Link, US
Aaron J. Link, Austin, TX US
Patent application number | Description | Published |
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20100247433 | Use of non-canonical amino acids as metabolic markers for rapidly-dividing cells - The invention provides methods, reagents and systems to preferentially mark fast-proliferating cells/tissues (such as cancer), by incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handle” to for a number of uses, such as imaging of cancer cells, targeting drugs to preferentially kill cancer cells, and proteomic analysis in the context of large scale or high throughput screening for candidate drug leads that affects the proliferation of a target cell, etc. | 09-30-2010 |
A. James Link, Princeton, NJ US
Patent application number | Description | Published |
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20150045310 | NOVEL ENGINEERED POTENT CYTOTOXIC STAPLED BH3 PEPTIDES - Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided. | 02-12-2015 |
A. James Link, Belle Meade, NJ US
Patent application number | Description | Published |
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20150225463 | ASTEXIN PEPTIDES - Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in | 08-13-2015 |
Alexander Link, Dallas, TX US
Patent application number | Description | Published |
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20110086353 | Identification of MicroRNAs (miRNAs) in Fecal Samples as Biomarkers for Gastroenterological Cancers - A simple, rapid, inexpensive, and promising commercial biomarker assay method for multiple diseases is described herein. The present invention detects miRNA-based biomarkers in human stool specimens. The method of the present invention amplifies miRNA directly from stool specimens without any prior miRNA extraction. Differential expression of specific microRNAs in stool of colorectal cancer CRC and adenoma patients suggest fecal microRNAs as a novel potential biomarker for colorectal neoplasia detection. The method of the present invention has diagnostic, prognostic, and therapeutic relevance for gastroenterological cancers/colorectal cancer and as well as further acquired or hereditary GI diseases. | 04-14-2011 |
Allen R. Link, Snohomish, WA US
Patent application number | Description | Published |
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20120260180 | Complex System Function Status Diagnosis and Presentation - Status of complex system functions is diagnosed and reported by analyzing traffic on a data network of the complex system. The network traffic may be placed on the data network by systems that perform functions for the complex system. A user may make a view selection via a remote user interface. The view selection identifies rules for determining a status of a selected subset of the functions or a status of selected ones of the functions for a selected state of operation, such as during initial power-up. The status of the functions may be determined from the network traffic using the rules and presented to the user via the user interface. The user may interact with the presentation to make different view selections. Multiple different view selections made via multiple different user interfaces may be supported simultaneously. | 10-11-2012 |
20140280851 | COMPLEX SYSTEM FUNCTION STATUS DIAGNOSIS AND PRESENTATION - Status of complex system functions is diagnosed and reported by analyzing traffic on a data network of the complex system. The network traffic may be placed on the data network by systems that perform functions for the complex system. A user may make a view selection via a remote user interface. The view selection identifies rules for determining a status of a selected subset of the functions or a status of selected ones of the functions for a selected state of operation, such as during initial power-up. The status of the functions may be determined from the network traffic using the rules and presented to the user via the user interface. The user may interact with the presentation to make different view selections. Multiple different view selections made via multiple different user interfaces may be supported simultaneously. | 09-18-2014 |
Bobby Link, Piedmont, OK US
Patent application number | Description | Published |
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20130309052 | SYSTEM AND METHOD FOR MITIGATING DUST MIGRATION AT A WELLSITE - A system and method for mitigating dust migration at a wellsite is described. An oilfield material reservoir is provided for receiving oilfield material, the oilfield material reservoir having an enclosure. A dust collector is provided for collecting dust generated at the oilfield material reservoir, and a duct in communication with the enclosure and the dust collector is provided for transferring dust generated at the oilfield material reservoir to the dust collector. | 11-21-2013 |
Brett R. Link, Algonquin, IL US
Patent application number | Description | Published |
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20120171772 | TAGGED JOINT COMPOUND AND METHOD OF IDENTIFICATION - At least one of these or other problems is reduced using a building material that is uniquely identifiable. A method of making an identifiable gypsum-based building product includes selecting a tagging material occurring naturally in a component of the building material and choosing a carrier substance having a high concentration of the tagging material. By selecting an amount of the carrier substance and adding it to the building material, a building product having a unique product characteristic is created. In a second embodiment of the invention, a second tagging material is combined with the first tagging material to create a unique product. In yet another embodiment of the invention, a supplemental amount of the tagging material is added to the gypsum-based composition in addition to the carrier substance. Some tagging materials are useful in a gypsum-based composition to produce a visual confirmation of the presence of the tagging material. | 07-05-2012 |
20140272404 | EXTERIOR SHEATHING PANEL WITH INTEGRATED AIR/WATER BARRIER MEMBRANE - An exterior sheathing cementitious panel which prevents water penetration and air leakage is provided. Methods for manufacturing exterior sheathing cementitious panels with a highly efficient integrated air/water barrier membrane are provided as well. | 09-18-2014 |
Brian Link, Boulder, CO US
Patent application number | Description | Published |
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20120132597 | CROSS-FLOW FILTRATION WITH TURBULENCE AND BACK-FLUSHING ACTION FOR USE WITH ONLINE CHEMICAL MONITORS - A filtration and monitoring system includes an online monitoring device and a filter block having a chamber therein. An inlet pipe provides fluid to the filter block chamber and has an inlet valve located therein configured to shut off the flow of the fluid through the inlet pipe. An outlet pipe removes fluid from the filter block chamber. A filtered fluid conduit fluidically connects the filter block with the monitoring device. The outlet axis of the outlet pipe is offset from the inlet axis of the inlet pipe such that the fluid undergoes a change of direction while passing through the filter block chamber thereby causing turbulent flow within the filter block chamber. The turbulent flow within the filter block sweeps off particles that accumulate on the filter block chamber-side of the filter element to reduce the buildup of filter cake on the filter element. Closing the inlet valve causes a relatively sharp stop to the flow of fluid through the filter block, resulting in a back-flushing flow of fluid through the filter element from a pressure accumulator located in the filtered fluid conduit to the filter block chamber. The back-flushing flow of fluid dislodges filter cake accumulated on the filter block chamber-side of the filter element. | 05-31-2012 |
Brian W. Link, Delaware, OH US
Patent application number | Description | Published |
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20130066673 | Adapting thresholds - Promoting a candidate content item included in a plurality of content items is disclosed. A plurality of user reputation scores is received. For the candidate content item in the plurality of candidate content items, a content reputation score is determined based at least in part on a portion of the received user reputation scores. A determination of whether to promote the candidate content item is made based at least in part on the content reputation score and a dynamically adjusted threshold. The candidate content item is promoted if it is determined that the candidate content item should be promoted. | 03-14-2013 |
Bruce Link, Rochester, NY US
Patent application number | Description | Published |
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20160109842 | AUDIO DETECTION OF MEDIUM JAM - A method of indicating a medium jam along a medium transport path; a plurality of microphones for detecting the sound of the medium being transported as it enters medium transport path and producing a signal representing the sound; a plurality of microphones for detecting the sound of the medium being transported in the medium transport path and producing a signal representing the sound in the medium transport; a plurality of microphones for detecting the sound of the medium being existing the medium transport path and producing a signal representing the sound of the medium existing the medium transport; a processor for producing sound values from the signal and computing the maximum sound responsive to the sound values per each microphone, and indicating the medium jam responsive to the sound values. | 04-21-2016 |
20160109843 | AUDIO DETECTION OF MEDIUM JAM - A method of indicating a medium jam along a medium transport path; a plurality of microphones for detecting the sound of the medium being transported as it enters medium transport path and producing a signal representing the sound; a plurality of microphones for detecting the sound of the medium being transported in the medium transport path and producing a signal representing the sound in the medium transport; a plurality of microphones for detecting the sound of the medium being existing the medium transport path and producing a signal representing the sound of the medium existing the medium transport; a processor for producing sound values from the signal and computing the maximum sound responsive to the sound values per each microphone, and indicating the medium jam responsive to the sound values. | 04-21-2016 |
Bruce A. Link, Rochester, NY US
Patent application number | Description | Published |
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20120019841 | DOCUMENT SCANNER - A document scanner ( | 01-26-2012 |
20120019874 | METHOD FOR DOCUMENT SCANNING - A method of determining document characteristics prior to processing the document in a document scanner ( | 01-26-2012 |
20120044547 | DOCUMENT SCANNER - A document scanner ( | 02-23-2012 |
20120044548 | METHOD OF SCANNING DOCUMENTS - A document scanner ( | 02-23-2012 |
20130135687 | METHOD FOR SCANNING DOCUMENTS - A method for scanning documents in a document scanner ( | 05-30-2013 |
