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Li, MD
Aiqun Li, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110212085 | LUNG CANCER DISEASE TARGETS AND USES THEREOF - The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung diseases (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung. | 09-01-2011 |
| 20110219464 | LUNG DISEASE TARGETS AND USES THEREOF - The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung cancer (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung. | 09-08-2011 |
Aiqun Li, North Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090232822 | LUNG DISEASE TARGETS AND USES THEREOF - The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung diseases (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung. | 09-17-2009 |
Albert P. Li, Columbia, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080274535 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate-metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 11-06-2008 |
| 20080286759 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 11-20-2008 |
| 20100035298 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 02-11-2010 |
| 20110117541 | Method for Screening of Agents for the Prevention of Hepatitis C Virus Infection with Cell Culture Tool - The invention relates to an improved method of screening of anti-HCV agents that may have an efficacy for prevention of hepatitis C virus. The method involves the isolation and cryopreservation of HCV-infected hepatocytes from multiple infected individuals. The isolated and cryopreserved hepatocytes are stored in a cryopreservation bank made up of HCV-infected hepatocytes representing the different genotypes of HCV. These stored hepatocytes then are co-cultured in a culture medium with uninfected hepatocytes, and anti-HCV screening of the hepatocytes is done by subjecting HCV infected hepatocytes and uninfected hepatocytes in parallel to the actions of different anti-HCV compounds at various concentrations. An effective anti-HCV agent will lead to prevention of increase in concentration of HCV content of uninfected cells in the co-culture. | 05-19-2011 |
Alqun Li, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110296544 | COLON CANCER TARGETS AND USES THEREOF - The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon. | 12-01-2011 |
Bei Li, Clarksville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090163137 | Systems and methods for communicating and rendering electronic program guide information via digital radio broadcast transmission - Methods and systems for preparing data for broadcast via digital radio broadcast transmission is disclosed comprising the steps of receiving a plurality of content files corresponding to programming information for program content to be broadcast; receiving an index file having a pointer for each of the plurality of content files, wherein the index file is associated with a first logical address; storing the index file and the plurality of content files; scheduling a broadcast rotation of the index file and the plurality of content files (wherein the index file is scheduled for repeated transmission intermittently relative to selected ones of the content files); and transmitting the index file and the plurality of content files to an importer in accordance with the broadcast rotation. | 06-25-2009 |
Changqing Li, Ellicottt City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110183917 | P53 Activator Peptides - The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides as well as methods of treating abnormal conditions, such as malignant tumors, with the methods comprising administering the pharmaceutical compositions of the present invention to a subject in need of treatment thereof. | 07-28-2011 |
Changyi Li, Laurel, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090281411 | HAND-HELD ELECTRIC FIELD IMAGER FOR MEASURING THE ELECTRIC FIELD IN MAMMALIAN SKIN AND OTHER EPITHELIAL STRUCTURES - The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface. | 11-12-2009 |
Chunqin Li, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100159507 | SHREDDER FOR MECHANICAL DISRUPTION BY GENTLE CONTROLLED COMPRESSIVE ROTATION - The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures. | 06-24-2010 |
Chunrong Li, Columbia, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110106496 | TESTING ANALYTICS TOOL - Embodiments of the invention relate to systems, methods, and computer program products for testing analytics. Embodiments herein disclosed provide for automating the collection and storage of test data, automating test performance calculations across a multitude of segments within the test group and automating test result information delivery. | 05-05-2011 |
