Patent application number | Description | Published |
20110268656 | J591 MINIBODIES AND CYS-DIABODIES FOR TARGETING HUMAN PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) AND METHODS FOR THEIR USE - In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided. | 11-03-2011 |
20140234215 | J591 MINIBODIES AND CYS-DIABODIES FOR TARGETING HUMAN PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) AND METHODS FOR THEIR USE - In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided. | 08-21-2014 |
Patent application number | Description | Published |
20100249779 | EXTERNAL FIXATION DEVICES AND METHODS OF USE - External fixation devices and methods of use are provided. A device for external fixation of a joint includes a first pin block for connection to a first skeletal element and a second pin block for connection to a second skeletal element. The device includes a connection assembly that is releasably attached to at least one of the pin blocks. The device is locked in an original position when the connection assembly is attached to both of the pin blocks, and is unlocked when the connection assembly is detached from at least one of the pin blocks. | 09-30-2010 |
20100274095 | EXPANDING CANNULA AND RETRACTOR DEVICE AND METHODS OF USE - Expanding cannula and retractor devices and methods of use are provided. An expanding cannula and retractor device includes a first tube, a second tube positioned within the first tube, and an expandable continuous membrane connecting distal portions of the first and second tubes. The membrane can expand into an annulus based on the movement of the second tube relative to the first tube in order to contact tissue and maintain the position of the device. | 10-28-2010 |
20120046526 | INSTRUMENTS FOR USE IN FEMOROACETABULAR IMPINGEMENT PROCEDURES - Improved instruments (tools) and surgical techniques are provided for use in surgical procedures that treat femoroacetabular impingement of both the Cam and Pincer types. | 02-23-2012 |
20120078258 | SHOULDER ARTHROPLASTY INSTRUMENTATION - Patient specific shoulder component implant instruments are described for hemi and total, normal and reverse shoulder arthroplasty. | 03-29-2012 |
20160022255 | INSTRUMENTS FOR USE IN FEMOROACETABULAR IMPINGEMENT PROCEDURES - Improved instruments (tools) and surgical techniques are provided for use in surgical procedures that treat femoroacetabular impingement of both the Cam and Pincer types. | 01-28-2016 |
Patent application number | Description | Published |
20110125274 | ELBOW REPLACEMENT APPARATUS AND METHODS - Apparatus and methods for total elbow replacement are provided to allow a surgeon to intraoperatively select a linked or unlinked constraint by utilizing a connection located on the body of the ulnar and/or humeral stem. Additional modularity also allows the selection of a cemented or cementless stem as described herein. The modularity and adjustability provides a number of advantages. | 05-26-2011 |
20110125275 | PROSTHETIC CONDYLAR JOINTS WITH ARTICULATING BEARING SURFACES HAVING A TRANSLATING CONTACT POINT DURING ROTATION THEREOF - A prosthetic joint according to the present invention includes a first implant component for attachment to a first bone and a second implant component for attachment to a second bone. The first implant component has a condylar portion that includes first and second condylar bearing surfaces and similarly, the second implant component has bearing surfaces that receive and are complementary to the first and second condylar bearing surfaces. Each of the first and second condylar bearing surfaces and each of the bearing surfaces of the second implant component has a cross-section in a coronal plane that exhibits two different radii and a contact point is established between the first and second condylar bearing surfaces and the bearing surfaces of the second implant component. The bearing surfaces of the respective implant components are configured such that varus and valgus rotation of the first implant component relative to the second implant component causes the contact point to move outwardly. | 05-26-2011 |
20110125279 | CONSTRAINED CONDYLAR KNEE DEVICE - A knee joint prosthesis includes a femoral component having a first condylar bearing surface and a second condylar bearing surface. Each of the first and second condylar bearing surfaces has a cross-section in a coronal plane that exhibits at least two different radii. The prosthesis also includes a tibial component and an insert component associated with the tibial component. The insert component has bearing surfaces that are complementary to the first and second condylar bearing surfaces, wherein a contact point is established between the bearing surfaces of the insert component and the first and second condylar bearing surface. In accordance with the present invention and as a result of the above construction, varus and valgus rotation of the femoral component relative to the insert component causes the contact point to move laterally as the knee is rotated. By shifting the contact pointy laterally/outwardly, the knee stability (i.e., stiffness) gradually increased. | 05-26-2011 |
20130046310 | METHOD FOR ORIENTING AN ACETUBULAR CUP AND INSTRUMENTS FOR USE THEREWITH - A patient-specific acetabular guide for use in orienting an acetabular component with respect to an acetabulum of a patient as part of a surgical procedure includes a body having a bottom contact surface that has a portion that is shaped and configured to initimately receive and interlockingly mate with an acetabular notch of the patient's acetabulum in accordance with a three-dimensional image of the acetabulum of the specific patient. The three-dimensional image can be in the form of a three-dimensional virtual model of the patient's acetabulum that is constructed at least in part on 3D image data of the pelvic region of the patient. | 02-21-2013 |
