Leung, San Diego
Donmienne Doen Mun Leung, San Diego, CA US
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20090136495 | ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF - Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject. | 05-28-2009 |
20110027261 | ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF - Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject. | 02-03-2011 |
20110189190 | ANTI-HEPCIDIN-25 SELECTIVE ANTIBODIES AND USES THEREOF - Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA. | 08-04-2011 |
20130122013 | ANTI-FERROPORTIN 1 MONOCLONAL ANTIBODIES AND USES THEREOF - Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo. | 05-16-2013 |
20130164304 | ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF - Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject. | 06-27-2013 |
20130324474 | VARIANTS OF HUMAN GDNF - The present invention relates to novel variants of human glial cell-derived neurotrophic factor (GDNF) and methods for their use. | 12-05-2013 |
20140255406 | ANTI-TNF-ANTI-IL-17 BISPECIFIC ANTIBODIES - Bispecific antibodies are provided that specifically bind both Tumor Necrosis Factor alpha (TNFα) and Interleukin-17 (IL-17). The bispecific antibodies of the invention are useful for treating various autoimmune diseases, including Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), and Ankylosing Spondylitis (AS). | 09-11-2014 |
George Leung, San Diego, CA US
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20100004650 | ANGIOPLASTY AND TISSUE ABLATION APPARATUS AND METHOD - A coaxial cable apparatus which transmits radio frequency (RF) energy for the ablation of biological tissues has inner and outer coaxial conductors extending substantially the entire length of the cable from a proximal end portion to a distal end portion. An RF antenna is disposed at the distal end portion of the cable and transmits RF energy for ablation of a tissue region to be treated. An angioplasty balloon is disposed over the RF antenna and communicates with a fluid supply and extraction passageway extending through the cable to allow the balloon to be inflated for an angioplasty procedure including tissue ablation, and to be deflated after the procedure is complete. | 01-07-2010 |
20100268218 | Electrically Tunable Tissue Ablation system and Method - An ablation system which transmits radio frequency (RF) energy for the ablation of biological tissues has a transmission line and an RF antenna disposed at the distal portion of the transmission line. An RF signal generator supplies RF energy to the proximal end of the cable for transmission to the antenna, and an electrically tunable transformer is connected between the signal generator and the antenna. The transformer is tuned based on detection of the reflected power level from the antenna so as to reduce or minimize reflected power, thereby increasing RF energy coupling between the antenna and tissue. | 10-21-2010 |
20100268219 | RADIO FREQUENCY BASED ABLATION SYSTEM AND METHOD WITH DIELECTRIC TRANSFORMER - An ablation device which transmits radio frequency (RF) energy for the ablation of biological tissues has elongate inner and outer coaxial conductors extending from a proximal portion to a distal portion. An RF antenna is disposed at the distal portion of the device and transmits RF energy for ablation of a tissue region to be treated. Reflection of energy from the tissue or the ablation point is reduced by providing multiple layers of dielectric media about the antenna, or by providing a gradual transition point from the conductors to the antenna tip, by means of a longitudinally stepped dielectric layer transformer. | 10-21-2010 |
George L. Leung, San Diego, CA US
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20090082762 | RADIO FREQUENCY ENERGY TRANSMISSION DEVICE FOR THE ABLATION OF BIOLOGICAL TISSUES - A radio frequency energy transmission device comprises a hollow coaxial electrically conductive cable adapted for conduction of radio frequency (RF) energy, particularly microwave energy, for the ablation of biological tissue. The hollow cable has a proximal end and a distal end and comprises coaxial inner and outer conductors extending substantially the entire length of the cable from the proximal end to a distal end portion of the cable. The inner conductor comprises an elongated electrically conductive tubular member having a hollow, axially extending lumen, and the outer conductor comprises an elongated electrically conductive tubular member disposed in a substantially coaxial relationship over at least a portion of the inner conductor. Dielectricity to impede conduction between the inner and outer conductors is introduced with a vacuum or dielectric medium disposed between the inner and outer conductors. An ablating member, which delivers radio frequency energy, particularly microwave energy, to body tissue is disposed at a distal end portion of the cable. The ablating member can be a helical coil, a monopole of a microstrip circuit. | 03-26-2009 |
