Li, IN
Anyin Li, West Lafayette, IN US
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20150075998 | SYSTEMS AND METHODS FOR PRODUCING METAL CLUSTERS; FUNCTIONALIZED SURFACES; AND DROPLETS INCLUDING SOLVATED METAL IONS - The invention generally relates to systems and methods for producing metal clusters; functionalized surfaces; and droplets including solvated metal ions. In certain aspects, the invention provides methods that involve providing a metal and a solvent. The methods additionally involve applying voltage to the solvated metal to thereby produce solvent droplets including ions of the metal containing compound, and directing the solvent droplets including the metal ions to a target. In certain embodiments, once at the target, the metal ions can react directly or catalyze reactions. | 03-19-2015 |
20150309001 | METHODS OF ANALYZING CRUDE OIL - The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps. | 10-29-2015 |
Changqing Li, Ellettsville, IN US
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20090024091 | Catheter assembly including coiled internal bolster - A catheter assembly including a medical catheter and an internal bolster. In a preferred embodiment, the catheter is an elongated, tubular structure preferably made of a flexible, biocompatible material. The catheter is shaped to include a generally cylindrical wall terminating in a first end and in a second end, the wall coaxially surrounding and defining a longitudinal bore preferably used to convey fluids, such as food and/or medications, to a patient in need thereof. The internal bolster is an elongated, semi-tubular structure preferably made of a flexible, biocompatible material. The bolster is resiliently and reversibly transformable between a generally planar shape, when at rest, and a straightened shape, when forcibly unfurled. The bolster has an inner end and an outer end, the inner end being generally centrally located. The inner end of the bolster is insert-molded around the first end of the catheter, with the catheter and the bolster being oriented relative to one another so that the longitudinal axis of the catheter extends generally perpendicularly to the plane of the bolster in its coiled state, with the open, semi-tubular structure of the bolster facing away from the catheter. | 01-22-2009 |
20110092912 | CATHETER ASSEMBLY INCLUDING INTERNAL BOLSTER - A catheter assembly including an internal bolster. According to one embodiment, the catheter assembly includes a medical catheter preferably made of extruded silicone rubber. The catheter is shaped to include a cylindrical wall defining a primary longitudinal bore. A plurality of secondary longitudinal bores are provided in the cylindrical wall, the secondary bores being evenly spaced around the primary bore. The assembly also includes a plurality of identical resilient members collectively forming an anchor at a first end of the catheter. Each resilient member comprises a resilient wire and a protective jacket. Each wire is made of a shape-memory material and is reversibly transformable between a spiral shape, when at rest, and a straightened shape, when forcibly unfurled. One end of each wire is disposed within a secondary bore of the catheter, with the remainder of each wire extending out from the catheter. Each jacket is preferably made of silicone rubber and encapsulates all of the length of its wire, except for the small portion of the wire inserted into the bore. | 04-21-2011 |
20120283643 | CATHETER ASSEMBLY INCLUDING INTERNAL BOLSTER - A catheter assembly includes an internal bolster comprising a plurality of resilient members collectively forming an anchor at a first end of the catheter. Each resilient member is reversibly transformable between a spiral shape, when at rest, and a straightened shape, when forcibly unfurled. The catheter assembly may be used in a method for inserting a gastrostomy tube into a patient. The catheter assembly is inserted into the patient's stomach with the resilient members in the unfurled straightened state. Once the resilient members have entered the patient, the resilient members are allowed to return to the relaxed spiral shape, thereby anchoring the catheter assembly in the patient. | 11-08-2012 |
Changqing Li, Bloomington, IN US
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20100094212 | METHOD FOR PERCUTANEOUSLY IMPLANTING A MEDICAL CATHETER AND MEDICAL CATHETER IMPLANTING ASSEMBLY - A method for percutaneously implanting a medical catheter, such as a gastrostomy feeding tube, and a medical catheter implanting assembly. In one embodiment, the implanting assembly includes a gastrostomy feeding tube, an inner sheath and an outer sheath. The feeding tube has an internal bolster integrally formed at its distal end. The inner sheath includes a bore extending distally from its proximal end to a point prior to its distal end and a transverse window communicating with the bore. The outer sheath includes a proximal end, a distal end and a longitudinal bore. The outer sheath is inserted over the inner sheath, and the feeding tube is inserted into the inner sheath, with the internal bolster being folded and tucked into the window and retained therein by the outer sheath. Movement of the outer sheath relative to the inner sheath to expose the window allows the bolster to decompress. | 04-15-2010 |
