Patent application number | Description | Published |
20090262664 | Method for identifying network similarity by matching neighborhood topology - A method of computing a measure of similarity between nodes of first and second networks is described. In particular, sets of pairwise scores are computed to find nodes in the individual networks that are good matches to one another. Thus, a pairwise score, referred to as R | 10-22-2009 |
20110047169 | Intelligent search tool for answering clinical queries - A scalable infrastructure for searching multiple disparate textual databases by mapping their contents onto a structured ontology, e.g., of medical concepts. This framework can be leveraged against any database where free-text attributes are used to describe the constituent records. | 02-24-2011 |
20110302127 | Method for identifying network similarity by matching neighborhood topology - A method of computing a measure of similarity between nodes of first and second networks is described. In particular, sets of pairwise scores are computed to find nodes in the individual networks that are good matches to one another. Thus, a pairwise score, referred to as R | 12-08-2011 |
20120301433 | BACTERIOPHAGES EXPRESSING AMYLOID PEPTIDES AND USES THEREOF - The present invention generally relates to engineered bacteriophages which express amyloid peptides for the modulation (e.g. increase or decrease) of protein aggregates and amyloid formation. In some embodiments, the engineered bacteriophages express anti-amyloid peptides for inhibiting protein aggregation and amyloid formation, which can be useful in the treatment and prevention of and bacterial infections and biofilms. In some embodiments, the engineered bacteriophages express amyloid peptides for promoting amyloid formation, which are useful for increasing amyloid formation such as promoting bacterial biofilms. Other aspects relate to methods to inhibit bacteria biofilms, and methods for the treatment of amyloid related disorders, e.g., Alzheimer's disease using an anti-amyloid peptide engineered bacteriophages. Other aspects of the invention relate to engineered bacteriophages to express the amyloid peptides on the bacteriophage surface and/or secrete the amyloid peptides, e.g., anti-amyloid peptides and pro-amyloid peptides, and uses thereof for modulation protein aggregates and amyloid formation. | 11-29-2012 |
20140108323 | Compressively-accelerated read mapping - A genomic read dataset is mapped from multiple individuals to a reference genome in a time- and storage-efficient manner. The approach begins by building a set of data structures that collectively represents a knowledge base of similarity information. The knowledge base comprises a set of data structures that, when combined, intrinsically represent all reads to whole-reference match (similarity) information for a reference genome. After this knowledge base is generated, it is then accessed and used in a mapping decision layer. The mapping layer taps into the similarity knowledge within the set of data structures to decide on the mappings and report them, thereby avoiding redundant and unnecessary computations that would otherwise be necessary to find matches and report mappings for each read individually. The approach exploits the redundancy in the read datasets to enable significant speed-up of the sequence matching layer, which preferably is performed collectively for all reads. | 04-17-2014 |
20140337365 | Method for identifying network similarity by matching neighborhood topology - A similarity measure is computed between nodes of first and second networks. Sets of pairwise scores are computed to find nodes in the individual networks that are good matches to one another. A pairwise score is computed for a node i in the first network and a node j in the second network. Similar pairwise scores are computed for each of the nodes in each network. The process identifies node pairs that exhibit high pairwise values. Preferably, nodes i and j are a good match if their neighbors are a good match. This technique produces a measure of network similarity. If node feature data is available, nodes i and j are considered a good match if their neighbors are a good match (network similarity) and their node features are a good match (node similarity). Using the similarity scores, a common subgraph between the first and second networks is computed. | 11-13-2014 |
Patent application number | Description | Published |
20080212492 | SYSTEM AND METHOD FOR RESOURCE DISCOVERY - In distributed networks of cooperating nodes, it is useful to perform resource discovery in a manner that is efficient but that also minimizes communication complexity. A system and method in which nodes in a network efficiently are provided with information about the presence of, and other information about, other nodes in the network provides tangible benefits. In general, in one aspect, a system and method according to the invention features a distributed method for communicating information among a plurality of nodes. The method includes choosing, by a first node, one second node from information about nodes that the first node is aware of. The method further includes communicating from the first node to the second node information about the first node and nodes that the first node is aware of. The method further includes adding or merging, by the second node, the information about the first node and nodes that the first node is aware of with information about nodes that the second node is aware of. The method further includes each of the plurality of cooperating nodes repeating these steps. | 09-04-2008 |