Dunling Li, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090059806 | METHOD, SYSTEM AND APPARATUS FOR PROVIDING SIGNAL BASED PACKET LOSS CONCEALMENT FOR MEMORYLESS CODECS - In a method, apparatus and system for transmitting packet loss concealment (PLC) information, a subscriber device divides a voice sample into a plurality of packets, each including a plurality of successive frames having portions of the voice sample. The subscriber device determines if a predetermined look ahead time duration from the final frame of the plurality of successive frames in a current packet of the plurality of packets includes a noise to voice transition. When the predetermined look ahead time duration is determined to include the noise to voice transition, the subscriber device packs packing information regarding the predetermined look ahead time duration into the current packet. Finally, the subscriber device encodes the plurality of successive frames into the current packet for transmission. | 03-05-2009 |
| 20090076828 | SYSTEM AND METHOD OF DATA ENCODING - A data encoding device is provided, comprising: a data frame encoder configured to receive an incoming frame of data and to generate an encoded frame of data using a frame encoding scheme; a data frame decoder configured to receive the encoded frame of data and to generate a decoded frame of data using the frame encoding scheme, and frame decoding parameters; a subtractor configured to subtract the decoded frame of data from the incoming frame of data to generate base quantization noise information; a quantization noise encoder configured to receive the base quantization noise information and the frame decoding parameters, and to generate encoded quantization noise information using a noise encoding scheme; and a transmitting circuit configured to transmit the encoded frame of data and the encoded quantization noise information. | 03-19-2009 |
| 20090310603 | Memory Optimization Packet Loss Concealment in a Voice Over Packet Network - A method to reduce memory requirements for a packet loss concealment algorithm in the event of packet loss in a receiver of pulse code modulated voice signals. A voice playout unit in the receiver shares its nominal delay buffer with a history buffer of a packet loss concealment algorithm up to a maximum limit described in a standard. This reduces or eliminates need to allocate memory for the history buffer. A history buffer can also be extended to retain an original portion of voice signal packets received prior to a packet loss as well as generated voice signals as they are generated. A scratch buffer is used as a working buffer and replaces the function of a pitch buffer. | 12-17-2009 |
Feipeng Li, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110153321 | SYSTEMS AND METHODS FOR IDENTIFYING SPEECH SOUND FEATURES - Systems and methods for detecting features in spoken speech and processing speech sounds based on the features are provided. One or more features may be identified in a speech sound. The speech sound may be modified to enhance or reduce the degree to which the feature affects the sound ultimately heard by a listener. Systems and methods according to embodiments of the invention may allow for automatic speech recognition devices that enhance detection and recognition of spoken sounds, such as by a user of a hearing aid or other device. | 06-23-2011 |
| 20110178799 | METHODS AND SYSTEMS FOR IDENTIFYING SPEECH SOUNDS USING MULTI-DIMENSIONAL ANALYSIS - Methods and systems of identifying speech sound features within a speech sound are provided. The sound features may be identified using a multi-dimensional analysis that analyzes the time, frequency, and intensity at which a feature occurs within a speech sound, and the contribution of the feature to the sound. Information about sound features may be used to enhance spoken speech sounds to improve recognizability of the speech sounds by a listener. | 07-21-2011 |
Haodong Li, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080274109 | Myeloid Progenitor Inhibitory Factor-1 (MPIF-1), Monocyte Colony Inhibitory Factor (M-CIF), and Macrophage Inhibitory Factor-4 (MIP-4) - There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. | 11-06-2008 |
| 20090036370 | Leukocyte Adhesion Inhibitor-1 (LAI-1) - There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine α1 (CKα1 or cka-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. | 02-05-2009 |
| 20090104622 | Extracellular/Epidermal Growth Factor Like Protein - The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention. | 04-23-2009 |
| 20100041136 | Connective Tissue Growth Factor-2 - The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed. | 02-18-2010 |
