Patent application number | Description | Published |
20100036450 | Carbon Nano-tube Power Cell - A device which converts mechanical deformation in electrical current, these mechanical deformations are generated as a result of liquid pressure over a part of the device. This device is integrated within an implantable lead and inserted into the cardiovascular system of a patient. The purpose of the device is to charge a battery which stores energy for various uses of other implantable devices. | 02-11-2010 |
20100237747 | Piezoelectric Composite Material - A composition of matter having multiple layers of different conductors separated by thin layers of dielectric materials has a high piezoelectric coefficient when the conductors are metals having a significant difference in work function and the dielectric materials have a low elastic modulus when the metal layers are connected to form a capacitive circuit. Alternatively, when the conductors are semi-conductors they should have a significant difference in Fermi levels. | 09-23-2010 |
20110282192 | MULTIMODAL DEPTH-RESOLVING ENDOSCOPE - A fiber-optic multimodal multi-spectral (MS), Optical Coherence Tomography (OCT), photoacoustic (PA) endoscope with beam scanning by a two-dimensional Microelectromechanical systems (MEMS) scanner present in the endoscopic head, combined in a synergetic way in a single endoscopic system. The PA, OCT and MS light sources are coupled to the endoscopic head through an optical switcher. Using a single optical endoscopic head and an electro-optical switch the endoscope of the invention is capable of sequential or parallel MS, OCT and PA imaging. The endoscope provides real-time imaging with a rate of 5 to 60 frames per second for each of the three imaging modalities. | 11-17-2011 |
20120241616 | META MATERIALS INTEGRATION, DETECTION AND SPECTRAL ANALYSIS - A detector and modulator of electromagnetic radiation is 3-dimensional structure made of substantially 2 dimensional high impedance metamaterial surfaces stacked one above the other with a dielectric layer in between and located above a conducting ground plane. Each 2 dimension surface may be formed by an open continuous conductive trace, such as metallic wire or a printed circuit line, which is cast or plated on or into a 2-D periodic arrangement of an element that belongs to the Hilbert space filling curves. | 09-27-2012 |
Patent application number | Description | Published |
20130210643 | Method for preparing a counter-tagged population of nucleic acid molecules. - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 08-15-2013 |
20130224743 | Method for accurately counting starting molecules - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 08-29-2013 |
20130237458 | Method of adding a DBR by primer extension - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 09-12-2013 |
Patent application number | Description | Published |
20120071331 | INCREASING CONFIDENCE OF ALLELE CALLS WITH MOLECULAR COUNTING - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 03-22-2012 |
20130203047 | Increasing Confidence of Allele Calls with Molecular Counting - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 08-08-2013 |
20130267424 | Method of tagging using a split DBR - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 10-10-2013 |
20150031559 | Increased Confidence of Allele Calls with Molecular Counting - Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications. | 01-29-2015 |
Patent application number | Description | Published |
20090146548 | Device for Illuminating Using Blue, Green, Yellow, or Red Light Emitting Diodes - The invention relates to an apparatus for illumination with blue, green, yellow or red light-emitting diodes (LEDS), comprising one or more coloured LEDs and a light-scattering cover associated with the LED colour and composed of coloured plastic and having a base colour derived from one or more non-fluorescent dyes, characterized in that the light-scattering cover comprises, in addition to the base colour, at least one fluorescent dye associated in terms of colour with the base colour, where the dye mixture has been adjusted in such a way that the reflectance of the light-scattering cover is at least 28% at the wavelength of the energy maximum of the LED(S) used, where, based on the standard chromaticity diagram and on the colour loci of the reflected light from the light-scattering cover and on the colour locus of the LED(s) used, the following alternative relationship applies to the absolute value of the difference between the x value of the light-scattering cover and the x value of the LED and the absolute value of the difference between the y value of the light-scattering cover and the y value of the LED:
| 06-11-2009 |
20130074930 | POLYMETHYL (METH)ACRYLATE MOULDINGS FOR FLUORESCENCE CONVERSION, PRODUCTION OF THESE BY THE SHEET CASTING PROCESS AND USE IN SOLAR COLLECTORS - The invention relates to a combination of fluorescence conversion dyes in plastics mouldings made of polymethyl (meth)acrylate, where these are used to convert natural insolation into light that can be used by the solar cells. The plastics mouldings are polymerized by the casting process | 03-28-2013 |
Patent application number | Description | Published |
