| Patent application number | Description | Published |
|---|
| 20080249600 | STENTS WITH DRUG RESERVOIR LAYER AND METHODS OF MAKING AND USING THE SAME - A method of making drug eluting stents comprises forming ceramic surface coatings of two or more levels of porosity on a stent body. The less porous coating is more conducive to endothelial cell growth, while the more porous coating is better suited for storing and releasing drugs. The surface coatings of different porosities can be produced by coating stent body surface of differing roughness with coatings made by sol-gel method. Differing roughness of the stent body surface can be produced by selective etching of the stent body surface. | 10-09-2008 |
| 20080262412 | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power - The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents. | 10-23-2008 |
| 20080287984 | Medical balloons and methods of making the same - Medical balloons are provided that have enhanced properties, such as thinner walls, enhanced tensile strength, and/or electrical conductivity. Methods are also disclosed. | 11-20-2008 |
| 20090029077 | Drug eluting medical devices having porous layers - In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent. | 01-29-2009 |
| 20090048659 | Medical devices having sol-gel derived ceramic regions with molded submicron surface features - According to one aspect of the present invention, implantable or insertable medical devices are provided, which contain sol-gel derived ceramic regions which have molded submicron surface features. | 02-19-2009 |
| 20090118815 | STENT - Endoprosthesis includes coatings of selected porosity formed of particulates of ceramics, metals, drugs and/or polymers. | 05-07-2009 |
| 20090118822 | STENT WITH EMBEDDED MATERIAL - An endoprosthesis such as a stent is composed of a metal or ceramic, such as Irox, embedded in the stent material. | 05-07-2009 |
| 20090118823 | ENDOPROSTHESIS WITH POROUS RESERVOIR - An endoprosthesis such as a coronary stent includes a porous metal reservoir of drug, e.g. directly in the body of the stent. And a method of loading drug into the porous reservoir includes applying an electrical potential to the endoprosthesis. | 05-07-2009 |
| 20090149948 | MEDICAL DEVICES CONTAINING SILICATE AND CARBON PARTICLES - According to one aspect of the present invention, implantable and insertable medical devices are provided which contain one or more particle-containing regions that comprise silicate particles and carbon particles. | 06-11-2009 |
| 20090281613 | Endoprostheses - An endoprosthesis includes a body defining a flow passage therethrough. The body is capable of maintaining patency in a blood vessel and includes iron or an alloy thereof. The body has a nano-structured surface comprising iron oxide in which the individual nano-structures have a height to thickness aspect ratio of at least 5:1. | 11-12-2009 |
| 20090294732 | COATINGS FOR MEDICAL DEVICES HAVING REVERSIBLE HYDROPHOBIC TO HYDROPHILIC PROPERTIES - A medical device including a coating disposed on at least a portion of a surface of the medical device, the coating including at least one polymer material having reversible wettability. | 12-03-2009 |
| 20090297581 | MEDICAL DEVICES HAVING ELECTRODEPOSITED COATINGS - According to one aspect, the present invention provides implantable or insertable medical devices that comprise a conductive substrate and an electrodeposited coating over the substrate. The electrodeposited coating includes (a) one or more types of inorganic materials, (b) one or more types of polymeric materials and (c) optionally, one or more types of therapeutic agents. Still other aspects of the invention concern methods of making and using such devices. | 12-03-2009 |
| 20090318848 | MEDICAL DEVICES EMPLOYING CONDUCTIVE POLYMERS FOR DELIVERY OF THERAPEUTIC AGENTS - In accordance with one aspect, the invention relates to medical devices which comprise at least one reservoir, a therapeutic-agent-containing region disposed within the reservoir and an electrode comprising a conductive polymer. The devices of the invention are configured such that a rate of release of the therapeutic agent from the reservoir changes upon a change in the oxidation state of the conductive polymer. | 12-24-2009 |
| 20090319032 | ENDOPROSTHESIS COATING - An endoprosthesis, e.g., a stent (e.g., a drug eluting stent), that includes a porous surface and hollow elements integrated with a coating on the surface and a method of making the same are disclosed. | 12-24-2009 |
| 20090324684 | MEDICAL DEVICES HAVING SURFACE COATINGS - According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid. | 12-31-2009 |
| 20090324685 | MEDICAL DEVICE COATINGS CONTAINING CHARGED MATERIALS - In accordance with certain aspects of the present invention, medical devices are provided which are configured for implantation or insertion into a subject. The medical devices include at least one coating region that comprises (a) a charged polyamino-acid-containing polymer having a first net charge and (b) an additional charged polymer having a second net charge that is opposite in sign to that of the first net charge. The additional charged polymer may or may not be a polyamino-acid-containing polymer. | 12-31-2009 |
