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Leslie, GB
Andrew G.w. Leslie, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20110112037 | CRYSTAL STRUCTURE - The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the turkey β1-AR structure listed in Table A, Table B, Table C or Table D, optionally varied by a root mean square deviation of residue backbone atoms of not more than 1.235 A, or selected coordinates thereof; and predicting the three-dimensional structural representation of the target protein, or part thereof, by modelling the structural representation on all or the selected coordinates of the turkey β1-AR. The invention also provides the use of the turkey β1-AR coordinates to select or design one or more binding partners of β1-AR. | 05-12-2011 |
Ben Leslie, Sydenham GB
| Patent application number | Description | Published |
|---|---|---|
| 20100306657 | Audio-Enhanced User Interface for Browsing - Embodiments of the present invention pertain to, but are not limited to, browsing a displayed listing of stored audio content such as music in a music player, PC, or portable electronic device, including MP3 players and mobile phones. Various embodiments of the present invention recognize that to improve the user's browsing experience, the user's selections from the listing should be accompanied by audio effects specifically configured to facilitate the corresponding content navigation. For example, the effects could be that as the currently selected item in the listing changes, an excerpt of the music track (or of a member of the group of music tracks) in the new item (i.e., “new currently-selected” item) in the listing is played with 3D audio effects such that the position from which the music track appears to be playing is in symphony with the new item's movement on the user interface. | 12-02-2010 |
Dario Lyall Leslie, Wiltshire GB
| Patent application number | Description | Published |
|---|---|---|
| 20100006453 | Detection System - A method for detecting a target nucleic acid sequence in a sample, by subjecting it to an amplification | 01-14-2010 |
Dario Lyall Leslie, Salisbury GB
| Patent application number | Description | Published |
|---|---|---|
| 20090325278 | Reaction System for Performing in the Amplification of Nucleic Acids - A method of carrying out an amplification reaction, said method comprising supplying to a well in a disposable unit (a) a sample which contains or is suspected of containing a target nucleic acid sequence (b) primers, nucleotides and enzymes required to effect said amplification reaction and (c) a buffer system, and subjecting the unit to thermal cycling conditions such that any target nucleic acid present within the sample is amplified; wherein the disposable unit comprises a thermally conducting layer and a facing layer having one or more reagent wells of up to 1000 microns in depth defined therebetween; and the reaction mixture comprises at least one of the following: A) a buffer system wherein the pH is above 8.3; B) a detergent; and/or C) a blocking agent. Apparatus for effecting the method as well as disposable units for use in the method are described. The method is particularly suitable for rapid PCR reactions. | 12-31-2009 |
Grant Leslie, East Lothian GB
| Patent application number | Description | Published |
|---|---|---|
| 20080269383 | Flame-Retardants - Organic polymer compositions can be made flame-retardant by addition of selected organic phosphate and other components, such as known flame-retardants or conventional additives for further improvements, e.g. in name retardancy or light stability. | 10-30-2008 |
Harold David Leslie, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20090259406 | CONTINUOUS MICROSEISMIC MAPPING FOR REAL-TIME 3D EVENT DETECTION AND LOCATION - A method for the detection and localization of microseismic events is proposed which operates in real-time. It provides hypocenters in three spatial dimensions along with an estimate of the event origin time. Sensor positions may be distributed in 3D space, and are not confined to linear arrays in vertical wells. The method combines and improves two existing approaches. For detection and localization purposes the method makes use of the generalized beam-forming and forward modeling properties defined in the “CMM” algorithm. For location refinement, the method uses a stabilized version of the generalized “Geiger” approach. | 10-15-2009 |
Harold David Leslie, Girton GB
| Patent application number | Description | Published |
|---|---|---|
| 20100262373 | METHODS AND SYSTEMS FOR MICROSEISMIC MAPPING - Methods and systems for the detection and localization of microseismic events are proposed which operate in real-time. Hypocenters in three spatial dimensions are provided along with an estimate of the event origin time. Sensor positions may be distributed in 3D space, and are not confined to linear arrays in vertical wells. A location of the event is approximated and a grid search, based on the approximate location of the event, is used to derive a residual function over a finer sampling followed by a gradient search of the residual function to optimize the location of the event. | 10-14-2010 |
Kevin William Leslie, Macclesfield GB
| Patent application number | Description | Published |
|---|---|---|
| 20080221322 | CHEMICAL PROCESS - The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline. | 09-11-2008 |
Luke Leslie, London GB
| Patent application number | Description | Published |
|---|---|---|
| 20100049673 | Forest Factory Valuation Model - Apparatuses, computer media, and methods for determining a value of a forest factory. A stump land value component and a biomass component of a forest factory are determined. A value of the forest factory is obtained by combining the components. The stump land value component may be normalized by a crop rotation time period. A carbon value component of a forest factory may be determined and the value of the forest factory adjusted. A land parcel may be partitioned into land partitions, in which forest parameters are associated with each land partition. A stump land value component, a biomass fuel value component, and a carbon credit value component may be determined from the land partitions. The carbon credit value component may be determined a percentage of coniferous trees, deciduous trees, and corresponding constant values of oxygen generation. | 02-25-2010 |
Stewart Thomas Leslie, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20090117191 | Controlled release tramadol formulations - A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient. | 05-07-2009 |
Thomas Leslie, Clay Coton GB
| Patent application number | Description | Published |
|---|---|---|
| 20090066370 | Track and Hold Circuit - Methods and apparatus are disclosed to track and hold a voltage. An example track and hold circuit comprises a first electronic switch, a second electronic switch, and a current mode logic amplifier. | 03-12-2009 |
Tom Leslie, Clay Coton GB
| Patent application number | Description | Published |
|---|---|---|
| 20080215947 | Debug Circuit and a Method of Debugging - A debug circuit for a multi-mode circuit driven by a clock signal, with an input for a clock signal, and a debug signal generator arranged to generate for each of a subset of the modes of the multi-mode circuit a corresponding debug signal based on a clock signal provided at the input. The frequency of debug signals is dependent on the frequency of a clock signal provided at the input, and each debug signal selects its respective mode for a length of time longer than that of each other mode of the multi-mode circuit, or each debug signal selects its respective mode for a length of time shorter than that of each other mode of the multi-mode circuit. | 09-04-2008 |