Littler
Ben Littler, Mount Prospect, IL US
Patent application number | Description | Published |
---|---|---|
20090124810 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES - Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: | 05-14-2009 |
20110071295 | PROCESS FOR PRODUCTION OF PIPERIDINE DERIVATIVES - Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: | 03-24-2011 |
Benjamin Littler, Carlsbad, CA US
Patent application number | Description | Published |
---|---|---|
20110065928 | Process for Preparing Azabicyclic Compounds - The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof. | 03-17-2011 |
20110124869 | Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 05-26-2011 |
20120259129 | Process for Preparing Azabicyclic Compounds - The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof. | 10-11-2012 |
20130072687 | Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 03-21-2013 |
20140187787 | PROCESS FOR PREPARING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 07-03-2014 |
20140336393 | PROCESS FOR PREPARING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 11-13-2014 |
Benjamin Littler, San Diego, CA US
Patent application number | Description | Published |
---|---|---|
20090221835 | PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF - The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH. | 09-03-2009 |
20110003996 | Crystal Forms of (3R)-1-(2-Methylalanyl-D-Tryptophyl)-3-(Phenylmethyl)-3-Piperidinecarboxy- lic Acid 1,2,2-Trimethylhydrazide - Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone. | 01-06-2011 |
20130281701 | CRYSTAL FORMS OF ANAMORELIN - Crystalline forms of anamorelin which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone. | 10-24-2013 |
Benjamin J. Littler, Mount Prospect, IL US
Patent application number | Description | Published |
---|---|---|
20090137813 | PROCESS FOR PRODUCTION OF CAREBASTINE - Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: | 05-28-2009 |
20110065923 | PROCESS FOR PRODUCTION OF CAREBASTINE - Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: | 03-17-2011 |
Benjamin Joseph Littler, Carlsbad, CA US
Patent application number | Description | Published |
---|---|---|
20130089625 | Compounds Useful as Inhibitors of ATR Kinase - The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. | 04-11-2013 |
20130116238 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 05-09-2013 |
20130184292 | Processes for Making Compounds Useful as Inhibitors of ATR Kinase - The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. | 07-18-2013 |
20130324743 | PROCESS OF PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS - The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis. | 12-05-2013 |
20150218122 | Process of Producing Cycloalkylcarboxamido-indole Compounds - The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis. | 08-06-2015 |
David Littler, Shanghai CN
Patent application number | Description | Published |
---|---|---|
20110164385 | LIQUID COOLER AND METHOD OF ITS MANUFACTURE - A liquid cooler including a heat sink. A hollow body is produced by extrusion having at least one flat outer surface between a first and a second end. At least one elongated cavity passes through the body from the first to the second end. The hollow body includes a plurality of parallel fins directed into and along the at least one cavity. An insert housed in the at least one cavity connects the tops of the fins in a fluid-tight manner thereby forming liquid channels for a coolant liquid between the insert and the hollow body. A lid is attached at both ends of the hollow body for forming a liquid cooling system. | 07-07-2011 |
Graham Littler, Nottingham GB
Patent application number | Description | Published |
---|---|---|
20120257964 | STATOR VANE ASSEMBLY - There is disclosed a stator vane assembly comprising a support structure | 10-11-2012 |
Graham Robert Littler, Nottingham GB
Patent application number | Description | Published |
---|---|---|
20150260049 | BLADED ROTOR - There is proposed a bladed rotor for a turbo-machine, the rotor having a rotational axis and including a hub defining a plurality of circumferentially spaced-apart slots around its periphery. Each slot slideably receives a root portion of a respective rotor blade, the root portion of each blade defining a radially inwardly open retaining groove within which a respective region of a retaining ring locates to retain the blades in said slots. The retaining ring also engages within a plurality of radially inwardly open hub grooves formed around the hub. The retaining ring engages each said hub groove such that a radial gap is defined between the retaining ring and a radially outermost region of each hub groove . | 09-17-2015 |
Ian Charles Murray Littler, New South Wales AU
Patent application number | Description | Published |
---|---|---|
20100315642 | SPECTROSCOPIC DETECTION SYSTEM AND METHOD - A system and method for spectroscopic detection of a loss in a resonator cavity. The system comprises: a tunable laser source for generating a laser beam; a frequency locking system for either locking the frequency of the laser beam to a resonance of the resonator cavity or locking the length of the cavity to the frequency of the laser beam; a first modulation element for modulating the laser beam at a first modulation frequency to generate a modulated laser beam; an input coupler adapted for directing the modulated laser beam into the resonator cavity; a first directing element for directing a first portion of light reflected from the input coupler to a first photodetector to generate a first detected signal; and a first demodulator capable of demodulating the first modulation signal from the first detected signal to generate a first error signal which is a function of the loss in the resonator cavity. | 12-16-2010 |
Ian C. M. Littler, Balmain Nsw AU
Patent application number | Description | Published |
---|---|---|
20110283795 | System, Device And Method For Detecting Seismic Acceleration - A device for detecting seismic acceleration including a proof mass; a base for providing a sensor acceleration, relative to the proof mass, based on the seismic acceleration; an optical fibre portion operatively connected between the proof mass and the base for providing a fibre tension based on the sensor acceleration, a fibre Fabry-Perot interferometer (FFPI) in the optical fibre portion for providing an optical characteristic representative of the fibre tension, and a compensator for applying a compensating tension to the FFPI to compensate for a change of the optical characteristic due to a temperature change of the FFPI. | 11-24-2011 |
Ian C. M. Littler, Balmain AU
Patent application number | Description | Published |
---|---|---|
20110122904 | Methods And Systems For Frequency Stabilisation Of Multiple Lasers - A system and method for stabilising a plurality of output frequencies (wavelengths) of a plurality of lasers ( | 05-26-2011 |
Scott Robert Littler, Nashville, TN US
Patent application number | Description | Published |
---|---|---|
20110144807 | POWER MONITOR FOR VAPOR COMPRESSION EQUIPMENT DIAGNOSTICS - A method of automatically detecting an anomalous condition relative to a nominal operating condition in a vapor compression system. An expected input power function in the form of a hyperplane is calculated based on three temperature readings: an intake temperature from an intake area of the condenser unit, a return temperature from an intake area of an evaporator unit, and a supply temperature from a supply output area of the evaporator unit. The function produces an estimate of the expected input power consumed by the compressor unit, and this expected input power is compared with an actual input power measured from the compressor unit. If the expected input power deviates from the measured input power by more than a predetermined tolerance, an indication is stored and communicated that an anomalous condition, such as a refrigerant loss, condenser unit fouling, or a malfunctioning fan, exists in the vapor compression system. | 06-16-2011 |
Stephen Littler, Morton GB
Patent application number | Description | Published |
---|---|---|
20090139440 | SUBMARINE ESCAPE SUIT - A submarine escape suit includes an ascent stole ( | 06-04-2009 |
Steve Littler, Merseyside GB
Patent application number | Description | Published |
---|---|---|
20090313747 | SUBMARINE ESCAPE SUITS - The submarine escape suit has a hood ( | 12-24-2009 |
Steve Littler, Moreton GB
Patent application number | Description | Published |
---|---|---|
20090301377 | SUBMARINE ESCAPE SUIT ASSEMBLIES - A submarine escape suit assembly comprises a submarine escape suit ( | 12-10-2009 |
20100024087 | SUBMARINE ESCAPE SUITS - A submarine escape suit is made longitudinally adjustable by elastic adjustment members ( | 02-04-2010 |