| 20110117095 | GROWTH FACTOR HTTER36 - The present invention discloses Growth Factor HTTER36 (GDF3) polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include the diagnosis, prevention, and treatment of wasting disorders. Also disclosed are antagonists against such polypeptide and their therapeutic uses which include the diagnosis, prevention, and treatment of obesity and obesity-related disorders. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention. | 05-19-2011 |
Hui Hui (faye) Li, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110319672 | Conversion Of Sugar, Sugar Alcohol, Or Glycerol To Valuable Chemicals Using A Promoted Zirconium Oxide Supported Catalyst - A process for converting a sugar, sugar alcohol, or glycerol to a valuable chemical is described. The process may use a support comprising zirconium oxide promoted by a polyacid or promoter material. A catalytically active metal may be impregnated on the polyacid-promoted zirconium oxide support and the catalyst may then be introduced the sugar, sugar alcohol, or glycerol a source of hydrogen under reaction conditions. At least 40 wt % of the sugar, sugar alcohol or glycerol may be converted to a polyol and/or a shorter carbon-chain alcohol that may include at least one of propylene glycol, ethylene glycol, glycerin, methanol, ethanol, propanol and butandiols. Specific processes for converting glycerin having a selectivity for propylene glycol and for converting sorbitol with a selectivity for propylene glycol, ethylene glycol, and/or glycerin are also described. | 12-29-2011 |
Huiping Li, Clarksville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100020970 | System And Method For Camera Imaging Data Channel - A system and method for using cameras to download data to cell phones or other devices as an alternative to CDMA/GPRS, BlueTooth, Infrared or cable connections. The data is encoded as a sequence of images such as 2D bar codes, which can be displayed in any flat panel display, acquired by a camera, and decoded by software embedded in the device. The decoded data is written to a file. The system and method meet the following challenges: (1) To encode arbitrary data as a sequence of images. (2) To process captured images under various lighting variations and perspective distortions while maintaining real time performance. (3) To decode the processed images robustly even when partial data is lost. | 01-28-2010 |
Jia-He Li, Cockeysville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090088407 | COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP - The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein. | 04-02-2009 |
| 20090298837 | COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP - The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein. | 12-03-2009 |
Jinong Li, Ellicott City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080311673 | Biomarkers for Breast Cancer - The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as breast cancer or non-breast cancer. The biomarkers can be detected by SELDI mass spectrometry. | 12-18-2008 |
King Chuen Li, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090048201 | USE OF TARGETED CROSS-LINKED NANOPARTICLES FOR IN VIVO GENE DELIVERY - The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e.g. blood vessels, endothelial cells, tumor cells, liver cells, and the like. | 02-19-2009 |
Limin Li, North Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090087438 | ANTI-TSG101 ANTIBODIES AND THEIR USES FOR TREATMENT OF VIRAL INFECTIONS - The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invention further provides methods of detecting viral infected cells using TSG101 antibodies. | 04-02-2009 |
| 20090186041 | ANTI-TSG101 ANTIBODIES AND THEIR USES FOR TREATMENT OF VIRAL INFECTIONS - The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection. | 07-23-2009 |
| 20090196874 | ANTI-TSG101 ANTIBODIES AND THEIR USES FOR TREATMENT OF VIRAL INFECTIONS - The invention involves the detection of virally infected cells by antibodies or antibody fragments which selectively bind to TSG101. TSG101 is on the surface of mammalian cells, and thus available for detection by antibodies, during viral budding—a phenomenon wherein viral particles escape a virally infected cell after propagation in that cell, so as to infect other cells. To achieve budding, a protein, TSG101 is “hijacked” and misdirected to, or mis-expressed on, the surface of the infected cell. Antibodies can be used to selectively detect such infected cells. Certain TSG101 antibodies may provide therapeutic benefit when administered to infected mammals. | 08-06-2009 |
Limin Li, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100272728 | MAMMALIAN TUMOR SUSCEPTIBILITY GENE PRODUCTS AND THEIR USES - The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein. | 10-28-2010 |
| 20100272729 | MAMMALIAN TUMOR SUSCEPTIBILITY GENE PRODUCTS AND THEIR USES - The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein. | 10-28-2010 |
