| Patent application number | Description | Published |
|---|
| 20080213785 | Method of predicting a benefit of antioxidant therapy for prevention or treatment of vasclar disease in hyperglycemic individuals - This invention relates to methods and compositions of determining the benefit of therapy using antioxidant for the treatment of cardiovascular events in individuals with diabetes mellitus based on their haptoglobin phenotype and the treatment of the cardiovascular events using antioxidants based on the haptoglobin phenotype. | 09-04-2008 |
| 20090018110 | Haptoglobin genotyping for prognosis and treatment of chronic vasospasm following subarachnoid hemorrhage (SAH) - This invention relates to methods and systems for providing a prognosis to a subject on developing vasospasm as a results of hemorrhagic event, and compounds and compositions for treatment thereof. Specifically, the invention relates to the use of haptoglobin genotyping in the prognosis of the development of vasospasm following SAH, and antioxidants such as glutathione peroxidase mimetics for treatment. | 01-15-2009 |
| 20090054390 | Use of haptoglobin genotyping in diagnosis and treatment of intraplaque hemorrhage resulting from plaque rupture - This invention relates to methods for providing prognosis of a subjects susceptibility to plaque rupture and compositions for treating plaque rupture and intraplaque hemorrhage. Specifically, the invention is directed to the use of haptoglobin genotyping in determining the susceptibility of a subject to develop intraplaque hemorrhage resulting from plaque rapture and treatment of the intraplaque hemorrhage using antioxidants. | 02-26-2009 |
| 20090074740 | Use of haptoglobin genotyping in diagnosis and treatment of defective reverse cholesterol transport (RCT) - A method of determining a potential of a nondiabetic or diabetic patient to benefit from reverse cholesterol transport therapy for treatment of a vascular complication, followed by methods and compositions of treating the diagnosed vascular complications comprising determining a haptoglobin phenotype of the patient. Reverse cholesterol transport therapy includes inhibition of cholesteryl ester transport protein, such as by using the compound torcetrapib. | 03-19-2009 |
| 20090137617 | USE OF HAPTOGLOBIN GENOTYPING IN DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASE - This invention is directed to methods and compositions for the treatment of cardiovascular disorders. Specifically, the invention is directed to compositions comprising vitamin E, statins and/or glutathione peroxidase mimetics; methods of treating diabetic patients expressing the Hp-2-2 haptoglobin genotype; a method of inhibiting or suppressing a cardiovascular disorder in a diabetic subject, treating cardiovascular disease in subjects exhibiting the Haptoglobin Hp-2-2 genotype; and methods of treating cardiovascular disease in subjects exhibiting the Haptoglobin Hp-2-2 genotype. | 05-28-2009 |
| 20090246770 | GLYCEMIC CONTROL FOR REDUCTION OF CARDIOVASCULAR DISEASE RISK IN DIABETIC PATIENTS EXPRESSING HAPTOGLOBIN 2-2 - This invention relates to methods of reducing risk of developing cardiovascular complications in diabetic patients. Specifically, the invention relates to the use of haptoglobin genotyping for determining the importance of maintaining tight glycemic control in diabetic subjects expressing Hp 2-2 allele. | 10-01-2009 |
| 20110294145 | REAGENTS AND METHODS FOR DETECTING A POLYMORPHIC PROTEIN - The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of a subject and methods for testing a subject for susceptibility to diabetic complications. | 12-01-2011 |
| Patent application number | Description | Published |
|---|
| 20080292510 | SYSTEM AND METHOD FOR STERILIZATION OF A LIQUID - Apparatus and method for sterilization of liquid includes a liquid container containing a liquid and having a piezoceramic ring that is connected to a power supply system. Power supply system supplies electric signals to the piezoceramic ring that are transformed into mechanical waves and cause vibrations in the liquid. | 11-27-2008 |
| 20090130623 | METHOD AND APPARATUS FOR EFFECTING DENTAL MEASUREMENTS USING A BODY-CONTACTING ELECTRODE - Some embodiments of the present invention provide an apparatus comprising: a) a root canal electrode insertable into the root canal of a tooth of a patient; b) a control unit including: i) a housing; ii) a current generator having a first terminal and a second terminal, the current generator being operative to produce a time varying current having a frequency of at least about 50 KHz and at most about 300 KHz between the first and second terminals, the current generator being deployed within the housing of the control unit; and iii) a detection element configured to sense an impedance-related parameter between the first and second terminals of the current generator, the detection element being deployed within the housing of the control unit; and c) an electrode patch detachably attached to the control unit, the electrode patch having a body-contactable surface that: i) is skin adhesive and ii) includes an electrically conductive region, the electrically-conductive region being in electrical contact with the first terminal of the current generator; and d) a wire (for example, an insulated wire that is at least 10 cm or at least 20 cm long) connecting the root canal electrode to the control unit such that the root canal electrode is in electrical contact with the second terminal of the current generator. | 05-21-2009 |
| 20090221931 | APICAL POSITION LOCATOR - A method and system are disclosed for detecting an apical position depending on the change in the impedance between a first electrode inserted into the root canal of the tooth of a patient and a second external electrode applied to a body surface of the patient. According to some embodiments, a regulated current such as an alternating current having a substantially constant amplitude is supplied between the two electrodes, and this current serves as a measurement signal. Alternatively or additionally, the frequency of the time varying (e.g. alternating) current is at least 50 KHZ, and/or at most about 300 KHZ. In some embodiments, the presently disclosed device includes a processing unit which determines a capacitance-governed function when the first electrode is in the apical region, and which determined a function at least moderately governed by resistance when the electrode is in the dental neck region. Optionally, the first electrode inserted into the root canal is a dental file or reamer. | 09-03-2009 |
