Lin, VA
Bing Lin, Yorktown, VA US
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20160047891 | HYPERFINE INTERPOLATED RANGE FINDING FOR CW LIDAR, RADAR, and SONAR USING REPEATING WAVEFORMS AND FOURIER TRANSFORM REORDERING - Systems, methods, and devices may enhance the apparent sample rate of data collected using Nyquist sampling from a system, such as Continuous Wave (CW) Light detection and ranging (“Lidar”), Radio detection and ranging (“Radar”), or Sound Navigation and Ranging (“Sonar”), that has been modulated with a repeating waveform, such as linear swept frequency, by reordering of the data in the frequency domain. The enhancement of the apparent sample rate may result in a highly interpolated range profile where the data resolution may be enhanced by a factor equal to the number of repeats in the signal being processed, and may result in a highly detained range measurement with a high precision. The various embodiments may combine data from multiple modulation repeats into a single highly interpolated pulse, which may result in a real-time finer range measurement from CW Lidar, Radar, or Sonar systems. | 02-18-2016 |
Chen-Yong Lin, Falls Church, VA US
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20080248566 | MATRIPTASE, A SERINE PROTEASE AND ITS APPLICATIONS - The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which have the phenotype of matriptase production by administering a tumor formation inhibiting effective amount of concentrate of Bowman-Birk inhibitor (BBIC), or other matriptase inhibitor. The invention also is directed to nucleic acids encoding a matriptase protein or fragments thereof, and their use for structure elucidation and modeling to identify other inhibitors of matriptase, as well as to methods of identifying matriptase modulating agents, including activators and inhibitors. | 10-09-2008 |
20120294800 | TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES - The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as doxorubicin (DOX) are introduced, which are equipotent to anticancer agents used in free form but exhibit significantly reduced cardiotoxicity and almost no adverse effects on normal bone marrow-derived mesenchymal stromal cells that do not express matriptase. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase. In addition, administration of a matriptase antibody or immunoconjugates of a matriptase antibody and a cytotoxic agent in combination with administration of an immunomodulatory agent, such as thalidomide or an analog thereof, provides a more effective treatment of these cancers. | 11-22-2012 |
20150250895 | Specific Delivery of Toxins Conjugated with Antiobodies to Activate Matripase - Disclosed are antibody drug conjugates (ADC) that include highly potent toxic agents with specific antibodies to target tumors. Also disclosed are related antibodies, polypeptides, nucleic acids, host cells, compositions, and uses. | 09-10-2015 |
20150338409 | Markers for Abnormal Cells - The present invention relates to methods of determining the presence or absence of abnormal lymphoid cells or abnormal myeloid cells in a cell sample, with the methods comprising subjecting the cell sample to conditions that will activate any inactive matriptase present in the cell sample and measuring the levels of activated matriptase in the cell sample. Once measured, these levels can then be compared to control levels of active matriptase to determine if the cell sample has elevated levels of activated matriptase over control levels of active matriptase. An elevation in the levels of activated matriptase in the cell sample is indicative that the cell sample contains abnormal lymphoid cells or abnormal myeloid cells. | 11-26-2015 |
Horn Bon Lin, Fairfax, VA US
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20140263694 | ELECTROSPRAYER FOR ARTHROPOD TAGGING - An electrosprayer for insect and arthropod tagging having a nozzle cartridge comprising a liquid reservoir, a high voltage connector, and at least one nozzle; a spray chamber where each nozzle is directed into the spray chamber; and a high voltage power supply, where the power supply applies voltage through the high voltage connector. Also disclosed is the related method for tagging insects and arthropods. | 09-18-2014 |
John C. Lin, Seaford, VA US
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20120153086 | Elastically Deformable Side-Edge Link for Trailing-Edge Flap Aeroacoustic Noise Reduction - A system is provided for reducing aeroacoustic noise generated by an aircraft having wings equipped with trailing-edge flaps. The system includes a plurality of elastically deformable structures. Each structure is coupled to and along one of the side edges of one of the trailing-edge flaps, and is coupled to a portion of one of the wings that is adjacent to the one of the side edges. The structures elastically deform when the trailing-edge flaps are deployed away from the wings. | 06-21-2012 |
Peck-Sun Lin, Richmond, VA US
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20140065139 | Induction of Tumor Hypoxia for Cancer Therapy - Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced. | 03-06-2014 |
Robert Lin, Lynchburg, VA US
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20130304669 | SYSTEM AND METHOD FOR POOL RISK ASSESSMENT - A system and method for assessing risk is provided. The method comprises determining an investment index associated with investment by an insurance company in an insurance pool. Next, the method comprises determining a return index associated with an expected return to the insurance company from participating in the insurance pool; and determining a benefit index based on the investment and return indices. The system for assessing risk comprises an assessment module for assessing risks associated with an insurance company's participation in an insurance pool based on at least one of: an investment index associated with the costs of participating in the insurance pool, and a return index associated with the benefits of participating in the insurance pool. | 11-14-2013 |
Sophie Lin, Charlottesville, VA US