20130135688 | DOCUMENT SCANNER - A document scanner ( | 05-30-2013 |
20130155448 | SCANNER WITH EXCEPTION PREVIEW - A scanning system is described providing an exception correction capability during multi-page scanning operations. A sensing system is used to sense exception conditions during a multi-page scanning operation. In response to detecting an exception, at least one scanned page associated with the exception condition is displayed on an image display and a user interface system is used to provide a plurality of user-selectable corrective actions associated with the exception condition. One or more corrective operations are then performed in response to a user selecting a particular corrective action. | 06-20-2013 |
20130194588 | IMAGE PROCESSING ADAPTER AND METHOD - An image processing adapter having an input connected to a digital image source for receiving digital image data generated or captured by the source. A processing system in the adapter automatically processes the received digital image data to produce processed image data customized for the digital image source. An output connected to the processing system outputs the processed image data to a connected PC or to a network node at a predetermined network destination. | 08-01-2013 |
20130194613 | PROCESSING IMAGES FROM MULTIPLE SCANNERS - An image processing system having a plurality of digital image sources connected to a plurality of interfaces each for receiving digital image data from the sources. A processing subsystem is connected to the interfaces for processing the received digital image data which produces customized processed image data. A program memory connected to the processing subsystem stores executable instructions configured for the processing subsystem to generate the processed image data customized according to the source of the digital images. | 08-01-2013 |
20130194614 | IMAGE PROCESSING MANAGEMENT - An image processing system with an input connected to a network receives digital image data. A plurality of processors coupled to the input also receives the image data. Each of the plurality of processors simultaneously processes one of the multiple digital images and produces processed image data. An output interface coupled to the processors sequentially outputs the processed digital images. | 08-01-2013 |
20130194615 | IMAGE SCANNING AND PROCESSING SYSTEM - An image processing system has an input for receiving digital image data and a plurality of processors receives the digital image data which comprises multiple digital images. The processors are each configured to simultaneously process one of the digital images. An output interface sequentially outputs the processed digital images and a system controller monitors the processing and determines a free processor based on image data received at the input and on processed image data appearing at the output. | 08-01-2013 |
20130194617 | IMAGE PROCESSING MANAGEMENT MEHTOD - A method comprising connecting hardware interfaces to a different digital image data source to receive digital image data and connecting processors to the hardware interfaces for simultaneously processing the image data. The digital image data includes source identifiers corresponding to digital images in the digital image data. Processing the image data includes using different types of processing according to the source identifiers. | 08-01-2013 |
20130194618 | METHOD OF IMAGE PROCESSING FROM MULTIPLE SCANNERS - A method of processing digital image data by providing a plurality of hardware interfaces for receiving the digital image data. Each interface is associated with one of a plurality of digital image data sources. A source identifier is included in the data and is used to select a process for the image data which generates processed image data and is sent out over an output interface. | 08-01-2013 |
20130194619 | IMAGE PROCESSING METHOD FOR SUPPORTING MULTIPLE SCANNERS - A computer implemented method of receiving digital image data over a network, determining a source of the digital image data, accessing a database for retrieving image processing preferences based on the source of the digital image data, and processing the received digital image data according to the retrieved image processing preferences. | 08-01-2013 |
20130194620 | IMAGE PROCESSING METHOD - A method comprising receiving digital image data from a plurality of digital image sources, which contains digital images and source identifiers. A plurality of processors are provided for simultaneously processing the digital images according to stored processing instructions which correspond to the source identifiers. | 08-01-2013 |
20130194639 | IMAGE PROCESSING UNIT FOR SUPPORTING MULTIPLE SCANNERS - An image processing unit for processing digital image data. A plurality of hardware interfaces each is associated with one of a plurality of digital image sources for receiving image data. There are means for determining a data source from the received image data, and an image processing unit connected to the interfaces processes the received image data to generate processed image data. An output interface connected to the image processing unit outputs the processed image data. | 08-01-2013 |
20140251016 | AUDIO DETECTION OF MEDIUM JAM - A method of indicating a medium jam along a medium transport path comprising one or more rollers for use in conveying the medium along the medium transport path; a microphone for detecting the sound of the medium being conveyed and producing a signal representing the sound; a processor for producing sound values from the signal and computing a moving window sum responsive to the sound values; computing a high amplitude count responsive to the sound values; and computing a post roller sum responsive to the sound values; and indicating the medium jam responsive to the moving window sum, high amplitude count, or post roller sum. | 09-11-2014 |
20140360275 | SELF-ADJUSTING AUDIO DETECTION OF MEDIUM JAM - A method of indicating a medium misfeed along a medium transport path comprising one or more rollers for conveying the medium along the medium transport path; a microphone for detecting the sound of the conveyed medium and producing a signal representing the sound; a processor for producing sound values from the signal; providing a sensitivity setting responsive to the sound values; and indicating the medium misfeed responsive to the sound values and the sensitivity setting. | 12-11-2014 |
Charles Link, Ames, IA US
Patent application number | Description | Published |
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20160089397 | CORRELATES OF EFFICACY RELATING TO TUMOR VACCINES - The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through a combination of ex vivo gene therapy protocols and cell enchment, tumor cells are engineered to express an α (1,3)galactosyl epitope and optionally the tumor associated antigens mesothelin and carcinoembryonic antigen. After administration of the compositions of the invention to patients, the production of increased antibody titers to certain cell-surface markers, including mesothelin, calreticulin, and carcinembryonic antigen (CEA) positively correlates with an increased overall survival. | 03-31-2016 |
Charles J. Link, Clive, IA US
Patent application number | Description | Published |
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20090060930 | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes - The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epitopes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal. | 03-05-2009 |
20110136796 | IDO Inhibitors - Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R | 06-09-2011 |
20120003251 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES - The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epi topes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal. | 01-05-2012 |
20130164318 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES - The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epitopes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal. | 06-27-2013 |
20130164319 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES - The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epitopes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal. | 06-27-2013 |
20130178613 | ENHANCED IMMUNOGENICITY OF TUMOR ASSOCIATED ANTIGENS BY ADDITION OF ALPHAGAL EPITOPES - The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epitopes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal. | 07-11-2013 |
20140323740 | IDO Inhibitors - Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R | 10-30-2014 |
Charles M. Link, Atlanta, GA US
Patent application number | Description | Published |
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20080259885 | DUAL MODE DEVICE WITH MAC ADDRESS CAPTURE AND PAIRING - Seamless connectivity by a user device between a licensed and an unlicensed network is provided through capturing of MAC address information relating to one or more access points servicing the licensed and/or the unlicensed networks. One or more access points can be chosen as a designated access point. If the access point is available for communication with the device and other device criteria is met, the access point is designated. If designated, when the device is in vicinity of the access point seamless and transparent connectivity is automatically established with that access point. | 10-23-2008 |
Christian Link, Plano, TX US
Patent application number | Description | Published |
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20110221416 | Battery charger and method for collecting maximum power from energy harvester circuit - An energy harvesting system for transferring energy from an energy harvester ( | 09-15-2011 |
20150300990 | SURFACE SENSING METHOD FOR CORROSION SENSING VIA MAGNETIC MODULATION - A method includes pulsating a magnetic field at a first location associated with an external surface of a wall containing magnetic material. The method also includes measuring at least one characteristic of the pulsating magnetic field at a second location associated with the external surface of the wall. The at least one characteristic changes based on corrosion on an internal surface the wall between the first and second locations. The magnetic field could be pulsated by applying an AC signal to a conductive coil or by vibrating a magnet. The method could also include analyzing the at least one measured characteristic to identify an amount of the corrosion and/or a change in the amount of the corrosion. Use of the internal surface the wall could be modified based on the amount or change of the corrosion. Multiple magnetic fields can be generated at multiple first locations, and the at least one characteristic can be measured at multiple second locations. | 10-22-2015 |
Christopher J. Link, Arlington, MA US
Patent application number | Description | Published |