20090248874 | METHOD AND APPARATUS FOR DISTRIBUTING REQUESTS AMONG A PLURALITY OF RESOURCES - The invention relates to a method and apparatus for distributing a request to one of a plurality of resources. A request is mapped to a location in mathematical mapping space. Each of the plurality of resources is mapped to a respective location or locations in the mathematical mapping space. The request is allocated to one of the resources based on a mathematical relationship between the request location and the resource location in the mathematical mapping space. An apparatus for distributing a request to one of a plurality of resources includes the plurality of resources and an input receiving a resource request. A mapper in communication with the input maps the request to a request location in a mathematical mapping space and maps each of the plurality of resources to at least one resource locations in the mathematical mapping space. A distributor distributes the request to one of the plurality of resources in response to a mathematical relationship between the locations of the request and resources in the mathematical mapping space. The invention also relates to a method and apparatus for requesting data from one of a plurality of servers. An virtual network of nodes is generated in response to a data request. A first node on the virtual network of nodes is chosen randomly, and a path generated from the first node to the root on the virtual network. At least one node on the path is mapped to a respective one of the plurality of servers and data is requested from a server. The node may be mapped to the server using the method and apparatus for distributing a request to one of a plurality of resources of the present invention. | 10-01-2009 |
20100011107 | HTML delivery from edge-of-network servers in a content delivery network (CDN) - A content delivery network is enhanced to provide for delivery of cacheable markup language content files such as HTML. To support HTML delivery, the content provider provides the CDNSP with an association of the content provider's domain name (e.g., www.customer.com) to an origin server domain name (e.g., html.customer.com) at which one or more default HTML files are published and hosted. The CDNSP provides its customer with a CDNSP-specific domain name. The content provider, or an entity on its behalf, then implements DNS entry aliasing (e.g., a CNAME of the host to the CDNSP-specific domain) so that domain name requests for the host cue the CDN DNS request routing mechanism. This mechanism then identifies a best content server to respond to a request directed to the customer's domain. The CDN content server returns a default HTML file if such file is cached; otherwise, the CDN content server directs a request for the file to the origin server to retrieve the file, after which the file is cached on the CDN content server for subsequent use in servicing other requests. The content provider is also provided with log files of CDNSP-delivered HTML. | 01-14-2010 |
20100198916 | Global hosting system - The present invention is a network architecture or framework that supports hosting and content distribution on a truly global scale. The inventive framework allows a Content Provider to replicate and serve its most popular content at an unlimited number of points throughout the world. The inventive framework comprises a set of servers operating in a distributed manner. The actual content to be served is preferably supported on a set of hosting servers (sometimes referred to as ghost servers). This content comprises HTML page objects that, conventionally, are served from a Content Provider site. In accordance with the invention, however, a base HTML document portion of a Web page is served from the Content Provider's site while one or more embedded objects for the page are served from the hosting servers, preferably, those hosting servers near the client machine. By serving the base HTML document from the Content Provider's site, the Content Provider maintains control over the content. | 08-05-2010 |
20100217801 | Network performance monitoring in a content delivery system - A method for Internet content delivery in a content delivery network established at network locations, the content delivery network comprising a plurality of content servers for serving content resources. The plurality of content servers includes a plurality of subsets of content servers, each subject being located at one of a plurality of Internet data centers. For each Internet Protocol (IP) address block from which requests for content resources are expected to be received, the method generates a candidate list of Internet data centers to be used to service the requests for content resources. For the IP address block, the method selects at least one of the Internet data centers from the candidate list to be used to service the requests for content resources. The selected Internet data center for the IP address block is written into a network map. The selecting step is carried out concurrently for each IP address block from which requests for content resources are expected to be received such that the network map comprises the selected Internet data center for each IP address block. The network map is then provided to a domain name service (DNS) associated with the content delivery network. In response to a DNS query received at the domain name service associated with the content delivery network, the network map is used to identify one of the Internet data centers from the candidate list to be used to service a request for a content resource. | 08-26-2010 |
20100250742 | Global load balancing across mirrored data centers - An intelligent traffic redirection system that performs global load balancing can be used in any situation where an end-user requires access to a replicated resource. The method directs end-users to the appropriate replica so that the route to the replica is good from a network standpoint and the replica is not overloaded. The technique preferably uses a Domain Name Service (DNS) to provide IP addresses for the appropriate replica. The most common use is to direct traffic to a mirrored web site. | 09-30-2010 |
20110106887 | SYSTEM AND METHOD FOR RESOURCE DISCOVERY - In distributed networks of cooperating nodes, it is useful to perform resource discovery in a manner that is efficient but that also minimizes communication complexity. A system and method in which nodes in a network efficiently are provided with information about the presence of, and other information about, other nodes in the network provides tangible benefits. In general, in one aspect, a system and method according to the invention features a distributed method for communicating information among a plurality of nodes. The method includes choosing, by a first node, one second node from information about nodes that the first node is aware of. The method further includes communicating from the first node to the second node information about the first node and nodes that the first node is aware of. The method further includes adding or merging, by the second node, the information about the first node and nodes that the first node is aware of with information about nodes that the second node is aware of. The method further includes each of the plurality of cooperating nodes repeating these steps. | 05-05-2011 |