| 20110251376 | Mammalian Tumor Susceptibility Genes and their Uses - TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 is reversible by restoration of TSG101 function. Decreased expression of TSG101 is associated with the occurrence of certain human cancers, including breast carcinomas. The TSG101 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene. | 10-13-2011 |
Limin Li, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090233993 | COMPOSITIONS AND METHODS FOR INHIBITING GSK3 ACTIVITY AND USES THEREOF - Disclosed herein are compositions and methods relating to peptides. The peptides can inhibit amyloid beta (Aβ) generation and reduce GSK-3 activities. Further provided are compositions and methods for treating or preventing, for example, Alzheimer's disease, cancer, and diabetes. | 09-17-2009 |
| 20100035925 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AN DMETHODS FOR INHIBITING HIV INFECTIVITY - Compounds that possess anti-infective activity are described. Methods of using these compounds for the treatment or prevention of infectious diseases such as acquired immunodeficiency syndrome (AIDS) are also described. The compounds inhibit HIV infectivity and do not exhibit significant cytotoxicity in HIV producing cells. | 02-11-2010 |
Limin Li, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090285819 | METHODS AND COMPOSITIONS FOR TREATING INFLUENZA - Genes relating to resistance to infection by influenza virus are identified. The genes and the gene products (i.e., the polynucleotides transcribed from and polypeptides encoded by the genes) can be used for the prevention and treatment of influenza. The genes and the gene products can also be used to screen agents that modulate the gene expression or the activities of the gene products. | 11-19-2009 |
Linhong Li, North Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090257991 | Engineering and Delivery of Therapeutic Compositions of Freshly Isolated Cells - The present invention relates to the transient modification of cells. In particular embodiments, the cells are immune systems, such as PBMC, PBL, T (CD3+ and/or CD8+) and Natural Killer (NK) cells. The modified cells provide a population of cells that express a genetically engineered chimeric receptor which can be administered to a patient therapeutically. The present invention further relates to methods that deliver mRNA coding for the chimeric receptor to unstimulated resting PBMC, PBL, T (CD3+ and/or CD8+) and NK cells and which delivers the mRNA efficiently to the transfected cells and promotes significant target cell killing. | 10-15-2009 |
Linjie Li, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110039213 | METHOD AND SYSTEM FOR PHOTOLITHOGRAPHIC FABRICATION WITH RESOLUTION FAR BELOW THE DIFFRACTION LIMIT - A method and system for photolithography is provided. The system includes a photoresist comprising a photoinitiator and a prepolymer resin. The system further includes a first light source operable to generate at least a first beam of light which is focused on a first area of the photoresist. The first beam of light is configured to excite the photoinitiator. The system further includes a second light source operable to generate at least a second beam of light which is focused on a second area of the photoresist, the second beam of light configured to deactivate at least temporarily the photoinitiator excited by the first beam of light. The first area and second area overlap at least partially. A time difference of at least 10 ns exists between the photoinitiator being excited by the first beam of light and the photoinitiator initiating polymerization. | 02-17-2011 |
| 20110183140 | Method for Polymer Coating and Functionalization of Metal Nanorods - The present invention relates to polymers and their use in coating metal nanorods (especially gold nanorods), and to the coated nanorods compositions. In particular, the invention relates to a process for forming cetyltrimethylammonium bromide (CTAB)-coated gold nanorods and to such coated nanorods that additionally comprise an external cross-linked polymer coating. | 07-28-2011 |
Meijuan Li, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110191892 | GENETIC MARKERS ASSOCIATED WITH DROUGHT TOLERANCE IN MAIZE - The presently disclosed subject matter relates to methods and compositions for identifying, selecting, and/or producing drought tolerant maize plants or germplasm. Maize plants or germplasm that have been identified, selected, and/or produced by any of the methods of the presently disclosed subject matter are also provided. | 08-04-2011 |