20140142712 | ELBOW REPLACEMENT APPARATUS AND METHODS - Apparatus and methods for total elbow replacement are provided to allow a surgeon to intraoperatively select a linked or unlinked constraint by utilizing a connection located on the body of the ulnar and/or humeral stem. Additional modularity also allows the selection of a cemented or cementless stem as described herein. The modularity and adjustability provides a number of advantages. | 05-22-2014 |
20140324169 | MULTI-COMPONENT NON-BIODEGRADABLE IMPLANT, A METHOD OF MAKING AND A METHOD OF IMPLANTATION - An implant comprising at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered “the hydrogel”), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant. | 10-30-2014 |
20150088143 | CUSTOMIZED UNICOMPARTMENTAL TIBIAL CUTTING GUIDE - A customized unicompartmental tibial cutting guide for orthopedic surgery is provided. The tibial cutting guide includes a first mating surface having a customized patient-specific negative contour to match a corresponding contour of an anterior region of a tibia of a patient and a second mating surface extending transverse to the first mating surface to a midpoint of a tibial plateau of a medial or lateral condyle of the tibia. The second mating surface includes a customized patient-specific negative contour to match a corresponding contour of a mid-region of the tibial plateau of the medial or lateral condyle. The second mating surface is limited to a region between an intercondyloid eminence and a lateral or medial edge of the tibial plateau. The tibial cutting guide also includes a first cutting guide surface and a second cutting guide surface positioned transverse to the first cutting guide surface. | 03-26-2015 |
20150230927 | POSTERIOR STABILIZED KNEE PROSTHESIS - A knee joint prosthesis includes a femoral component having an anterior side, a posterior side, a pair of laterally spaced condylar portions, and an intercondylar portion joining the condylar portions and including a recess. A cam surface is located adjacent the intercondylar recess on the anterior side of the femoral component and has a saddle shape that is defined by an at least substantially concave first radius of curvature and a convex third radius of curvature that is perpendicular to the concave first radius of curvature. The prosthesis also includes a tibial component including a platform having an upper surface that includes first and second laterally spaced concavities. Each concavity is adapted for receiving one condylar portion of the femoral component. The tibial component has a tibial post for reception in the intercondylar recess of the femoral component. The tibial post has a saddle shaped anterior earn surface that is complementary to the saddle shaped anterior cam surface of the femoral component and is defined by an at least substantially convex second radius of curvature and a concave fourth radius of curvature that is perpendicular to the convex second radius of curvature. | 08-20-2015 |
20150238272 | METHOD FOR ORIENTING AN ACETABULAR CUP AND INSTRUMENTS FOR USE THEREWITH - A patient-specific acetabular guide for use in orienting an acetabular component with respect to an acetabulum of a patient as part of a surgical procedure includes a body having a bottom contact surface that has a portion that is shaped and configured to initimately receive and interlockingly mate with an acetabular notch of the patient's acetabulum in accordance with a three-dimensional image of the acetabulum of the specific patient. The three-dimensional image can be in the form of a three-dimensional virtual model of the patient's acetabulum that is constructed at least in part on 3D image data of the pelvic region of the patient. | 08-27-2015 |
Patent application number | Description | Published |
20100010374 | Body fluid sampling device - sampling site interface - An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes: a housing, the housing comprising a first opening; a skin interface member disposed in the first opening, the skin interface member comprising an inner member having a second opening, and an outer member at least partially surrounding the inner member and attached to the first opening; and at least one skin-penetration member configured and arranged to project within the second opening. Arrangements having alternatively constructed skin interface members are also described. | 01-14-2010 |
20100021948 | Medical diagnostic devices and methods - A medical diagnostic device includes a wirelessly transmitted time data receiver and processor. Associated devices, methods and functionality are also described. | 01-28-2010 |
20100066543 | Health Monitoring Apparatus and Methods - A measurement module for glucose testing includes a glucose testing measurement module housing, a test strip receptacle formed in the housing, and a connector portion formed in the housing and shaped to permit mechanical removable attachment of the housing to a hand-held computer. Electronics determine the amount of glucose present in a sample of body fluid, when the test strip is positioned in the receptacle and the body fluid is placed on a test strip, and communicate the glucose amount to the hand-held computer via the connector portion. | 03-18-2010 |
20110294152 | CALIBRATION MATERIAL DELIVERY DEVICES AND METHODS - A device is described that includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. Related arrangements and methods are also described. | 12-01-2011 |
20120166090 | Analyte Monitoring Methods and Systems - A method is disclosed involving monitoring the concentration of at least one target analyte in a sample of body fluid using a meter, the meter including a user interface, the method including: obtaining a sample of body fluid; testing the sample to determine the concentration of the at least one target analyte contained therein; and presenting the user with a reminder to associate the test with an appropriate time corresponding to before or after a particular meal using the user interface. Associated devices, systems and arrangements are also disclosed. | 06-28-2012 |