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20140064539 | VIBRATION-REDUCING PASSIVE RADIATORS - An audio system includes a passive radiator that is attached to one end of a lever arm. The other end of the lever arm is attached to a mass that serves to move out of phase of the passive radiator to cancel mechanical vibrations of the passive radiator, but without significantly affecting audio output. The lever arm is attached to a mechanical ground, which may be the enclosure on which the passive radiator is mounted. A system may use multiple lever arms to reduce rocking of the passive radiator. | 03-06-2014 |
Craig Link, Seattle, WA US
Patent application number | Description | Published |
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20130226453 | SYSTEMS AND METHODS FOR MOBILE COMMUNICATION INTEGRATION - A mobile application for integrating a location sharing event with a messaging platform such as a text messaging or email platform allows users to be prompted about location sharing when at least a part of the message includes location or time information. In one embodiment, the mobile application takes the form of an integrated location sharing application that parses the message to discern the relevant location or time information. The application may also provide a notification of a future event and may optionally generate a location sharing event based on the notification. In another embodiment, the application permits interactive route sharing between at least two computing devices. | 08-29-2013 |
20150195235 | SYSTEMS AND METHODS FOR MOBILE COMMUNICATION INTEGRATION - A mobile application for integrating a location sharing event with a messaging platform such as a text messaging or email platform allows users to be prompted about location sharing when at least a part of the message includes location or time information. In one embodiment, the mobile application takes the form of an integrated location sharing application that parses the message to discern the relevant location or time information. The application may also provide a notification of a future event and may optionally generate a location sharing event based on the notification. In another embodiment, the application permits interactive route sharing between at least two computing devices. | 07-09-2015 |
20150262275 | CREATION AND USE OF PUBLIC AND PRIVATE GROUPS IN A LOCATION SHARING APPLICATION - A mobile application uses computer-readable instructions for exchanging, viewing or providing location sharing information in a context of a public group, a private group or both. The location sharing information may be made available to aid or enhance commerce-related activities performed by a merchant, a consumer or both. In another embodiment, a method for authenticating a private group permits an authenticating user to restrict the private group and selectively allow subsequent participants restricted access to the private group. | 09-17-2015 |
Darren Link, Guildford, CT US
Patent application number | Description | Published |
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20090005254 | Compartmentalized Screening by Microfluidic Control - The invention describes a method for the identification of compounds which bind to a target component of a bio-chemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into micro-capsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development. | 01-01-2009 |
Darren Link, Lexington, MA US
Patent application number | Description | Published |
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20090197248 | VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 08-06-2009 |
20090197772 | Compartmentalised combinatorial chemistry by microfluidic control - The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules. | 08-06-2009 |
20100022414 | Droplet Libraries - The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays. | 01-28-2010 |
20110000560 | Manipulation of Microfluidic Droplets - The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control. | 01-06-2011 |
20120244043 | ELASTOMERIC GASKET FOR FLUID INTERFACE TO A MICROFLUIDIC CHIP - The present invention relates to microfluidic devices that include a reliable seal between a substrate of the device and a fluid transport mechanism. The devices of the invention include at least one internal channel, and at least one port in fluid communication with the channel. A seal is associated with the port and is configured to receive a fluid transport mechanism. The seal is formed from an elastomeric material that is compatible for use with fluorinated oil and resists flaking and degradation. | 09-27-2012 |
20120309002 | SAMPLE MULTIPLEXING - The invention generally relates to methods for sample multiplexing. In certain embodiments, methods of the invention obtaining a plurality of different reactant molecules, attaching a unique identifier to the reactant molecules, and forming a droplet including the reactant molecules. | 12-06-2012 |
20130109575 | MICROFLUIDIC SYSTEMS AND METHODS FOR REDUCING THE EXCHANGE OF MOLECULES BETWEEN DROPLETS | 05-02-2013 |
20130157872 | IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 06-20-2013 |
20130178368 | IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 07-11-2013 |
20130217583 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds. | 08-22-2013 |
20140076430 | MANIPULATION OF MICROFLUIDIC DROPLETS - The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control. | 03-20-2014 |
20140295421 | ENZYME QUANTIFICATION - The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number. | 10-02-2014 |
Darren R. Link, Lexington, MA US
Patent application number | Description | Published |
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20100137163 | Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds. | 06-03-2010 |
20100172803 | METHOD AND APPARATUS FOR FLUID DISPERSION - A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques. | 07-08-2010 |
20120264646 | ENZYME QUANTIFICATION - The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number. | 10-18-2012 |
20130090248 | SELECTION OF COMPARTMENTALISED SCREENING - The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids. | 04-11-2013 |
20130183659 | MICROFLUIDIC DEVICES - The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids. | 07-18-2013 |
20130210639 | MICROFLUIDIC DEVICES - The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids. | 08-15-2013 |
20130260447 | SYSTEMS AND METHODS FOR HANDLING MICROFLUIDIC DROPLETS - The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel. | 10-03-2013 |
20140256568 | SAMPLE MULTIPLEXING - The invention generally relates to methods for sample multiplexing. In certain embodiments, methods of the invention obtaining a plurality of different reactant molecules, attaching a unique identifier to the reactant molecules, and forming a droplet including the reactant molecules. | 09-11-2014 |
20140256595 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | 09-11-2014 |
20140303005 | RARE CELL ANALYSIS AFTER NEGATIVE SELECTION - The invention generally relates to rare cell analysis after negative selection. | 10-09-2014 |
20140323317 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS - The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | 10-30-2014 |
20140329239 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 11-06-2014 |
20150027892 | MANIPULATION OF MICROFLUIDIC DROPLETS - The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control. | 01-29-2015 |
20150099266 | DIGITAL ANALYSIS OF NUCLEIC ACID MODIFICATION - In certain aspects, methods of the invention involve performing modification state specific enzymatic reaction of nucleic acid in a sample, determining a value associated with efficiency of the modification state specific enzymatic reaction based on a control, determining an amount of target nucleic acid in the sample, and normalizing the amount of target nucleic acid based on the efficiency value. Based on the normalized amount of target nucleic acid, the method further includes determining whether the normalized amount of target nucleic acid is indicative of a condition. | 04-09-2015 |
20150126400 | MOLECULAR DIAGNOSTIC SCREENING ASSAY - The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step. | 05-07-2015 |
20150184256 | SYSTEM AND METHOD FOR DETECTION OF RNA SPECIES - The invention includes methods for determining the presence of a latent viral population by analyzing an RNA population from the virus with digital techniques, such as digital PCR or by sequencing cDNA produced from the RNA. The invention additional includes methods for determining the presence of latent viral populations by detecting and/or quantifying enzymes that are uniquely associated with the virus, e.g., reverse transcriptases. | 07-02-2015 |
Darren Roy Link, Guilford, CT US
Patent application number | Description | Published |
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20090131543 | Method and Apparatus for Forming Multiple Emulsions - The present invention generally relates to multiple emulsions, and to methods and apparatuses for making multiple emulsions. A multiple emulsion generally describes larger droplets that contain one or more smaller droplets therein. The larger droplets may be suspended in a third fluid in some cases. These can be useful for encapsulating species such as pharmaceutical agents, cells, chemicals, or the like. In some cases, one or more of the droplets can change form, for instance, to become solidified to form a microcapsule, a liposome, a polymerosome, or a colloidosome. Multiple emulsions can be formed in one step in certain embodiments, with generally precise repeatability, and can be tailored to include one, two, three, or more inner droplets within a single outer droplet (which droplets may all be nested in some cases). | 05-21-2009 |
Darren Roy Link, Lexington, MA US
Patent application number | Description | Published |
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20100105866 | MICROFLUIDIC MANIPULATION OF FLUIDS AND REACTIONS - The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including microreactors for manipulating fluids and reactions. In some embodiments, structures and methods for manipulating many (e.g., 1000) fluid samples, i.e., in the form of droplets, are described. Processes such as diffusion, evaporation, dilution, and precipitation can be controlled in each fluid sample. These methods also enable conditions within the fluid samples (e.g., concentration) to be controlled. Manipulation of fluid samples can be useful for a variety of applications, including testing for reaction conditions, e.g., in crystallization, chemical, and biological assays. | 04-29-2010 |
20110244455 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 10-06-2011 |
20110250597 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 10-13-2011 |
20120122714 | SANDWICH ASSAYS IN DROPLETS - The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte. | 05-17-2012 |
20120208241 | THERMOCYCLING DEVICE FOR NUCLEIC ACID AMPLIFICATION AND METHODS OF USE - The present invention provides thermocycling devices useful for amplification of nucleic acids in droplets. The thermocycling device utilizes the flow of one or more fluids through a main compartment at temperatures sufficient to conduct a polymerase chain reaction. Methods of amplifying nucleic acids in droplets are also provided. | 08-16-2012 |
