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| 20100105953 | Human Adam-10 Inhibitors - The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. | 04-29-2010 |
| 20120071653 | Human Adam-10 Inhibitors - The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. | 03-22-2012 |
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| 20100129482 | Intermittent flow extrusion process and food product - An extrusion process incorporates a forming manifold where a tubular flow of a second material is intermittently interrupted while a core flow of a first material is discharged substantially continuously. Subsequently, the core flow is severed to form individual food items or treats for humans, animals, and the like, where the tubular flow results in an outer component surrounding an inner component which protrudes from one or both ends of the outer component. Material of the core flow is bone-like, while material of the tubular flow is meat like. Material of the tubular flow may include material from the core flow subjected to mixing in a static mixer to achieve a marbled texture of the outer material. | 05-27-2010 |
| 20100129498 | Intermittent flow extrusion process and food product - An extrusion process incorporates a forming manifold where a tubular flow of a second material is intermittently interrupted while a core flow of a first material is discharged substantially continuously. Subsequently, the core flow is severed to form individual food items or treats for humans, animals, and the like, where the tubular flow results in an outer component surrounding an inner component which protrudes from one or both ends of the outer component. Material of the core flow is bone-like, while material of the tubular flow is meat like. Material of the tubular flow may include material from the core flow subjected to mixing in a static mixer to achieve a marbled texture of the outer material. | 05-27-2010 |
| 20100303970 | CAT TREAT - A pet treat having a sugar-based edible portion including a palatant material and a support portion. Incorporation of starch provides a hard-candy texture for the edible portion. The pet treat may be formed as a lollipop, a toy, or a lozenge using either a batch process or a continuous process. Features to interest a pet include a resilient mount, or a rotatable mount. An adhesive mount can attach the support to a variety of surfaces. A replaceable cover and rejuvenant container may be used. | 12-02-2010 |
| 20100304002 | CAT TREAT - A pet treat having a sugar-based edible portion including a palatant material and a support portion. Incorporation of starch provides a hard-candy texture for the edible portion. The pet treat may be formed as a lollipop, a toy, or a lozenge using either a batch process or a continuous process. Features to interest a pet include a resilient mount, or a rotatable mount. An adhesive mount can attach the support to a variety of surfaces. A replaceable cover and rejuvenant container may be used. | 12-02-2010 |
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| 20080224735 | Frequency Synthesis Rational Division - A system and method are provided for synthesizing signal frequencies using rational division. The method accepts a reference frequency value and a synthesized frequency value. In response to dividing the synthesized frequency value by the reference frequency value, an integer value numerator (dp) and an integer value denominator (dq) are determined. The method reduces the ratio of dp/dq to an integer N and a ratio of p/q (dp/dq=N(p/q)), where p/q<1 (decimal). The numerator (p) and the denominator (q) are supplied to a flexible accumulator module, and a divisor is generated as a result. N is summed with a k-bit quotient to create the divisor. In a phase-locked loop (PLL), the divisor and the reference signal are used to generate a synthesized signal having a frequency equal to the synthesized frequency value. | 09-18-2008 |
| 20090201066 | Digitally Clock with Selectable Frequency and Duty Cycle - A system and method are provided for controlling the duty cycle and frequency of a digitally generated clock. The method accepts a first clock signal having a fixed first frequency. A frequency control word with a first pattern is loaded into a first plurality of serially-connected registers. A duty cycle control word with a second pattern is loaded into a second plurality of serially-connected registers. A register clock signal is generated in response to the first clock and the first pattern. Then, a digital clock signal is generated having a frequency and duty cycle responsive to the register clock signal and the second pattern. | 08-13-2009 |
| 20100092174 | Differential Inverse Multiplexing Virtual Channels in 40G Ethernet Applications - A system and method are provided for deinterleaving differential inverse multiplexed (DIM) virtual channels in a 40G Ethernet receiver. The method accepts a 10.3125 gigabits per second (Gbps) (10G) Ethernet virtual channel with 64B/86B blocks, including periodic Lane Alignment Marker (LAM) blocks. The 10G virtual channel is deinterleaved into two 5.15625 Gbps (5G) virtual channels by: 1) deinterleaving consecutive blocks from the 10G virtual channel into the 5G virtual channels in an alternating order, and 2) reversing the order of deinterleaving in response to each detected LAM block. Then, the method supplies the 5G virtual channels (i.e. to a MAC module). | 04-15-2010 |
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| 20100031071 | Platform-Based Idle-Time Processing - A system and method for transitions a computing system between operating modes that have different power consumption characteristics. When a system management unit (SMU) determines that the computing system is in a low activity state, the SMU transitions the central processing unit (CPU) into a low power operating mode after the CPU stores critical operating state of the CPU in a memory. The SMU then intercepts and processes interrupts intended for the CPU, modifying a copy of the critical operating state. This effectively extends the time during which the CPU stays in lower power mode. When the SMU determines that the computing system exits a low activity state, the copy of the critical operating state is stored in the memory and the SMU transitions the CPU into a high power operating mode using the modified critical operating state. | 02-04-2010 |
| 20110087860 | PARALLEL DATA PROCESSING SYSTEMS AND METHODS USING COOPERATIVE THREAD ARRAYS - Parallel data processing systems and methods use cooperative thread arrays (CTAs), i.e., groups of multiple threads that concurrently execute the same program on an input data set to produce an output data set. Each thread in a CTA has a unique identifier (thread ID) that can be assigned at thread launch time. The thread ID controls various aspects of the thread's processing behavior such as the portion of the input data set to be processed by each thread, the portion of an output data set to be produced by each thread, and/or sharing of intermediate results among threads. Mechanisms for loading and launching CTAs in a representative processing core and for synchronizing threads within a CTA are also described. | 04-14-2011 |
| 20110238955 | METHODS FOR SCALABLY EXPLOITING PARALLELISM IN A PARALLEL PROCESSING SYSTEM - Parallelism in a parallel processing subsystem is exploited in a scalable manner. A problem to be solved can be hierarchically decomposed into at least two levels of sub-problems. Individual threads of program execution are defined to solve the lowest-level sub-problems. The threads are grouped into one or more thread arrays, each of which solves a higher-level sub-problem. The thread arrays are executable by processing cores, each of which can execute at least one thread array at a time. Thread arrays can be grouped into grids of independent thread arrays, which solve still higher-level sub-problems or an entire problem. Thread arrays within a grid, or entire grids, can be distributed across all of the available processing cores as available in a particular system implementation. | 09-29-2011 |
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| 20080207683 | BIARYL-SUBSTITUTED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S - Biaryl-substituted tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. | 08-28-2008 |
| 20080269241 | BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S - Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. | 10-30-2008 |
| 20090118274 | MONOCYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S - Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. | 05-07-2009 |
| 20100179123 | THIENOPYRIMIDINES USEFUL AS AURORA KINASE INHIBITORS - The present invention provides compounds having the formula: | 07-15-2010 |
| 20110020278 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 01-27-2011 |
| 20110123493 | 2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS - Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R | 05-26-2011 |
| 20110178058 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 07-21-2011 |
| 20110178129 | INHIBITORS OF FLAVIVIRIDAE VIRUSES - Provided are compounds of Formula I: | 07-21-2011 |
