance of a business, as derived from data maintained (perhaps in an associated data store) by the business application(s). In an aspect, a user can select two or more metrics to be displayed on a summary page and/or can invoke a detail page to view detailed information about one of the two or more metrics. | 05-10-2012 |
Maozi Liu, Loveland, CO US
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20140151546 | MULTI-CAPILLARY COLUMN AND HIGH-CAPACITY IONIZATION INTERFACE FOR GC-MS - A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the mass analyzer. The ion beam may be converging. | 06-05-2014 |
Suo Win Liu, Longmont, CO US
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20100261236 | Genetically Stable Plasmid Expressing PDH and FDH Enzymes - Bi-cistronic plasmids used for the expression of formate dehydrogenase (FDH) and modified phenylalanine dehydrogenase (PDHmod) are provided. | 10-14-2010 |
Xuedong Liu, Niwot, CO US
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20130203681 | Macrocyclic Compounds Useful as Inhibitors of Histone Deacetylases - The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound. | 08-08-2013 |
Yingfang Liu, Denver, CO US
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20080306000 | Three-Dimensional Structures of TALL-1 and its Cognate Receptors and Modified Proteins and Methods Related Thereto - Disclosed are TALL-1 and TALL-1 receptor protein homologues (agonists and antagonists) designed based on the three-dimensional structure of sTALL-1, eBCMA and eBAFF-R; agonist homologues of APRIL; methods of using wild-type APRIL to inhibit the activity of TALL-1; compositions comprising such homologues, nucleic acid molecules encoding such homologues, and therapeutic methods of using such compounds and compositions. Also disclosed are crystalline complexes of sTALL-1 and sTALL-1 in complex with either BCMA or BAFF-R; models of three-dimensional structures of such crystalline complexes and related structures, methods of drug design using any portion of such structures; methods of design and/or identification of regulatory peptides derived from the such structures; compounds identified by drug design using such structures; and the use of such compounds in therapeutic compositions and methods. | 12-11-2008 |
20120165274 | THREE-DIMENSIONAL STRUCTURES OF TALL-1 AND ITS COGNATE RECEPTORS AND MODIFIED PROTEINS AND METHODS RELATED THERETO - Disclosed are TALL-1 and TALL-1 receptor protein homologues (agonists and antagonists) designed based on the three-dimensional structure of sTALL-1, eBCMA and eBAFF-R; agonist homologues of APRIL; methods of using wild-type APRIL to inhibit the activity of TALL-1; compositions comprising such homologues, nucleic acid molecules encoding such homologues, and therapeutic methods of using such compounds and compositions. Also disclosed are crystalline complexes of sTALL-1 and sTALL-1 in complex with either BCMA or BAFF-R; models of three-dimensional structures of such crystalline complexes and related structures, methods of drug design using any portion of such structures; methods of design and/or identification of regulatory peptides derived from the such structures; compounds identified by drug design using such structures; and the use of such compounds in therapeutic compositions and methods. | 06-28-2012 |
Youjian Liu, Westminster, CO US
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20150146646 | MAXIMIZING EFFICIENCY OF MULTI-USER COMMUNICATIONS NETWORKS - Systems and methods are described for jointly optimizing communications in a multi-user network to maximize the weighted sum-rate of its data links. For example, embodiments seek to maximize overall link transmit rates, while minimizing link interference and/or noise in general multi-in multi-out (MIMO) interference networks having multiple interfering data links, each with one or more antennas at the transmitter and receiver. Novel algorithmic approaches, including an “iterative minimax” approach and a “dual link” approach, are described for solving the weighted sum-rate maximization in a manner that converges quickly and reliably on an optimal point. Some embodiments implement these approaches in a centralized transmission controller, while others implement these approaches in a distributed fashion. | 05-28-2015 |
Yuntao Liu, Centennial, CO US
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20150339358 | MANAGING QUERIES IN BUSINESS INTELLIGENCE PLATFORMS - A method is provided for managing queries in business intelligence platforms. The method includes receiving, by a processor, a first query requesting data from at least one business intelligence content, the first query having a first format. The method further includes determining, by the processor, at least one requirement to complete the first query. The method further includes converting, by the processor, the first query to a second query configured to be used by an Extract, Transform, and Load (ETL) program, in response to determining that the at least one requirement exceeds a threshold, the second query having a second format. | 11-26-2015 |
Yuxiang Liu, Superior, CO US
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20120154584 | TECHNIQUES FOR ATMOSPHERIC AND SOLAR CORRECTION OF AERIAL IMAGES - Techniques for atmospheric and solar correction of aerial images are described. An apparatus may comprise an atmospheric and solar component arranged for execution by a logic device and operative to correct solar and atmosphere artifacts from an aerial image. The atmospheric and solar component may comprise an image information component operative to generate an image record for each aerial image of a group of aerial images, the image record comprising statistical information and image context information for each aerial image, a filter generation component operative to generate an atmospheric filter and a solar filter from the statistical information and the image context information stored in the image records, and an image correction component operative to correct atmospheric and solar artifacts from the aerial image using the respective atmospheric filter and solar filter. Other embodiments are described and claimed. | 06-21-2012 |
20120170842 | TONE MAPPING OF VERY LARGE AERIAL IMAGE MOSAIC - A method for tone mapping a high dynamic range image of a large terrestrial area into a lower dynamic range image uses: globally aware, locally adaptive approach whereby local tonal balancing parameter values are derived from known tone mapping parameters for a local 3×3 matrix of image tiles and used in turn to derive a local sigmoid transfer function for pixels in the tile in the middle of the matrix. A global sigmoid transfer function is derived based on values of the tone mapping parameters applicable to the entire image. A lower dynamic range image pixel will have a local tone mapped value and a globally tone mapped value, which are combined by giving each a weighted value to provide a final low dynamitic range pixel value. | 07-05-2012 |