20120219947 | METHODS FOR FORMING MIXED DROPLETS - The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet. | 08-30-2012 |
20120220494 | COMPOSITIONS AND METHODS FOR MOLECULAR LABELING - The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR. | 08-30-2012 |
20120302448 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided. | 11-29-2012 |
20130099018 | MANIPULATING DROPLET SIZE - The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid. | 04-25-2013 |
20130196324 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 08-01-2013 |
20130210659 | MOLECULAR DIAGNOSTIC SCREENING ASSAY - The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step. | 08-15-2013 |
20130217601 | IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 08-22-2013 |
20130224751 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 08-29-2013 |
20130295567 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 11-07-2013 |
20130295568 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 11-07-2013 |
20140037514 | METHOD AND APPARATUS FOR FLUID DISPERSION - A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques. | 02-06-2014 |
20140045712 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to detecting target molecules. | 02-13-2014 |
20140154695 | MANIPULATING DROPLET SIZE - The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid. | 06-05-2014 |
20140305799 | ELECTRONIC CONTROL OF FLUIDIC SPECIES - Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. | 10-16-2014 |
20150283546 | FORMATION AND CONTROL OF FLUIDIC SPECIES - This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like. | 10-08-2015 |
20150285282 | METHOD AND APPARATUS FOR FORMING MULTIPLE EMULSIONS - The present invention generally relates to multiple emulsions, and to methods and apparatuses for making multiple emulsions. A multiple emulsion generally describes larger droplets that contain one or more smaller droplets therein. The larger droplets may be suspended in a third fluid in some cases. These can be useful for encapsulating species such as pharmaceutical agents, cells, chemicals, or the like. In some cases, one or more of the droplets can change form, for instance, to become solidified to form a microcapsule, a liposome, a polymerosome, or a colloidosome. Multiple emulsions can be formed in one step in certain embodiments, with generally precise repeatability, and can be tailored to include one, two, three, or more inner droplets within a single outer droplet (which droplets may all be nested in some cases). | 10-08-2015 |
David Link, Shakopee, MN US
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20120085019 | PORTABLE, SELF-COOLING BAIT CONTAINER - A live aqueous animal container having: | 04-12-2012 |
20130094916 | INSULATOR DRILLING JIG - A jig enabled method of attaching structures such as insulators to support. The jig has: a jig frame comprising a top surface, and two two sides have parallel contact edges at ends of the sides; the top surface has two holes passing through the top surface; within each of the holes is a hollow guide pipe passing from an exterior surface of the top surface through an interior surface of the top surface; and the hollow guide pipe passing past the interior surface of the top surface a distance that is less than a distance to plane formed by the two parallel contact edges. At least one bubble level may be oriented parallel to a surface on the jig and/or parallel to an edge of the jig. | 04-18-2013 |
David Link, Falls Church, VA US
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20100094981 | Dynamically Deployable Self Configuring Distributed Network Management System - Systems, software, and methods for managing networks of connected electronic devices are described. In one example, network management policy and network management applications are transferred automatically upon detection and identification of a new device, protocol or application on the network. In another example, information related to at least one aspect of the network is obtained by an NMAS, and at least one applicable management policy is identified by the NMAS; and the identified policy is used to manage at least one aspect of the network's operation. | 04-15-2010 |
David Link, New York, NY US
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20150112709 | METHOD AND SYSTEM FOR ENABLING LAY USERS TO OBTAIN RELEVANT, PERSONALIZED HEALTH RELATED INFORMATION - The invention features methods, systems, and computer programs for generating a customized set of possible medical conditions, thereby providing access to medical information relevant to the user's state of health. The methods and systems involve at least some of the following steps: receiving a list of symptoms specified in terms selected from a first language set; translating the list of symptoms into a translated list of symptoms specified in terms selected from a second language set; using the translated list of symptoms to generate possible medical conditions, the possible medical conditions described in terms of the second language set; and translating the possible medical conditions into descriptions that are specified in terms selected from the first language set. | 04-23-2015 |
David F. Link, Falls Church, VA US
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20080228908 | Management techniques for non-traditional network and information system topologies - Systems, software, and methods for managing traditional (i.e., TCP/IP-based), non-traditional, and traditional—non-traditional hybrid networks of connected electronic devices are described. In one example, network management policy and network management applications are downloaded automatically upon detection and identification of a new device, application or service on a network. In another example, information related to at least one aspect of the network is obtained by a network management device through connection to a non-TCP/IP network, or by way of a gateway device or application, at least one applicable management policy is identified, and the identified policy is used to manage at least one aspect of the network's operation. In another example, devices, applications or services presenting various behaviors under various scenarios are evaluated and placed under management. | 09-18-2008 |
Douglas F. Link, Plymouth, MN US
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20100034410 | HEARING AID ADAPTED FOR EMBEDDED ELECTRONICS - A hearing aid comprising a microphone, a receiver, hearing aid electronics coupled to the microphone and the receiver, and conductive traces overlaying an insulator, the conductive traces configured to interconnect the hearing aid electronics and to follow non-planar contours of the insulator. Examples are provided wherein the insulator includes a hearing aid housing. | 02-11-2010 |
20100158296 | HEARING ASSISTANCE DEVICE WITH STACKED DIE - The present subject matter relates to a hearing assistance device for an ear of a wearer comprising a microphone for receiving sound, hearing assistance electronics in communications with the microphone, the hearing assistance electronics including a hybrid circuit, and a wearable housing adapted to house at least the hearing assistance electronics. The hybrid circuit comprises a first integrated circuit die having one or more through-silicon-vias (TSVs), a first redistribution layer disposed on a surface of the first integrated circuit, and a second integrated circuit die having one or more contacts, the second integrated circuit die disposed on the first redistribution layer, wherein the first redistribution layer is adapted to connect one or more of the one or more TSVs of the first integrated circuit die to one or more of the one or more contacts of the second integrated circuit die. | 06-24-2010 |
20150071470 | INTEGRATED CIRCUIT DIE INSIDE A FLEXIBLE CIRCUIT SUBSTRATE FOR A HEARING ASSISTANCE DEVICE - Disclosed herein, among other things, are systems and methods for improved circuit design for hearing assistance devices. One aspect of the present subject matter includes a hearing assistance device configured to compensate for hearing losses of a user. The hearing assistance device includes a flexible circuit substrate and an integrated circuit die embedded within the flexible circuit substrate. The integrated circuit die includes a digital signal processor (DSP) die, in an embodiment. In various embodiments, the DSP die includes a DSP configured to provide processing for the hearing assistance device. | 03-12-2015 |
20150086051 | HEARING AID ADAPTED FOR EMBEDDED ELECTRONICS - A hearing aid comprising a microphone, a receiver, hearing aid electronics coupled to the microphone and the receiver, and conductive traces overlaying an insulator, the conductive traces configured to interconnect the hearing aid electronics and to follow non-planar contours of the insulator. Examples are provided wherein the insulator includes a hearing aid housing. | 03-26-2015 |
20150146899 | SOLDERLESS HEARING ASSISTANCE DEVICE ASSEMBLY AND METHOD - Disclosed herein, among other things, are systems and methods for solderless assembly for hearing assistance devices. One aspect of the present subject matter includes a method of manufacturing a hearing assistance device. According to various embodiments, the method includes providing a molded interconnect device (MID) housing and inserting a flexible circuit module having conductive surface traces into the MID housing. One or more hearing assistance electronic modules are connected to the MID housing using direct compression without the use of wires or solder, according to various embodiments. In one embodiment, the MID housing includes a laser-direct structuring (LDS) housing. | 05-28-2015 |
20150264475 | INTERPOSER STACK INSIDE A SUBSTRATE FOR A HEARING ASSISTANCE DEVICE - Disclosed herein, among other things, are systems and methods for improved circuit design for hearing assistance devices. One aspect of the present subject matter includes a hearing assistance device configured to compensate for hearing losses of a user. The hearing assistance device includes a substrate and an interposer embedded into the substrate to form a system in package module. According to various embodiments, the interposer includes one or more integrated circuits (ICs) on the interposer, the one or more ICs configured to provide electronics for the hearing assistance device. | 09-17-2015 |
Eric Anthony Link, Jacksonville, AL US
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20160075098 | BAG FOLDING MACHINE - A bag folding apparatus is provided. The bag folding apparatus includes a platform formed to support a bag in an upright position. The present invention may further include an overhead thruster comprising a plurality of fingers extending towards the platform. The overhead thruster is configured to thrust the plurality of fingers towards and away from the platform, and thereby places the plurality of fingers within the bag and removes the plurality of fingers from the bag. The present invention may further include actuators operatively connected to the plurality of fingers. The actuator is operable to move the plurality of fingers from side to side and front to back along a plane substantially parallel with the platform. | 03-17-2016 |