20100191101 | CATHETER WITH ISOLATION BETWEEN ULTRASOUND TRANSDUCER AND POSITION SENSOR - Medical apparatus includes an invasive probe, for insertion into a body of a living subject. An ultrasonic subsystem includes an ultrasonic transducer contained in the probe and image processing circuitry, which is located outside the probe and is coupled to communicate with the ultrasonic transducer in the probe. A position sensing subsystem includes a position transducer contained in the probe and position tracking circuitry, which is located outside the probe and is coupled to communicate with the position transducer so as to determine position coordinates of the ultrasonic transducer in the body. The position sensing subsystem is electrically isolated from the ultrasonic subsystem. | 07-29-2010 |
20110137151 | REDUCTION OF CATHETER ELECTRODE LOADING - A method for position sensing includes inserting a probe having a first probe-electrode and a second probe-electrode into a body of a subject, and coupling body-surface electrodes to a surface of the body. Currents passing between the first probe-electrode and the body-surface electrodes are measured, using first circuitry coupled to at least the first probe-electrode and having a first electrical ground, and position coordinates of the probe are determined responsively to the measured currents. Second circuitry, having a second electrical ground, is coupled to at least the second probe-electrode, and the first electrical ground is isolated from the second electrical ground. | 06-09-2011 |
20120035467 | CATHETER ENTANGLEMENT INDICATION - A method includes, while an operator of an elongated probe, having proximal and distal ends, manipulates the proximal end so as to move the distal end within a body of a patient, automatically measuring a cumulative angle of rotation that is applied by the operator to the proximal end. An indication of the cumulative angle of rotation is presented to the operator. | 02-09-2012 |
20120109242 | ROUTING OF PACING SIGNALS - An apparatus includes a sensing unit and control circuitry. The sensing unit is connected to a channel that delivers Electro-Physiological (EP) signals from a cardiac catheter to an EP recording system and pacing signals from the EP recording system to the catheter. The sensing unit is configured to automatically identify time intervals during which the pacing signals are delivered. The control circuitry is configured to route the EP signals on the channel from the catheter to the EP recording system via an intervening system that is detrimental to the pacing signals, to switch the channel to an alternate path that bypasses the intervening system during the identified time intervals, and to route the pacing signals from the EP recording system to the cardiac catheter over the alternate path. | 05-03-2012 |
20140330111 | VALVE VIEW MAP - A method, including generating a three-dimensional (3D) map as a plurality of points illustrating a characteristic of a 3D heart chamber, the 3D heart chamber having an opening bounded by a perimeter. The method further includes transforming the perimeter into a closed two-dimensional (2D) figure having an interior. The plurality of points illustrating the characteristic are projected onto the interior of the 2D figure so as to generate a 2D map of the characteristic of the 3D heart chamber. | 11-06-2014 |
20140371563 | MULTIPLE BIPOLAR SAMPLING - Apparatus, which consists of a plurality of modules. Each of the modules has: an insulating frame, a pair of electrodes fixed to the frame at respective locations that are spaced apart, and circuitry configured to receive signals from the pair of electrodes and in response output a differential signal. The apparatus further consists of an insertion tube having distal and proximal ends and containing the plurality of modules in locations spaced longitudinally in proximity to the distal end. There is cabling running through the tube that is connected to convey differential signals from the modules to the proximal end. | 12-18-2014 |
20140378902 | ELECTROCARDIOGRAM NOISE REDUCTION - Methods and systems of catheterization include a flexible catheter adapted for insertion into a heart of a living subject. The catheter has a lumen for passing an electrically conductive fluid therethrough with the fluid exiting the catheter at the distal portion. The lumen is connectable to an irrigation pump to form a fluid communication therewith. A fluid reservoir connected to the lumen supplies the fluid to the catheter. Electrocardiogram circuitry is connectable to the subject for monitoring electrical activity in the heart. An electrically conductive cable diverts induced charges in the fluid from the catheter electrodes, for example by connection to an isolated ground of the electrocardiogram. | 12-25-2014 |
20150038900 | MULTISHAPE CATHETER - A probe, consisting of a flexible insertion tube, for insertion into a subject via a body lumen. The probe includes a sequence of tubular modules contained within the insertion tube, each module having a rigid tube segment having a preset shape and containing internal grooves on an interior surface of the tube segment. The probe further includes a flexible expander tube, which is threaded through the sequence of tubular modules and has external grooves configured to engage the internal grooves within the tube segment of each of the tubular modules when the expander tube is expanded, so as to hold the tubular modules in mutual alignment, wherein the tubular modules are able to move out of mutual alignment when the expander tube is unexpanded. The probe also has an expansion element, which is insertable through the flexible expander tube so as to expand the expander tube. | 02-05-2015 |