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Li, Burnaby

Paul Li, Burnaby CA

Patent application numberDescriptionPublished
20080237146APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising: providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.10-02-2008
20100326826APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.12-30-2010
20110048945APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS - An on-chip packed reactor bed design is disclosed that allows for an effective exchange of packing materials such as beads at a miniaturized level. Also disclosed is a method of treating a sample within a microfluidic analysis system, comprising; providing a main channel having a trapping zone; providing a slurry of a reagent treated packing material; inducing a flow of said packing material into said trapping zone through a flow channel connected to said trapping zone to load said trapping zone and form a packed bed of said packing material; and flowing a sample containing analytes through said packed bed, said reagent treating the sample. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.03-03-2011

Patent applications by Paul Li, Burnaby CA

Qingguo Li, Burnaby CA

Patent application numberDescriptionPublished
20080277943Method and apparatus for harvesting biomechanical energy - Methods and apparatus are disclosed for harvesting energy from motion of one or more joints. Energy harvesters comprise: a generator for converting mechanical energy into corresponding electrical energy; one or more sensors for sensing one or more corresponding characteristics associated with motion of the one or more joints; and control circuitry connected to receive the one or more sensed characteristics and configured to assess, based at least in part on the one or more sensed characteristics, whether motion of the one or more joints is associated with mutualistic conditions or non-mutualistic conditions. If conditions are determined to be mutualistic, energy harvesting is engaged. If conditions are determined to be non-mutualistic, energy harvesting is disengaged.11-13-2008
20080278028Methods and apparatus for harvesting biomechanical energy - Methods and apparatus are disclosed for harvesting energy from motion of one or more joints. Energy harvesters comprise: a generator for converting mechanical energy into corresponding electrical energy; one or more sensors for sensing one or more corresponding characteristics associated with motion of the one or more joints; and control circuitry connected to receive the one or more sensed characteristics and configured to assess, based at least in part on the one or more sensed characteristics, whether motion of the one or more joints is associated with mutualistic conditions or non-mutualistic conditions. If conditions are determined to be mutualistic, energy harvesting is engaged. If conditions are determined to be non-mutualistic, energy harvesting is disengaged.11-13-2008
20100276944METHODS AND APPARATUS FOR HARVESTING BIOMECHANICAL ENERGY - Methods and apparatus are disclosed for harvesting energy from motion of one or more joints. Energy harvesters comprise: an energy converter for converting mechanical energy into corresponding electrical energy; one or more sensors for sensing one or more corresponding characteristics associated with motion of the one or more joints; and a controller connected to receive the one or more sensed characteristics and configured to assess, based at least in part on the one or more sensed characteristics, whether motion of the one or more joints is associated with mutualistic conditions or non-mutualistic conditions. If conditions are determined to be mutualistic, energy harvesting is engaged. If conditions ate determined to be non-mutualistic, energy harvesting is disengaged.11-04-2010

Wenyuan Li, Burnaby CA

Patent application numberDescriptionPublished
20090027066Method and system of real-time estimation of transmission line parameters in on-line power flow calculations - A system and method for estimating parameters of transmission lines employing phasor measurement units is provided, wherein measurements are provided from the phasor measurement units relating to a transmission line. These measurements are filtered to remove invalid measurements. Using the remaining valid measurements, resistance, reactance and grounding admittance are calculated and estimated and checked for errors.01-29-2009
20090027067Method and system for real time identification of voltage stability via identification of weakest lines and buses contributing to power system collapse - A method of identifying voltage instability in a power system via identification of a weakest line and bus that contribute to the collapse of the system is provided. The method includes periodically calculating an extended line stability index for the transmission lines monitored in the power system; and using the extended line stability index to determine the distance of an operation state in the power system from a collapse point of the system caused by voltage instability.01-29-2009