Eric Michael Link, Dallas, TX US
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20130116526 | Handheld Blood Glucose Monitoring Device with Messaging Capability - A patient monitoring network pertaining to blood glucose and other analyte measurements includes wireless blood glucose or other analyte measuring devices and a networked computer or server. Each monitoring device is associated with a patient and is configured to measure the glucose level or other analyte from a given blood sample via inserted test strips, transmit the measurements to the networked computer, and display received messages. The messages may relate to the current or past measurements, or may include an alert prompting the user of the monitoring device to order more supplies, such as test strips. The measurements received by the networked computer may be stored in a record of a database, which may be accessed by a remote computer. The remote computer may also access a script editor to edit certain scripts which produce certain messages sent to the monitoring device. | 05-09-2013 |
Garrett Link, Seattle, WA US
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20080281686 | DYNAMIC CONTENT INSERTION METHOD AND SYSTEM - A method and computer program product for initializing an event timer. A first portion of a computer application is executed. After completion of the execution of the first portion of the computer application, it is determined if the event timer has reached a predetermined amount. If the event timer has reached the predetermined amount, a first advertisement is rendered. | 11-13-2008 |
Garry N. Link, Pacific City, OR US
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20080272842 | Calibrated feedback - A differential feedback amplifier is provided with a feedback network wherein that feedback network is adjustable so as to improve the PSRR of the amplifier. In another aspect of the present invention, a differential feedback amplifier is provided with a feedback network wherein that feedback network is adjustable so as to improve the CMRR of the amplifier. In a further aspect of the present invention, a Class D amplifier is provided with a passive differential feedback, summing with an input current at a differential virtual ground produced by an amplifier which is a sub-section of the Class D amplifier. | 11-06-2008 |
George Brian Link, Knoxville, TN US
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20100253366 | Broadband high impedance pickoff circuit - A measuring system minimizes the parasitic affects of lumped circuit elements. The system includes two or more in-situ interfaces configured to conductively link a source to an internal load and an external load. The in-situ interfaces are linked to a shunt conductor. Two or more linear and dynamic elements conductively link the in-situ interfaces in series. The dynamic elements are configured to overwhelm the parasitic self-capacitance of an input circuit coupled to at least one of the in-situ interfaces. A shield enclosing at least one of the linear and dynamic elements has a conductive surface to fields and electromagnetic interference. The shield has attenuation ratios that substantially dampen the parasitic capacitance between the linear and dynamic elements that bridge some of the in-situ interfaces. | 10-07-2010 |
Gregory Link, Canton, MI US
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20120105623 | System for Detecting Surface Variations on Engine Cylinder Head Valve Seats - A machine vision inspection system that detects defects on machined valve seats that may be caused by a broken cutting tool insert. The system also measures the valve seat width to detect a missing cutting tool insert and monitor reactions to cutting tool forces and tool wear. The system uses high resolution cameras and stable LED light sources. A method is disclosed for manufacturing cylinder heads that are 100% inspected inline for valve seat surface defects. | 05-03-2012 |
James Link, West Bloomfield, MI US
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20140265307 | AC DUAL JOINT-BLOCK DESIGN - A dual joint block for pressing a seal against an air conditioner thermal expansion valve housing. The dual joint block includes a body having an inner face and an outer face. The body defines a first aperture and a second aperture. The first aperture extends through the body between the inner face and the outer face. The first aperture is configured to completely surround a first conduit extending therethrough. The second aperture extends through the body between the inner face and the outer face, and is configured to completely surround a second conduit extending therethrough. | 09-18-2014 |
Jamie R. Link, Arlington, VA US
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20080204752 | SYSTEM AND METHOD FOR REMOTE, FREE-SPACE OPTICAL DETECTION OF POTENTIAL THREAT AGENT - A system and method for free space, optical remote sensing of a potential threat agent using spectrally responsive sensor material. In one example the sensor material is formed by particles, which in one particular form are porous photonic crystals. The particles are dispersed into an area being monitored for the presence of the potential threat agent. A pair of lasers is used to generate optical light beams that are directed at the sensor particles after the particles have been dispersed. The light reflected by the sensor particles is then analyzed. The presence of the potential threat agent causes a shift in the spectral peak of light reflected from the sensor particles that can be sensed using photo detectors and a processing subsystem. The system can be tuned to remotely detect for specific chemical, biological or environmental agents that may be present within a given area. | 08-28-2008 |
Jason Link, Portland, OR US
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20080260760 | Prostate-Specific Antigen-Derived Mhc Class H-Restricted Peptides and Their Use in Vaccines to Treat or Prevent Prostate Cancer - The present invention relates to immunogenic peptides derived from human prostate cancer antigen (PSA-derived peptides) and their use as vaccines to treat or prevent prostate cancer. The invention is also related to dendritic cells from a patient having prostate cancer, which dendritic cells have been exposed to one or more PSA-derived peptides, and their use to treat or prevent prostate cancer in the patient. The invention is also directed to T-cells from a patient which cells are specific for PSA-activated peptide(s), and their uses to treat or prevent prostate cancer. | 10-23-2008 |
Jason J. Link, Bethlehem, PA US
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20130220777 | CENTERLINE ADJUSTABLE WIDTH CONVEYOR SYSTEM AND METHOD - A centerline adjustable conveyor system and method may include a plurality of conveyor beams for conveying product within the system and an adjustor for controlling the outer width of the plurality of beams. The system and method may include a second adjustor that operates in conjunction with the adjustor for controlling the outer width of the plurality of beams. The system and method may also include an adjustor belt coupling the adjustor and the second adjustor that transfers activation of one of the adjustor and second adjustor to the other of the adjustors. The system and method may use an adjustor that is a trapezoidal lead screw. The adjustor may be a 5 mm per rev. pitched screw having opposite direction pitches emanating from the center of the screw and each opposite pitch of the adjustor may adjust one of the plurality of conveyor beams. | 08-29-2013 |
Jeffrey S. Link, Verona, VA US
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20150305536 | Combination boot jack, boot tray, and boot rack - A combination boot jack, boot tray and boot rack for the removal, cleaning, movement and storage of mud boots, muck boots, galoshes, snow boots, work boots and similar rubber boots. The boot tray is broad enough for a user to step into the top surface of its base with both booted feet. The invention has a pair of U-shaped notches elevated above the top surface of the base, as well as an open-back/closed toe foot box, built into the boot tray. The user may thus step into the boot tray, use the pair of U-shaped notches as a boot jack to grip and secure the heels of both boots at once, and remove them, one at a time. During removal of the second boot, the user's unbooted foot is placed into the protected foot box, keeping it dry and out of contact with the ground, the outside of the boots, or any part of the boot jack and boot tray touched or soiled by the boots during their removal. Further, the boot jack and boot tray may be used as a boot rack for moving a pair of boots from place to place without touching them, as well as for later cleaning or storage. | 10-29-2015 |
Jeffrey S. Link, Londonderry, NH US
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20100249109 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS - The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 09-30-2010 |
20110166127 | Substituted Benzo-Pyrimido-Tetrazolo-Diazepine Compounds - The present invention relates to substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 07-07-2011 |
20110245236 | Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds - The present invention relates to substituted benzo-pyrido-triazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrido-triazolo-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof. | 10-06-2011 |
20120015935 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds - The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. | 01-19-2012 |
Jeff S. Link, Londonderry, NH US
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20090136499 | RAF Inhibitors and Uses Thereof - The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAF | 05-28-2009 |
John Link, The Woodlands, TX US
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20150308000 | ALKENYL SUCCINIC ACIDS OR ANHYDRIDES AS CORROSION INHIBITORS FOR METAL SURFACES - Methods of inhibiting corrosion in a benzene distillation or dryer unit are provided wherein alkenyl succinic acids or anhydrides (ASA) are brought into contact with metal surfaces thereby protecting the metal from an acidic corrosive medium flowing through the overhead. The benzene distillation column or drying tower may be utilized to purify benzene for subsequent feed of the purified benzene to an alkylation process such as in the alkylation of benzene by ethene to form ethylbenzene utilizing a zeolite alkylation catalyst. | 10-29-2015 |
John Link, Humble, TX US
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20090032768 | WATER-SOLUBLE PHENYLENEDIAMINE COMPOSITIONS AND METHODS FOR STABILIZING ETHYLENICALLY UNSATURATED COMPOUNDS AND MONOMERS - Compositions and methods for inhibiting polymerization of ethylenically unsaturated monomers are provided. The compositions include a water-soluble phenylenediamine composition. | 02-05-2009 |