20140365245 | METHOD FOR MANAGING TREATMENT OF A HEALTH CONDITION USING SUBJECTIVE SYMPTOM DATA - A method for managing treatment of a particular health condition afflicting a patient includes programming a processor with a health management application program that prompts a user for entry of health condition data, including a patient physiological data, subjective patient health condition data, and medication delivery data, compiles the health condition data into a data summary, and transmits the data summary through a communication unit. A drop-down list related to subjective symptoms is provided, which includes stress and depression. A display touch method is used to enter data, selections, and controls. The health management program also provides prompts for the entry of diet data, and further displays drop-down lists related to daily activities and alerts for medication delivery. | 12-11-2014 |
20140376762 | ANALYTE MONITORING SYSTEM WITH AUDIBLE FEEDBACK - Described here are devices, systems, and methods for analyte measurement. The analyte measurement devices and systems may be configured to produce a prompt that may convey information, instructions and/or encouragement to a user. In some variations, analyte measurement devices may be configured to change a prompt based on the replacement or addition of components of/to the device. In some instances, a prompt may be an auditory prompt and/or a visual prompt. In some variations, a system may comprise an analyte measurement device comprising a housing, a speaker, and a control unit. The housing may comprise a releasable housing portion comprising an identifier that is associated with a prompt. In some variations, a system may comprise an analyte measurement device and a skin that may releasably attach to the analyte measurement device and may comprise an identifier that is associated with a prompt. | 12-25-2014 |
20150153351 | CALIBRATION MATERIAL DELIVERY DEVICES AND METHODS - A device includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. | 06-04-2015 |
20150302164 | Method for Managing Treatment of a Health Condition Using Subjective Symptom Data - A method for managing treatment of a particular health condition afflicting a patient includes programming a processor with a health management application program that prompts a user for entry of health condition data, including a patient physiological data, subjective patient health condition data, and medication delivery data, compiles the health condition data into a data summary, and transmits the data summary through a communication unit. A drop-down list related to subjective symptoms is provided, which includes stress and depression. A display touch method is used to enter data, selections, and controls. The health management program also provides prompts for the entry of diet data, and further displays drop-down lists related to daily activities and alerts for medication delivery. | 10-22-2015 |
Patent application number | Description | Published |
20110019572 | METHOD AND APPARATUS FOR SHARED SHAPING - A method and a network device for sharing bandwidth among a group of classes of traffic for an interface are provided. Bandwidth may be allocated to at least one traffic class of a first priority for the interface. At least some unused bandwidth of the at least one traffic class may be allocated to at least one other traffic class of a second priority for the interface. In some implementations, weighted constituents may be allocated unused interface bandwidth based on an assigned weight of each of the weighted constituents of the interface. | 01-27-2011 |
20120027015 | Application of Services in a Packet Switching Device - A service is applied in a packet switching device to both directions of a flow of packets through the packet switching device, with the application of this Layer-4 to layer-7 service to one direction requiring state information shared from the application of the service to packets traversing in the other direction. The service (e.g. firewall, network address translation) can be applied by different processing complexes which do not share memory; thus, state information is communicated between the processing complexes. When the service is applied by a single processing complex, packets can be directed explicitly to the single processing complex. The inline application of services in a packet switching system typically eliminates the need to change a packet's path through the packet switching system to that through a dedicated application server, and may eliminate the need for a dedicated services card or blade server. | 02-02-2012 |
20120266181 | SCALABLE PACKET PROCESSING SYSTEMS AND METHODS - A data processing architecture includes multiple processors connected in series between a load balancer and reorder logic. The load balancer is configured to receive data and distribute the data across the processors. Appropriate ones of the processors are configured to process the data. The reorder logic is configured to receive the data processed by the processors, reorder the data, and output the reordered data. | 10-18-2012 |
20130114613 | Virtual Machines in a Packet Switching Device - In one embodiment, a packet switching device creates multiple virtual packet switching devices within the same physical packet switching device using virtual machines and sharing particular physical resources of the packet switching device. One embodiment uses this functionality to change the operating version (e.g., upgrade or downgrade) of the packet switching device by originally operating according to a first operating version, operating according to both a first and second operating version, and then ceasing operating according to the first operating version. Using such a technique, a packet switching device can be upgraded or downgraded while fully operating (e.g., without having to reboot line cards and route processing engines). | 05-09-2013 |
