Leppert, US
Brian James Leppert, Kenmore, WA US
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20140303238 | OLIGONUCLEOTIDES FOR TREATING EXPANDED REPEAT DISEASES - The invention provides for a method for selectively reducing the expression of a mutant mRNA and/or protein having an expanded nucleotide repeat relative to a wild-type mRNA, comprising contacting a cell with an antisense oligonucleotide of sufficient length and complementarity to the expanded nucleotide repeat. More particularly it relates to selectively reducing the expression of mutant Huntington protein associated with Huntington's disease. The antisense oligonucleotide comprising either a nucleotide or a repeated three nucleotide sequence as defined in the claims. | 10-09-2014 |
20140329772 | INDUCED EXON INCLUSION IN SPINAL MUSCLE ATROPHY - The invention relates to the use of an antisense compound for inducing exon inclusion as a treatment for Spinal Muscle Atrophy (SMA). More particularly it relates to inducing inclusion of exon 7 to restore levels of Survival Motor Neuron (SMN) protein encoded by the Survival Motor Neuron (SMN) gene. | 11-06-2014 |
Christian P. Leppert, Dallas, TX US
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20140019406 | SYSTEM AND METHOD FOR UNIVERSAL STORAGE AND PRESENTATION OF DATA - A method includes receiving, on an electronic device, one or more logical entities from a storage system having a universe of data. The one or more logical entities encapsulate data from the universe of data on the storage system. Each of the one or more logical entities belong to one of a plurality of logical-entity types defined by a universal representation format. The method additionally includes, for each of the one or more logical entities, rendering a representation of the logical entity on a spatial interface, the spatial interface comprising a plurality of spatial components. | 01-16-2014 |
20140358851 | SYSTEM AND METHOD FOR UNIVERSAL STORAGE AND PRESENTATION OF DATA - A method includes receiving, on an electronic device, one or more logical entities from a storage system having a universe of data. The one or more logical entities encapsulate data from the universe of data on the storage system. Each of the one or more logical entities belong to one of a plurality of logical-entity types defined by a universal representation format. The method additionally includes, for each of the one or more logical entities, rendering a representation of the logical entity on a spatial interface, the spatial interface comprising a plurality of spatial components. | 12-04-2014 |
Greg Leppert, Austin, TX US
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20100251145 | System to provide search results via a user-configurable table - In a particular embodiment, a graphical user interface (GUI) generated by a processor of a search system includes a search results window operable to display a set of search results within a table that includes a plurality of sub-tables corresponding to a plurality of categories. Each sub-table represents at least one category and includes a respective subset of the set of search results. The GUI further includes a plurality of local control elements, where each local control element is associated with a respective sub-table of the plurality of sub-tables. Each local control element is accessible to a user to selectively sort the respective subset of the set of search results within the respective sub-table according to a user-selected local sort parameter without altering a sort order of respective subsets of the set of search results within other sub-tables of the plurality of sub-tables. | 09-30-2010 |
Johnathan Leppert, Mountain View, CA US
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20140325399 | FRONT-END TOOL FOR DISPLAYING DIAGNOSTIC INFORMATION TO FACILITATE WEB PAGE DEVELOPMENT - The disclosed embodiments relate to a system that displays diagnostic information to facilitate web page development. While a web page is being assembled at a front-end system using data gathered from one or more back-end systems, the system accumulates metadata associated with the assembly process. Next, the system renders the web page using the gathered data. Finally, the system sends the rendered web page along with the metadata to a browser to be displayed to a user, wherein the browser is configured to selectively display the metadata when the web page is displayed. | 10-30-2014 |
Joshua J. Leppert, Coeur D Alene, ID US
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20130035557 | METHOD AND APPARATUS FOR LEVELING PRESSURE TRANSDUCERS - A hinged level and method for utilizing the same in connection with the leveling of a pressure transducer with respect to a reference point are provided. The hinged level includes a plurality of elongate members interconnected to one another by a hinge. The hinge allows the elongate members to be pivoted relative to one another within a first plane. A level device is aligned with the first plane. The level or elevation of a pressure transducer relative to a reference point, which corresponds to the elevation of an implanted catheter, is determined by placing the free ends of the hinged level relative to the reference point and the pressure transducer. The height of the pressure transducer is then adjusted until the level device indicates that the elongate members are level. | 02-07-2013 |
