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Leong, US
Benny Leong, Lafayette, IN US
| Patent application number | Description | Published |
|---|---|---|
| 20110016452 | METHOD AND SYSTEM FOR IDENTIFYING REGRESSION TEST CASES FOR A SOFTWARE - The present invention provides a method, system and computer program product for identifying regression test cases for a software application by identifying one or more units of functionalities of the software application, structuring the use case activity diagrams using the identified units of functionalities, modifying the structured use case activity diagrams when there is a change in the software application, and analyzing the modifications made to the structured use case activity diagrams to identify regression test cases for the changes in the software application. | 01-20-2011 |
Chee-Onn Leong, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100035257 | METHODS TO DETERMINE THE RESPONSIVENESS TO CISPLATIN TREATMENT - The present invention relates, generally, to methods to identity subjects responsive to p73/p63 targeting agents such as platinum-based chemotherapy agents such as, but not limited to, cisplatin and cisplatin derivatives and analogues thereof. More particularly, the present invention relates to methods to identify a cancer responsive to a p73/p63 targeting treatment, such as chemotherapeutic agents such as cisplatin, by determining if the cancer expresses and/or has the activity of p63 isoforms such as DNp63 isoforms, and expresses and/or has the activity of p73 isoforms such as TAp73 or DNp73 isoforms. The present invention also relates to methods to identify a cancer unresponsive to a p73/p63 targeting treatment, such as chemotherapeutic agents such as cisplatin by determining if the cancer lacks the expression and/or activity of p63 isoforms such as DNp63 isoforms. The invention further provides kits to determine the expression and/or activity of p63 isoforms such as DNp63 isoforms, and/or the expression and/or activity of p73 isoforms such as TAp73 and/or DNp73 isoforms in a biological sample. | 02-11-2010 |
John M. Leong, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080241104 | ESPFU NUCLEIC ACIDS AND PROTEINS AND USES THEREOF - Disclosed are EspF | 10-02-2008 |
| 20110059086 | ESPFU NUCLEIC ACIDS AND PROTEINS AND USES THEREOF - Disclosed are EspF | 03-10-2011 |
Kam Leong, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100184822 | Method of modulating the activity of a nucleic acid molecule - The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid molecules in a sequence independent manner and modulate (e.g., inhibit or reverse) their activity. The invention also relates to compositions comprising such agents and to methods of using same. | 07-22-2010 |
Kam W. Leong US
| Patent application number | Description | Published |
|---|---|---|
| 20110306657 | POLYALKYLENEIMINE-GRAFT-BIODEGRADABLE POLYMERS FOR DELIVERY OF BIOACTIVE AGENTS - The invention provides poly(alkyleneimine)-graft-biodegradable polymers and methods for preparing such polymers. The poly(alkyleneimine)-graft-chitosan polymers may optionally contain a targeting element. The poly(alkyleneimine)-graft polymers may be used to deliver a bioactive agent into a cell. | 12-15-2011 |
Kam W. Leong, Ellicott City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080199531 | Methods And Products For Delivering Biological Molecules To Cells Using Multicomponent Nanostructures - This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be selectively bonded to discrete regions of different composition in sufficiently close physical relationship to enhance delivery or effectiveness within the cell. The preferred nanostructures are multicomponent nanorods. Important applications include delivery of missing DNA sequences for gene therapy and delivery of antigens or DNA encoding antigens for vaccination. | 08-21-2008 |
| 20100303881 | Therapeutic Electrospun Fiber Compositions - The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits. | 12-02-2010 |
Kam W. Leong, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100055154 | COAXIAL ELECTROSPUN FIBERS AND STRUCTURES AND METHODS OF FORMING THE SAME - Nanofibers and microfibers having a core and a polymer shell surrounding the core are provided. The shell includes a plurality of channels that extend from an outer shell surface to the core, and one or more agents, such as pharmacological materials, proteins, viruses, plasmid DNA, bacterial cells, drug-loaded nanoparticles, are encapsulated within the core. The one or more agents discharge from the core through the channels at a controlled rate. The channels are formed by porogen material within the polymer shell. | 03-04-2010 |
| 20100211151 | DEVICE AND METHOD FOR HEALING WOUNDS - Embodiments of the invention include a method and device for promoting healing of an injury in a living being. The embodiments comprise an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both. | 08-19-2010 |