20100258480 | PROCESSES FOR INHIBITING FOULDING IN HYDROCARBON PROCESSING - A method for inhibiting the formation of fouling materials including contacting hydrocarbon media containing carbonyl compounds with hydroxylamine and naphthalene sulfonate while treating the hydrocarbon media with a basic wash. | 10-14-2010 |
20110297878 | METHODS AND COMPOSITIONS FOR INHIBITING VINYL AROMATIC MONOMER POLYMERIZATION - Methods and compositions are provided for inhibiting the polymerization of a vinyl aromatic monomer, such as styrene monomer, during elevated temperature processing thereof or during storage or shipment of polymer containing product. The compositions comprise a combination of a quinone methide derivative A) and a phenol compound B). The methods comprise adding from about 1-10,000 ppm of the combination to the monomer containing medium, per one million parts of the monomer. | 12-08-2011 |
20120217444 | COMPOSITION AND METHOD FOR INHIBITING PREMATURE POLYMERIZATION - The invention relates to composition comprising: at least one free radical polymerizable vinyl compound; and an active amount of inhibition composition comprising metal ions, halogen ions and a ligand having a donor atom selected from oxygen, nitrogen, sulfur, phosphorus and a combination thereof, the metal ions being selected from ions of Ti, Mo, Re, Ru, Fe, Rh, Ni, Pd, Co, Os, Cu and any combination thereof; wherein the composition is free of a nitroxyl compound of a secondary amine having no hydrogen atom on α-C atom. A method for inhibiting the premature polymerization of at least one free radical polymerizable vinyl compound, comprising: adding an active amount of the inhibition composition to the at least one free radical polymerizable vinyl compound. | 08-30-2012 |
20130030225 | METHODS AND COMPOSITIONS FOR INHIBITING VINYL AROMATIC MONOMER POLYMERIZATION - Methods and compositions are provided for inhibiting the polymerization of a vinyl aromatic monomer, such as styrene monomer, during elevated temperature processing thereof or during storage or shipment of polymer containing product. The compositions comprise a combination of a quinone methide derivative A) and a phenol compound B). The methods comprise adding from about 1-10,000 ppm of the combination to the monomer containing medium, per one million parts of the monomer. | 01-31-2013 |
20130072729 | METHODS AND COMPOSITIONS FOR INHIBITING POLYSTYRENE FORMATION DURING STYRENE PRODUCTION - Methods and compositions are provided for inhibiting the polymerization of a vinyl aromatic monomer, such as styrene monomer, during elevated temperature processing or distillation thereof. The compositions comprise an inhibitor combination of (A) a hydroxylamine and (B) a stable free radical plus a retarder that is either; (C) dinitrobutylphenol or (D) quinone methide. The ratio of (A) to (B) ranges from about 5% (A) to 95% (B) to about 95% (A) to about 5% (B). The compositions are added to the vinyl aromatic monomer in amounts sufficient to prevent polymerization during the distillation process. Typically the inhibitor combination is added to the vinyl aromatic monomer in an amount ranging from about 10 to 150 ppm of the monomer. Retarders are typically added in an amount ranging from 50 to 1500 ppm of the vinyl aromatic monomer. | 03-21-2013 |
20130204053 | METHODS AND COMPOSITIONS FOR STYRENE INHIBITION VIA IN SITU GENERATION OF QUINONE METHIDES - Methods and compositions are provided for inhibiting the polymerization of a vinyl aromatic monomer, such as styrene monomer, during elevated temperature processing or distillation thereof or during storage or shipment of polymer containing product. The compositions include a combination of a hydroxybenzyl alcohol (1) and a dehydration catalyst (2). The combination is added to a vinyl aromatic monomer. Typically, the hydroxybenzyl alcohol is dehydrated in the styrene solution by the use of a strong acid catalyst acting as the dehydration catalyst, and the resultant reaction product is a quinone methide styrene inhibitor. | 08-08-2013 |
20160052840 | METHODS AND COMPOSITIONS FOR INHIBITING POLYSTYRENE FORMATION DURING STYRENE PRODUCTION - Methods and compositions are provided for inhibiting the polymerization of a vinyl aromatic monomer, such as styrene monomer, during elevated temperature processing or distillation thereof. The compositions comprise an inhibitor combination of (A) a hydroxylamine and (B) a stable free radical plus a retarder that is either; (C) dinitrobutylphenol or (D) quinone methide. The ratio of (A) to (B) ranges from about 5% (A) to 95% (B) to about 95% (A) to about 5% (B). The compositions are added to the vinyl aromatic monomer in amounts sufficient to prevent polymerization during the distillation process. Typically the inhibitor combination is added to the vinyl aromatic monomer in an amount ranging from about 10 to 150 ppm of the monomer. Retarders are typically added in an amount ranging from 50 to 1500 ppm of the vinyl aromatic monomer. | 02-25-2016 |
John Link, Redmond, WA US
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20140139629 | ASSOCIATING AN OBJECT WITH A SUBJECT - A method comprises receiving one or more depth images from a depth camera, the depth images indicating a depth of a surface imaged by each pixel of the depth images. The method may further comprise identifying a human subject imaged by the depth images and recognizing within one or more of the depth images a beacon emitted from a control device. A position of the control device may be assessed in three dimensions, and the control device may be associated with the human subject based on a proximity of the control device to the human subject or other parameter of the control device with relation to the human subject. | 05-22-2014 |
John Link, Chestnut Ridge, NY US
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20080256729 | Teeth Whitening Toothbrush - A toothbrush for enhancing the whiteness of teeth while carrying out normal prophylactic brushing with a material that includes a light/heat activated whitening agent. The whitening agent is usually activated by light of a certain wavelength. The toothbrush comprises a handle and a head and optical transmission material bringing light of a predetermined frequency to the head portion. The head portion has a clear surface into which the bristles are secured so as to cause light to shine on the teeth surfaces as they are being brushed by the bristles. | 10-23-2008 |
John F. Link, Calumet City, IL US
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20090013661 | Remote control system and apparatus for enabling accessing the interior of a chamber of a harvester - A remote control system and apparatus enabling safely accessing the interior of a cotton compacting chamber and other regions of a cotton harvester, and also operating aspects of the compacting apparatus contained therein and thereabout, and which system is optionally operable for operating other aspects of the harvester, for inspection, maintenance and/or service, as well as other purposes. The system requires initial steps, including to safely neutralize or lock out operating systems of the harvester, then enables accessing designated interior locations of the compactor and the ability to operate systems therein, including aspects of the compacting apparatus. | 01-15-2009 |
20150027311 | Air Intake System for a Work Vehicle - An air intake system for a work vehicle may include a filter assembly having a pre-cleaner and an air filter. The filter assembly may define at least one outlet port. The air intake system may also include an air valve movable between an opened position and a closed position and a blower coupled to the outlet port via a conduit. The blower may be configured to create a vacuum within the conduit such that particulates are removed from the filter assembly through the outlet port. When the air valve is in the opened position, an airflow may be directed through the filter assembly in an intake direction from the pre-cleaner through the air filter and, when the air valve is in the closed position, the airflow may be directed through the air filter in a reverse direction. | 01-29-2015 |
John M. Link, Redmond, WA US
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20120158089 | LEAD FAULT DETECTION FOR IMPLANTABLE MEDICAL DEVICE - An implantable medical device can include a therapy circuit coupled to a therapy delivery terminal, the therapy circuit configured to generate a specified electrostimulation therapy for delivery to a tissue site via the therapy delivery terminal, and a measurement circuit for measuring at least two impedances of a first terminal combination including the therapy delivery terminal, the two impedances corresponding to at least two instances of excitation separated enough in time to capture an impedance artifact due at least in part to a motion of the heart, such as to determine an electrostimulation therapy lead status at least in part using the at least two impedances. | 06-21-2012 |
John Robert Link, Wilmington, DE US
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20110151461 | DETECTION ALGORITHM FOR PCR ASSAY - The application provides methods for improving the detection accuracy of the binding of labeled nucleic acid probes, such as those used in PCR reactions. One such method comprises measuring the label intensity, e.g. fluorescence, at two different temperatures, a higher temperature and a lower temperature, and then calculating the ratio of the label intensity at the lower temperature over the label intensity at the higher temperature. Another method comprises measuring the label intensity at least two points in time post-PCR and calculating the slope of the label intensity as a function of time. Measuring the hybridization kinetics of the probe binding to the target nucleic acid allows an on-rate slope to be calculated which gives this method good specificity of detection. | 06-23-2011 |
Kenneth Link, Portland, OR US
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20080216355 | Lightweight and Flexible Article of Footwear - An article of footwear with an outer member including slots that increase flexibility is disclosed. The outer member also includes an inner plate including a set of protective strips. The inner plate is disposed along an inner surface of the outer member so that the protective strips are aligned with and cover the slots in the outer member. | 09-11-2008 |
20100313447 | Lightweight And Flexible Article Of Footwear - An article of footwear with an outer member including slots that increase flexibility is disclosed. The outer member also includes an inner plate including a set of protective strips. The inner plate is disposed along an inner surface of the outer member so that the protective strips are aligned with and cover the slots in the outer member. | 12-16-2010 |
20130333245 | Lightweight And Flexible Article Of Footwear - An article of footwear with an outer member including slots that increase flexibility is disclosed. The outer member also includes an inner plate including a set of protective strips. The inner plate is disposed along an inner surface of the outer member so that the protective strips are aligned with and cover the slots in the outer member. | 12-19-2013 |