Ming-Chiang Li, Mitchellville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100074379 | Tuning replica generation methods and apparatus for their most optimum performance in processing transient signals - The embodiments of the present invention are most optimum methods and apparatus for processing transient (pulsed, non-cooperative, non-reproducible, complex, or simultaneous) signals; in particular, for their unbeatable vigor in passive source identifications; for their ultra precision transient spatial range and Doppler measurements; for their supreme powers in rejection noise and interference contamination; for their utmost abilities in deciphering random, chaotic, turbulent, explosive, thermo nuclear, and other countless transient phenomena. In particular, an embodiment of the present invention is an apparatus for processing transient signals that uses replica generations and which comprises: (a) a signal receiving apparatus which receives one or more signals having transient in nature, at least one of them cannot be repeatedly produced or is a signal of opportunity, and the signals have pulse lengths ranging from less than tenth of a picosecond to higher than several microseconds, and frequency widths from less than 0.10 MHz to higher than 40 GHz; (b) a tuning apparatus which accepts signals from the receiving apparatus as inputs, tunes one or more of these signals in response to a requirement of interest, where the requirement of interest includes, but not limited to, shortening or elongating the one or more of signals; (c) a replica generation apparatus, which accepts signals from the tuning apparatus as inputs, and outputs a train of replica pairs, where relative separations between two members in the replica pairs are same or different; (d) an integration apparatus which performs correlation integrations that is to correlate between two members in the replica pairs and to convert the train of replica pairs into a baseband signal. | 03-25-2010 |
| 20100259440 | Apparatus and Method for Receiving Electromagnetic Waves Using Photonics - An apparatus and method for receiving electromagnetic waves using photonics includes a transmission unit transmitting electromagnetic waves in intervals; a time delay unit coupled to the transmission unit and controlling the transmission unit to transmit the electromagnetic waves in the intervals; an antenna receiving the electromagnetic waves reflected from the target; an interferoceiver coupled to the antenna and receiving the electromagnetic waves from the antenna, the interferoceiver comprising an optical recirculation loop to produce replica electromagnetic waves; and a computer identifying the target from the reflected electromagnetic waves. | 10-14-2010 |
Minglin Li, Ellicott City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100183680 | Purified Plasmodium and Vaccine Compositions - Disclosed are substantially purified | 07-22-2010 |
Peter W. Li, Brookeville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100129802 | Method of Sequencing a Genome - A method and computer-program product for sequencing nucleic acid sequences using restriction fragment maps derived from end-sequenced nucleotide fragments. The initial nucleotide sequence can be processed to form a shot-gun-data set. The present teachings employ a technique called Restriction Site Shotgun Sequencing (RSSS.) It can reduce the amount of overlap required between fragment ends while still producing a good assembly. A decrease in overlap can be achieved by using additional information in the fragments to assist in determining that two fragments overlap. | 05-27-2010 |
Ronald A. Li, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090291068 | Modulation of bio-electrical rhythms via a novel engineering approach - The present invention relates to novel compositions and methods to induce, and/or modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc). | 11-26-2009 |
| 20110008888 | Novel Genetic Approaches to Reduce or Inhibit Tumorgenicity of Human Embryonic Stem Cells and Derivatives Following Transplantation - Self-renewable embryonic stem cells (ESCs), derived from the inner cell mass of blastocysts, can propagate indefinitely in culture while maintaining their normal karyotypes and pluripotency to differentiate into all cell types. Therefore, ESCs may provide an unlimited supply of even specialized cells such as brain and heart cells for transplantation and cell-based therapies that are otherwise limited by donor availability. However, this promising application is hampered by concerns that ESCs or their multipotent derivatives also possess the potential to form malignant tumors after transplantation in vivo. The present invention provides for a novel genetic method to arrest undesirable cell division (of ESCs and other unwanted lineages) as a means to inhibit or eliminate their tumorgenic potential after transplantation. | 01-13-2011 |