20120010570 | METHOD FOR PERCUTANEOUSLY IMPLANTING A MEDICAL CATHETER AND MEDICAL CATHETER IMPLANTING ASSEMBLY - A method for percutaneously implanting a medical catheter, such as a gastrostomy feeding tube, and a medical catheter implanting assembly. In one embodiment, the implanting assembly includes a gastrostomy feeding tube, an inner sheath and an outer sheath. The feeding tube has an internal bolster integrally formed at its distal end. The inner sheath includes a bore extending distally from its proximal end to a point prior to its distal end and a transverse window communicating with the bore. The outer sheath includes a proximal end, a distal end and a longitudinal bore. The outer sheath is inserted over the inner sheath, and the feeding tube is inserted into the inner sheath, with the internal bolster being folded and tucked into the window and retained therein by the outer sheath. Movement of the outer sheath relative to the inner sheath to expose the window allows the bolster to decompress. | 01-12-2012 |
20130066230 | SINGLE PIECE BIOPSY FORCEPS - Single piece biopsy forceps having jaws that are caused to open and close in response to longitudinal movement of an actuation rod. The single piece forceps are formed from a single metal blank with opposing jaw sections connected via a self-hinge. The metal blank includes a self-hinge portion, a channel section on either end of the hinge portion and a jaw section on distal ends of the channel sections. The jaws are formed from the jaw section of the metal blank and the channel sections are bent to provide generally U-shaped channel sections. The hinge portion is bent so that the jaws are oriented in opposed aligned relation. A fixed and a movable pin are disposed through slots in the channel sections. Movement of the movable pin with respect to the fixed pin via an actuator rod or wire causes the jaws of the biopsy forceps to open and close. | 03-14-2013 |
20130123818 | CLIP APPARATUS FOR LIGATURE OF LIVING TISSUE - A clip apparatus for ligature of living tissue is provided. The clip apparatus includes a clip that can be opened and closed multiple times prior to locking in a closed position on the tissue. | 05-16-2013 |
20130131544 | BIOPSY FORCEPS INCLUDING SELF ALIGNING JAWS WITH DRAINAGE OPENINGS - Improved biopsy forceps include pivotally coupled self aligning jaws with drainage holes therethrough. The biopsy forceps include a pair of jaw members that include cup shaped jaws. The biopsy forces may be formed by a series of metal etching and forming operations to allow the manufacture of the biopsy forceps using high volume manufacturing techniques. | 05-23-2013 |
Chunsheng Li, Fishers, IN US
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20160034604 | Casting Design Advisor Toolkit - A system for providing casting design advisement for designing a cast component is provided. The system includes an integrated design environment, the integrated design environment receiving a concept design for the cast component, the concept design being user-modifiable. The system also includes a plurality of design advisory modules, the plurality of design advisory modules determining physics models associated with the concept design for the cast component and providing advisement analysis for the concept design based on the physics models. The system includes a design rule logic solver for receiving concept design features associated with the concept design and comparing the concept design features with stored casting design rules to determine a geometry modification guide. | 02-04-2016 |
Danxi Li, Zionsville, IN US
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20080241131 | SPHKS as modifiers of the p53 pathway and methods of use - Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided. | 10-02-2008 |
20090068186 | MAP3Ks as modifiers of the p53 pathway and methods of use - Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided. | 03-12-2009 |
20110159508 | GFATS as Modifiers of the P53 Pathway and Methods of Use - Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided. | 06-30-2011 |
Fangzheng Li, Carmel, IN US
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20130296371 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 11-07-2013 |
20130296373 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 11-07-2013 |
20130296375 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 11-07-2013 |
20140187588 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The disclosure relates to macrocyclic picolinamides of Formula (I) and to the use of these compounds as fungicides. | 07-03-2014 |
20140275171 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 09-18-2014 |
20150094281 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 04-02-2015 |
20150094341 | MACROCYCLIC PICOLINAMIDES COMPOUNDS WITH FUNGICIDAL ACTIVITY - The invention relates to compounds of macrocyclic picolinamides of Formula I suitable to control or prevent growth of fungi. | 04-02-2015 |
20150289508 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES - The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 10-15-2015 |
20150322051 | Macrocyclic picolinamides as fungicides - This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. | 11-12-2015 |
Fengyuan Li, Carmel, IN US
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20160007107 | GRADIENT MICRO-ELECTRO-MECHANICAL SYSTEMS (MEMS) MICROPHONE WITH VARYING HEIGHT ASSEMBLIES - In at least one embodiment, a micro-electro-mechanical systems (MEMS) microphone assembly is provided. The assembly comprises an enclosure, a single micro-electro-mechanical systems (MEMS) transducer, a substrate layer, and an application housing. The single MEMS transducer is positioned within the enclosure. The substrate layer supports the single MEMS transducer. The application housing supports the substrate layer and defining at least a portion of a first transmission mechanism to enable a first side of the single MEMS transducer to receive an audio input signal and at least a portion of a second transmission mechanism to enable a second side of the single MEMS transducer to receive the audio input signal. | 01-07-2016 |
