Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Lee, MD
Byungkook Lee, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110236385 | BLOCKING MESOTHELIN PEPTIDE FRAGMENTS - The present invention provides mesothelin peptide fragments corresponding to the CA125 binding site of mesothelin. The peptide fragments find use in disrupting the binding interaction between mesothelin and CA 125, for example, in the treatment and prevention of cancers that require the interaction of mesothelin and CA125 for growth, progression and/or metastasis. | 09-29-2011 |
Byungkook Lee, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090142341 | Mutated pseudomonas exotoxins with reduced antigenicity - The invention provides mutated | 06-04-2009 |
| 20090202552 | GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE - A new polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Novel Gene Expressed in Prostate (NGEP). Polynucleotides encoding NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies are disclosed that specifically bind NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an NGEP polypeptide, an antibody that specifically binds NGEP, or a polynucleotide encoding NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer. | 08-13-2009 |
| 20090304702 | GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE - A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer. | 12-10-2009 |
Candy Lee, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090035299 | Methods and compositions for treating diseases targeting MABA1 - Methods and compositions for diagnosing, detecting and treating a colon disease associated with differential expression of MABA1 in comparison to healthy cells. Also provided are antagonists or agonists of MABA1, and methods for screening agents that modulate the MABA1 level or activity in vivo or in vitro. | 02-05-2009 |
| 20090196873 | Methods and compositions for treating diseases targeting CDCP1 - Methods and compositions for detecting and treating a disease, particularly cancer, associated with differential expression of CDCP1 in disease cells compared to healthy cells. Also provided are antagonists or agonists of CDCP1, and methods for screening agents that modulate the CDCP1 level or activity in vivo or in vitro. | 08-06-2009 |
| 20100172908 | METHODS AND COMPOSITIONS FOR TREATING DISEASES TARGETING MABA1 - Methods and compositions for diagnosing, detecting and treating a colon disease associated with differential expression of MABA1 in comparison to healthy cells. Also provided are antagonists or agonists of MABA1, and methods for screening agents that modulate the MABA1 level or activity in vivo or in vitro. | 07-08-2010 |
Candy N. Lee, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100061977 | METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DISEASES - Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro. | 03-11-2010 |
| 20110250204 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING DISEASES - Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods. | 10-13-2011 |
| 20120177659 | METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DISEASES - Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro. | 07-12-2012 |
Chang Lee, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110262502 | PULMONARY DELIVERY OF 17-HYDROXYPROGESTERONE CAPROATE (17-HPC) - The invention relates to 17-HPC pulmonary formulations for administration by inhalation comprising 17-HPC and a pharmaceutically acceptable excipient. Particle size reduction of 17-HPC is required for the pulmonary delivery, and can be achieved with a surfactant or water without the surfactant. Preferred pulmonary formulations include a powder blend comprising a therapeutically effective amount of at least one steroid hormone (progestogen) as a glucocorticoid sensitizer, and at least one pharmaceutically acceptable excipient, wherein the at least one steroid hormone (progestogen) has a particle size distribution profile ranging from about one nanometer to about ten microns in the powder blend. | 10-27-2011 |
Chang Hwa Lee, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090188805 | SUPERCONFORMAL ELECTRODEPOSITION OF NICKEL IRON AND COBALT MAGNETIC ALLOYS - A process for electrodepositing at least one ferromagnetic material into a three dimensional pattern within a substrate is provided. The process comprises providing a substrate material, dielectric or conductor, having a three dimensional recessed pattern in at least one outer surface thereof, dielectric substrate materials also having an electrical conductive seed layer at least within the three dimensional pattern. An electrolytic bath is prepared comprising at least one ferromagnetic material and at least one accelerating, inhibiting, or depolarizing additive. The at least one ferromagnetic material comprises at least one metal cation selected from the group consisting of Ni | 07-30-2009 |
Che-Hung Robert Lee, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090092632 | Methods for preparing complex multivalent immunogenic conjugates - Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. | 04-09-2009 |
