Patent application number | Description | Published |
20080206738 | Compositions and methods for modulating S-nitrosoglutathione reductase - Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions. | 08-28-2008 |
20100015121 | INHIBITING GS-FDH TO MODULATE NO BIOACTIVITY - Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase. | 01-21-2010 |
20100266581 | COMPOSITIONS AND METHODS FOR MODULATING S-NITROSOGLUTHIONE REDUCTASE - Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions. | 10-21-2010 |
20120245116 | Inhibiting GS-FDH to Modulate No Bioactivity - Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase. | 09-27-2012 |
20130196342 | Compositions And Methods For Modulating S-Nitrosogluthione Reductase - Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions. | 08-01-2013 |
20140235528 | INHIBITING GS-FDH TO MODULATE NO BIOACTIVITY - Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase. | 08-21-2014 |
Patent application number | Description | Published |
20090022818 | HIGH-FOAMING, VISCOUS CLEANSER COMPOSITION WITH A SKIN CARE AGENT - A liquid cleansing composition comprising a cleansing surfactant, an adsorbed skin-care agent, adsorptive polymeric particles having an adsorption capacity of at least 2 g of skin care agent per gm of dry polymeric particles, a polymeric thickening agent having a molecular weight in the range of 500,000-10,000,000 Dalton, a water-soluble polymer having a molecular weight in the range of 200-50,000 Dalton, and a hydrophilic liquid, the said cleansing composition having the following features i) the low molecular weight, water-soluble polymer component functions as a foam-boosting and thixotropy-boosting agent; ii) the ratio of the Brookfield viscosity at 1 rpm of spindle speed to the Brookfield viscosity at 100 rpm of spindle speed is at least 10; and iii) the foam-volume is at least 20% higher with the water-soluble, polymeric, foam-boosting component than without it. | 01-22-2009 |
20100008959 | Cosmetic and Therapeutic Stick Products - A composition wherein phase or chemically incompatible components are introduced into a stick composition through the use of a microparticle delivery system. | 01-14-2010 |
20100183688 | Delivery System and Method of Manufacturing the Same - A microparticle delivery system for an active compound which includes an active compound loaded onto polymeric microparticles, wherein the loaded microparticles are encased by a matrix material comprising about 68% to about 99%, by weight, of the microparticle delivery system. Compositions containing the microparticle delivery system, and methods of manufacturing the microparticle delivery system, also are disclosed. | 07-22-2010 |
20110189249 | Low pH Retinoid Topical Compositions - A low pH composition containing a retinol and a method for treating skin is disclosed. The composition contains (a) a retinoid and (b) an active acid, like an alpha-hydroxy acid or a beta-hydroxy acid, and has a pH of less than 5. | 08-04-2011 |
20120014888 | Matte Skin Finish Compositions - A composition and method for reducing the shine of human skin is disclosed. The composition imparts a topical matte finish to the skin for an extended time period. The composition contains polymeric microparticles, optionally loaded with a cosmetic or therapeutic skin care compound. | 01-19-2012 |
20150050227 | Compositions Having Perspiration Reduction Properties - A composition containing polymeric microparticles is disclosed. The composition effectively reduces perspiration in the absence of aluminum/zirconium antiperspirant compounds. | 02-19-2015 |
Patent application number | Description | Published |
20080261829 | ANTIBODY-BASED ARRAYS FOR DETECTING MULTIPLE SIGNAL TRANSDUCERS IN RARE CIRCULATING CELLS - The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies. | 10-23-2008 |
20080299597 | METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention. | 12-04-2008 |
20100025264 | ELECTROCHEMICAL BIOSENSOR FOR DIRECT DETERMINATION OF PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides electrochemical biosensors for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The invention provides methods for using the electrochemical biosensors. | 02-04-2010 |
20100167945 | DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS - The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments. | 07-01-2010 |
20110189712 | METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention. | 08-04-2011 |
20110250627 | METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention. | 10-13-2011 |
