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Lei Zhu
Lei Zhu, Atlanta, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20110085643 | Radiation therapy inverse treatment planning using a regularization of sparse segments - A method of reducing a total number of beam segments in a dose distribution for a radiation therapy field is provided. The method includes providing a multiobjective radiation therapy treatment plan using a suitably programmed computer, where the multiobjective radiation therapy treatment plan includes a radiation beam dose performance objective and a fluence map sparsity objective in a given fluence function domain, and providing a Pareto frontier of tradeoff criteria between the beam dose performance and a total number of radiation segments (or sub-fields) of the multiobjective radiation therapy treatment plan using the suitably programmed computer, where an achieved set of radiation beam dose distributions associated with efficiency points of the Pareto frontier are evaluated using a clinical acceptance criteria, where a clinically acceptable radiation beam dose distribution having a smallest number of the multileaf collimator segments is a final solution for the multiobjective radiation therapy treatment plan. | 04-14-2011 |
| 20120263360 | SCATTER CORRECTION METHODS - Described herein are improved methods for correcting cone beam computed tomography signals to reduce scatter contamination contained therein. Generally, the improved methods involve generating a plurality of two-dimensional projection images of a subject from a three-dimensional multi-detector computed tomography image of the subject. This is followed by subtracting the plurality of two-dimensional projection images from a plurality of two-dimensional cone beam projection images of the subject to produce a plurality of two-dimensional estimated error projections that comprise an estimated error in the plurality of two-dimensional cone beam projection images. The plurality of two-dimensional estimated error projection images are subtracted from the plurality of two-dimensional cone beam projection images to generate a plurality of two-dimensional corrected cone beam projection images. A three-dimensional corrected cone beam computed tomography image of the subject is then constructed from the plurality of two-dimensional corrected cone beam projection images. | 10-18-2012 |
Lei Zhu, Milford, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20090047687 | Indane Acetic Acid Derivatives and Their Use as Pharmaceutical Agents, Intermediates, and Method of Preparation - This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation. | 02-19-2009 |
| 20090197795 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY - This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. | 08-06-2009 |
| 20090253762 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY - This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. | 10-08-2009 |
| 20090270468 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity - This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. | 10-29-2009 |
| 20110065129 | INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION - This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation. | 03-17-2011 |
| 20110152330 | INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION - This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation. | 06-23-2011 |
| 20110152331 | INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION - This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation. | 06-23-2011 |
Lei Zhu, Bellevue, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20090060908 | Monoclonal Antibodies Against Prostate Specific Membrane Antigen (PSMA) Lacking in Fucosyl Residues - The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided. | 03-05-2009 |
| 20110028696 | MONOCLONAL ANTIBODIES AGAINST PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LACKING IN FUCOSYL RESIDUES - The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA | 02-03-2011 |
| 20130023653 | Tissue Specific Expression Of Antibodies In Chickens - Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are preferably expressed in the oviduct for collection in the egg. Tissue specificity is provided by selecting the content of the transgene accordingly. Birds whose genome is comprised of trangene-derived exogenous antibody-encoding DNA express exogenous antibodies having desirable chemical properties with increased therapeutic utility compared to antibodies derived from bacterial expression systems. | 01-24-2013 |
Lei Zhu, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090083871 | Targeting constructs for the functional disruption of avian immunoglobulin genes - A transgenic chicken is disclosed having disrupted endogenous immunoglobulin production. In one embodiment, a targeting construct is stably integrated into the genome of the chicken by homologous recombination in embryonic stem cells, and injection of the engineered embryonic stem cells into recipient embryos, thereby knocking out the endogenous immunoglobulin gene locus in resulting animals. The targeted disruption of the locus in embryonic stem cells is particularly useful in combination with the insertion of genetic elements encoding exogenous immunoglobulin molecules. After these chickens are cross-bred, a line of chickens is produced that has a reduction of endogenous immunoglobulin molecule production. | 03-26-2009 |