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20110093219 | Methods for modeling the structural health of a civil structure based on electronic distance measurements - Methods are disclosed wherein the structural health of a civil structure, such as, but not limited to, a bridge or the like is measured by electronic distance measurement (EDM) from a plurality of stable locations to a plurality of cardinal points on the structure in a methodical manner. By measuring the coordinates of the cardinal points, the dynamic and long-term static behavior of the structure provide an indication of the health of the structure. Analysis includes: comparison to a Finite Element Model (FEM); comparison to historical data; and modeling based on linearity, hysteresis, symmetry, creep, damping coefficient, and harmonic analysis. | 04-21-2011 |
20120250004 | Methods for measuring and modeling the structural health of pressure vessels based on electronic distance measurements - Methods are disclosed wherein the structural health of a civil structure, pressure vessel, or the like is measured by electronic distance measurement (EDM) from a plurality of stable locations to a plurality of cardinal points on the structure in a methodical manner. By measuring the coordinates of the cardinal points, the dynamic and long-term static behavior of the structure provide an indication of the health of the structure. Analyses includes: comparison to a Finite Element Model (FEM); comparison to historical data; and modeling based on linearity, hysteresis, symmetry, creep, damping coefficient, and harmonic analysis. | 10-04-2012 |
Yi Lin, Yorktown, VA US
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20130315816 | Bulk preparation of holey graphene via controlled catalytic oxidation - A scalable method allows preparation of bulk quantities of holey carbon allotropes with holes ranging from a few to over 100 nm in diameter. Carbon oxidation catalyst nanoparticles are first deposited onto a carbon allotrope surface in a facile, controllable, and solvent-free process. The catalyst-loaded carbons are then subjected to thermal treatment in air. The carbons in contact with the carbon oxidation catalyst nanoparticles are selectively oxidized into gaseous byproducts such as CO or CO | 11-28-2013 |
20140103558 | Polyaniline/carbon nanotube sheet nanocomposites - A method allows for preparation of CNT nanocomposites having improved mechanical, electrical and thermal properties. Structured carbon nanotube forms such as sheet, yarn, and tape are modified with π-conjugated conductive polymers, including polyaniline (PANI), fabricated by in-situ polymerization. The PANI modified CNT nanocomposites are subsequently post-processed to improve mechanical properties by hot press and carbonization. | 04-17-2014 |
20140134352 | Amorphous carbon-boron nitride nanotube hybrids - A method for joining or repairing boron nitride nanotubes (BNNTs). In joining BNNTs, the nanotube structure is modified with amorphous carbon deposited by controlled electron beam irradiation to form well bonded hybrid a-C/BNNT structures. In repairing BNNTs, the damaged site of the nanotube structure is modified with amorphous carbon deposited by controlled electron beam irradiation to form well bonded hybrid a-C/BNNT structures at the damage site. | 05-15-2014 |
20150104372 | Single-Step, Solvent-Free, Catalyst-Free Preparation of Holey Carbon Allotropes - Methods for forming holey carbon allotropes and graphene nanomeshes are provided by the various embodiments. The various embodiments may be applicable to a variety of carbon allotropes, such as graphene, graphene oxide, reduced graphene oxide, thermal exfoliated graphene, graphene nanoribbons, graphite, exfoliated graphite, expanded graphite, carbon nanotubes (e.g., single-walled carbon nanotubes, double-walled carbon nanotubes, few-walled carbon nanotubes, multi-walled carbon nanotubes, etc.), carbon nanofibers, carbon fibers, carbon black, amorphous carbon, fullerenes, etc. The methods may produce holey carbon allotropes without the use of solvents, catalysts, flammable gas, additional chemical agents, or electrolysis to produce the pores (e.g., holes, etc.) in the carbon allotropes. In an embodiment, a carbon allotrope may be heated at a working window temperature for a working period of time to create holes in the carbon allotrope. | 04-16-2015 |
Zhiyuan Lin, Blacksburg, VA US
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20150258760 | PROCESS FOR BONDING LIGNOCELLULOSIC SUBSTRATES WITHOUT AN ADDED ADHESIVE AND PRODUCTS THEREOF - Processes for bonding lignocellulosic substrates without an added adhesive are described. The processes of the invention may include exposing the surfaces of the lignocellulosic substrate to a rapid heating source to cause one or more physical, chemical, or other modifications on the surface of the substrate. As a result of the modifications, the surfaces may form a bond with another substrate under elevated temperatures and pressures, for example, produced by a means for pressing such as a conventional hot press used in the woodworking arts. The processes allow a variety of composites such as wood materials for use in the furniture making or construction industries to be manufactured. As the processes forgo the need for petroleum-based adhesives, they are more environmentally sound and occupationally safe than prior art wood product manufacturing methods. Additionally, composite materials made by the processes of the invention are described. | 09-17-2015 |
Zongli Lin, Charlottesville, VA US
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20130069773 | INTELLIGENT TRAFFIC SAFETY SYSTEM BASED ON COMPREHENSIVE STATE DETECTION AND DECISION METHOD THEREOF - The present invention discloses an intelligent traffic safety system based on comprehensive state detection and decision method thereof. The intelligent traffic safety system includes a person condition detection unit, a vehicle condition detection unit, a road condition detection unit, an intelligent decision unit, a driver warning unit, a current vehicle mandatory processing unit, a barrier warning unit, a pursuer warning unit and an after-crash warning unit. The person condition detection unit, the vehicle condition detection unit and the road condition detection unit are separately connected to the intelligent decision unit; the intelligent decision unit implements an intelligent traffic safety decision method based on comprehensive state detection, and respectively sends corresponding crash avoidance warnings and processing instructions to the driver warning unit, the current vehicle mandatory processing unit, the barrier warning unit, the pursuer warning unit and the after-crash warning unit connected to the intelligent decision unit. | 03-21-2013 |