Rong Li, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110305668 | METHODS FOR USING INTERFERON GAMMA TO ABSORB FLUID FROM THE SUBRETINAL SPACE - Particular aspects of the invention provide methods for decreasing the amount of fluid present in the subretinal space of the eye by administering interferon gamma to the basolateral side of the retinal pigment epithelium. Adverse ocular conditions associated with the accumulation of fluid in the subretinal space can be treated by administering an amount of interferon gamma to the basolateral side of the retinal pigment epithelium effective to remove excess fluid from the subretinal space. | 12-15-2011 |
Ruiping Li, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080212853 | Computer Aided Diagnosis Using Dual Energy Subtraction Images - Computer-aided diagnosis techniques may be combined with dual-energy radiography techniques to provide enhanced computer-aided diagnosis of, for example, lung nodules. | 09-04-2008 |
| 20100104163 | ORIENTATION DETECTION FOR CHEST RADIOGRAPHIC IMAGES - A method for identifying the orientation of a radiographic image of a patient generates a reduced-scale image having a smaller number of pixel elements than the original radiographic image and generates a reduced bit-depth image from the reduced-scale image. The method determines whether the image has portrait or landscape orientation by sectioning either the reduced-scale image or the reduced bit-depth image into at least two sections and calculating at least one value related to relative symmetry for each of the at least two sections. | 04-29-2010 |
| 20110164802 | COMPUTER AIDED DIAGNOSIS USING DERIVED IMAGES - Computer-aided diagnosis techniques may be combined with techniques to obtain derived images from radiographic images to provide enhanced computer-aided diagnosis of, for example, lung nodules. | 07-07-2011 |
Shuwei Li, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110318771 | DEUTERIUM ISOBARIC TAG REAGENTS FOR QUANTITATIVE ANALYSIS - Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more | 12-29-2011 |
Si Li, Cantonsville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110314976 | Multiple Slope or Multiple or Multiple Offset Tool Mechanism - Use of multiple-slope and/or multiple-offset mechanism or equivalent to address the issues with current mechanical clickers that have single-slope spring mechanism. The varying-slope can be a continuously varying-slope non-linear spring, or a combination of discretely varying multiple-slope springs. This invention is useful for clicker type torque wrenches, clicker type torque screw drivers, beam type torque wrenches, beam type torque screw drivers and shock absorbers. The present invention is equally applicable to clickers that click in both the CW (clockwise) and CCW (counterclockwise) directions or clickers that click only in one direction. The invention is generally characterized by placing a non-linear spring or combination of springs in the tool body to achieve multiple slope operation rather than using one single slope spring. The multiple slope configuration is superior in performance by moving closer to the ideal case of 0% error in operation. This error performance can be maintained with multiple slope configurations over the entire range of operation. The multiple slope configuration prolongs the life of the product as well as decreasing the need for recalibration as well as increasing the range of operation. | 12-29-2011 |
Steven X. Li, Ellicott City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110150012 | PASSIVELY Q-SWITCHED SIDE PUMPED MONOLITHIC RING LASER - Disclosed herein are systems and methods for generating a side-pumped passively Q-switched non-planar ring oscillator. The method introduces a laser into a cavity of a crystal, the cavity having a round-trip path formed by a reflection at a dielectrically coated front surface, a first internal reflection at a first side surface of the crystal at a non-orthogonal angle with the front, a second internal reflection at a top surface of the crystal, and a third internal reflection at a second side surface of the crystal at a non-orthogonal angle with the front. The method side pumps the laser at the top or bottom surface with a side pump diode array beam and generates an output laser emanating at a location on the front surface. The design can include additional internal reflections to increase interaction with the side pump. Waste heat may be removed by mounting the crystal to a heatsink. | 06-23-2011 |