| 20090165155 | Tissue Specific Expression of Exogenous Proteins in Transgenic Chickens - Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white. | 06-25-2009 |
| 20110023160 | Functional Disruption Of Avian Immunoglobulin Genes - A transgenic chicken is disclosed having disrupted endogenous immunoglobulin production. In one embodiment, a targeting construct is stably integrated into the genome of the chicken by homologous recombination in embryonic stem cells, and injection of the engineered embryonic stem cells into recipient embryos, thereby knocking out the endogenous immunoglobulin gene locus in resulting animals. The targeted disruption of the locus in embryonic stem cells is particularly useful in combination with the insertion of genetic elements encoding exogenous immunoglobulin molecules. After these chickens are cross-bred, a line of chickens is produced that has a reduction of endogenous immunoglobulin molecule production. | 01-27-2011 |
| 20110277048 | Transgenic Aves Producing Human Polyclonal Antibodies - Human antibodies are produced in transgenic chickens having functional genetic components of the human immune system stably integrated in the genome. Techniques are described to integrate unrearranged human heavy and light chain immunoglobulin loci into the genome of the transgenic chicken. | 11-10-2011 |
| 20120156771 | FUNCTIONAL DISRUPTION OF AN IMMUNOGLOBULIN GENE IN AN AVIAN EMBRYONIC STEM CELL - A transgenic chicken is disclosed having disrupted endogenous immunoglobulin production. In one embodiment, a targeting construct is stably integrated into the genome of the chicken by homologous recombination in embryonic stem cells, and injection of the engineered embryonic stem cells into recipient embryos, thereby knocking out the endogenous immunoglobulin gene locus in resulting animals. The targeted disruption of the locus in embryonic stem cells is particularly useful in combination with the insertion of genetic elements encoding exogenous immunoglobulin molecules. After these chickens are cross-bred, a line of chickens is produced that has a reduction of endogenous immunoglobulin molecule production. | 06-21-2012 |
Lei Zhu, Schenectady, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20110003739 | AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF - Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention. | 01-06-2011 |
| 20110306605 | COUMARIN-BASED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND CANCER - Compounds including those of the Formula I | 12-15-2011 |
| 20120035102 | AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF - Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention. | 02-09-2012 |
Lei Zhu, Durham, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20100273661 | Methods and Kits for Predicting Treatment Response in Type II Diabetes Mellitus Patients - A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosiglitazone. The biomarkers include, at least, interleukin-8, histidine, citrate. These biomarkers are identified in at least one classification analyses selected from the group consisting of a majority-vote based classifier and support-vector machine (SVM) classifier. Also provided is a method for predicting treatment response of a type II diabetes patient to glyburide at 8 weeks post-initiation of therapy. The method involves obtaining a sample from a type II diabetes patient who has been treated with glyburide for about 4 weeks and analyzing biomarkers predictive of a patient who will respond to treatment with glyburide at 8 weeks. The biomarkers useful in this method include, at least, sphingomyelin 23:1 and L-phenylalanine. Also provided are kits useful for the methods of the invention. | 10-28-2010 |
Lei Zhu, Singapore SG
| Patent application number | Description | Published |
|---|---|---|
| 20100021769 | METHOD TO IMPROVE CORROSION PERFORMANCE OF EXCHANGE COUPLED GRANULAR PERPENDICULAR MEDIA - The invention relates to a granular perpendicular magnetic recording medium comprising a top magnetic layer on a granular layer wherein the magnetic layer comprises a continuous Co alloy film that results in the recording medium having less than 10% CoOx on the surface of the protective overcoat when the recording medium is exposed to 80% relative humidity at 80° C. for 4 days. | 01-28-2010 |
| 20110108412 | Method to Improve Corrosion Performance of Exchange Coupled Granular Perpendicular Media - The invention relates to a granular perpendicular magnetic recording medium comprising a top magnetic layer on a granular layer wherein the magnetic layer comprises a continuous Co alloy film that results in the recording medium having less than 10% CoOx on the surface of the protective overcoat when the recording medium is exposed to 80% relative humidity at 80° C. for 4 days. | 05-12-2011 |
Lei Zhu, Mountain View, CA US
Lei Zhu, Austin, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20090005329 | NUCLEIC ACID BASED LADDER COPOLYMERS - The present invention relates to a copolymer termed a ladder copolymer because it has two backbones that serve as legs/sides of a ladder structure. These two backbones, one of which is a nucleic acid or nucleic acid-like polymer, are linked together as the legs/sides of a ladder are linked together by the rungs. | 01-01-2009 |