20140202042 | CLEATED FOOTWEAR - Cleat structures, e.g., for football shoes, may include: (a) a cleat base; (b) a cleat free end; and (c) a concave side edge and at least two additional side edges extending between the cleat base and the cleat free end. Such cleats may be incorporated into sole structures (e.g., outsole components) that have one or more of: a base plate having a V-shaped support structure with lateral and medial support members extending forward from a base support area located in a heel or rear midfoot area of the outsole component; a base plate having a matrix structure with recesses or openings formed between rib elements that make up the matrix structure; and/or a base plate having a rear heel support. The cleats and base plates may be made, at least in part, as unitary, one-piece constructions, using selective laser sintering or other three-dimensional printing and/or rapid manufacturing additive fabrication techniques. | 07-24-2014 |
Kevin Link, Atlanta, GA US
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20100228404 | Method and system for configuring and provisioning a vehicle - A telematics method and system facilitates customizing a plurality of vehicle content files, parameters, and features based on edits and selections from a user interface. A telematics provider maintains a database comprising a table, or tables that associate(s) user identification information with a vehicle VIN and equipment/features/content installed in/on vehicle devices associated with the VIN. Database updates may occur automatically, or upon a user instruction, when a TCU wirelessly transmits current equipment, content, and feature configuration information to a TOC coupled with the database. The telematics provider's server may provide the interface that facilitates the user logging in and editing features, content, and operational and performance parameters currently configured/installed in/on the vehicle' equipment and devices. The telematics provider may forward the user input from the interface to another provider after it verifies user log in credentials before the other provider begins a download to vehicle devices associated with the VIN. | 09-09-2010 |
Kevin W. Link, Atlanta, GA US
Patent application number | Description | Published |
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20090222200 | METHODS, SYSTEMS, AND APPARATUSES FOR TELEMATICS NAVIGATION - Provided are methods, systems, and apparatuses for telematics navigation. | 09-03-2009 |
20130116882 | Methods, systems, and apparatuses for telematics navigation - Provided are methods, systems, and apparatuses for telematics navigation. | 05-09-2013 |
Kristian Hurd Link, Hamden, CT US
Patent application number | Description | Published |
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20120004115 | SYSTEM AND METHOD FOR PURIFICATION AND USE OF INORGANIC PYROPHOSPHATASE FROM AQUIFEX AEOLICUS - The present invention provides a nucleic acid that comprises a nucleic acid of SEQ ID NO: 1 or 3 encoding an Aae pyrophosphatase protein, an enzyme protein of SEQ ID NO: 2 or 4, and methods of sequencing using an isolated Aae pyrophosphatase protein. | 01-05-2012 |
Kurt Link, Mundelein, IL US
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20140322073 | HAND RAIL SANITIZIER - A hand rail sanitizing system for sanitizing a hand rail of an escalator stairway from germs and bacteria on the hand rail is provided. The hand rail has a top wall, a bottom wall, and a pair of side walls. The hand rail sanitizing system comprises a container having a top wall and a bottom wall with the container positioned nearingly adjacent the hand rail. A UV-light emitting diode (LED) bulb is encased within the container. As the hand rail continuously passes by the container, the LED bulb irradiates through the bottom wall of the container toward the top wall of the hand rail. | 10-30-2014 |
Marie Link, Chagrin Falls, OH US
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20140249832 | REMS MANAGEMENT TOOL - The various technologies presented herein relate to assisting a prescriber in obtaining and maintaining Risk Evaluation and Mitigation Strategy (REMS) compliance. A centralized approach is presented for obtaining REMS compliance data from a drug manufacturer, federal regulator, etc., and based on identifying one or more REMS medications associated with a prescriber, compliance of the prescriber with regard to the REMS compliance data for the one or more REMS medications can be determined. Interaction and notifications, etc., can be performed utilizing internet access. In the event of a prescriber failing a compliance requirement, one or more actions can be identified to facilitate bringing the prescriber into REMS compliance. REMS compliance data can be shared with the drug manufacturer, regulatory body, etc., to facilitate understanding of success of REMS compliance. Stored REMS compliance data can be forwarded to a third party. | 09-04-2014 |
Matthew Paul Link, Kapolei, HI US
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20090187466 | Location-Based Information-Geo Retail Notification - Sales information corresponding to one or more retailers is collected and stored. A customer/user can access the sales information using a client application running on his mobile device. The access may be responsive to a customer profile that establishes the customer's preferences or tastes. The access may be responsive to detecting that the customer's mobile device is within a threshold distance of one or more matching retailers. The access may be responsive to a customer request to obtain the sales information. One or more reminder notes may be sent to the customer to serve as a reminder that the customer likely needs to acquire a product or service. | 07-23-2009 |
Michael Link, Chesterfield, MI US
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20130053979 | PROSTHETIC SENSING SYSTEMS AND METHODS - Systems and methods are disclosed for sensing forces, moments, temperature, inclination, acceleration and other parameters associated with prosthetic limbs. The system is capable of measuring forces in three designated axes, and moments about the same designated axes, for a total of six possible degrees of freedom. The system can be readily fitted onto a conventional prosthetic limb with no, or relatively minor, modification thereto. A plurality of sensor arrays are disposed on a support member, each array including a plurality of strain gauge sensors, each sensor outputting an electrical signal responsive to loading imposed on the support member through the prosthetic limb. Electronic circuitry in communication with the gauges is operative to receive the electrical signals from the strain gauges and provide a signal useful in the form, fit or function of the prosthetic limb. | 02-28-2013 |
Michael A. Link, Hillsboro, OR US
Patent application number | Description | Published |
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20110154656 | SYSTEMS AND METHODS FOR MANUFACTURING MODIFIED IMPEDANCE COAXIAL CABLES - Systems and methods for manufacturing modified impedance coaxial cables including providing a coaxial cable having an inner conductor, a dielectric layer at least partially covering an outer surface of the inner conductor, and an outer conductor at least partially covering an outer surface of the dielectric layer. The coaxial cable may include a first section having a first impedance configured to allow a first frequency band to pass. A discontinuity section may be formed in at least one of the inner conductor, the dielectric layer, and the outer conductor. The discontinuity section may have an impedance different than the first impedance and a length which is configured to attenuate a second frequency band. | 06-30-2011 |
Michael John Link, St. Paul, MN US
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20090132894 | Soft Output Bit Threshold Error Correction - A communications channel is provided that includes an encoder that receives user data and generates corresponding encoded symbols for transmission through a channel medium. A channel detector has an input coupled to receive an output signal from the channel medium and a reliability information output which produces reliability information regarding logic states of detected bits in the output signal. A binary reliability value is provide for each of the detected bits. The channel further includes a decoder having a reliability information input coupled to the reliability information output of the channel detector to generate corresponding user data words as a function of the binary reliability value. | 05-21-2009 |
20090132897 | Reduced State Soft Output Processing - An approach to reducing processing of soft output is disclosed. Candidate sequences of bits can be compared to soft output decisions to reduce at least one of the candidate sequences. Branch metric calculations can be performed for remaining candidate sequences and a most likely path can be selected from the remaining candidate sequences. | 05-21-2009 |
Michael L. Link, Byron, GA US
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20100285959 | HERBICIDAL MIXTURES - Disclosed is a herbicidal mixture comprising (a) at least one herbicide compound selected from the pyrimidines of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof: | 11-11-2010 |
Patrick J. Link, Carnation, WA US
Patent application number | Description | Published |
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20130095922 | HAND-HELD VIDEO GAME PLATFORM EMULATION - A software emulator for emulating a handheld video game platform such as GAME BOY®, GAME BOY COLOR® and/or GAME BOY ADVANCE® on a low-capability target platform (e.g., a seat-back display for airline or train use, a personal digital assistant, a cell phone) uses a number of features and optimizations to provide high quality graphics and sound that nearly duplicates the game playing experience on the native platform. Some exemplary features include use of bit BLITing, graphics character reformatting, modeling of a native platform liquid crystal display controller using a sequential state machine, and selective skipping of frame display updates if the game play falls behind what would occur on the native platform. | 04-18-2013 |
Paula O. Link, Verona, VA US
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20150305536 | Combination boot jack, boot tray, and boot rack - A combination boot jack, boot tray and boot rack for the removal, cleaning, movement and storage of mud boots, muck boots, galoshes, snow boots, work boots and similar rubber boots. The boot tray is broad enough for a user to step into the top surface of its base with both booted feet. The invention has a pair of U-shaped notches elevated above the top surface of the base, as well as an open-back/closed toe foot box, built into the boot tray. The user may thus step into the boot tray, use the pair of U-shaped notches as a boot jack to grip and secure the heels of both boots at once, and remove them, one at a time. During removal of the second boot, the user's unbooted foot is placed into the protected foot box, keeping it dry and out of contact with the ground, the outside of the boots, or any part of the boot jack and boot tray touched or soiled by the boots during their removal. Further, the boot jack and boot tray may be used as a boot rack for moving a pair of boots from place to place without touching them, as well as for later cleaning or storage. | 10-29-2015 |