| 20100266625 | Meningococcal and Pneumococcal Conjugate Vaccine and Method of Using Same - This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both | 10-21-2010 |
| 20120009213 | Meningococcal And Pneumococcal Conjugate Vaccine And Method Of Using Same - This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both | 01-12-2012 |
| 20120076817 | POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES - Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products. | 03-29-2012 |
| 20120195922 | METHODS FOR PREPARING COMPLEX MULTIVALENT IMMUNOGENIC CONJUGATES - Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. | 08-02-2012 |
Chunghee Lee, Clarksburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100310593 | Vaccines Against Chlamydia Infection - The present invention is directed to providing a vaccine to enhance the immune response of an animal in need of protection against a | 12-09-2010 |
David B. Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100215450 | Depth Gauge For Drill Bit - A depth gauge for use with a drill bit includes a body configured to receive a drill bit, a retention mechanism coupled to the body and configured to removably couple the body to the drill bit, and a cap configured to be removably coupled to the body. The cap can be coupled to the body in one of a first position relative to the body where the cap contacts a workpiece surface to prevent the drill bit from entering the workpiece more than a first depth, and a second position relative to the body where the cap contacts the workpiece surface to prevent the drill bit from entering the workpiece more than a second depth that is different from the first depth. | 08-26-2010 |
| 20100260565 | Depth Gauge For Drill Bit - A drill bit has a shank portion having a plurality of SDS-type slots, a cutting portion comprising at least one cutting flute, and an intermediate portion connecting the shank to the cutting portion, the intermediate portion including at least one additional slot. A depth gauge includes a body configured to receive the drill bit, a retention mechanism coupled to the body and having an inward projection to removably couple the body to the at least one additional slot in the drill bit, and a cap coupled to the body such that the cap contacts a workpiece surface to prevent the drill bit from entering the workpiece more than a predetermined depth, wherein the cap is movable relative to the body among a plurality of positions, wherein each of the plurality of positions corresponds to a different predetermined drilling depth. | 10-14-2010 |
| 20110048988 | Method And Package For Displaying Magnetic Tool Container - A display package includes a blister assembly and a storage container. The blister assembly includes a front blister surface having a first opening therein and a rear blister surface coupled to the front blister surface and defining a first cavity. The storage container includes a first container portion secured within the first cavity, a second container portion hingedly coupled to the first container portion for pivotal displacement between an open position and a closed position, and a magnet fixed to an outer surface of the second container portion. The magnet is located at or beyond an outer perimeter of the blister assembly when the first container portion is secured within the first cavity. The magnet is configured to secure the display package to a metallic structure. | 03-03-2011 |
| 20110081214 | Dust Collector for use with Drill Bit or Drill Bit Depth Stop - A dust collector is disclosed for use with a drill bit or a depth stop that is coupled to a drill bit. The dust collector includes a rear attachment portion configured to be axially fixed to a drill bit or to a drill bit depth stop that is axially fixed to a drill bit. An intermediate non-collapsible portion is attached to a front end of the rear attachment portion. The intermediate non-collapsible portion defines a dust-collecting pocket and is structured to inhibit collapse as the drill bit is inserted into a workpiece. A front collapsible portion is attached to a front end of the intermediate non-collapsible portion and at least partially collapses as the drill bit is inserted into a workpiece. | 04-07-2011 |
David J. Lee, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090041556 | TIEDOWN PROVISION PRODUCT - The tiedown product comprises a rod having a first end which passes through a first opening at a first side of a load. The rod also has a second end which passes through a second opening at a second side of the load. A first tiedown attaching provision is on the rod first end. A second tiedown attaching provision is on the rod second end. The rod carries force from tiedown means thus preventing this force from harming the load. In one form of the invention the first tiedown provision and the second tiedown provision can each rotate about an axis orthogonal to the long axis of the rod and can rotate about the long axis of the rod, which also helps transfer forces from the tiedown means to the rod. | 02-12-2009 |