Guangtao Li, Carmel, IN US
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20130280819 | SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE - The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface. | 10-24-2013 |
20130344610 | SYSTEMS AND METHODS FOR SAMPLE ANALYSIS - The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer. | 12-26-2013 |
20140051180 | SYNCHRONIZATION OF ION GENERATION WITH CYCLING OF A DISCONTINUOUS ATMOSPHERIC INTERFACE - The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface. | 02-20-2014 |
20150102218 | SYSTEMS AND METHODS FOR SAMPLE ANALYSIS - The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer. | 04-16-2015 |
Guoqiang Li, Indianapolis, IN US
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20150113947 | SYSTEMS AND METHODS FOR THERMAL MANAGEMENT OF AFTERTREATMENT SYSTEM COMPONENTS - An exhaust aftertreatment system includes an oxidation catalyst and a selective catalytic reduction (SCR) catalyst disposed in an exhaust stream of an internal combustion engine. A stay warm thermal management strategy is employed after warm-up of the aftertreatment system is complete to maintain the aftertreatment system above a temperature providing a desired performance threshold of one or more components of the aftertreatment system, such as the oxidation catalyst or the SCR catalyst. | 04-30-2015 |
Guoqiang Li, Columbus, IN US
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20150361915 | SYSTEM AND METHOD FOR DETERMINING SMART TORQUE CURVE OPTIMIZING USER PERFORMANCE - Systems and methods for controlling performance characteristics of a vehicle are provided. A system for controlling performance characteristics of a vehicle includes a memory storage device including at least one torque curve profile stored thereon. The at least one torque curve profile includes a mapping of accessible torque for the vehicle with respect to an engine speed of an engine coupled to the vehicle. The system also includes an electronic control unit operatively coupled to the memory storage device, the electronic control unit configured to re-map the at least one torque curve profile in response to receipt by the electronic control unit of an electronic signal indicating a change in a vehicle condition. | 12-17-2015 |
Guoquiang Li, Indianapolis, IN US
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20140033683 | SYSTEM, METHOD, AND APPARATUS FOR AFTERTREATMENT SYSTEM MONITORING - A method includes determining whether a urea refill event is detected, and clearing a quality accumulator value and clearing a latching abort command. The method includes determining whether urea fluid quality check abort conditions are met, and clearing the urea quality accumulator, latching the abort command, and exiting the reductant fluid quality check. In response to the abort conditions not being met, incrementing the urea quality accumulator according to an amount of urea being injected, and comparing the accumulated urea quantity to a low test threshold. The method includes, in response to the accumulated urea quantity being greater than the low test threshold, comparing the accumulated urea quantity to a high test threshold, and in response to the urea quantity being greater than the high test threshold, determining whether the a NO | 02-06-2014 |
Hairong Li, Newburgh, IN US
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20130061620 | SEQUENTIAL DUAL EVAPORATOR REFRIGERATOR AND METHOD OF CONTROLLING SAME - A refrigerator and method are provided where the refrigerator includes at least a refrigerator compartment (C | 03-14-2013 |
Haoxiang Howell Li, West Lafayette, IN US
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20160071412 | METHODS AND SYSTEMS FOR REAL-TIME ADVANCED CONGESTION IDENTIFICATION AND WARNING - The present disclosure relates to a system and method for locating slow or stopped vehicles on a roadway and alerting drivers approaching the back of a queue, and in particular to intelligent transportation systems and traffic management. | 03-10-2016 |
Hong-Yu Li, Zionsville, IN US
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20080262004 | Tgf-Beta Inhibitors - The present invention is directed to inhibitors of TGF-β of Formula I: | 10-23-2008 |
20100076001 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER - The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. wherein: R | 03-25-2010 |
20100081641 | IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER - The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. Formula I wherein: R | 04-01-2010 |
20100087431 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS - The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer. | 04-08-2010 |
20100130466 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS - The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer. | 05-27-2010 |
20100286209 | VINYL INDAZOLYL COMPOUNDS - The present invention provides vinyl indazolyl compounds useful in the treatment of cancer. | 11-11-2010 |
Huarong Li, Zionsville, IN US
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20120174258 | NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 07-05-2012 |