| 20110142806 | Electroactive Scaffold - A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound. | 06-16-2011 |
Kam W. Leong, Ellicot City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090286278 | MULTI-LAYER CELL ENCAPSULATION FOR TISSUE ENGINEERING - A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection. | 11-19-2009 |
Kam Weng Leong, Ellicott City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090004741 | BIODEGRADABLE POLYPHOSPHORAMIDATES FOR CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES - The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity. | 01-01-2009 |
| 20090012027 | BIODEGRADABLE POLYPHOSPHORAMIDATES FOR CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES - The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity. | 01-08-2009 |
Ken Ming Leong, Rochester Hills, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20090200104 | DEVICE AND METHOD FOR ATTENUATING ENERGY ALONG A CONDUIT - A device for attenuating energy along a conduit, comprising a first member having an essentially semi-cylindrical outer surface and a first cavity extending substantially longitudinally from end to end. A second member having an essentially semi-cylindrical outer surface is provided, with the outer radii of the first and second members being the same. The second member also has a longitudinally extending cavity. When the two members are secured to one another to form the device, the two cavities face one another to form a bore that extends from end to end and has respective opposed tapered portions having a circular cross-sectional configuration that decreases in diameter inwardly. The bore also has a central, cylindrical portion disposed between the tapered portions and having an axial length that is no greater than one third of the overall axial length of the device. | 08-13-2009 |
Louis Leong, Junction City, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20090176975 | METHODS AND COMPOSITIONS FOR DETECTING PROMOTER ACTIVITY AND EXPRESSING FUSION PROTEINS - The present invention provides nucleic acid molecules comprising one or more nucleic acid sequences encoding a polypeptide having a detectable activity. The present invention also provides methods of joining such nucleic acid molecules to nucleic acid molecules to be assayed for promoter activity. The present invention also relates to methods of preparing fusion proteins comprising a polypeptide of interest and a polypeptide having a detectable activity. | 07-09-2009 |
| 20100009342 | CONTROL OF CHEMICAL MODIFICATION - Provided is a method for controlling the degree of labeling (DOL) of a carrier molecule or solid support by the addition of a reactive label competitor to the labeling reaction. When the reactive label competitor is added to the labeling solution the competitor competes with the carrier molecule or solid support for the label, reducing the number of labels available to conjugates to the carrier molecule or solid support. This provides for a facile method that predictably alters the DOL of a carrier molecule or solid support. | 01-14-2010 |
| 20110046201 | METHODS AND COMPOSITIONS FOR SEAMLESS CLONING OF NUCLEIC ACID MOLECULES - The present invention is in the fields of biotechnology and molecular biology. More particularly, the present invention relates to cloning or subcloning one or more nucleic acid molecules comprising one or more type IIs restriction enzyme recognition sites. The present invention also embodies cloning such nucleic acid molecules using recombinational cloning methods such as those employing recombination sites and recombination proteins. The present invention also relates to nucleic acid molecules (including RNA and iRNA), as well as proteins, expressed from host cells produced using the methods of the present invention. | 02-24-2011 |
| 20110269120 | METHODS AND COMPOSITIONS FOR DETECTING PROMOTER ACTIVITY AND EXPRESSING FUSIONPROTEINS - The present invention provides nucleic acid molecules comprising one or more nucleic acid sequences encoding a polypeptide having a detectable activity. The present invention also provides methods of joining such nucleic acid molecules to nucleic acid molecules to be assayed for promoter activity. The present invention also relates to methods of preparing fusion proteins comprising a polypeptide of interest and a polypeptide having a detectable activity. | 11-03-2011 |
Madeline Leong, Chevy Chase, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110033519 | Device with Aromatase Inhibitor for the Treatment and Prevention of Uterine Fibroids and Method of Use - The invention provides a device and a compound for the prevention and/or treatment of uterine fibroids in human patients, wherein the compound is dispensed from the device and is administered locally to the uterine tissue. | 02-10-2011 |