Xueman Li, Burnaby CA

Patent application numberDescriptionPublished
20090110209SYSTEM FOR COMFORT NOISE INJECTION - A noise injection system adds comfort noise to an audio signal. The system includes a background noise estimator that determines a spectral content of a background noise associated with the audio signal. A comfort noise generator generates a comfort noise signal having a random phase. A gain circuit adjusts the comfort noise signal based on the spectral content of the background noise. A combining circuit combines a gain-adjusted comfort noise signal and the audio signal to generate an output signal.04-30-2009
20090112579SPEECH ENHANCEMENT THROUGH PARTIAL SPEECH RECONSTRUCTION - A system improves speech intelligibility by reconstructing speech segments. The system includes a low-frequency reconstruction controller programmed to select a predetermined portion of a time domain signal. The low-frequency reconstruction controller substantially blocks signals above and below the selected predetermined portion. A harmonic generator generates low-frequency harmonics in the time domain that lie within a frequency range controlled by a background noise modeler. A gain controller adjusts the low-frequency harmonics to substantially match the signal strength to the time domain original input signal.04-30-2009
20090112584DYNAMIC NOISE REDUCTION - A speech enhancement system improves the speech quality and intelligibility of a speech signal. The system includes a time-to-frequency converter that converts segments of a speech signal into frequency bands. A signal detector measures the signal power of the frequency bands of each speech segment. A background noise estimator measures a background noise detected in the speech signal. A dynamic noise reduction controller dynamically models the background noise in the speech signal. The speech enhancement renders a speech signal perceptually pleasing to a listener by dynamically attenuating a portion of the noise that occurs in a portion of the spectrum of the speech signal.04-30-2009
20090222268SPEECH SYNTHESIS SYSTEM HAVING ARTIFICIAL EXCITATION SIGNAL - A speech synthesis system synthesizes a speech signal corresponding to an input speech signal based on a spectral envelope of the input speech signal. A glottal pulse generator generates a time series of glottal pulses, that are processed into a glottal pulse magnitude spectrum. A shaping circuit shapes the glottal pulse magnitude spectrum based on the spectral envelope and generates a shaped glottal pulse magnitude spectrum. A harmonic null adjustment circuit reduces harmonic nulls in the shaped glottal pulse magnitude spectrum and generates a null-adjusted synthesized speech spectrum. An inverse transform circuit generates a null-adjusted time-series speech signal. An overlap and add circuit synthesizes the speech signal based on the null-adjusted time-series speech signal.09-03-2009
20090287481SPEECH ENHANCEMENT SYSTEM - A speech enhancement system improves speech conversion within an encoder and decoder. The system includes a first device that converts sound waves into operational signals. A second device selects a template that represents an expected signal model. The selected template models speech characteristics of the operational signals through a speech codebook that is further accessed in a communication channel.11-19-2009
20090292536Speech enhancement with minimum gating - A speech enhancement system enhances transitions between speech and non-speech segments. The system includes a background noise estimator that approximates the magnitude of a background noise of an input signal that includes a speech and a non-speech segment. A slave processor is programmed to perform the specialized task of modifying a spectral tilt of the input signal to match a plurality of expected spectral shapes selected by a Codec.11-26-2009
20110026734System for Suppressing Wind Noise - A voice enhancement logic improves the perceptual quality of a processed voice. The voice enhancement system includes a noise detector and a noise attenuator. The noise detector detects a wind buffet and a continuous noise by modeling the wind buffet. The noise attenuator dampens the wind buffet to improve the intelligibility of an unvoiced, a fully voiced, or a mixed voice segment.02-03-2011
20110123044Method and Apparatus for Suppressing Wind Noise - The invention includes a method, apparatus, and computer program to selectively suppress wind noise while preserving narrow-band signals in acoustic data. Sound from one or several microphones is digitized into binary data. A time-frequency transform is applied to the data to produce a series of spectra. The spectra are analyzed to detect the presence of wind noise and narrow band signals. Wind noise is selectively suppressed while preserving the narrow band signals. The narrow band signal is interpolated through the times and frequencies when it is masked by the wind noise. A time series is then synthesized from the signal spectral estimate that can be listened to. This invention overcomes prior art limitations that require more than one microphone and an independent measurement of wind speed. Its application results in good-quality speech from data severely degraded by wind noise.05-26-2011

Patent applications by Xueman Li, Burnaby CA

Yunchao Li, Burnaby CA

Patent application numberDescriptionPublished
20080274917Surface activation methods for polymeric substrates to provide biochip platforms and methods for detection of biomolecules thereon - A surface activation method is provided to convert polycarbonate (PC) substrates, e.g., plastic bases of optical discs, to biochip platforms. Such surface activation methods comprise providing an ozone enriched environment in a vicinity of the surface and irradiating the surface with UV radiation. Once activated, the surfaces can be used for DNA probe immobilization and target detection or other bioassays.11-06-2008
20110103212METHODS FOR ASSESSING THE RESULTS OF DISC-BASED BIOASSAYS WITH STANDARD COMPUTER OPTICAL DRIVES - Methods and systems are described for assessing the results of a bioassay between probe biomolecules and target biomolecules using a conventional optical disc drive. Particular methods involve: bonding the probe biomolecules to a polycarbonate (PC) surface of an optical disc having digital data comprising error-detection redundancies recorded thereon; introducing the target biomolecules to the PC surface of the optical disc in a vicinity of the bonded probe biomolecules; processing the bioassay to alter a manner in which a read light from the optical disc drive interacts optically with the optical disc in a vicinity of positive bioassay results where the target biomolecules have bonded to the probe biomolecules; reading the digital data from the optical disc using the optical drive and using the error-detection redundancies to detect errors in the digital data read by the optical drive; mapping the detected errors to corresponding locations on the optical disc; and determining that positive bioassay results have occurred at the locations of the detected errors.05-05-2011