20120174259 | NUCLEIC ACID MOLECULES THAT TARGET THE VACUOLAR ATPASE C SUBUNIT AND CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 07-05-2012 |
20120174260 | NUCLEIC ACID MOLECULES THAT TARGET THE RHO1 SMALL GTP-BINDING PROTEIN AND CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 07-05-2012 |
20120198586 | NUCLEIC ACID MOLECULES THAT TARGET THE VACUOLAR ATPASE H SUBUNIT AND CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 08-02-2012 |
20130091600 | NUCLEIC ACID MOLECULES THAT TARGET PP1-87B AND CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 04-11-2013 |
20130091601 | NUCLEIC ACID MOLECULES THAT TARGET RPA70 AND CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 04-11-2013 |
20130097729 | Aphicidal Toxins and Methods - Provided are chimeric aphicidal and insecticidal toxin proteins comprising peptide, peptide multimer or fusion protein containing such peptide which binds to the gut of sap-sucking insects, e.g., aphids, thrips, leafhoppers, or other target interest. When bound, this peptide mediates the binding of the chimeric aphicidal or other insecticidal protein to the target insect gut. Also described are coding sequences, vectors, and transgenic plants genetically modified to contain and express such aphicidal or insecticidal proteins. Thus, the use of such transgenic plants reduces economic loss due to feeding by the target insect and also reduces loss due to plant diseases spread by the target insect. | 04-18-2013 |
20130097730 | NUCLEIC ACID MOLECULES THAT TARGET RPS6 AND CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 04-18-2013 |
20130167268 | COMBINATIONS INCLUDING CRY34AB/35AB AND CRY3Aa PROTEINS TO PREVENT DEVELOPMENT OF RESISTANCE IN CORN ROOTWORMS (DIABROTICA SPP.) - The subject invention relates in part to Cry34Ab/35Ab in combination with Cry3Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry3Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm ( | 06-27-2013 |
20130167269 | COMBINATIONS INCLUDING Cry34Ab/35Ab AND Cry6Aa PROTEINS TO PREVENT DEVELOPMENT OF RESISTANCE IN CORN ROOTWORMS (DIABROTICA SPP.) - The subject invention relates in part to Cry34Ab/35Ab in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry34Ab/Cry35Ab and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm ( | 06-27-2013 |
20130180016 | COMBINATIONS INCLUDING CRY34AB/35AB AND CRY3BA PROTEINS TO PREVENT DEVELOPMENT OF RESISTANCE IN CORN ROOTWORMS (DIABROTICA SPP.) - The subject invention relates in part to Cry34Ab/35Ab in combination with Cry3Ba. The subject invention relates in part to the surprising discovery that Cry34Ab/Cry35Ab and Cry3Ba are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm ( | 07-11-2013 |
20130263331 | COMBINATIONS INCLUDING CRY3AA AND CRY6AA PROTEINS TO PREVENT DEVELOPMENT OF RESISTANCE IN CORN ROOTWORMS (DIABROTICA SPP.) - The subject invention relates in part to Cry3Aa in combination with Cry6Aa. The subject invention relates in part to the surprising discovery that combinations of Cry3Aa and Cry6Aa are useful for preventing development of resistance (to either insecticidal protein system alone) by a corn rootworm ( | 10-03-2013 |
20140298536 | NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 10-02-2014 |
20150176009 | RNAPII-140 NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 06-25-2015 |
20150176025 | RAS OPPOSITE (ROP) AND RELATED NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN AND/OR HEMIPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran and/or hemipteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran and/or hemipteran pests. The disclosure also concerns methods for making that express nucleic acid molecules useful for the control of coleopteran and/or hemipteran pests, and the plant cells and plants obtained thereby. | 06-25-2015 |
20150232859 | NUCLEIC ACID MOLECULES THAT TARGET THE VACUOLAR ATPASE C SUBUNIT AND CONFER RESISTANCE TO COLEOPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran pests, and the plant cells and plants obtained thereby. | 08-20-2015 |
20150322455 | SEC23 NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN AND HEMIPTERAN PESTS - This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran and/or hemipteran pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in coleopteran and/or hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of coleopteran and/or hemipteran pests, and the plant cells and plants obtained thereby. | 11-12-2015 |
Huiling Li, Columbus, IN US
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20160084136 | SYSTEM AND METHOD FOR CREATING CATALYST OBD LIMIT PARTS FOR EXHAUST AFTERTREATMENT APPLICATIONS - Catalyst diagnostic limit parts and methods for making catalyst diagnostic limit parts are disclosed. An exemplary catalyst diagnostic limit part includes a substrate and a washcoat coating the substrate. The washcoat includes an active catalyst and an inactive catalyst at a predetermined ratio of active catalyst to inactive catalyst so as to control the performance of the catalyst diagnostic limit part. | 03-24-2016 |
Jianming Li, Lafayette, IN US
