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Little, WA

Blake Little, Bothell, WA US

Patent application numberDescriptionPublished
20090171252THERAPY HEAD FOR USE WITH AN ULTRASOUND SYSTEM - Therapy heads and related medical systems having an actuation assembly for controlling the position/orientation of a directional energy applicator in at least two planes are disclosed. A therapy head includes an enclosure, a partition separating a lower compartment from an upper compartment, an aperture in the partition, a control arm extending through the aperture, an actuation assembly positioned within the upper compartment, and a directional energy applicator positioned in the lower compartment for transmitting energy through a window. The control arm includes an upper end disposed within the upper compartment and a lower end disposed within the lower compartment. The actuation assembly is coupled with the upper end of the control arm such that the control arm is movable by the actuation assembly in at least two planes. The directional energy applicator is coupled with the lower end of the control arm.07-02-2009
20100241034ANALYSIS OF REAL TIME BACKSCATTER DATA FOR FAULT SIGNAL GENERATION IN A MEDICAL HIFU DEVICE - A method and system for checking functionality of an ultrasound therapy head. The waveform profile for typical ultrasound reflections for a functional therapy head are stored, and before use of a therapy head, an ultrasound energy burst (09-23-2010
20100249669ULTRASONIC TREATMENT OF ADIPOSE TISSUE AT MULTIPLE DEPTHS - Methods and apparatus (09-30-2010

Blake W. Little, Bothell, WA US

Patent application numberDescriptionPublished
20090275835MODULAR APPARATUS FOR DIAGNOSTIC ULTRASOUND - A modular diagnostic ultrasound apparatus is provided comprising a core unit, system electronics and an I/O port. The core unit comprises a housing and a system electronics package within the housing. The system electronics has one or more concatenated filters, including a front end transmit/receive circuit, a processor, a back end circuit for scan conversion, a system clock and a programmable system memory device. There is at least one I/O port connected to the front end and the back end of the system electronics package and extending through the core unit housing wherein all system data processing information is transmitted or received through the I/O port.11-05-2009
20100274131Balance Body Ultrasound System - The present invention relates to a hand held ultrasound system having a balance body, a transducer assembly connected to said balance body via a communication means and a plurality of control elements arranged in an ergonomic fashion on said balance body, such that a user may hold said system and operate at least one of said control elements with the same hand. In particular a medical ultrasound system comprising a balance body incorporating system electronics, a power supply and a user interface wherein the user interface comprises a D-controller and a touch screen and a transducer assembly attached to the balanced body by a cable. The present invention relates to a hand held ultrasound system having a balance body, a transducer assembly connected to said balance body via a communication means and a plurality of control elements arranged in an ergonomic fashion on said balance body, such that a user may hold said system and operate at least one of said control elements with the same hand. In particular a medical ultrasound system comprising a balance body incorporating system electronics, a power supply and a user interface wherein the user interface comprises a D-controller and a touch screen and a transducer assembly attached to the balanced body by a cable.10-28-2010
20110077556CARTRIDGE FOR USE WITH AN ULTRASOUND THERAPY HEAD - A medical ultrasound system. A base unit is included having system electronics, a user interface and ultrasound control electronics. An ultrasound therapy head is in electronic communication with the base unit. The therapy head includes a replaceable, sealed transducer cartridge with a coupling fluid therein. A cooling system is provided for cooling the coupling fluid. A plurality of guide indicators are positioned around the therapy head to align with crossed lines on a patient so as to properly align the therapy head prior to use. The therapy head can provide variable treatments to an area while the therapy head is in contact with a patient.03-31-2011
20110077557MEDICAL ULTRASOUND DEVICE WITH LIQUID DISPENSING DEVICE COUPLED TO A THERAPY HEAD - A medical ultrasound system. A base unit is included having system electronics, a user interface and ultrasound control electronics. An ultrasound therapy head is in electronic communication with the base unit. The therapy head includes a replaceable, sealed transducer cartridge with a coupling fluid therein. A cooling system is provided for cooling the coupling fluid. A plurality of guide indicators are positioned around the therapy head to align with crossed lines on a patient so as to properly align the therapy head prior to use. The therapy head can provide variable treatments to an area while the therapy head is in contact with a patient.03-31-2011

