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Lionel C. Sevrain, West Palm Beach US

Lionel C. Sevrain, West Palm Beach, FL US

Patent application numberDescriptionPublished
20090068097METHOD FOR NON-INVASIVE DETECTION AND TREATMENT OF CEREBRAL ANEURYSMS - Described herein is a method for non-invasive detection and treatment of intra-cranial aneurysms. Antibodies are provided to specifically react/bind with antigens of the cerebral aneurism wall. The antibodies may be bound to a label and/or to a therapeutic agent for diagnosis and/or for treatment purposes thereof. Intra-cranial aneurysms are thus non-invasively detected before rupture occurs and are specifically treated.03-12-2009
20100160970ANCHORING DEVICE FOR POSTERIORLY ATTACHING ADJACENT VERTERBRAE - An anchoring device for attaching an upper vertebra adjacent to a lower vertebra comprises a clamp having a first end and a second end opposite the first end, adapted to be positioned around upper and lower lateral masses of the adjacent vertebrae, and a fastener which in an installed position engages opposite ends of the clamp and which engages adjacent vertebrae thereby attaching the adjacent vertebrae together.06-24-2010
20100216210METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR - Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.08-26-2010
20100222732ANTI-CLOGGING VENTRICULAR CATHETER FOR CEREBROSPINAL FLUID DRAINAGE - A novel ventricular catheter designed to reduce CSF shunt obstruction is disclosed comprising a tip using a membrane without any opening and capable of filtering the CSF. When the CSF flows through the membrane, neither tissue (choroid plexus, blood cells, tumor cells, suctioned ependymal tissue) nor proteins can break through the membrane, making this ventricular catheter capable of preventing obstruction from tissue invasion but also preventing clogging from protein precipitation, coagulation or flocculation along the downstream shunt system.09-02-2010
20100285090METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR - Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.11-11-2010
20100285091METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR - Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.11-11-2010
20100285092METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR - Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.11-11-2010
20100285093METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR - Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.11-11-2010
20110022066UNIVERSAL ANCHOR FOR ATTACHING OBJECTS TO BONE TISSUE - An anchoring device and method for attaching an object to a bone comprises an anchoring member having proximal and distal ends, with the proximal end being adapted to hold the object to the bone while the distal end is in the bone, and a locking member having proximal and distal ends, with the proximal end adapted to secure the anchoring member into the bone and oppose its pull-out or loosening by stopping its backing or preventing its unscrewing while the distal end is in the bone. Also provided are first and second fasteners, with the first fastener adapted to fit to the proximal end of the anchoring member, and the second fastener adapted to fit to the proximal end of the locking member. The end of the second fastener can have an angle that matches an angle of the locking member.01-27-2011
20110034959SPRING-ASSISTED CRANIAL CLAMP - A cranial clamp for attaching a cranial flap to the skull comprises a clamp having a base to be placed against the lamina interna, and a cap acting as a locking member against the lamina externa. The clamp and the cap are linked together by an extension spring within the diploe through a burr hole or along/within the line of a craniotomy.02-10-2011

Patent applications by Lionel C. Sevrain, West Palm Beach, FL US