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20130336899 | ANTIMICROBIAL FORMULATIONS THAT AID IN WOUND HEALING - The invention discloses compositions and formulations for the treatment of clean or infected wounds, some of the inventive formulations can be used to reduce or eliminate microbial contamination from surfaces such as skin, and inanimate objects such as countertops, cooking utensils, medical devices, cookware, food, grooming aids and agricultural biocides, and the like. Some of these compositions and formulations are well suited for use in wound dressings. Some of the formulation can kill and/or inhibit the growth of pathogenic bacteria, fungi, spores and viruses. The formulations comprise a compound such as an osmoticum in high enough concentration to create an osmotic gradient and at least one compound that acts to comprise the integrity of a microorganism's membrane or cell wall. These formulations may optimally include at least one agent that thickens the formulations. In some aspects the formulation is in the form of an emulsion. | 12-19-2013 |
Jianquan Li, Zionsville, IN US
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20120156803 | BIOLOGICALLY-ACTIVE RADIOLABELED CRY1FA AND RECEPTOR BINDING ASSAY METHODS - Cysteine-specific radiolabeled Cry1Fa protein retains insecticidal activity against insect pests and binds to insect brush border membrane vesicle receptors in a saturable manner. The biologically-active radiolabeled Cry1Fa protein is useful in competitive binding assays with other Cry toxins. | 06-21-2012 |
20130205421 | PLANT TRANSACTIVATION INTERACTION MOTIFS AND USES THEREOF - This disclosure concerns compositions and methods for increasing the expression of a polynucleotide of interest. Some embodiments concern novel transactivation polypeptides and variants thereof that have been identified in plants, and methods of using the same. Particular embodiments concern the use of at least one DNA-binding polypeptide in a fusion protein to target at least one transactivation polypeptide or variant thereof to a specific binding site on a nucleic acid comprising the polynucleotide of interest, such that its expression may be increased. | 08-08-2013 |
Jingying Li, Fishers, IN US
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20110321025 | Enhanced Upgrade Path - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for establishing upgrade paths. In one aspect, a method includes establishing an interim environment and platform, migrating the data from the legacy environment and platform to the interim environment and platform, and migrating the data from the interim environment and platform to the upgraded environment and platform. | 12-29-2011 |
20140337825 | Enhanced Upgrade Path - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for establishing upgrade paths. In one aspect, a method includes establishing an interim environment and platform, migrating the data from the legacy environment and platform to the interim environment and platform, and migrating the data from the interim environment and platform to the upgraded environment and platform. | 11-13-2014 |
20150193218 | ENHANCED UPGRADE PATH - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for establishing upgrade paths. In one aspect, a method includes establishing an interim environment and platform, migrating the data from the legacy environment and platform to the interim environment and platform, and migrating the data from the interim environment and platform to the upgraded environment and platform. | 07-09-2015 |
20150309785 | Enhanced Upgrade Path - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for establishing upgrade paths. In one aspect, a method includes establishing an interim environment and platform, migrating the data from the legacy environment and platform to the interim environment and platform, and migrating the data from the interim environment and platform to the upgraded environment and platform. | 10-29-2015 |
Junhui Li, Columbus, IN US
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20140065041 | EMISSIONS AFTERTREATMENT COMPONENT RECOVERY SYSTEM AND METHOD - Methods and systems include an operation to interpret a face-plugging index and/or a reduction in an expected oxidation efficiency of an oxidation catalyst disposed in an internal combustion engine aftertreatment system, and in response to the face-plugging index or the reduction oxidation efficiency reaching a threshold value, an operation to provide a catalyst element reversal command. | 03-06-2014 |
20150072855 | DIAGNOSIS AND TREATMENT OF SELECTIVE CATALYTIC REDUCTION CATALYST - Described herein is a selective catalytic reduction (SCR) catalyst treatment system that includes a vanadium-based SCR catalyst contaminated with a water-soluble contaminant. The SCR catalyst treatment system also includes a water delivery system that is configured to apply water to the vanadium-based SCR catalyst to remove the water-soluble contaminant from the vanadium-based SCR catalyst. | 03-12-2015 |
20150231625 | DIAGNOSIS AND TREATMENT OF SELECTIVE CATALYTIC REDUCTION CATALYST - Described herein is a selective catalytic reduction (SCR) catalyst treatment system that includes a vanadium-based SCR catalyst contaminated with a water-soluble contaminant. The SCR catalyst treatment system also includes a water delivery system that is configured to apply water to the vanadium-based SCR catalyst to remove the water-soluble contaminant from the vanadium-based SCR catalyst. | 08-20-2015 |
Lang Li, Carmel, IN US