20140112342 | Cascaded Communication of Serialized Data Streams Through Devices and Their Resulting Operation - In one embodiment, an apparatus cascades groups of serialized data streams through devices, and performs operations based on information communicated therein. A received group of serialized data streams is aligned, but not framed, and forwarded to a next device (e.g., a next stage in a linear or tree cascaded formation of devices). Eliminating the framing and subsequent serialization operations performed on the received group of serialized data streams reduces the latency of communications through the cascaded devices, which can be significant when considered in relation to the high-speed communication rates. The received group of serialized data streams is also framed to create a sequence of data frames for processing (e.g., associative memory lookup operations, controlling multiplexing of received downstream serialized data streams, general or other processing) within the device. | 04-24-2014 |
20140379938 | HIERARCHICAL LOAD BALANCING IN A NETWORK ENVIRONMENT - An example method for load balancing in a network environment is provided and includes receiving a packet from a first stage load-balancer in a network environment, where the packet is forwarded from the first stage load-balancer to one of a plurality of second stage load-balancers in the network according to a hash based forwarding scheme, and routing the packet from the second stage load-balancer to one of a plurality of servers in the network according to a per-session routing scheme. The per-session routing scheme includes retrieving a session routing state from a distributed hash table in the network. In a specific embodiment, the hash based forwarding scheme includes equal cost multi path routing. The session routing state can include an association between a next hop for the packet and the packet's 5-tuple representing a session to which the packet belongs. | 12-25-2014 |
20150215819 | Method for Providing Sticky Load Balancing - Presented herein are techniques to reduce the number of redirected subscriber packet flows while performing sticky hierarchical load balancing. An Nth head end network element may be activated such that a plurality of N head end network elements are active and capable of receiving and processing one or more packet flows. A primary load balancer may then be directed to overwrite a portion of pointers of a hash table in an evenly distributed manner with pointers to the Nth head end network element such that packet flows are forwarded to the Nth head end network element, wherein the hash table retains a static number of entries as the number of head end network elements is modified. | 07-30-2015 |
20150309805 | Booting a Physical Device Using Custom-Created Frozen Partially-Booted Virtual Machines - In one embodiment, a physical device (e.g., packet switching device, computer, server) is booted using custom-created frozen partially-booted virtual machines, avoiding the time required for an end-to-end boot process. In one embodiment while the system is operating under a current version, a partially-booted virtual image of a new operating version for each of multiple processing elements of the device is produced according to static configuration information specific to the device, with each of these partially-booted virtual machines frozen. The device is rebooted to a fully operational device by unfreezing these partially-booted virtual machines, thus removing this portion of a boot process from the real-time booting of the device. The generation of the frozen partially-booted virtual machines is advantageously performed by the device itself based on current static configuration information and the availability of the specific hardware configuration of the device. | 10-29-2015 |
20160021002 | Virtual Machines in a Packet Switching Device - In one embodiment, a packet switching device creates multiple virtual packet switching devices within the same physical packet switching device using virtual machines and sharing particular physical resources of the packet switching device. One embodiment uses this functionality to change the operating version (e.g., upgrade or downgrade) of the packet switching device by originally operating according to a first operating version, operating according to both a first and second operating version, and then ceasing operating according to the first operating version. Using such a technique, a packet switching device can be upgraded or downgraded while fully operating (e.g., without having to reboot line cards and route processing engines). | 01-21-2016 |
Patent application number | Description | Published |
20140028631 | INPUT SYSTEM FOR CONTROLLING ELECTRONIC DEVICE - An electronic device includes a display for displaying data stored on said electronic device; input means; sensing means for sensing the three-dimensional position of the input means relative to said device; and control means for controlling the data displayed on said display in dependence on the three-dimensional position of the input means relative to said device. The input means includes a source of electromagnetic radiation for directing an infrared conical beam onto the display. The sensing means can sense the elliptical eccentricity of the electromagnetic radiation incident on the display to determine the angle at which it strikes the display, and can sense the area of the electromagnetic radiation incident on the display to determine the distance of the input means from the display. | 01-30-2014 |