Donald T. Lee, Frederick, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100253588 | Portal Stand for RFID Antenna - A portal stand for an RFID antenna comprises a pair of upright members and a front cover. The front cover is formed of a sheet of plastic that is resiliently biased to assume a flat configuration, with the front cover defining a flat width when it is in the flat configuration. The upright members include vertical slots and are spaced apart at a distance that is less than the flat width of the front cover. The front cover is disposed in the vertical slots and is bowed outwardly. The portal stand also includes a plurality of platforms that may be used for mounting RFID equipment such as antennas and readers. The platforms are secured to rails that are also secured to the upright members. The portal stand also includes a top cover, bottom cover, and rear cover, with the platforms being positioned between the front cover and rear cover. | 10-07-2010 |
Donna Ma Lee, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090196838 | Arthropod Repellent Pharmacophore Models, Compounds Identified as Fitting the Pharmacophore Models, and Methods of Making and Using Thereof - Disclosed herein is a pharmacophore model for arthropod repellent activity and methods of making and using thereof. The pharmacophore comprises two hydrophobic aliphatic functions, one aromatic function and one hydrogen bond acceptor function. The pharmacophore model was made using a test set of arthropod repellent compounds. Also disclosed are arthropod repellent compounds identified by screening databases with the pharmacophore model. Also disclosed are methods of repelling arthropods from a surface or area. Compositions and formulations comprising the compounds of the present invention as well as objects having the compounds of the present invention are disclosed. | 08-06-2009 |
Dustin Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100252293 | Ergonomic Handle for Power Tool - An ergonomic handle for use with a power tool defines a first region that includes a switch, adapted to receive a thumb and forefinger when the forefinger is actuating the switch, a second region adapted to receive a middle finger, a third region adapted to receive a ring finger; and a fourth region adapted to receive a pinky finger. Each of the second, third, and fourth region includes a generally oval cross section having a major axis and a minor axis. The longest major axis is in the third region, the shortest major axis is in the fourth region, the shortest minor axis is in the second region, and the longest minor axis is positioned in the fourth region. | 10-07-2010 |
Dustin Lee, Abingdon, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120081074 | STATE OF CHARGE INDICATOR FOR A BATTERY CHARGER - A method is provided for indicating state of charge of a battery being charged by a charger. The method includes: supplying a charging current from a battery charger to a battery pack; determining voltage of battery cells residing in the battery pack; and illuminating a visual indicator on the battery charger to indicate state of charge of the battery pack, where brightness of the visual indicator correlates to the voltage of the battery cells in the battery pack. | 04-05-2012 |
Gilbert F. Lee, Greenbelt, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100236393 | Composite Armor Including Geometric Elements for Attenuating Shock Waves - The present invention's stratified composite material system of armor, as typically embodied, comprises a strike stratum and a backing stratum. The strike stratum includes elastomeric matrix material and inventive ceramic-inclusive elements embedded therein and arranged (e.g., in one or more rows and one or more columns) along a geometric plane corresponding to the front (initial strike) surface of the strike stratum. More rigid than the strike stratum, the backing stratum is constituted by, e.g., metallic (metal or metal alloy) material or fiber-reinforced polymeric matrix material. Some inventive embodiments also comprise a spall-containment stratum fronting the strike stratum. The inventive ceramic-inclusive elements geometrically describe any of various inventive modes, including: first mode, having a flat front face and a textured back face; second mode, having a pyramidal front section and a prismatoidal (especially, prismoidal, e.g., truncated pyramidal or prismatic) body section; hybrid mode, combining features of first and second modes. | 09-23-2010 |
Gyusung Lee, Lutherville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120035507 | Device and method for measuring anatomic geometries - Provided herein is a device and system for measuring an object geometry. The device comprises a probe with contacting and tracking ends and a tracking means and actuation control unit positioned on the probe. The system further comprises a measurement and post processing unit in electronic communication with the tracking means and/or the actuation control unit. Also provided is a method for measuring a geometry of an anatomic object, for example, a hernia. One or more locations of interest on the object are touched directly with the contacting probe end and the location or motion data of the probe end and of the tracking means are tracked and transmitted to the measurement and post processing unit as the point(s) of interest are touched. The data is processed into the geometric measurement and a representative image may be displayed. | 02-09-2012 |