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20110269636 | MATERIALS AND METHODS FOR IDENTIFYING PATIENTS AT HEIGHTEN RISK FOR DEVELOPING HER2+ RELATED BRAIN TUMORS - Aspects of the invention include methods for identifying patients with HER2+ cancers that are at a heightened risk for developing brain metastasis within three years of having been diagnosed with HER2+ cancer. Some embodiments are methods that include the steps of contacting at least a portion of the tumor tissue from patients with probes that interact with the products of a set of thirteen genes that are expressed in these patients at markedly higher levels than in similarly situated patients that are not a heightened risk for developing brain metastasis within this three year window. In some embodiments the tissue samples are assayed from the presence of RNA indicative of the expression of member of a set of 13 genes identified as being differentially expressed in patients with and without a heightened risk for developing brain metastasis. | 11-03-2011 |
20120088247 | MATERIALS AND METHODS FOR TREATING PATIENTS WITH TAXOXIFEN - A pathway for the metabolism of tamoxifen is identified including the activity of at least 2 different isoforms of UGY2B7. This pathway includes isozymes of CYP3A which convert tamoxifen (TAM) to N-desmethyl-TAM, which is then converted to endoxifen by the action of CYP2D6. Once formed, endoxifen may be degraded by at least one isozyme of UGT2B7. Patients that have highly active isoforms of CYP2D6 and slow acting isoforms of UGT2B7 accumulate high levels of endoxifen and are good candidates for treatment with tamoxifen. Also disclosed are methods for screening patients with a high likelihood of benefiting from treatment with tamoxifen. These methods include testing patients for various alleles of genes known to be involved in tamoxifen metabolism and treating patients accordingly. | 04-12-2012 |
Liang-Shi Li, Bloomington, IN US
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20120279570 | SOLUBLE GRAPHENE NANOSTRUCTURES AND ASSEMBLIES THEREFROM - Disclosed herein is a method for preparing large soluble graphenes. The method comprises attaching one or more hindering groups to the graphene, which can prevent face-to-face graphene stacking by reducing the effects of inter-graphene attraction. The large graphenes can absorb a wide spectrum of light from UV to near infrared, and are useful in photovoltaic devices and sensitizers in nanocrystalline solar cells. | 11-08-2012 |
Lina Li, Bloomington, IN US
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20100093051 | LIGHT REGULATED TRANSCRIPTION SYSTEM FOR USE IN PROKARYOTIC ORGANISMS - A process for regulating transcriptional activity of a gene is provided. The process comprises introducing genetic material into an organism, placing a gene downstream of a light-regulated promoter within the organism having a light responsive element and subjecting the organism to an exogenous light source. The genetic material is selected from a photosynthetic bacterium and the light source is configured to control the level of transcriptional activity of the gene. | 04-15-2010 |
Linfan Li, West Lafayette, IN US
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20150325423 | SYSTEMS AND METHODS FOR ANALYZING AN EXTRACTED SAMPLE - The invention generally relates to systems for analyzing a sample and methods of use thereof. In certain aspects, the invention provides systems that include an ionization probe and a mass analyzer. The probe includes a hollow body that has a distal tip. The probe also includes a substrate that is at least partially disposed within the body and positioned prior to the distal tip so that sample extracted from the substrate flows into the body prior to exiting the distal tip. The probe also includes an electrode that operably interacts with sample extracted from the substrate. | 11-12-2015 |
Lingxi Li, Zionsville, IN US
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20130135110 | ADVANCED BATTERY EARLY WARNING AND MONITORING SYSTEM - Systems, apparatuses and methods for detecting internal cell faults using online and real-time sensing techniques, and providing an accurate and reliable early warning for the incoming failure of battery cells hours or days prior to failure. A system is configured to perform real-time and direct measurement of battery cell parameters of temperature, voltage, and AC impedance through online sensing. These parameters may be simultaneously processed using advanced probabilistic and/or fuzzy logic-based algorithms to provide an early warning for the incoming failure of battery cells in a battery pack. This technology may safeguard the LIB battery packs while allowing them to operate at or near 100% capacity in both transportation and stationary applications. | 05-30-2013 |
20160055736 | ADVANCED BATTERY EARLY WARNING AND MONITORING SYSTEM - Systems, apparatuses and methods for detecting internal cell faults using online and real-time sensing techniques, and providing an accurate and reliable early warning for the incoming failure of battery cells hours or days prior to failure. A system is configured to perform real-time and direct measurement of battery cell parameters of temperature, voltage, and AC impedance through online sensing. These parameters may be simultaneously processed using advanced probabilistic and/or fuzzy logic-based algorithms to provide an early warning for the incoming failure of battery cells in a battery pack. This technology may safeguard the LIB battery packs while allowing them to operate at or near 100% capacity in both transportation and stationary applications. | 02-25-2016 |
Panjian Li, Fort Wayne, IN US