Wan-Ju Li, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100061962 | Tissue Engineered Cartilage, Method of Making Same, Therapeutic and Cosmetic Surgical Applications Using Same - Cartilage has been constructed using biodegradable electrospun polymeric scaffolds seeded with chondrocytes or adult mesenchymal stem cells. More particularly engineered cartilage has been prepared where the cartilage has a biodegradable and biocompatible nanofibrous polymer support prepared by electrospinning and a plurality of chondocytes or mesenchymal stem cells dispersed in the pores of the support. The tissue engineered cartilages of the invention possess compressive strength properties similar to natural cartilage. Methods of preparing engineered tissues, including tissue engineered cartilages, are provided in which an electrospun nanofibrous polymer support is provided, the support is treated with a cell solution and the polymer-cell mixture cultured in a rotating bioreactor to generate the cartilage. The invention provides for the use of the tissue engineered cartilages in the treatment of cartilage degenerative diseases, reconstructive surgery, and cosmetic surgery. | 03-11-2010 |
Wu Bo Li, N. Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090264304 | NORMALIZED NUCLEIC ACID LIBRARIES AND METHODS OF PRODUCTION THEREOF - The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In particular, the present methods comprise subtractive hybridization of a nucleic acid library with haptenylated (e.g., biotinylated, avidinated or streptavidinated) nucleic acid molecules that are complementary to one or more of the nucleic acid molecules of the library, such that the variation in the abundances of the individual nucleic acid molecules in the library is reduced. The invention also relates to production of normalized nucleic acid libraries (particularly cDNA libraries) in which contaminating nucleic acid molecules have been reduced or eliminated, and to normalized nucleic acid libraries produced by such methods. | 10-22-2009 |
| 20100279898 | NORMALIZED NUCLEIC ACID LIBRARIES AND METHODS OF PRODUCTION THEREOF - The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In particular, the present methods comprise subtractive hybridization of a nucleic acid library with haptenylated (e.g., biotinylated, avidinated or streptavidinated) nucleic acid molecules that are complementary to one or more of the nucleic acid molecules of the library, such that the variation in the abundances of the individual nucleic acid molecules in the library is reduced. The invention also relates to production of normalized nucleic acid libraries (particularly cDNA libraries) in which contaminating nucleic acid molecules have been reduced or eliminated, and to normalized nucleic acid libraries produced by such methods. | 11-04-2010 |
| 20100317063 | COMPOSITIONS FOR IMPROVED cDNA SYNTHESIS - The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention. | 12-16-2010 |
| 20110151521 | cDNA SYNTHESIS IMPROVEMENTS - The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention. | 06-23-2011 |
Wu-Bo Li, North Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080287321 | cDNA synthesis improvements - The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for making the cDNA molecules and libraries of the invention. | 11-20-2008 |
| 20100183628 | RANDOM HOMOZYGOUS GENE PERTURBATION (RHGP) WITH THERMAL ASSYMETRIC INTERLACED (TAIL)-PCR - A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL)-PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail. | 07-22-2010 |
| 20100286248 | HUMAN FG01 GENE AND ITS APPLICATIONS - A human gene, fg01, on chromosome 8, is identified. This gene, and its expression product, human fg01, shares a homology under 70% with the corresponding murine gene, which has been linked to presentation of the Alzheimer's phenotype of Aβ plaques and hyperphosphorylated tau tangles. Upregulation appears to suppress the Alzheimer's phenotype, which may be effective in preventing the onset of symptoms or progression of symptoms associated with AD. Screening methods are also set forth. | 11-11-2010 |
| 20100286252 | HUMAN FG01 GENE AND ITS APPLICATIONS - A human gene, fg01, on chromosome 8, is identified, as well as a truncated form on chromosome 5. Upregulation appears to suppress the Alzheimer's phenotype, (AB plaques and hyperphosphorylated tau tangles) which may address the onset of symptoms or progression of symptoms associated with AD. Screening methods are also set forth. | 11-11-2010 |
Wu-Bo Li, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090233993 | COMPOSITIONS AND METHODS FOR INHIBITING GSK3 ACTIVITY AND USES THEREOF - Disclosed herein are compositions and methods relating to peptides. The peptides can inhibit amyloid beta (Aβ) generation and reduce GSK-3 activities. Further provided are compositions and methods for treating or preventing, for example, Alzheimer's disease, cancer, and diabetes. | 09-17-2009 |