20110307584 | HTML delivery from edge-of-network servers in a content delivery network (CDN) - A content delivery network is enhanced to provide for delivery of cacheable markup language content files such as HTML. To support HTML delivery, the content provider provides the CDNSP with an association of the content provider's domain name (e.g., www.customer.com) to an origin server domain name (e.g., html.customer.com) at which one or more default HTML files are published and hosted. The CDNSP provides its customer with a CDNSP-specific domain name. The content provider, or an entity on its behalf, then implements DNS entry aliasing (e.g., a CNAME of the host to the CDNSP-specific domain) so that domain name requests for the host cue the CDN DNS request routing mechanism. This mechanism then identifies a best content server to respond to a request directed to the customer's domain. The CDN content server returns a default HTML file if such file is cached; otherwise, the CDN content server directs a request for the file to the origin server to retrieve the file, after which the file is cached on the CDN content server for subsequent use in servicing other requests. The content provider is also provided with log files of CDNSP-delivered HTML. | 12-15-2011 |
20120124214 | Method and Apparatus for Distributing Requests Among a Plurality of Resources - The invention relates to an apparatus for responding to data requests made by a client. The apparatus includes an input receiving a first data request that includes a sequence of nodes corresponding to a sequence of servers. The apparatus also includes decision logic determining whether the data specified in the data request is available on a selected server, and if the data is not available determining a next node from the sequence of nodes. The apparatus also includes a mapper mapping a server to the next node, and an output requesting the data by transmitting a second data request to the server mapped to the next node. | 05-17-2012 |
20120143997 | GLOBAL HOSTING SYSTEM - A network architecture or framework supports hosting and content distribution on a truly global scale. The inventive framework allows a Content Provider to replicate and serve its most popular content at an unlimited number of points throughout the world. The inventive framework comprises a set of servers operating in a distributed manner. The actual content to be served is preferably supported on a set of hosting servers (sometimes referred to as ghost servers). This content comprises HTML page objects that, conventionally, are served from a Content Provider site. A base HTML document portion of a Web page is served from the Content Provider's site while one or more embedded objects for the page are served from the hosting servers, preferably, those hosting servers near the client machine. By serving the base HTML document from the Content Provider's site, the Content Provider maintains control over the content. | 06-07-2012 |
20120324060 | Method of data collection among participating content providers in a distributed network - A content delivery network (CDN) service provider extends a content delivery network to gather information on atomically identifiable web clients (called “user agents”) as such computer-implemented entities interact with the CDN across different domains being managed by the CDN service provider. The data system tracks user agents, preferably via cookies, although one or more passive techniques may be used. A user agent may be a cookie-able device having a cookie store. As the user agent navigates across sites, a CDN-specific unique identifier used by the system to correlate user agents is generated. Preferably, the unique identifier is stored as an encrypted cookie. The unique identifier represents one user agent (and, thus, one cookie-able device's store). The system tracks user agent behavior on and across customer sites that are served by the CDN, and these behaviors are classified into identifiable “segments” that may be used to create a profile. | 12-20-2012 |
20130013748 | Global hosting system - Network architecture supports hosting and content distribution on a global scale. The architecture allows a Content Provider to replicate and serve its most popular content at an unlimited number of points throughout the world. The inventive framework comprises a set of servers operating in a distributed manner. The actual content to be served is preferably supported on a set of hosting servers (sometimes referred to as ghost servers). This content comprises HTML page objects that, conventionally, are served from a Content Provider site. A base HTML document portion of a Web page is served from the Content Provider's site while one or more embedded objects for the page are served from the hosting servers, preferably, those hosting servers near the client machine. By serving the base HTML document from the Content Provider's site, the Content Provider maintains control over the content. | 01-10-2013 |
20130179567 | Network performance monitoring in a content delivery system - A method for Internet delivery in a delivery network established at network locations, the delivery network comprising a plurality of content servers for serving resources. The servers include a plurality of subsets, each subset being located at one of a plurality of Internet data centers. For each Internet Protocol (IP) address block from which requests for content resources are expected to be received, the method generates a candidate list of data centers to be used to service the requests. For the IP address block, the method selects at least one of the data centers from the candidate list. The selected Internet data center for the IP address block is written into a network map. In response to a DNS query, the map is used to identify one of the Internet data centers from the candidate list to be used to service a request for a content resource. | 07-11-2013 |