Zhiming Liu, Englewood, CO US
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20090056991 | Methods of Treating a Surface to Promote Binding of Molecule(s) of Interest, Coatings and Devices Formed Therefrom - The present invention generally relates to methods of treating a surface of a substrate, and to the use of the method and resulting films, coatings and devices formed therefrom in various applications including but not limited to electronics manufacturing, printed circuit board manufacturing, metal electroplating, the protection of surfaces against chemical attack, the manufacture of localized conductive coatings, the manufacture of chemical sensors, for example in the fields of chemistry and molecular biology, the manufacture of biomedical equipment, and the like. In another aspect, the present invention provides a printed circuit board, a printed circuit board, comprising: at least one metal layer; a layer of organic molecules attached to the at least one metal layer; and an epoxy layer atop said layer of organic molecules. | 03-05-2009 |
20090056994 | Methods of Treating a Surface to Promote Metal Plating and Devices Formed - Embodiments of the present invention provide methods of treating a surface of a substrate. In one particular aspect, embodiments of the present invention provide methods of treating a surface of a substrate that promote binding of one or more metal elements to the surface. According to some embodiments of the invention, films are formed on any conducting, semiconductive or non-conductive surface, by thermal reaction of molecules containing reactive groups in an organic solvent or in aqueous solution. The thermal reaction may be produced under a variety of conditions. In another aspect, the present invention provides a printed circuit board, comprising: at least one substrate; a layer of organic molecules attached to the at least one substrate; and a metal layer atop said layer of organic molecules. | 03-05-2009 |
20100071938 | METHODS OF TREATING A SURFACE TO PROMOTE METAL PLATING AND DEVICES FORMED - Embodiments of the present invention provide methods of treating a surface of a substrate. In one particular aspect, embodiments of the present invention provide methods of treating a surface of a substrate that promote binding of one or more metal elements to the surface. According to some embodiments of the invention, films are formed on any conducting, semiconductive or non-conductive surface, by thermal reaction of molecules containing reactive groups in an organic solvent or in aqueous solution. The thermal reaction may be produced under a variety of conditions. In another aspect, the present invention provides a printed circuit board, comprising: at least one substrate; a layer of organic molecules attached to the at least one substrate; and a metal layer atop said layer of organic molecules. | 03-25-2010 |
20100075427 | METHODS OF TREATING A SURFACE TO PROMOTE METAL PLATING AND DEVICES FORMED - Embodiments of the present invention provide methods of treating a surface of a substrate. In one embodiment a kit for carrying out the binding of metals to a substrate is provided, comprising: a container comprising a heat-resistant organic molecule derivatized with an attachment group Y and a binding group X, the binding group X promotes binding of metals; and instructional materials teaching coupling the organic molecule to the substrate by heating the molecule and/or the surface to a temperature of at least 25° C. | 03-25-2010 |
20120125514 | Methods Of Treating Copper Surfaces For Enhancing Adhesion To Organic Substrates For Use In Printed Circuit Boards - Embodiments of the present invention relates generally to the manufacture of printed circuit boards (PCB's) or printed wiring boards (PWB's), and particularly to methods for treating smooth copper surfaces to increase the adhesion between a copper surface and an organic substrate. More particularly, embodiments of the present invention related to methods of achieving improved bonding strength of PCBs without roughening the topography of the copper surface. The bonding interface between the treated copper and the resin layer of the PCB exhibits excellent resistance to heat, moisture, and chemicals involved in post-lamination process steps. | 05-24-2012 |
20140251502 | Methods of Treating Metal Surfaces and Devices Formed Thereby - Embodiments of the present invention relate generally to methods of treating metal surfaces to enhance adhesion or binding to substrates, and devices formed thereby. In some embodiments of the present invention, methods of achieving improved bonding strength without roughening the topography of a metal surface are provided. The metal surface obtained by this method provides strong bonding to resin layers. The bonding interface between the treated metal and the resin layer exhibits resistance to heat, moisture, and chemicals involved in post-lamination process steps, and therefore can suitably be used in the production of PCB's. Methods according to some embodiments of the present invention are especially useful in the fabrication of high density multilayer PCB's, in particular for PCB's having circuits with line/spacing of equal to and less than 10 microns. Methods according to other embodiments of the present invention are particularly useful in the coating of metal surfaces in a wide variety of applications. | 09-11-2014 |
20140261897 | Methods of Treating Metal Surfaces and Devices Formed Thereby - Embodiments of the present invention relate generally to methods of treating metal surfaces to enhance adhesion or binding to substrates, and devices formed thereby. In some embodiments of the present invention, methods of achieving improved bonding strength without roughening the topography of a metal surface are provided. The metal surface obtained by this method provides strong bonding to resin layers. The bonding interface between the treated metal and the resin layer exhibits resistance to heat, moisture, and chemicals involved in post-lamination process steps, and therefore can suitably be used in the production of PCB's. Methods according to some embodiments of the present invention are especially useful in the fabrication of high density multilayer PCB's, in particular for PCB's having circuits with line/spacing of equal to and less than 10 microns. Methods according to other embodiments of the present invention are particularly useful in the coating of metal surfaces in a wide variety of applications. | 09-18-2014 |
20150050422 | METHOD FOR PROMOTING ADHESION BETWEEN DIELECTRIC SUBSTRATES AND METAL LAYERS - The present invention relates to novel processes for metallization of dielectric substrate surfaces applying organosilane compositions followed by oxidative treatment. The method results in metal plated surfaces exhibiting high adhesion between the substrate and the plated metal while at the same time leaves the smooth substrate surface intact. | 02-19-2015 |