| 20090137738 | LADDER COPOLYMERS - The present invention relates to a copolymer termed a ladder copolymer because it has two backbones that serve as legs/sides of a ladder structure. These two backbones, one of which is a nucleic acid or nucleic acid-like polymer, are linked together as the legs/sides of a ladder are linked together by the rungs. | 05-28-2009 |
Lei Zhu, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090036678 | Process for the synthesis of E1 activating enzyme inhibitors - The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1S,2S,4R)-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity. | 02-05-2009 |
| 20110155171 | Cleaning and Conditioning Cloth - A cleaning and conditioning cloth for an ice skate, including hockey and speed skates, as well as other objects, includes a rectangular body, or a body selected from one of other various shapes such as circle, square, and diamond, of cut-resistant, water-absorbent fabric and an oil impregnated fabric affixed to the approximate center of the cleaning and conditioning cloth body wherein the method includes the steps of holding the cleaning and conditioning cloth in one hand and the ice skate in the other, placing the blade of the ice skate in the middle of the oil impregnated fabric, and moving the ice skate and the cleaning and conditioning cloth relative to each other, so that the blade moves from the cleaning and conditioning cloth body to the oil impregnated fabric. The body and the oil impregnated fabric may be of various sizes. | 06-30-2011 |
| 20120291802 | MULTI-USE CLEANING AND CONDITIONING CLOTH - A multi-use cloth for cleaning and conditioning metal and non-metal objects includes a two-layer, three-layer or multi-layer structure. Each layer is made of material either capable of retaining an oil, aqueous solution, aqueous suspension or solid or capable of preventing penetration of an oil, aqueous solution, aqueous suspension or solid. In a three-layer or multi-layer cloth, the separation layer is affixed in between two layers having one or both layers embedded with an oil, aqueous solution, or aqueous suspension. In a two-layer cloth, the separation layer is affixed to one side of the layer that is embedded with an oil, aqueous solution or an aqueous suspension. The cloth is folded with the oil, or aqueous solution, or aqueous suspension embedded side on an inner side. A user's hand holds the outside of the cloth and no contamination from oil, aqueous solution, or aqueous suspension or solid occurs. | 11-22-2012 |
Lei Zhu, Shanghai CN
| Patent application number | Description | Published |
|---|---|---|
| 20110225132 | Provisioning Method and Sytem - A method and system of provisioning one or more Network Elements, as well as a method and apparatus for resuming a failed Customer Service Order for provisioning one or more Network Elements, is disclosed. A provisioning logic framework receives a Customer Service Order CSO from a Business Support System, calls respective provisioning logic for performing said Customer Service Order and detects if the received Customer Service Order is a CSO to be resumed. During the performing time of said Customer Service Order, historical processing data is stored. If it is detected that the received Customer Service Order is a CSO to be resumed, the provisioning logic framework builds up a fake environment on the basis of historical processing data stored previously for the CSO to be resumed. Then the successful part of the CSO is directed to the fake environment and the uncompleted part of the CSO is directed to actual Network elements. | 09-15-2011 |
Lei Zhu, Sunnyvale, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110259750 | METHOD OF DIRECT PLATING OF COPPER ON A RUTHENIUM ALLOY - A method is disclosed for depositing a copper seed layer onto a substrate surface. In one embodiment, the method includes providing a substrate having a barrier layer disposed on a substrate surface, wherein the barrier layer has a barrier surface comprising a material selected from the group consisting of cobalt, ruthenium, tungsten, titanium, and a compound of two or more thereof, and exposing the substrate to a non-complexed, acid electrochemical plating solution with a plating bias applied across the substrate surface to deposit a copper-containing seed layer directly on the barrier surface without intervening layer disposed therebetween. | 10-27-2011 |
Lei Zhu, San Jose, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110314105 | SYSTEM AND METHOD FOR ATTRIBUTE DETECTION IN USER PROFILE CREATION AND UPDATE - In one embodiment, a scheduled collaboration session in a social network is detected, the scheduled collaboration session to occur at a time in the future and at that time provide real-time communication among participants. A plurality of participants expected to attend the scheduled collaboration session are detected. A subject matter of the scheduled collaboration session is detected. One or more key words are derived from the detected subject matter of the scheduled collaboration session. Profiles maintained in the social network for the plurality of participants expected to attend the scheduled collaboration session are updated based on the one or more key words, the updating to include refining an area of expertise indicated in the profiles. | 12-22-2011 |
Lei Zhu, Komaki-Shi JP
| Patent application number | Description | Published |
|---|---|---|
