| Patent application number | Description | Published |
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| 20080227844 | Methods for Treatment with Bucindolol Based on Genetic Targeting - The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the Arg 389 polymorphism in the β1-adrenergic receptor (AR). | 09-18-2008 |
| 20090092964 | Methods for Individualizing Cardiovascular Disease Treatment Protocols Based on Beta-1 Adrenergic Receptor Haplotype - A method is provided for determining whether a treatment protocol for a human patient who is suffering from heart failure, ischemic heart disease, cardiac arrhythmias, or hypertension includes administration of a beta blocker, the method including obtaining a biological sample from the patient, determining a β | 04-09-2009 |
| 20090149376 | Pharmaceutical and Therapeutic Applications Relating to a Type 9 Adenylyl Cyclase Polymorphism in Asthma and Reversible Bronchial Obstruction - A pharmaceutical composition comprising an expression product of a Type Nine adenylyl cyclase gene polymorphism, along with a suitable physiological carrier, are provided. In addition, methods related to treating patients having asthma or a reversible bronchial obstruction, kits for determining the responsiveness of an individual to treatment regimens, and assays for screening pharmaceutical for efficacy in treatment are also provided. | 06-11-2009 |
| 20100233677 | FULL GENOME SEQUENCES OF HUMAN RHINOVIRUS STRAINS - Infection by human rhinovirus (HRV) causes upper and lower respiratory tract disease with varying degrees of virulence. The molecular basis of diversity was examined by completing the genome sequences for all known serotypes (n=99) as well as novel field samples. Superimposition of capsid crystal structure and optimal-energy RNA configurations established the alignments. The phylogeny revealed conserved motifs, Glade-specific diversity including a potential new species (clade-D), pan-genome mutations in field isolates, and unexpected recombination that contributes to heterogeneity. A spacer tract near a 5′-UTR cloverleaf was hypervariable, and in analogy with poliovirus, may be associated with virulence. A previously unidentified configuration consistent with non-scanning internal ribosome entry may account for rapid protein translation. The data density from complete sequences of the HRV reference serotypes provided high resolution for this degree of modeling, and serves as a platform for full genome-based epidemiologic studies, for viral diagnostics and prognostics, and for antiviral compounds and vaccines. | 09-16-2010 |
| 20100248976 | G-PROTEIN COUPLED RECEPTOR KINASE-5 POLYMORPHISM - The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of the beta adrenergic receptor signaling pathway in an individual, assessing partial protection against heart failure progression in an individual, and assessing an individual's response to beta-blocker therapy. The compositions include polynucleotides or fragments thereof of a nucleotide sequence encoding for a G-protein receptor kinase-5 molecule with a thymine at amino acid position 122 and oligonucleotide primers that hybridize thereto. | 09-30-2010 |
| 20120289573 | METHODS FOR TREATMENT WITH BUCINDOLOL BASED ON GENETIC TARGETING - The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the Arg 389 polymorphism in the β1-adrenergic receptor (AR). | 11-15-2012 |
| Patent application number | Description | Published |
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| 20080205843 | Fiber optic drop terminals for multiple dwelling units - There is provided fiber drop terminals (“FDTs”) and related equipment for providing selective connections between optical fibers of distribution cables and optical fibers of drop cables, such as in multiple dwelling units. The FDTs require relatively little area and/or volume while providing convenient connectivity for a relatively large number of optical connections. The FDTs include adapters for optically connecting the connectors, and the adapters of some FDTs are adapted to rotate, move, or otherwise be removed to provide convenient access for technicians. Some FDTs and the related equipment are adapted for use with microstructured optical fiber having preferred bend characteristics. | 08-28-2008 |
| 20090148119 | Fiber Optic Drop Terminals for Multiple Dwelling Units - There is provided fiber drop terminals (“FDTs”) and related equipment for providing selective connections between optical fibers of distribution cables and optical fibers of drop cables, such as in multiple dwelling units. The FDTs require relatively little area and/or volume while providing convenient connectivity for a relatively large number of optical connections. The FDTs include adapters for optically connecting the connectors, and the adapters of some FDTs are adapted to rotate, move, or otherwise be removed to provide convenient access for technicians. Some FDTs and the related equipment are adapted for use with microstructured optical fiber having preferred bend characteristics. | 06-11-2009 |
| 20110262099 | FIBER OPTIC DROP TERMINALS FOR MULTIPLE DWELLING UNITS - There is provided fiber drop terminals (“FDTs”) and related equipment for providing selective connections between optical fibers of distribution cables and optical fibers of drop cables, such as in multiple dwelling units. The FDTs require relatively little area and/or volume while providing convenient connectivity for a relatively large number of optical connections. The FDTs include adapters for optically connecting the connectors, and the adapters of some FDTs are adapted to rotate, move, or otherwise be removed to provide convenient access for technicians. Some FDTs and the related equipment are adapted for use with microstructured optical fiber having preferred bend characteristics. | 10-27-2011 |
| Patent application number | Description | Published |
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| 20100235111 | MANAGING NON-DESTRUCTIVE EVALUATION DATA - A method, apparatus and program product manage non-destructive evaluation (“NDE”) data. NDE data and inspection information for at least a portion of an asset are received and at least one alignment algorithm to align the NDE data to a simulated model of the at least a portion of the asset is determined based upon at least one of the NDE data and the inspection information. The NDE data is automatically aligned to the simulated model with the at least one alignment algorithm and a display representation that visually represents the aligned NDE data on the simulated model is generated. | 09-16-2010 |
| 20100235112 | MANAGING NON-DESTRUCTIVE EVALUATION DATA - Embodiments of the invention include methods to manage non-destructive evaluation (“NDE”) data. The method includes receiving NDE data for at least a portion of an asset along with inspection information associated with the at least a portion of the asset, and determining at least one alignment algorithm to align the NDE data to a simulated model of the at least a portion of the asset based on at least one of the NDE data or the inspection information. The method further includes automatically aligning The NDE data to the simulated model with the at least one alignment algorithm and analyzing the aligned NDE data on the simulated model to determine coverage of the simulated model by the NDE data. Additional methods include retrieving NDE data that has previously been aligned to the simulated model and determining coverage or determining trends associated with indications thereof. | 09-16-2010 |
| 20100235153 | MANAGING NON-DESTRUCTIVE EVALUATION DATA - Methods manage non-destructive evaluation (“NDE”) data. NDE data for an asset is received and at least one alignment algorithm to align the NDE data to a simulated model associated therewith is determined. The NDE data is automatically aligned to the simulated model, a display representation that visually represents the aligned NDE data on the simulated model is generated, and information about the aligned NDE data is exported. Additionally, second NDE data associated with the at least a portion of the asset may also be received, at least one alignment algorithm to align the data determined, and the second NDE data aligned. Respective indications associated with the first and second NDE data may be determined and visually represented on the simulated model. Moreover, a shot descriptor file may be analyzed to determine whether additional NDE data is required to complete an alignment of NDE data. | 09-16-2010 |