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20090220675 | Apparatus for producing a biomimetic coating on a medical implant - An apparatus for producing a biomimetic coating on an implantable article is provided. The apparatus includes an outer reactor for containing a biomimetic coating solution and an inner reactor arranged within the outer reactor. The inner reactor is smaller than the outer reactor so as to define a space between the inner and outer reactors. The apparatus also includes a pump system for circulating the biomimetic coating solution. The pump system is arranged to operate in the space between the inner and outer reactors. The inner reactor includes a flow control system that is selectively operable to control the flow of biomimetic coating solution between the outer and inner reactors. | 09-03-2009 |
Pengyun Li, Bloomington, IN US
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20150299285 | CTP-BASED INSULIN ANALOGS FOR TREATMENT OF DIABETES - Insulin analogs comprising a non-native glycosylation site sequence are provided having high potency and specificity for the insulin receptor. In one embodiment a peptide sequence of greater than 18 amino acids is used as a linking moiety to link human insulin A and B chains, or analogs or derivatives thereof, to provide high potency single chain insulin analogs. In one embodiment the linking moiety comprises one or more glycosylation sites. Also disclosed are prodrug and conjugate derivatives of the insulin analogs. | 10-22-2015 |
20150374795 | O-GLYCOSYLATED CARBOXY TERMINAL PORTION (CTP) PEPTIDE-BASED INSULIN AND INSULIN ANALOGUES - Compositions and formulations comprising insulin or insulin analogues comprising a carboxy terminal portion (CTP) peptide comprising amino acids 112-188 to 142 of the beta subunit of human chorionic gonadotropin (hCGβ) or a partial variant thereof that includes at least one O-glycosylation site of the CTP peptide, wherein the CTP peptide of the CTP peptide-based insulin or insulin analogue is O-glycosylated are described. In particular embodiments, the O-glycosylated insulin analogues are produced in vivo and in further embodiments, the O-glycosylated CTP-based insulin analogues comprise predominantly mannotriose and mannotetrose O-glycans or predominantly mannose O-glycans. | 12-31-2015 |
20160024169 | INSULIN-INCRETIN CONJUGATES - Disclosed herein are insulin agonist peptides conjugated to incretins wherein the insulin/incretin conjugate has agonist activity at both the insulin receptor and the corresponding incretin receptor. Insulin is a proven therapy for the treatment of juvenile-onset diabetes and later-stage adult-onset diabetes. The peptide is biosynthesized as a larger linear precursor of low potency (approximately 2% to 9% of native insulin), named proinsulin. Proinsulin is proteolytically converted to insulin by the selective removal of a 35-residue connecting peptide (C peptide). | 01-28-2016 |
Renhua Li, Fishers, IN US
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20090099182 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 - The present invention discloses novel compounds of Formula I: | 04-16-2009 |
20090111800 | CYCLOHEXYLPYRAZOLE-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 - The present invention discloses novel compounds of Formula (I): having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I), as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity. | 04-30-2009 |
20090111809 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 - The present invention discloses novel compounds of Formula I: (I) having 11-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11-HSD type 1 activity. | 04-30-2009 |
20090156571 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 - The present invention discloses novel compounds of Formula I: possessing 11 β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 β-HSD type 1 activity. | 06-18-2009 |
20090221633 | INHIBITORS OF AKT (PROTEIN KINASE B) - 4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt inhibitors that are antineoplastic and/or antiviral agents as well as compositions comprising these compounds and methods of using these compounds. | 09-03-2009 |
20090275613 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 - The present invention discloses novel compounds of Formula I: (I) possessing 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11β-HSD type 1 activity. | 11-05-2009 |
20120129902 | 4-SUBSTITUTED-3-PHENYLSULFANYLMETHYL-BICYCLO[3.1.0]HEXANE COMPOUNDS AS mGluR 2/3 ANTAGONISTS - A mGlu2/3 receptor antagonist of the formula: | 05-24-2012 |
Shu Li, Columbus, IN US
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20150241399 | SYSTEMS AND METHODS FOR DETERMINING COMBUSTION PROPERTIES OF WELLHEAD GAS - Disclosed are methods, systems, and computer-readable mediums for determining combustion properties of wellhead gas. A methane concentration of a gas mixture is measured. A non-methane hydrocarbon concentration of the gas mixture is measured. An inert concentration of the gas mixture is calculated. A first surrogate for the non-methane hydrocarbon concentration is selected, where the first surrogate is selected as propane if the methane concentration is greater than a first threshold, and where the first surrogate is selected as pentane if the methane concentration is less than or equal to the first threshold. A methane number of the gas mixture is determined, where the methane number is based on the methane concentration, the first surrogate, and the inert concentration. | 08-27-2015 |
Shun Li, Carmel, IN US
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20090118190 | MUTEINS OF FIBROBLAST GROWTH FACTOR 21 - The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients. | 05-07-2009 |