20110009858 | RADIO FREQUENCY-BASED CATHETER SYSTEM WITH IMPROVED DEFLECTION AND STEERING MECHANISMS - A RF catheter system includes a catheter with a proximal portion, a distal portion having a distal end and a lumen extending from the proximal portion to the distal portion. Inner and outer coaxially aligned conductors extend within the catheter and are coaxial with the lumen. A deflectable catheter guide is disposed within the catheter lumen and extends proximally within the catheter lumen and terminates distally of the distal end of the catheter to define a biological ablation pathway. A radio-frequency antenna is disposed at the distal portion of the catheter and is in electrical communication with the inner and outer coaxially aligned conductors. The radio-frequency antenna is adaptable to receive and transmit radio-frequency energy for ablating biological tissue along the ablation pathway. | 01-13-2011 |
20110130750 | RADIO FREQUENCY ABLATION SYSTEM WITH TRACKING SENSOR - An RF ablation system has a hollow conductive coaxial cable comprising inner and outer coaxial tubular conductors, and an ablating member mounted at the distal end portion of the cable for delivery of radio frequency energy including microwaves to the target body tissue. The inner conductor has a central lumen and extends at least up to the ablating member. At least one electromagnetic tracking sensor coil with a magnetic core is located in the central lumen at the distal end portion of the cable, close to the distal tip of the cable, and connected to a signal processing unit. An electromagnetic field generator positioned in the vicinity of a patient undergoing treatment generates an electromagnetic field which induces a voltage in the sensor coil. The signal processing unit uses the induced voltage to calculate the position and orientation of the distal end portion or tip of the catheter in a patient's body. | 06-02-2011 |
Lai Kan Leung, San Diego, CA US
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20120092053 | ADAPTIVE CLOCK SWITCHING TO CAPTURE ASYNCHRONOUS DATA WITHIN A PHASE-TO-DIGITAL CONVERTER - A Phase-to-Digital Converter (PDC) within a Phase-Locked Loop (PLL) includes a PDC portion and a PDC decoder portion. The PDC portion receives a reference signal FR and a feedback signal FV and generates therefrom a stream of multi-bit digital values. Each multi-bit value is indicative of a time difference between an edge of FR and a corresponding edge of FV. The PDC decoder portion includes sequential logic elements that are clocked to capture the multi-bit digital values. In order to prevent metastability, the timing of when the sequential logic elements are clocked to capture the multi-bit digital values is adjusted as a function of the phase difference between FR and FV. In one specific example, if the phase difference is small then the falling edge of FR is used to clock the sequential logic elements, whereas if the phase difference is large then the rising edge of FR is used. | 04-19-2012 |
20120201338 | TWO POINT MODULATION DIGITAL PHASE LOCKED LOOP - A two point modulation digital phase locked loop circuit is disclosed. The circuit includes a sampling clock input that is switchable between a plurality of frequencies. The circuit also includes a sigma-delta modulator in a feedback path that receives low-pass modulation data. The circuit also includes a voltage-mode digital-to-analog converter (VDAC) that receives high-pass modulation data. The circuit also includes an analog voltage controlled oscillator coupled to the feedback path and the output of the VDAC. The circuit also includes a phase-to-digital converter (PDC) coupled to the feedback path, the sampling clock and a loop filter. | 08-09-2012 |
Lauren K. Leung, San Diego, CA US
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20130231760 | REAL-TIME EVENT FEEDBACK - Methods, systems and devices are provided for presenting event feedback information regarding participants to an event. A first radio of a first participant device carried by a first participant receives a first checkpoint communication from a checkpoint device at a first checkpoint located along a first course of the event. The first checkpoint communication includes a first checkpoint identifier and a first event time reflecting when the first participant crossed the first checkpoint. A first checkpoint event time is determined based upon the first checkpoint identifier and the first event time. Also, the first checkpoint event time is displayed on the first participant device. Further, a checkpoint device and an event server may be used to in presenting the event feedback information. | 09-05-2013 |