Sang Leong, New Jersey, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20110004554 | INTERNATIONAL BANKING SYSTEM AND METHOD - A system and method for providing banks with access to a previously inaccessible existing international infrastructure. A provider bank first establishes on its system, a set of accounts for each of the customers of a client bank (the client bank environment). The client bank environment has its own Demand Deposit Account (DDA) module to process account entries and calculate interest and its own funds transfer module to initiate and to receive funds transfers. The primary interface into the funds transfer section in the client bank environment is to the funds transfer section of the provider bank environment. The funds transfer section of the provider bank is coupled to the systems which constitute the international banking infrastructure that is able to process banking transactions on a global basis for the customers of the client bank. A customer requests a particular international transaction to be performed by its client bank. The client bank then communicates the requested transaction to the funds transfer section in the client bank environment within the system of the provider bank. Once the client bank funds transfer section has received the requested transaction, it references the customer's accounts in the client bank environment (e.g., to debit the customer's account) and then transmit a transaction message (e.g., a payment message) to the funds transfer section of the provider bank environment. The funds transfer section of the provider bank processes the transaction as a typical correspondent bank payment across the Nostro account(s) of the client bank environment (e.g., a high value wire transfer) through one of the clearing systems. Incoming funds (i.e., credits) intended for accounts of customers of the client bank follow this flow in reverse. | 01-06-2011 |
Susan J. Leong, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080290814 | Power Controls for Tube Mounted Leds With Ballast - A power saving device for a light emitting diode (LED) lamp mounted to an existing fixture for a fluorescent lamp having a ballast assembly and LEDs positioned within a tube and electrical power delivered from the ballast assembly to the LEDs. The LED lamp includes means for controlling the delivery of the electrical power from the ballast assembly to the LEDs wherein the use of electrical power can be reduced or eliminated automatically during periods of non-use. Such means for controlling can include an on-off switch mounted in the tube or can also include a current driver dimmer mounted in the tube that regulates the amount of power delivered to the LEDs. A computer or logic arrays control the dimmer or power switch. A sensor such as an occupancy motion detection sensor mounted external to the tube or within the tube can send signals to the computer or logic array to trigger a switch or control a dimmer. Two or more such LED lamps with one or more computers or logic arrays in network communication with sensors can be controlled, so as to reduce flickering between lamps when illumination areas are being alternately occupied. Preset or manually set timers can control switches or be used in combination with the computer, logic array, and dimmer. | 11-27-2008 |
Timothy Gar-Ming Leong, Alexandria, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20090311190 | SELF-ASSEMBLED, MICROPATTERNED, AND RADIO FREQUENCY (RF) SHIELDED BIOCONTAINERS AND THEIR USES FOR REMOTE SPATIALLY CONTROLLED CHEMICAL DELIVERY - The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations. | 12-17-2009 |
Timothy Gar-Ming Leong, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100326071 | RECONFIGURABLE LITHOGRAPHIC STRUCTURES - A lithographically structured device has an actuation layer and a control layer operatively connected to the actuation layer. The actuation layer includes a stress layer and a neutral layer that is constructed of materials and with a structure such that it stores torsional energy upon being constructed. The control layer is constructed to maintain the actuation layer substantially in a first configuration in a local environmental condition and is responsive to a change in the local environmental condition such that it permits a release of stored torsional energy to cause a change in a structural configuration of the lithographically structured device to a second configuration, the control layer thereby providing a trigger mechanism. The lithographically structured device has a maximum dimension that is less than about 10 mm when it is in the second configuration. | 12-30-2010 |
Waihong Leong, Roswell, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20080263749 | BANDLESS HEARING PROTECTION MUFFS - The present disclosure generally relates to devices for covering an ear, and more particularly to such devices that are self-attaching and used for sound optimization, such as noise reduction. More specifically, the present disclosure is directed to hearing protection muffs that comprise a sound attenuating cap, a self-attachment member for engaging the sound attenuating cap to the ear of a user, and optionally a sealing member. Advantageously, the muffs of the present disclosure have good sound attenuating properties and do not require a band or other external attachment device to secure the muffs to the ear. | 10-30-2008 |
