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Lewis, AL

Brian Allen Lewis, Bimingham, AL US

Patent application numberDescriptionPublished
20080255917Method For Business Management - A method for managing the complete workflow of a personnel network-oriented business that allows those at varying levels of the company hierarchy to manage, monitor, assign, accept and fulfill their client obligations through an interactive software-based process. Secure levels of administration and delegation combine with an array of links that ultimately organize workflow from beginning of a client file to the end.10-16-2008

Danny Lewis, Hartselle, AL US

Patent application numberDescriptionPublished
20080292712METHODS AND COMPOSITIONS FOR ENHANCED DELIVERY OF BIOACTIVE MOLECULES - Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly (lactic acid) (PLA), poly (glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.11-27-2008

Danny H. Lewis, Hartselle, AL US

Patent application numberDescriptionPublished
20090042825Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer - Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.02-12-2009
20090042829Nucleic Acid-Lipopolymer Compositions - Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.02-12-2009

Patent applications by Danny H. Lewis, Hartselle, AL US

James M. Lewis, Moulton, AL US

Patent application numberDescriptionPublished
20090129585Exclusive encryption system - An encryption system includes a plurality of encryption operations including individual encryption operations and group encryption operations available for application in the encryption of data. The plurality of encryption operations are selected from the group consisting of functional variance, functional alignment, mathematical offset, wide XOR function, short logical rotation, long logical rotation, functional order, and address encryption. The system includes at least one round of encryption composed of a first encryption operation and a second encryption operation. The first encryption operation is selected from the plurality of encryption operations acting upon input data to generate a first encrypted data set. The second encryption operation is selected from the plurality of encryption operations acting upon the first encrypted data set to generate a second encrypted data set. The first encryption operation and the second encryption operation are different.05-21-2009
20100213951METHOD AND SYSTEM FOR DETECTION OF TAMPERING RELATED TO REVERSE ENGINEERING - A sensor system for protecting products and technology from reverse engineering by detecting attempts to probe electronic circuitry includes a sensor electrically linked to electronic circuitry. The sensor detects interaction of probe devices with the electronic circuitry for the purpose of reverse engineering the electronic circuitry. The sensor includes an exciter and an impedance counter linked to the exciter. A count rate of the impedance counter is a function of the impedance of the electronic circuitry due to the fact that oscillation frequency generated by the exciter is also a function of the impedance of the electronic circuitry. The sensor also includes an impedance register storing the binary count value from the impedance counter, wherein after the impedance counter data is transferred into the impedance register, the data is referred to as impedance data. The sensor also includes a reference oscillator monitoring count rate of the impedance counter and a sensor evaluation system comparing the impedance value to threshold values to determine if a significant change has occurred. When changes have occurred this is indicative of abnormal behavior and may be indicative of tampering relating to the evaluation of the electronic circuit for the purpose of reverse engineering.08-26-2010
20100232600Exclusive encryption system - An encryption system includes a plurality of encryption operations including individual encryption operations and group encryption operations available for application in the encryption of data. The plurality of encryption operations are selected from the group consisting of functional variance, functional alignment, mathematical offset, wide XOR function, short logical rotation, long logical rotation, functional order, and address encryption. The system includes at least one round of encryption composed of a first encryption operation and a second encryption operation. The first encryption operation is selected from the plurality of encryption operations acting upon input data to generate a first encrypted data set. The second encryption operation is selected from the plurality of encryption operations acting upon the first encrypted data set to generate a second encrypted data set. The first encryption operation and the second encryption operation are different.09-16-2010

Patent applications by James M. Lewis, Moulton, AL US

Thomas P. Lewis, Birmingham, AL US

Patent application numberDescriptionPublished
20090129983Device For the Growth of Macromolecular Crystals and Drug Screening - The invention is a device for counter-diffusion applications comprising a removable cartridge having a plurality of capillary tubes that may be disposed between first and second members. The first member may be moveable into at least a first and second position. The second member may be moveable into a sealing position wherein the distal ends of the capillary tubes contact a sealant material. In the first position, the proximal ends of the capillary tubes may contact a macromolecular solution, which may cause the macromolecular solution to diffuse into the interior space of the capillary tube. In the second position, the proximal ends of the capillary tubes may be inserted into a corresponding reservoir well having a precipitating solution. The macromolecular solution and the precipitating solution may then counter diffuse against each other in each capillary tube. The removable cartridge may then be removed and replaced with a new removable cartridge.05-21-2009

Tom Lewis, Birmingham, AL US

Patent application numberDescriptionPublished
20090042743METHOD FOR DETERMINING CRYSTALLIZATION PARAMETERS AND APPARATUS FOR USE WITH THE SAME - The present disclosure provides a method to allow a user to pre-screen numerous crystallization conditions in the crystallization space to identify those conditions with the highest probability of yielding crystals and high quality diffracting crystals. In one embodiment, the dilute solution thermodynamic virial coefficient, termed B, is used to aid in the determination crystallization conditions that increase the probability of producing crystals for the crystallant of interest. The present disclosure also provide methods for predicting solution conditions that generate beneficial solubility and/or stability conditions for a polypeptide of interest using the B parameter. Devices for use in the described methods are also described.02-12-2009