20140118286 | INTERACTIVE DEVICES - An interactive assembly including at least one interactive surface element, at least a first region of the at least one interactive surface element having first user sensible functionality and at least a second region of the at least one interactive surface element having second functionality, different from the first user sensible functionality, input sensor functionality, including at least one input sensor located in propinquity to at least one of the at least one interactive surface element, operative to sense impingement of an electromagnetic radiation spot on at least one of the at least one first region and the at least one second region of the at least one interactive surface element and utilization functionality for employing outputs of the input sensor functionality in respect of impingement on either or both of the at least one first region and the at least one second region. | 05-01-2014 |
20140132542 | DISPLAYS AND INFORMATION INPUT DEVICES - An integrated display and input device including a pixel array operative to provide a visually sensible output, at least one sensor operative to sense at least a position of at least one object with respect to the pixel array when the at least one object has at least a predetermined degree of propinquity to the pixel array and circuitry receiving an output from the at least one sensor and providing a non-imagewise input representing the position of the at least one object relative to the pixel array to utilization circuitry. | 05-15-2014 |
20140362058 | INPUT SYSTEM FOR CONTROLLING ELECTRONIC DEVICE - An electronic device includes a display for displaying data stored on said electronic device; input means; sensing means for sensing the three-dimensional position of the input means relative to said device; and control means for controlling the data displayed on said display in dependence on the three-dimensional position of the input means relative to said device. The input means includes a source of electromagnetic radiation for directing an infrared conical beam onto the display. The sensing means can sense the elliptical eccentricity of the electromagnetic radiation incident on the display to determine the angle at which it strikes the display, and can sense the area of the electromagnetic radiation incident on the display to determine the distance of the input means from the display. | 12-11-2014 |
Patent application number | Description | Published |
20140028631 | INPUT SYSTEM FOR CONTROLLING ELECTRONIC DEVICE - An electronic device includes a display for displaying data stored on said electronic device; input means; sensing means for sensing the three-dimensional position of the input means relative to said device; and control means for controlling the data displayed on said display in dependence on the three-dimensional position of the input means relative to said device. The input means includes a source of electromagnetic radiation for directing an infrared conical beam onto the display. The sensing means can sense the elliptical eccentricity of the electromagnetic radiation incident on the display to determine the angle at which it strikes the display, and can sense the area of the electromagnetic radiation incident on the display to determine the distance of the input means from the display. | 01-30-2014 |
20140118286 | INTERACTIVE DEVICES - An interactive assembly including at least one interactive surface element, at least a first region of the at least one interactive surface element having first user sensible functionality and at least a second region of the at least one interactive surface element having second functionality, different from the first user sensible functionality, input sensor functionality, including at least one input sensor located in propinquity to at least one of the at least one interactive surface element, operative to sense impingement of an electromagnetic radiation spot on at least one of the at least one first region and the at least one second region of the at least one interactive surface element and utilization functionality for employing outputs of the input sensor functionality in respect of impingement on either or both of the at least one first region and the at least one second region. | 05-01-2014 |
20140132542 | DISPLAYS AND INFORMATION INPUT DEVICES - An integrated display and input device including a pixel array operative to provide a visually sensible output, at least one sensor operative to sense at least a position of at least one object with respect to the pixel array when the at least one object has at least a predetermined degree of propinquity to the pixel array and circuitry receiving an output from the at least one sensor and providing a non-imagewise input representing the position of the at least one object relative to the pixel array to utilization circuitry. | 05-15-2014 |
20140362058 | INPUT SYSTEM FOR CONTROLLING ELECTRONIC DEVICE - An electronic device includes a display for displaying data stored on said electronic device; input means; sensing means for sensing the three-dimensional position of the input means relative to said device; and control means for controlling the data displayed on said display in dependence on the three-dimensional position of the input means relative to said device. The input means includes a source of electromagnetic radiation for directing an infrared conical beam onto the display. The sensing means can sense the elliptical eccentricity of the electromagnetic radiation incident on the display to determine the angle at which it strikes the display, and can sense the area of the electromagnetic radiation incident on the display to determine the distance of the input means from the display. | 12-11-2014 |