| 20120026700 | WIRING BODY CONNECTION STRUCTURE - A wiring body connection structure includes a first wiring body and a second wiring body, the first wiring body having a first base material made of an elastomer and a first wiring containing an elastomer and a conductive material, the second wiring body having a second base material and a second wiring. In the wiring body connection structure, a laminated section is partitioned where a first end of the first wiring body and a second end of the second wiring body overlap in a front-rear direction. The wiring body connection structure further includes a cover member arranged on a front surface of the first wiring body, and a conductive adhesive layer bonding the first end and the second end in the laminated section while ensuring a conductive property. The cover member is interposed between a frontmost end of the second end and the first wiring in the laminated section. | 02-02-2012 |
Lei Zhu, Beijing CN
| Patent application number | Description | Published |
|---|---|---|
| 20120093113 | METHOD AND APPARATUS FOR REDUCING DELAY IN ESTABLISHING SESSION - Embodiments of the present invention disclose a method and an apparatus for reducing a delay in establishing a session, relating to the field of communication technologies. The method for reducing a delay in establishing a session includes: sending a measurement report to a network control device after establishing a connection with the network control device; receiving a radio bearer reconfiguration message sent by the network control device and performing state transition to a CELL_DCH state; sending a radio bearer reconfiguration confirmation message to the network control device to notify the network control device that the state transition is completed; and receiving a session confirmation message sent by the network control device to enter into a session state. | 04-19-2012 |
| 20120155375 | Method and Apparatus for Header Compression in Network Relay Scenario - Embodiments of the present application disclose a method and an apparatus for header compression in a network relay scenario. The method includes: receiving, by a relay node, a first header-compressed data packet sent by user equipment or another relay node; encapsulating a transport protocol header for the first data packet and performing header compression for the header to form a second data packet; and sending the second data packet to an eNodeB or a next relay node in an uplink direction. | 06-21-2012 |
| 20120294211 | METHOD AND APPARATUS FOR COMPRESSING NESTED PROTOCOL PACKET HEADER - Embodiments of the present invention disclose a method for compressing a nested protocol packet header, which relate to the field of wireless communication technologies and are used to improve efficiency in compressing a nested protocol packet header in a data packet. The method for compressing a nested protocol packet header provided in the embodiments of the present invention includes: receiving a data packet sent by at least one sending end, where the data packet includes a first compression protocol packet header; taking the received data packet as a whole and nesting a second protocol packet header in it; and processing the data packet nested with the second protocol packet header, where the processing includes: coordinating part of function fields in the first compression protocol packet header and the second protocol packet header to remove a duplicate field, and compressing the second protocol packet header; and sending the processed data packet. | 11-22-2012 |
| 20120307634 | METHOD FOR HANDLING LOCAL LINK CONGESTION AND APPARATUS - The present invention relates to the field of congestion control, and discloses a method for handling local link congestion and an apparatus. The method includes: negotiating, by a local link control entity, a local congestion notification capability with a local terminal; setting, by the local link control entity, a congestion identifier in a downlink data packet corresponding to the local congestion notification capability when a local link is congested between the local link control entity and the local terminal; and performing, by the local link control entity, congestion control on the local link, or performing, by the local terminal, congestion control on the local link according to the congestion identifier. The apparatus includes a local link control entity and a terminal device. | 12-06-2012 |
Lei Zhu, Roswell, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20130032715 | X-RAY COMPTON SCATTER IMAGING ON VOLUMETRIC CT SYSTEMS - Briefly described, in an exemplary form, the present invention discloses a system, method and apparatus for X-ray Compton scatter imaging. In one exemplary embodiment, the present invention uses two detectors in a volumetric CT system. A first detector is positioned generally in-line with the angle of attack of the incoming energy, or, generally in-line of path x, where x is the path of the incoming energy. The first, or primary, detector detects various forms of radiation emanating from an object undergoing testing. In some embodiments, the present invention further comprises a Compton scattering system positioned generally normal to path x. In some embodiments, the Compton scattering subsystem comprises a second detector and a pin-hole collimator. The second detector detects Compton scattering energy from the object being tested. | 02-07-2013 |