20120270745 | DRUG SELECTION FOR CANCER THERAPY BY PROFILING SIGNAL TRANSDUCTION PROTEINS IN ASCITES OR PLEURAL EFFLUX SAMPLES - The present invention provides methods for selecting a suitable anticancer therapy and for identifying and predicting response for the treatment of a gastric cancer by determining the expression level and/or activation level of one or more analytes in a cell such as a cancer cell from an ascites sample. The present invention also provides methods for selecting a suitable anticancer therapy and for identifying and predicting response for the treatment of a lung cancer such as a non-small cell lung cancer by determining the expression level and/or activation level of one or more analytes in a cell such as a cancer cell from a pleural efflux sample. | 10-25-2012 |
20130045880 | DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS - The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments. | 02-21-2013 |
20130078664 | METHODS FOR ASSAYING PERCENTAGE OF GLYCATED HEMOGLOBIN - The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention. | 03-28-2013 |
20140187445 | ANTIBODY-BASED ARRAYS FOR DETECTING MULTIPLE SIGNAL TRANSDUCERS IN RARE CIRCULATING CELLS - The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies. | 07-03-2014 |
20140349865 | DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS - The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments. | 11-27-2014 |
20150051107 | ANTIBODY-BASED ARRAYS FOR DETECTING MULTIPLE SIGNAL TRANSDUCERS IN RARE CIRCULATING CELLS - The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies. | 02-19-2015 |
Patent application number | Description | Published |
20130240169 | FORMING MACHINE WITHOUT PATTERN CASTING - The disclosure provides a forming machine without pattern casting, including: a multi-axis motion system which at least includes an X-axis motion system, a Y-axis motion system and a Z-axis motion system, and a workbench which is below the multi-axis motion system; and further includes: a moving platform system below the workbench, including a moving bracket which can reciprocate along the direction parallel to the X axis, a lifting device provided on the moving bracket, which is used for lifting and supporting the workbench to enable the linkage between the workbench and the moving bracket. The forming machine without pattern casting of the disclosure can move the workbench without a lifting tool, and machine a casting mold with a large size and a complex cavity, and causes little pollution to the environment. | 09-19-2013 |
20140053668 | LOCATING BEAM AND ROBOT LINEAR MOTION UNIT HAVING THE SAME - The present invention provides a locating beam and a robot linear motion unit having the same. The locating beam comprises a first support beam ( | 02-27-2014 |
20140284017 | FORMING MACHINE WITHOUT PATTERN CASTING - The disclosure provides a forming machine without pattern casting, including: a multi-axis motion system; a cutting system, connected with the multi-axis motion system; a driving system, driving the multi-axis motion system to move; and a machining base, wherein the machining base includes a fixing seat and a turnover mechanism, wherein the turnover mechanism is revolvably connected with the fixing seat. Since the forming machine without pattern casting of the disclosure adopts a tilting type and needs no working platform, most of the waste sand grains generated from cutting fall freely into the shakeout groove arranged below the fixing seat, and will not fly into the multi-axis motion system, and will not cause stop failure; thus the precision and service life of the forming machine without pattern casting are improved. | 09-25-2014 |
20150379677 | RADIATION IMAGE INSPECTION SYSTEM AND METHOD BASED ON B/S ARCHITECTURE - The present disclosure provides a radiation image inspection system based on B/S architecture. The system comprises: at least one client terminal, configured to initiate an image operation request to a Web server, and display an image operation result on a browser of the client terminal upon receiving a response from the Web server; an image processing assembly, configured to query, based on the image operation request from the client terminal and forwarded by the Web server, an image which the client terminal desires to process, perform an operation on an image as requested by the client terminal, convert the resulted image into an image in a designated format and quality and return the converted image to the browser of the client terminal via the Web server for displaying; and the Web server, configured to receive the image operation request from the client terminal, forward the image operation request to the image processing assembly, and return the image operation result from the image processing assembly to the client terminal. | 12-31-2015 |