Kerry W. Leppert, Dubuque, IA US
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20120193492 | CLAMP - The subject invention is a clamp that has two halves of an annular ring hingedly connected at one end and capable of being securely fastened to each other at the opposite end. The annular ring is sized to fit tightly around a vertical support post. An upper surface of the annular ring has an upper annular channel, while the lower surface of the annular ring has a lower annular channel. When the clamp is fixed to the vertical support post, a horizontal support adaptor may fit into both the upper and lower annular channels. A resilient engagement strip or button on the adaptor is placed into contact with the lower annular channel in this position and frictionally engages the lower annular channel to prevent lateral movement of the adaptor on the annular ring until such time as the adaptor may be securely attached to the annular ring. | 08-02-2012 |
Kevin Leppert, Lanexa, VA US
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20080295898 | Apparatus and Methods for Containing a Fuel Pressure Regulator - An apparatus includes a first portion and a second portion. The first portion includes a mounting surface configured to support a mounting portion of a pressure regulator. The first portion defines a cavity configured to receive at least a portion of the pressure regulator, and an opening configured to provide fluid communication between the cavity and an area outside of the first portion. The second portion includes a mounting surface configured to support the mounting portion of the pressure regulator. The second portion defines a cavity and an opening configured to provide fluid communication between the cavity of the second portion and an area outside of the second portion. The second portion is configured to be coupled to the first portion to form a fluid-tight seal. | 12-04-2008 |
Kevin L. Leppert, Lanexa, VA US
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20090184044 | IN-TANK FUEL DELIVERY MODULE HAVING AN ACCESSIBLE FUEL FILTER - A fuel delivery module includes a fuel filter housing and a cover. The fuel filter housing defines a cavity configured to receive at least a portion of a fuel filter. A first end portion of the fuel filter housing includes a flange configured to be disposed outside of and coupled to a fuel tank. A second end portion of the fuel filter housing is configured to be disposed within the fuel tank and includes an inlet connector configured to fluidically couple the cavity to a fuel pump. The cover is configured to be removably coupled to the first end portion of the fuel filter housing. The cover defines a first lumen and a second lumen. The first lumen is configured to fluidically couple the cavity to a fuel outlet line. The second lumen is configured to fluidically couple the cavity to a regulator. | 07-23-2009 |
20110200472 | INTEGRATED FUEL DELIVERY MODULE AND METHODS OF MANUFACTURE - An apparatus includes a housing defining a first cavity containing a pump, a second cavity containing a filter and a lumen configured to provide fluid communication between the first cavity and the second cavity. The housing has a first end portion configured to be disposed within a fluid reservoir and a second end portion including a flange configured to be disposed outside of and coupled to the fluid reservoir. A surface of the first end portion defines a first opening in fluid communication with the first cavity. A surface of the second end portion defines a second opening in fluid communication with the second cavity. A cover is configured to be removably coupled to the second end portion of the housing about the second opening such that the filter can be removed from the second cavity when the flange is coupled to the fluid reservoir. | 08-18-2011 |
20120080367 | IN-TANK FUEL DELIVERY MODULE HAVING AN ACCESSIBLE FUEL FILTER - A fuel delivery module includes a fuel filter housing and a cover. The fuel filter housing defines a cavity configured to receive at least a portion of a fuel filter. A first end portion of the fuel filter housing includes a flange configured to be disposed outside of and coupled to a fuel tank. A second end portion of the fuel filter housing is configured to be disposed within the fuel tank and includes an inlet connector configured to fluidically couple the cavity to a fuel pump. The cover is configured to be removably coupled to the first end portion of the fuel filter housing. The cover defines a first lumen and a second lumen. The first lumen is configured to fluidically couple the cavity to a fuel outlet line. The second lumen is configured to fluidically couple the cavity to a regulator. | 04-05-2012 |