Leon Y. Leung, San Diego, CA US
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20120212245 | CIRCUIT AND METHOD FOR TESTING INSULATING MATERIAL - An integrated circuit is disclosed. The integrated circuit includes an insulating material layer. The integrated circuit also includes a metal structure. Furthermore, the integrated circuit includes a via through the insulating material layer that is coupled to the metal structure for testing insulating material by applying dynamic voltage switching to two adjacent metal components of the metal structure. | 08-23-2012 |
Nikolai K. Leung, San Diego, CA US
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20100142432 | Method and Apparatus For Data Packet Transport In a Wireless Communication System Using an Internet Protocol - Method and apparatus for data packet transport in a wireless transmission system supporting broadcast transmissions. A multicast tree is built between nodes through neighboring routers. The multicast tree forms a tunnel through which the broadcast content is transmitted. The broadcast message is encapsulated in an Internet Protocol packet for transmission through the multicast tree. At least one multicast tree is formed between the Internet portion of the system and the wireless portion of the system, such as the Access Network. In one embodiment, an external multicast tree is formed between a content source and a packet data service node, and an internal multicast tree is formed between the packet data service node and a packet control function node. | 06-10-2010 |
Nikolai K.n. Leung, San Diego, CA US
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20120257563 | METHOD AND SYSTEM FOR A MULTICAST SERVICE INITIATION IN A COMMUNICATION SYSTEM - Method and a system for multicast service notification in cellular telephone system to enable the cellular telephone systems to provide both multicast and point-to-point services are disclosed. Several embodiments describe the signaling interaction between an access network and subscriber stations belonging to a multicast group to allow the access network to properly notify the subscriber stations of a the multicast service. Such a signaling further allows the subscriber stations to recognize the multicast service notification to participate in the multicast service. | 10-11-2012 |
Nikolai Konrad Nepomucceno Leung, San Diego, CA US
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20110075563 | METHODS AND APPARATUS FOR ENABLING RATE ADAPTATION ACROSS NETWORK CONFIGURATIONS - Systems and methods for implementing explicit congestion notification (ECN) across disparate networks, configurations, and protocols are disclosed. Local rate adaptation using ECN may be provided without relying on other operators to upgrade or ensure their networks are ECN transparent or ECN capable. | 03-31-2011 |
Wingching Vincent Leung, San Diego, CA US
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20110300914 | REDUCING POWER CONSUMPTION BY IN-CIRCUIT MEASUREMENT OF RECEIVE BAND ATTENUATION AND/OR NOISE - Although the duplexer in a full-duplex transceiver circuit may only be guaranteed by the duplexer manufacturer to have a transmit band rejection from its TX port to its RX port of a certain amount, and may only be guaranteed to have a receive band rejection of another amount, the actual transmit band rejection and the actual receive band rejection of a particular instance of the duplexer may be better than specified. Rather than consuming excess power in the receiver and/or transmitter in order to meet performance requirements assuming the duplexer only performs as well as specified, the duplexer's in-circuit performance is measured as part of a transmitter-to-receiver isolation determination. Transmitter and/or receiver power settings are reduced where possible to take advantage of the measured better-than-specified in-circuit duplexer performance, while still meeting transceiver performance requirements. Power settings are not changed during normal transmit and receive mode operation. | 12-08-2011 |
20130135016 | DIVIDING A FREQUENCY BY 1.5 TO PRODUCE A QUADRATURE SIGNAL - An apparatus for dividing a frequency by 1.5 to produce a quadrature signal is disclosed. The apparatus includes a divider that receives a differential input signal with a first frequency and two phases and creates a six-phase signal at a second frequency. The second frequency is the first frequency divided by 3. The apparatus also includes precision phase rotation circuitry that receives the six-phase signal and produces an eight-phase signal. The apparatus also includes a doubler that receives the eight-phase signal and produces a quadrature signal. The quadrature signal has a third frequency that is the first frequency divided by 1.5. | 05-30-2013 |