H. Janice Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110002997 | PHOTOINITIATED TISSUE FILLER - Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional polymeric material, such as HA, together with a modified, cross-linkable polymer, such as PEG or PEODA, to permit the formation of crosslinks within the polymer matrix in situ on exposure to a visible light source, such as an IPL device. The preparations provide for a more stabilized composition that is contourable during gelation. | 01-06-2011 |
Houcheng Lee, Beltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090235068 | Method and Apparatus for Identity Verification - A method for identity verification includes receiving a request for proof of identity from a service provider and receiving biometric information associated with a user of a communication device. The method also includes determining that the received biometric information matches a biometric profile that contains biometric information associated with a registered user of the communication device. The method also includes unlocking a private key associated with the registered user in response to determining that the received biometric information matches a biometric profile and sending a request for a digital certificate that is signed with the private key associated with the registered user. The method further includes receiving the digital certificate that includes a public key associated with the registered user and satisfies the request for proof of identity. The method also includes with forwarding the digital certificate to the service provider. | 09-17-2009 |
Hyeseung J. Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080287342 | Compositions Comprising Modified Collagen and Uses Therefor - The invention provides modified collagen and related therapeutic and diagnostic methods. | 11-20-2008 |
Hyo Sang Lee, Silver Spring, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080259340 | AIRBORNE TUNABLE MID-IR LASER GAS-CORRELATION SENSOR - A method and apparatus for measuring target gas concentrations in an atmosphere. The method and apparatus emit in the atmosphere a laser beam tuned to a molecular absorption line of a target gas, receive a reflected signal affected by gas absorption of the target gas in the atmosphere, divide and direct the received signal into a first optical path and a second optical path including in one of the paths a correlation gas cell filled with a predetermined concentration of the target gas, detect transmitted signals through the first optical path and the second optical path, and calculate a target gas concentration by comparing a first signal transmitted through the first optical path to a second signal transmitted through the second optical path. The apparatus includes a laser source tunable to a specific molecular absorption line of a target gas and configured to emit in the atmosphere a laser beam having a spectral bandwidth greater than a full width of the molecular absorption line of the target gas, a receiver configured to receive a reflected signal affected by gas absorption of the target gas in the atmosphere, and at least one detector configured to detect transmitted signals through the first optical path and the second optical path. | 10-23-2008 |
| 20100006760 | Ultraviolet lidar for detection of biological warfare agents - A system and method for detecting airborne agents. The system includes a semiconductor ultraviolet optical source configured to emit an ultraviolet light, a controller configured to generate a pseudo-random code for emission of the ultraviolet light modulated at the pseudo-random code, a telescope configured to focus the ultraviolet light to a distance from the source and to receive elastically backscattered signals and fluorescence signals from the distance, and a sensor configured to detect the elastically backscattered and fluorescence signals. The method generates a pseudo-random code and emits at least one wavelength of ultraviolet light modulated at the pseudo-random code, transmits the modulated ultraviolet light pulses to a distance from the source, receives elastically backscattered signals and fluorescence signals from the distance, and detects the elastically backscattered and fluorescence signals. | 01-14-2010 |
| 20100163733 | AIRBORNE TUNABLE MID-IR LASER GAS-CORRELATION SENSOR - A method and apparatus for measuring target gas concentrations in an atmosphere. The method and apparatus emit in the atmosphere a laser beam tuned to a molecular absorption line of a target gas, receive a reflected signal affected by gas absorption of the target gas in the atmosphere, divide and direct the received signal into a first optical path and a second optical path including in one of the paths a correlation gas cell filled with a predetermined concentration of the target gas, detect transmitted signals through the first optical path and the second optical path, and calculate a target gas concentration by comparing a first signal transmitted through the first optical path to a second signal transmitted through the second optical path. The apparatus includes a laser source tunable to a specific molecular absorption line of a target gas and configured to emit in the atmosphere a laser beam having a spectral bandwidth greater than a full width of the molecular absorption line of the target gas, a receiver configured to receive a reflected signal affected by gas absorption of the target gas in the atmosphere, and at least one detector configured to detect transmitted signals through the first optical path and the second optical path. | 07-01-2010 |