Robert Link, Webster, NY US
Patent application number | Description | Published |
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20110109675 | PHASE SHIFTS FOR PRINTING AT TWO SPEEDS - The method includes forming first size drops by applying drop forming pulses during a unit time period τ | 05-12-2011 |
20110109677 | DYNAMIC PHASE SHIFTS TO IMPROVE STREAM PRINT - A method of forming print drops includes forming drops of a first size by applying drop forming energy pulses during a unit time period, τ | 05-12-2011 |
20110109705 | PHASE SHIFTS FOR TWO GROUPS OF NOZZLES - A method includes forming drops of first size by applying drop-forming pulses during unit time period, τ | 05-12-2011 |
20110242169 | CONTINUOUS PRINTER WITH ACTUATOR ACTIVATION WAVEFORM - A method for operating a drop generating device for selective formation of large-volume droplets and small-volume droplets, said method includes the steps of defining a small-drop waveform at least a pulse to form a small volume drop; defining a large-drop waveform that includes a set of pulses to form a large volume drop; creating a sequence of waveforms comprising waveforms of the small-drop and large-drop waveforms in response to image data the sequence of waveforms; and selectively inserting a perturbation pulse in the time interval between pulses of any two consecutive waveforms. | 10-06-2011 |
20110242170 | METHOD FOR OPERATING CONTINUOUS PRINTERS - A method for operating a continuous inkjet printer, the method includes forming drops with a drop formation period being the time between consecutive drop formations; creating a portion of the drops that strike the print media for forming print drops; creating a portion of the created drops that do not strike the print media for forming catch drops; creating the print drops to print on a series of consecutive pixel locations; wherein a time between the creation of consecutive print drops is inconsistent which causes an additional catch drop so that a gap is created; wherein when a gap is created, adjusting a velocity of the print drop adjacent to the gap to cause the print drop to shift slightly toward the gap. | 10-06-2011 |
20110242228 | DROP PLACEMENT METHOD FOR CONTINUOUS PRINTERS - A method for providing drop placement adjustment of drops deposited on a print media by a printhead in a continuous inkjet printer, the method comprising the steps of providing the printhead with a drop generator having at least one nozzle; moving the printhead relative to the print media; causing the printhead to form drops from the at least one nozzle with a drop formation period being the time between consecutive drop formations; wherein a portion of the formed drops are allowed to strike pixel locations on the print media for forming print drops, while other drops are directed toward a catcher and do not strike the print media for forming catch drops; creating a series of the print drops to print on a series of consecutive pixel locations; and adjusting a velocity of a portion of the formed print drops relative to a velocity of other print drops to adjust the placement of the print drop within the pixel locations. | 10-06-2011 |
20130235103 | METHOD OF ADJUSTING DROP VOLUME - A method for operating a jetting module includes applying to a drop forming mechanism a sequence of drop formation waveforms in which a small-drop waveform applied after another identical small-drop waveform causes a small drop of volume Vs to be formed; applying a large-drop waveform after another identical large-drop waveform causes a large drop of volume V | 09-12-2013 |
20130278689 | CONTINUOUS INKJET PRINTING METHOD - A method of printing an image with a continuous inkjet printer system employing bimodal drop size generation with pigmented inkjet ink compositions comprising a polymer additive, wherein the liquid ink is an aqueous inkjet ink comprises dispersed pigment colorant particles having a mean particle size of less than 150 nanometers and at least about 0.1 wt % of polymer additive distinct from any polymer dispersant used to disperse the pigment particles, and recirculating liquid ink supplied to the nozzle if the printer system from a liquid ink source is in-line filtered with a filter selected to be effective at retaining particles having particle sizes equal to and greater than 0.6 micrometers from the liquid ink and to pass the dispersed pigment particles. The invention enables high quality drop control in a continuous inkjet printing system. | 10-24-2013 |
Robert John Link, Northville, MI US
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20160052409 | OFF-BOARD CHARGER FOR HIGH-VOLTAGE BATTERY CHARGING - An off-board battery charger for a vehicle may include a high-voltage connector having first, second and power supply connector ports. The first connector port connects to a vehicle controller via a first cable. The second connector port connects to a vehicle battery via a second cable. And, the power supply connector port is electrically connected with the second port and receives power via a power supply cable from a separate and external power supply. | 02-25-2016 |
20160096438 | HIGH-VOLTAGE BATTERY OFF-BOARD CHARGERS - A vehicle charging system includes a charger configured to receive power form an external power source and a connector. The connector is configured to receive power from the charger and transmit the received power to a vehicle via a high-voltage cable. The cable is configured to connect the connector to a vehicle battery. Each of the charger and the connector includes a high voltage interlock loop (HVIL) configured to cause the charger to cease power transfer upon recognizing a predetermined voltage difference at a pair of ports of the HVIL. | 04-07-2016 |
Rodrigo Link, Joinville, SC US
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20120261022 | THERMAL ISOLATION, SUITABLE FOR ISOLATING THE GAS DISCHARGE TUBE OF A REFRIGERATING COMPRESSOR, AND A PROCESS OF ASSEMBLING THE ISOLATION IN THE GAS DISCHARGE TUBE - The present invention relates to a thermal isolation, suitable for isolating the gas discharge tube ( | 10-18-2012 |
Ross Link, Evanston, IL US
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20140019208 | METHODS AND APPARATUS TO EVALUATE MODEL STABILITY AND FIT - Methods, apparatus, systems and articles of manufacture are disclosed to evaluate model stability and fit. An example method disclosed herein includes building a fit function based on causal factors associated with a marketing mix model, building a stability function based on override factors associated with corresponding ones of the causal factors, and integrating scaling factors into the stability function to facilitate a combined regression analysis of the fit function and the stability function, the scaling factors respectively associated with corresponding causal factors. | 01-16-2014 |
20140278930 | METHODS AND APPARATUS TO INCORPORATE SATURATION EFFECTS INTO MARKETING MIX MODELS - Methods and apparatus to incorporate saturation effects into marketing mix models are disclosed. A disclosed method includes calculating adstocked gross rating points associated with an advertising campaign during segments of a period of time. The adstocked gross rating points are based on raw gross rating points corresponding to the advertising campaign. The raw gross rating points are delivered during the segments of the period of time. The example method further includes calculating an effective reach realized during the segments of the period of time for the advertising campaign. The effective reach realized is based on the adstocked gross rating points. | 09-18-2014 |
Ryan Link, Houston, TX US
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20110182730 | WIND TURBINE BLADE WITH DAMPING ELEMENT FOR EDGEWISE VIBRATIONS | 07-28-2011 |
Steve Link, St. Paul, MN US
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20150067665 | SELF-UPDATING APPLICATION AGENT - Methods, apparatuses, and computer program products are described herein that are configured to enable a self-update. In some example embodiments, a method is provided that comprises receiving a communication from a data center update module, the communication comprising an expected agent version identifier. The method of this embodiment may also include determining whether the expected agent version identifier is equal to a current agent version identifier. The method of this embodiment may also include causing an application agent to perform a self-update in an instance in which the expected agent version identifier is not equal to a current agent version identifier. | 03-05-2015 |
Steven G. Link, Rochester, NY US
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20090181170 | MONOAZO COLORANTS FROM PYRAZOLOBENZODIAZINEDIOXIDES - The invention relates to monoazo colorants derived from pyrazolobenzodiazinedioxides of Formula 1: | 07-16-2009 |
20090205533 | INKJET INKS CONTAINING AZO PYRAZOLOBENZOPYRIMIDINEONE CLASS OF COLORANTS - The present invention relates to an aqueous ink comprising at least water, and a colorant of Formula 1 | 08-20-2009 |
Todd M. Link, Mcdonald, PA US
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20140072674 | LEAK-PROOF CONTAINERS, MADE FROM EXPANDABLE THERMOPLASTIC RESIN BEADS - This invention discloses a leak proof disposable container, comprising of a bottom portion composed of expandable thermoplastic resin beads and a lidding film, for containing non-carbonated drinks or food products that do not require heating prior to consumption. The inventive container eliminates the use of polypropylene and polystyrene snap-on lids currently used for cups and containers. The snap-on lid is replaced with a thermoplastic lidding film, a leak proof seal is formed between the lidding film and upper flange of the bottom portion. Replacement of the snap-on lid with lidding film, reduces the weight of the disposable lidding material by 74 percent. Through the appropriate selection of materials, one can produce a leak proof container that is 100 percent recyclable under the #6 PS (polystyrene) symbol. | 03-13-2014 |
William Link, Mundelein, IL US
Patent application number | Description | Published |
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20140322073 | HAND RAIL SANITIZIER - A hand rail sanitizing system for sanitizing a hand rail of an escalator stairway from germs and bacteria on the hand rail is provided. The hand rail has a top wall, a bottom wall, and a pair of side walls. The hand rail sanitizing system comprises a container having a top wall and a bottom wall with the container positioned nearingly adjacent the hand rail. A UV-light emitting diode (LED) bulb is encased within the container. As the hand rail continuously passes by the container, the LED bulb irradiates through the bottom wall of the container toward the top wall of the hand rail. | 10-30-2014 |