Xiao-Ling Li, Columbia, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100317677 | Methods of Treating a Microbial Infection by Modulating RNase-L Expression and/or Activity - The invention relates to methods and compositions for treating a microbial infection. In the present invention, RNase-L activity has been shown to play an integral role in innate immunity and for defense against invading microbes. The present invention is drawn to exploiting the role of RNase-L in innate immunity for methods of treating a microbial infection. The present invention is also drawn to exploiting the role of RNase-L in innate immunity for methods of treating an immune related disease or disorder. | 12-16-2010 |
Xuan Li, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090098647 | Recombinant antigens for the detection of coxiella burnetii - The invention relates to a method for the detection of prior exposure to | 04-16-2009 |
| 20090176214 | Recombinant antigens for the detection of Coxiella burnetii - The invention relates to a method for the detection of prior exposure to | 07-09-2009 |
| 20110160075 | Diagnostic assay for orientia tsutsugamushi by detection of responsive gene expression - The inventive subject matter relates to a method for the diagnosis of | 06-30-2011 |
Xuhang Li, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110251100 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE AND RELATED DISORDERS - The present invention features biomarkers capable of diagnosing inflammatory bowel disease and methods of using such biomarkers to diagnose and selecting treatments for inflammatory bowel diseases. | 10-13-2011 |
Xuhong Li, North Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110229490 | Lyophilized Formulations of Engineered Anti-IL-23p19 Antibodies - The present invention provides lyophilized formulations of antibodies, such as antibodies that specifically bind to human interleukin-23 p19 (IL-23p19), or antigen binding fragments thereof. | 09-22-2011 |
Xuri Li, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110318365 | METHODS FOR TREATMENT OF DEGENERATIVE DISEASE ASSOCIATED WITH APOPTOSIS - A method for treating a degenerative disease or neurodegenerative disease in a mammalian subject is provided. The method provides administering VEGF-B polypeptide or functional variant or mimetic thereof in an amount effective to reduce or eliminate the degenerative disease in the mammalian subject without having any substantial angiogenic effect across all dosage levels. | 12-29-2011 |
Yongfang Li, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100210602 | PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA - The PhoU protein is a widely expressed protein in bacteria, but not in eukaryotes. The PhoU protein is required for persister formation in bacteria. The invention includes compositions to reduce persister formation and their use as therapeutic agents. The invention further includes methods for identification of compounds to reduce persister formation. The invention further includes kits for the identification of agents that modulate the activity and expression of PhoU. | 08-19-2010 |
Zhensheng Li, Frederick, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100247595 | POROUS STRUCTURES AND METHODS OF USE - The present invention provides porous structures that each comprise chitosan, alginate and divalent metal cations, wherein: (a) the chitosan is ionically linked to the alginate; and (b) the structure is porous and has a compressive yield strength of at least 0.35 MPa. The present invention also provides methods for making the porous structures, and methods for using the porous structures as substrates to grow living cells. | 09-30-2010 |
| 20110076254 | POROUS SCAFFOLDS FOR STEM CELL RENEWAL - A method for expanding a population of stem cells using a porous scaffold, a porous scaffold populated with renewed stem cells, methods of administering stem cells using the porous scaffold and cells collected from the porous scaffold, and methods for tissue engineering and treating a condition treatable by administration of stem cells using the porous scaffold and cells collected from the porous scaffold. | 03-31-2011 |
Zhlyu Li, Woodstock, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100272644 | COMPLEXATION OF FATTY ACID-CONJUGATED MOLECULES WITH ALBUMIN - The technology described herein is directed to conjugating various therapeutic or functional molecules, such small chemical drugs, peptides, oligonucleotides, isotopes and imaging regents with fatty acids, such as LCFAs. The fatty acid-conjugated molecules are complexed with a human serum albumin protein in vitro. | 10-28-2010 |
Zhongming Li, Gaithersberg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080199952 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOCOCCAL INFECTION - The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individual and/or therapeutically to induce a therapeutic immune response in an infected individual. | 08-21-2008 |