20090312236 | PEGYLATED INSULIN LISPRO COMPOUNDS - The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses. | 12-17-2009 |
20110105392 | Pegylated Insulin Lispro Compounds - The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses. | 05-05-2011 |
20150297681 | Pegylated Insulin Lispro Compounds - The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses. | 10-22-2015 |
Tiancheng Li, West Lafayette, IN US
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20100212017 | SYSTEM AND METHOD FOR EFFICIENT TRUST PRESERVATION IN DATA STORES - The invention provides a method and system for preserving trustworthiness of data, the method includes storing data on an untrusted system, and committing the data to a trusted computing base (TCB). The committing includes upon an end of a predetermined time interval, transmitting a constant size authentication data from the untrusted system to the TCB, and the TCB preserving trustworthiness of the authentication data based on performing a single hash operation of a first root and a second root of a general hash tree representing authenticated data. | 08-19-2010 |
20110321169 | Generating Minimality-Attack-Resistant Data - The present disclosure is directed to systems, methods, and computer-readable storage media for generating data and data sets that are resistant to minimality attacks. Data sets having a number of tuples are received, and the tuples are ordered according to an aspect of the tuples. The tuples can be split into groups of tuples, and each of the groups may be analyzed to determine if the group complies with a privacy requirement. Groups that satisfy the privacy requirement may be output as new data sets that are resistant to minimality attacks. | 12-29-2011 |
Tiechao Li, Fishers, IN US
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20080269244 | Kinase Inhibitors - The present invention provides kinase inhibitors of Formula (I). Wherein R | 10-30-2008 |
20080306068 | Kinase Inhibitors - The present invention provides kinase inhibitors of Formula I: | 12-11-2008 |
20100022529 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET - The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer. | 01-28-2010 |
Tongcang Li, West Lafayette, IN US
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20150192767 | MULTIPLANE OPTICAL MICROSCOPE - This disclosure provides systems, methods, and apparatus related to optical microscopy. In one aspect, an apparatus includes a sample holder, a first objective lens, a plurality of optical components, a second objective lens, and a mirror. The apparatus may directly image a cross-section of a sample oblique to or parallel to the optical axis of the first objective lens, without scanning. | 07-09-2015 |
Weixu Li, Indianapolis, IN US
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20130188019 | System and Method for Three Dimensional Imaging - A method of operating a camera with a microfluidic lens to identify a depth of an object in image data generated by the camera has been developed. The camera generates an image with the object in focus, and a second image with the object out of focus. An image processor generates a plurality of blurred images from image data of the focused image, and identifies blur parameters that correspond to the object in the second image. The depth of the object from the camera is identified with reference to the blur parameters. | 07-25-2013 |
Yihong Li, Carmel, IN US
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20080207685 | Heterocyclic Compounds As Modulators Of Peroxisome Proliferator Activated Receptors, Useful For The Treatment And/Or Prevention Of Disorders Modulated By A Ppar - The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases. | 08-28-2008 |
20090105229 | PURINE DERIVATIVES AS KINASE INHIBITORS - The present invention provides kinase inhibitors of Formula I. | 04-23-2009 |
20110207721 | PURINE DERIVATIVES AS KINASE INHIBITORS - The present invention provides kinase inhibitors of Formula I. | 08-25-2011 |
20110294792 | PURINE DERIVATIVES AS KINASE INHIBITORS - The present invention provides kinase inhibitors of Formula I. | 12-01-2011 |
Ze-Sheng Li, Westfield, IN US
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20090221501 | MIXING AND MATCHING TC PROTEINS FOR PEST CONTROL - The subject invention relates to the surprising discovery that toxin complex (TC) proteins, obtainable from | 09-03-2009 |
20100004177 | TOXIN COMPLEX PROTEINS AND GENES FROM XENORHABDUS BOVIENII - The subject invention relates to novel | 01-07-2010 |
Zhou Li, Bloomington, IN US
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20130339158 | DETERMINING LEGITIMATE AND MALICIOUS ADVERTISEMENTS USING ADVERTISING DELIVERY SEQUENCES - Known legitimate and malicious display advertisements are selected, and the ordered sequence of entities involved in the delivery of each display advertisement is observed and used to generate advertisement delivery sequences. The entities include the various servers, publishers, and advertising networks that are involved in the delivery of a display advertisement. Attributes of the entities in each sequence are determined and used to generate a set of rules that identify a display advertisement as legitimate or malicious based on the attributes of the advertising delivery sequence associated with the delivery of the display advertisement. The generated rules are used to identify possible malicious advertisements, and to identify one or more sources of malicious display advertisements. | 12-19-2013 |