| 20080264429 | Clip-style hearing protector - A hearing protection device for a human ear. The device has an arm that clips about the pinna. A plug member caps or enters ear canal. The device is biased to provide some force against the plug member so that is stays in position during use. An optional handle may be provided to assist with temporarily pulling the plug member away from the ear canal or providing adjustment. The device may be adapted for use as an ear phone. | 10-30-2008 |
| 20080264715 | Bandless hearing protector and method - A hearing protection device and method for a human ear. A plug member caps or enters ear canal, and may be shaped to conform to the external auditory meatus. The device is biased at least in part by a pressure pad to provide some force against the plug member. An optional handle may be provided to assist with temporarily pulling the plug member away from the ear canal or providing adjustment. An optional bow member clips about the pinna. The device may be adapted for use as an ear phone. | 10-30-2008 |
| 20080314393 | Self-conforming sound attenuation earplug - A self-conforming sound attenuation earplug, including: a stem, at least one support joined with the stem and extending radially outward from the stem, and a shell engaging the support and encircling the stem to form a space between the shell and the stem. At least one of the support material and the shell material is a deformable-resilient material. | 12-25-2008 |
| 20090095566 | Bandless hearing protector and method - A hearing protection device and method of use intended for a human ear. A plug member caps or enters ear canal, and may be shaped to conform to the external auditory meatus. The plug member may be part of a replacement assembly. The device is biased at least in part by a pressure pad to provide some force against the plug member. An optional handle may be provided to assist with temporarily pulling the plug member away from the ear canal or providing adjustment. An optional bow member clips about the pinna. The device may be adapted for use as an ear phone. | 04-16-2009 |
| 20100043806 | Self-conforming sound attenuation earplug - A self-conforming sound attenuation earplug for location in an ear canal. The earplug includes a stem. At least one support is joined with the stem and located between the stem ear end and the stem user end, and extends radially outward from the stem. A shell is made of a deformable-resilient shell material and has a tapered exterior that increases in circumference when moving from the stem ear end to the stem user end. The shell engages at least a portion of the support and engages at least a portion of the stem located between the stem ear end and the stem user end. At least a portion of the support is free from contact with the shell and the support material is a different type of material than the shell material. | 02-25-2010 |
Weng Keong Peter Anthony Leong, Redmond, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110264993 | Multi-Threaded Sort of Data Items in Spreadsheet Tables - To perform a sort operation on a spreadsheet table, data items in the spreadsheet table are divided into a plurality of blocks. Multiple threads are then used to sort the data items in the blocks. After the data items in the blocks are sorted, multiple threads are used to merge the blocks into a final block. The final block contains each of the data items in the spreadsheet table. A sorted version of the spreadsheet table is then displayed. Data items in the sorted version of the spreadsheet table have the same order as an order of data items in the final block. | 10-27-2011 |
William Leong, Westfield, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20090093496 | PREPARATION OF PHARMACEUTICAL SALTS OF PIPERAZINE COMPOUNDS - The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer. | 04-09-2009 |
| 20100036125 | SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS - The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl- | 02-11-2010 |
William W. Leong, Westfield, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100063280 | PROCESS FOR PREPARING CCR-5 RECEPTOR ANTAGONISTS UTILIZING 4-SUBSTITUTED 1-CYCLOPROPANE-SULFONYL-PIPERIDINYL COMPOUNDS - The present invention discloses a novel process to prepare 4-substituted 1-Cyclopropane-sulfonyl-Piperidinyl compounds, which are useful intermediates for the preparation of antagonists of CCR5 receptor and therefore useful for the treatment of HIV virus infected mammals. It specifically discloses a novel process to synthesize 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine] compounds. | 03-11-2010 |
William Wei-Hwa Leong, Westfield, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20110137028 | METHODS OF SYNTHESIS AND PURIFICATION OF HETEROARYL COMPOUNDS - Provided herein are methods to prepare Heteroaryl Compounds having the following structure: | 06-09-2011 |