20130246612 | HTML delivery from edge-of-network servers in a content delivery network (CDN) - A content delivery network provides delivery of cacheable content files, such as HTML. To support HTML delivery, the content provider provides the CDNSP with an association of the content provider's domain name to an origin server domain name at which default HTML files are published. The CDNSP provides its customer with a CDNSP-specific domain name. The content provider then implements DNS entry aliasing so that domain name requests for the host cue the CDN DNS request routing mechanism. This mechanism identifies a content server to respond to a request directed to the customer's domain. The CDN content server returns a default HTML file if such file is cached; otherwise, the content server directs a request for the file to the origin server to retrieve the file, after which the file is cached on the content server for subsequent use. | 09-19-2013 |
20130311433 | Stream-based data deduplication in a multi-tenant shared infrastructure using asynchronous data dictionaries - Stream-based data deduplication is provided in a multi-tenant shared infrastructure but without requiring “paired” endpoints having synchronized data dictionaries. In this approach, data objects processed by the dedupe functionality are treated as objects that can be fetched as needed. Because the compressed objects are treated as just objects, a decoding peer does not need to maintain a symmetric library for the origin. Rather, if the peer does not have the chunks in cache that it needs, it follows a conventional content delivery network (CDN) procedure to retrieve them. In this way, if dictionaries between pairs of sending and receiving peers are out-of-sync, relevant sections are the re-synchronized on-demand. The approach does not require that libraries maintained at a particular pair of sender and receiving peers are the same. Rather, the technique enables a peer, in effect, to “backfill” its dictionary on-the-fly. | 11-21-2013 |
20140059248 | Global hosting system - Network architecture supports hosting and content distribution on a global scale. The architecture allows a Content Provider to replicate and serve its most popular content at an unlimited number of points throughout the world. The inventive framework comprises a set of servers operating in a distributed manner. The actual content to be served is preferably supported on a set of hosting servers (sometimes referred to as ghost servers). This content comprises HTML page objects that, conventionally, are served from a Content Provider site. A base HTML document portion of a Web page is served from the Content Provider's site while one or more embedded objects for the page are served from the hosting servers, preferably, those hosting servers near the client machine. By serving the base HTML document from the Content Provider's site, the Content Provider maintains control over the content. | 02-27-2014 |
20140189040 | Stream-based data deduplication with cache synchronization - Stream-based data deduplication is provided in a multi-tenant shared infrastructure but without requiring “paired” endpoints having synchronized data dictionaries. Data objects processed by the dedupe functionality are treated as objects that can be fetched as needed. As such, a decoding peer does not need to maintain a symmetric library for the origin. Rather, if the peer does not have the chunks in cache that it needs, it follows a conventional content delivery network procedure to retrieve them. In this way, if dictionaries between pairs of sending and receiving peers are out-of-sync, relevant sections are then re-synchronized on-demand. The approach does not require that libraries maintained at a particular pair of sender and receiving peers are the same. Rather, the technique enables a peer, in effect, to “backfill” its dictionary on-the-fly. On-the-wire compression techniques are provided to reduce the amount of data transmitted between the peers. | 07-03-2014 |
20140189071 | Stream-based data deduplication with peer node prediction - Stream-based data deduplication is provided in a multi-tenant shared infrastructure but without requiring “paired” endpoints having synchronized data dictionaries. Data objects processed by the dedupe functionality are treated as objects that can be fetched as needed. As such, a decoding peer does not need to maintain a symmetric library for the origin. Rather, if the peer does not have the chunks in cache that it needs, it follows a conventional content delivery network procedure to retrieve them. In this way, if dictionaries between pairs of sending and receiving peers are out-of-sync, relevant sections are then re-synchronized on-demand. The approach does not require that libraries maintained at a particular pair of sender and receiving peers are the same. Rather, the technique enables a peer, in effect, to “backfill” its dictionary on-the-fly. On-the-wire compression techniques are provided to reduce the amount of data transmitted between the peers. | 07-03-2014 |
20140195653 | Connected-media end user experience using an overlay network - An Internet infrastructure delivery platform (e.g., operated by a service provider) provides an overlay network (a server infrastructure) that is used to facilitate “second screen” end user media experiences. In this approach, first media content, which is typically either live on-demand, is being rendered on a first content device (e.g., a television, Blu-Ray disk or other source). That first media content may be delivered by servers in the overlay network. One or multiple end user second content devices are then adapted to be associated with the first content source, preferably, via the overlay network, to facilitate second screen end user experiences (on the second content devices). | 07-10-2014 |
20140337238 | Method and system for handling sensitive data in a content delivery network - Using cryptographic techniques, sensitive data is protected against disclosure in the event of a compromise of a content delivery network (CDN) edge infrastructure. These techniques obviate storage and/or transfer of such sensitive data, even with respect to payment transactions that are being authorized or otherwise enabled from CDN edge servers. | 11-13-2014 |