20130061939 | IN-TANK FLUID TRANSFER ASSEMBLY - A fluid transfer assembly includes a housing within which at least a portion of a pump element can be disposed. The housing includes a first surface and a second surface and defines a cavity therethrough. The housing is configured to be coupled to a reservoir such that the first surface is disposed within an interior volume of the reservoir and the second surface is disposed outside the interior volume of the reservoir. The housing includes a seal portion configured to fluidically isolate the first surface from the second surface. The cavity is configured to receive at least a portion of the pump element such that movement of the pump element produces a fluid flow from an inlet opening defined by the first surface and an outlet opening defined by the second surface. | 03-14-2013 |
Mark Leppert, Salt Lake City, UT US
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20080227093 | PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR - The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor. | 09-18-2008 |
20090029930 | Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter - The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention. | 01-29-2009 |
20100151476 | PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR - The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor. | 06-17-2010 |
20120040456 | METHODS OF GENE THERAPY USING NUCLEIC ACID SEQUENCES FOR ATP-BINDING CASSETTE TRANSPORTER - The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention. | 02-16-2012 |
20130143752 | GENE BIOMARKERS OF LUNG FUNCTION - Described herein are a group of 1,013 genes and 1 phenotypic variable are identified as candidate predictors that differentiated smokers (current or former) with or without COPD. The full predictor set can be reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE, and RPL14) with similar performance. Also described herein is the use of the full predictor set and the reduced nine gene set in methods of diagnosing lung disease or an increased risk of developing lung disease, such as COPD, in a subject. Also described herein is the use of the full predictor set and the reduced nine gene set in methods of providing a prognosis for a subject with lung disease, such as COPD. | 06-06-2013 |
20130149389 | BIOMARKERS OF LUNG FUNCTION - Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions. | 06-13-2013 |
20130150250 | RISK FACTORS OF CIGARETTE SMOKE-INDUCED SPIROMETRIC PHENOTYPES - The technology provided herein relates to the SNPs identified as described herein, both singly and in combination, as well as to the use of these SNPs, and others in linkage disequilibrium with these SNPs, for diagnosis, prediction of clinical course, and/or treatment response for pulmonary disease such as COPD, development of new treatments for pulmonary disease such as COPD based upon comparison of the variant and normal versions of the gene or gene product, and development of cell-culture based and animal models for research and treatment of pulmonary disease such as COPD. The technology provided herein further relates to novel compounds, pharmaceutical compositions, and kits for use in the diagnosis, treatment, and evaluation of such disorders. | 06-13-2013 |
Mark F. Leppert, Salt Lake City, UT US
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20100167421 | METHODS FOR IDENTIFICATION AND PREDICTION OF MULTIPLE SCLEROSIS DISEASE AND THERAPY RESPONSE - Methods and compositions for diagnosing multiple sclerosis (“MS”) in an individual or the predisposition or risk of MS, and for the prediction of the response to treatment of MS in an individual. More particularly, methods and compounds for the use of clinical, neuroradiological, genetic, biological and/or immunological markers as prognostic indicators, diagnostic markers, or predictors of response to MS therapy. | 07-01-2010 |
20100210471 | AUTISM ASSOCIATED GENETIC MARKERS - The present disclosure relates to the identification of a subject that is affected with, or predisposed to, autism or to one or more autism spectrum disorders (ASD). The present disclosure includes methods related to the association of certain genetic markers with autism and/or ASD. More particularly, the present disclosure is related to methods and diagnostic tests for diagnosing or predicting ASD in an individual. | 08-19-2010 |
20110104665 | MUTANT SODIUM CHANNEL NAV 1.7 AND METHODS RELATED THERETO - Described are mutant Na | 05-05-2011 |
20120283116 | Mutant Sodium Channel Nav1.7 and Methods Related Thereto - Described are mutant Na | 11-08-2012 |
20140165219 | MUTANT SODIUM CHANNEL Nav1.7 AND METHODS RELATED THERETO - Described are mutant Na | 06-12-2014 |
Phyllis Carolyn Leppert, Durham, NC US
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20140271612 | Treatment Method and Product for Uterine Fibroids using Purified Collagenase - The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid. | 09-18-2014 |
20140287032 | Treatment Method and Product for Uterine Fibroids using Purified Collagenase - The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid. | 09-25-2014 |