| 20090326638 | MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION - According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both. | 12-31-2009 |
| 20100004733 | Implants Including Fractal Structures - An endoprosthesis includes a member having a surface that includes a fractal structure. | 01-07-2010 |
| 20100008970 | Drug-Eluting Endoprosthesis - A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent. | 01-14-2010 |
| 20100042205 | MEDICAL DEVICES HAVING ELECTRODEPOSITED CONDUCTIVE POLYMER COATINGS - According to one aspect, the present invention provides implantable or insertable medical devices that comprise a substrate and a coating over the substrate that comprises at least one type of conductive polymer and at least one type of additional polymer. | 02-18-2010 |
| 20100137978 | Medical Implants Including Iridium Oxide - A medical implant includes iridium oxide. The iridium oxide has a plurality of Ir—O σ bonds and a plurality of Ir═O σ bonds. The iridium oxide has a ratio of the Ir—O σ bonds to the Ir═O π bonds that is greater than 1.3. | 06-03-2010 |
| 20100145436 | Bio-erodible Stent - Endoprostheses such as stents are disclosed that are, or that include portions that are, bioerodible. | 06-10-2010 |
| 20100222873 | Self-Buffering Medical Implants - A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body. | 09-02-2010 |
| 20100241071 | Polymeric/Inorganic Composite Materials for Use in Medical Devices - In one aspect, the present invention provides composite coatings for implantable or insertable medical devices. These composite coatings comprise (a) an inorganic portion and (b) a polymeric portion that comprises a poly(vinyl pyrrolidone) (PVP) block. | 09-23-2010 |
| 20100269838 | MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION - A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel. | 10-28-2010 |
| 20100318020 | ELECTROCHEMICAL THERAPEUTIC AGENT DELIVERY DEVICE - A therapeutic agent delivery device and method for eluting a therapeutic agent to a target location are disclosed. The device may comprise a first conductive element, a second conductive element, an electrochemical composition including an electrolyte and a therapeutic agent, and a permeable membrane covering the electrochemical composition. The first conductive element and the second conductive element are adapted to be connected to a voltage source. When the voltage source is connected to the first conductive element and the second conductive element, an electrochemical reaction occurs causing the therapeutic agent to pass through the permeable membrane and thereby to elute to a target location. | 12-16-2010 |
| 20100331760 | BIODEGRADABLE IMPLANT FOR TREATING OR PREVENTING REPERFUSION INJURY - A biodegradable implant for iontophoretic therapeutic agent delivery is provided. The implant comprises a biodegradable battery and at least one biodegradable iontophoresis electrode assembly. The biodegradable battery comprises first and second biodegradable electrodes and a biodegradable polymer electrolyte layer between the first and second biodegradable electrodes. The biodegradable iontophoresis electrode assembly comprises a biodegradable iontophoresis electrode and a charged therapeutic agent. When the biodegradable battery is electrically connected to generate an electric current through the biodegradable iontophoresis electrode assembly, the charged therapeutic agent is delivered by iontophoresis to a target location. The charged therapeutic agent may be a scavenger for reactive oxygen species. The electrical connection of the biodegradable battery may be controlled remotely. | 12-30-2010 |
| 20100331775 | IMPLANTABLE SELF-POWERED BIODEGRADABLE MEDICAL DEVICE TO TREAT OR PREVENT REPERFUSION INJURY - In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent. | 12-30-2010 |
| 20110022162 | ENDOPROSTHESES - An endoprosthesis includes an endoprosthesis wall that includes a ceramic coating and a polymer coating containing a therapeutic agent. A ceramic coating can be formed on the wall by electrochemical deposition. Cyclic voltammetry can be conducted to modify the density of the hydroxyl groups on the surface of the ceramic coating. | 01-27-2011 |
| 20110046539 | INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER - The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents. | 02-24-2011 |
| 20110160839 | Endoprosthesis - An endoprosthesis, e.g., a bioerodable stent, that is treated by plasma immersion ion implantation on the surface and optionally in the bulk. Releasable therapeutic agent, drug, or pharmaceutically active compound may be incorporated into the treated surface of the endoprosthesis to provide desired medical benefits. | 06-30-2011 |
