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Leuschner
Carola Leuschner, Baton Rouge, LA US
| Patent application number | Description | Published |
|---|---|---|
| 20090061006 | Layered Nanoparticles for Sustained Release of Small Molecules - Nanoparticle compositions and methods are disclosed for the sustained release of small molecules, such as pharmaceutical compounds in vivo, for example ligand-lytic peptide conjugates. The construction of the nanoparticles helps to prevent self-aggregation of the molecules, and the consequent loss of effectiveness. The system employs layer-by-layer self-assembly of biocompatible polyelectrolyte layers, and layers of charged small molecules such as drug molecules, to form a multilayer nanoparticle in which the drug or other small molecule itself acts as one of the alternating charged layers in the multilayer assembly. The small molecules can then be released over time in a sustained manner. The LbL nano-assemblies can specifically target cancers, metastases, or other diseased tissues, while minimizing side effects. | 03-05-2009 |
| 20090169478 | In Vivo Imaging and Therapy with Magnetic Nanoparticle Conjugates - A non-invasive in vivo technique is disclosed, useful for example in detecting cancers and micrometastases. The technique may be used to selectively deliver drugs to target cells such as tumors, metastases, micrometastases, and individual malignant cells. Ligands with specificity for a target cell receptor, and optionally drug molecules as well, are covalently bound to magnetic nanoparticles, either directly or through a spacer molecule. The ligand precludes the need for a separate coating layer. For example, human breast cancer cells express receptors both for luteinizing hormone/chorionic gonadotropin (LH/CG), and for luteinizing hormone releasing hormone (LHRH). These cells can be specifically targeted by iron oxide nanoparticles covalently linked to LH/CG or LHRH. The nanoparticles are incorporated into the cancer cells through receptor-mediated endocytosis. The specific accumulation in targeted cancer cells enhances resolution for imaging, therapy, or both. The ligand may, for example, be a hormone, receptor, or antibody, or a fragment thereof. | 07-02-2009 |
| 20090269341 | LYTIC DOMAIN FUSION CONSTRUCTS AND METHODS OF MAKING AND USING SAME - The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies. | 10-29-2009 |
| 20110124564 | NUCLEOLIN-BINDING PEPTIDES, NUCLEOLIN- BINDING LYTIC PEPTIDES, FUSION CONSTRUCTS AND METHODS OF MAKING AND USING SAME - The invention relates to nucleolin binding peptides, nucleolin binding peptides and anti-nucleolin antibody conjugates with cytotoxic activity, fusion constructs, methods of using nucleolin binding peptides and antibodies and fusion constructs thereof, and methods of treating various disorders, undesirable conditions and diseases treatable with nucleolin binding peptides and fusion constructs, such as undesirable or aberrant cell proliferation (hyperproliferation) or hyperproliferative disorders, including tumors, cancers, neoplasia and malignancies, angiogenesis related or dependent diseases, and inflammatory diseases and inflammation. | 05-26-2011 |
| 20110217702 | METHODS FOR DIAGNOSIS OF AND PREDICTING TREATMENT EFFICACY OF HORMONE RECEPTOR EXPRESSING TUMORS, CANCERS AND NEOPLASIAS - The invention relates to diagnosis, detection, screening, identifying and predicting methods. In various embodiments, methods of the invention include diagnosis, detection, or screening for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject; identifying a subject that will or is likely to respond to a therapy for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia); and predicting therapeutic efficacy of a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) treatment in a subject. | 09-08-2011 |
Jeff Leuschner, Rowlett, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100228916 | Apparatus & Method for Virtualizing Data Storage Media, Such as for Use in a Data Storage Library Providing Resource Virtualization - A system and method for use in an automated data storage cartridge library defines cartridges for use with an external host computer (“open” cartridges), and cartridges for use only internal to the library (“closed” cartridges). Cartridges may be “virtualized” by storing data from them on disk or closed cartridges, and then “realized” by writing data to physical cartridges. Virtual cartridges may be logically exported from one library to another. When new cartridges are introduced to the library, they may be designated with one of multiple designations or uses. | 09-09-2010 |
Jeffery D. Leuschner, Rowlett, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090259701 | METHODS AND SYSTEMS FOR SPACE MANAGEMENT IN DATA DE-DUPLICATION - The present invention is directed toward methods and systems for data de-duplication. More particularly, in various embodiments, the present invention provides systems and methods for data de-duplication that may utilize storage reclamation. In various embodiments, data de-duplication may be performed using data storage reclamation by reconciling a list of all active tags against a list of all tags present within the object store itself. Any tags found to be in the object store that have no corresponding active usage may then be deleted. In some embodiments additional steps may be taken to avoid race conditions in deleting tags that are needed by incoming data. In some embodiments the object store may request the lists. In other embodiments, a runtime list, in which each new tag is entered as they are returned from the object store. In another embodiment the object store may maintain this list directly. | 10-15-2009 |
Mark B. Leuschner, Bloomington, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110238440 | Intelligent Particle Beam Allocation System and Related Method for Treatment in Multi-Room Medical Centers - A computer-implemented system and method for controlling work flow management to improve the operational efficiency of a multi-room particle therapy medical center are disclosed. In one embodiment, the system includes a monitoring system configured through an active connection to receive real-time information about the current actions of the people, hardware and software at the center, an analysis system configured through an active connection to synthesize the information attained through the monitoring system, and a control system configured through an active connection that uses information acquired by the monitoring system to continuously update information made available through a set of user interfaces to an end user. Features also are provided to automatically synchronize, obtain, and update status information on the shared resources in the particle therapy medical center. Various ways of handling the data aggregation issues associated with compiling status data are also described. | 09-29-2011 |
Rainer Leuschner, Samoreau FR
| Patent application number | Description | Published |
|---|---|---|
| 20090085121 | Condensed Memory Cell Structure Using a FinFET - An integrated circuit and method for manufacturing an integrated circuit are described. In one embodiment, the integrated circuit includes a memory cell that includes a resistivity changing memory element. The resistivity changing memory element is electrically coupled to a select transistor that includes a FinFET including a source, a drain, and a fin structure formed above a surface of a substrate between the source and the drain. The fin structure includes a channel area extending in a direction substantially parallel to the surface of the substrate, and a dielectric layer formed around at least a portion of the channel area such that an effective channel width of the select transistor depends at least in part on a height of the fin structure. | 04-02-2009 |