Patent applications by Blake W. Little, Bothell, WA US

Charles Reeves Little, Bellevue, WA US

Patent application numberDescriptionPublished
20110258562CROSS-BROWSER WEB DIALOG PLATFORM - A cross-browser dialog platform is provided for supporting hosted web pages in a dialog, such that a web page may be used inside or outside the dialog. Select elements on the hosted page may be hidden when in a dialog, different behavior may be specified for hyperlinks inside or outside the dialog, and a proper size of the dialog may be inferred from its contents without designer input.10-20-2011

James W. Little, Seattle, WA US

Patent application numberDescriptionPublished
20100234728ULTRASOUND GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES - A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.09-16-2010
20110009734IMAGE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES - A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.01-13-2011
20110040171IMAGE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES - A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.02-17-2011
20110040214IMAGE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES - A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.02-17-2011

Patent applications by James W. Little, Seattle, WA US

Mark L. Little, Auburn, WA US

Patent application numberDescriptionPublished
20090064787ULTRASONIC INSPECTION APPARATUS, SYSTEM, AND METHOD - Improved apparatus, systems, and methods for inspecting a structure are provided that use a pedestal robot mounted on a rail system, a probe extension coupler, and an inspection probe capable of performing pulse echo ultrasonic inspection. A probe may also include sled appendages and an axial braking system to inspect over holes and off edges. A probe may also include an ultrasonic pulse echo transducer array for high rate inspection; the transducer array may be mounted in a bubbler shoe for individually coupling each of the transducers in the array. A rail system may also include an optical encoder for providing location information for the robot and axial braking system. A probe extension coupler presses the inspection probe against the structure for adjusting to changes in surface contours.03-12-2009

Robert A. Little, Redmond, WA US

Patent application numberDescriptionPublished
20080209551File Conversion in Restricted Process - Embodiments are described for removing malicious code from a file in a first file format by converting the file into a converted file of a second file format. In embodiments, converting the file eliminates malicious code embedded within the file from being stored in the converted file. The conversion is performed within a restricted computer process that has restricted privileges limiting its access to an operating system and an underlying computer system. As a result, even if malicious code embedded within the file executes while the file is being converted into the converted file, the damage to a computer system is mitigated because of the limited privileges provided to the restricted process.08-28-2008
20080243892Automatic file conversion to a target format - A conversion tool that is automatically launched enables file formats not understood by a given application to be opened by that application. The converter registers for file types that are not already associated with an application used by the system. When a file that is not supported by another application is opened, the converter automatically converts the file to the target format and then opens the file causing the application that is registered for the target format to be launched.10-02-2008
20090172709Text Editor Virtual Backing Store - At an interface between a text engine and a first client application, text and first client application properties associated with the text may be received from the first client application. Then the interface may map the first client application properties associated with the text to text engine properties associated with the text. Next, the interface may provide the text and the text engine properties associated with the text to the text engine. The text engine may process the text. Next, the text engine may provide the processed text and the text engine properties associated with the processed text to the interface. The interface may then map the text engine properties associated with the processed text to the first client application properties associated with the processed text. The interface may then provide the processed text and the first client application properties associated with the processed text to the first client application.07-02-2009
20100299371AUTOMATIC FILE CONVERSION TO A TARGET FORMAT - A conversion tool that is automatically launched enables file formats not understood by a given application to be opened by that application. The converter registers for file types that are not already associated with an application used by the system. When a file that is not supported by another application is opened, the converter automatically converts the file to the target format and then opens the file causing the application that is registered for the target format to be launched.11-25-2010

Patent applications by Robert A. Little, Redmond, WA US

Thomas Little, Redmond, WA US

Patent application numberDescriptionPublished
20090062353Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders - Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.03-05-2009
20090131374PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF - The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.05-21-2009
20090326074Alkoxy compounds for disease treatment - The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.12-31-2009

Patent applications by Thomas Little, Redmond, WA US

Thomas L. Little, Redmond, WA US

Patent application numberDescriptionPublished
20110224202PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS - Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.09-15-2011

Zachary W. Little, Redmond, WA US

Patent application numberDescriptionPublished
20110113485CREDENTIAL DEVICE PAIRING - In one or more implementations, a computing device receives an indication that a device is attempting to pair with the computing device. If a user is not currently authenticated with respect to the computing device, inputs received by the device are restricted from being used by the computing device for uses other than authenticating the user.05-12-2011