Ian Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100331677 | MARKER DELIVERY SYSTEM - A marker delivery system including a surgical needle defining a lumen. The surgical needle is adapted to receive a marker. The surgical needle includes a side opening substantially adjacent to a first end of the surgical needle. The marker delivery system also includes a plunger insertable into the surgical needle at a second end of the surgical needle. Depression of the plunger inside the lumen of the surgical needle pushes the marker through the side opening of the surgical needle. | 12-30-2010 |
In Hwa Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090275984 | REFORMING DEVICE - The present invention relates to a reforming device. A reforming device according to the present invention includes a main body that is locked to bones of a human body and of which a length is extensible depending on growth of the human body; an external controller that transmits a wireless control signal for a length of the main body to be extended inside of the human body; and an internal controller that is mounted inside of the human body and extends the length of the main body depending on the wireless control signal. | 11-05-2009 |
Insu Lee, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080260772 | Extract From Agaricus Blazei Murill Capable of Suppressing Breast Cancer - A food material capable of suppressing the genesis of breast cancer or proliferation of terminal breast cancer. An extract of | 10-23-2008 |
Jaeho Lee, College Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080305157 | Encapsulation and separation of charged organic solutes inside catanionic vesicles - Catanionic vesicles including solute ion, methods for forming these, and methods of using these. | 12-11-2008 |
James W. Lee, Cockeysville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110172092 | Biochar Production Method and Composition Therefrom - The invention is directed to a method for producing an oxygenated biochar material possessing a cation-exchanging property, wherein a biochar source is reacted with one or more oxygenating compounds in such a manner that the biochar source homogeneously acquires oxygen-containing cation-exchanging groups in an incomplete combustion process. The invention is also directed to oxygenated biochar compositions and soil formulations containing the oxygenated biochar material. | 07-14-2011 |
James Weifu Lee, Cockeysville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100239923 | Photobiological hydrogen production with switchable photosystem-II designer algae - A process for enhanced photobiological H | 09-23-2010 |
| 20100330637 | Designer Organisms for Photobiological Butanol Production from Carbon Dioxide and Water - The present invention provides a biosafety-guarded photobiological butanol production technology based on designer transgenic plants, designer algae, designer blue-green algae (cyanobacteria and oxychlorobacteria), or designer plant cells. The designer photosynthetic organisms are created such that the endogenous photobiological regulation mechanism is tamed, and the reducing power (NADPH) and energy (ATP) acquired from the photosynthetic process are used for synthesis of butanol (CH | 12-30-2010 |
| 20100330639 | Designer Oxyphotobacteria and Greenhouse Distillation for Photobiological Ethanol Production from Carbon Dioxide and Water - The present invention provides a photobiological ethanol production and harvesting technology using greenhouse distillation systems with designer photosynthetic organisms, such as designer transgenic oxyphotobacteria. The designer oxyphotobacteria are created such that the endogenous photobiological regulation mechanism is tamed, and the reducing power (NADPH) and energy (ATP) acquired from the photosynthetic process are used for synthesis of ethanol (CH | 12-30-2010 |
| 20110120854 | PHOTOVOLTAIC PANEL-INTERFACED SOLAR-GREENHOUSE DISTILLATION SYSTEMS - A hybrid photovoltaic panel-interfaced solar-greenhouse distillation technology is provided that is capable of utilizing solar waste heat to perform liquid distillation while co-generating solar electricity. Solar waste heat co-generated at a photovoltaic panel is effectively utilized by in situ distillation liquid as an immediate heat sink in thermo contact with the photovoltaic panel front surface, thus providing beneficial cooling of the photovoltaic panel and co-making of distillation products while generating electricity with significant improvement on total-process solar energy utilization efficiency. Its enabled beneficial utilization of waste heat can provide a series of distillation-related products such as: freshwater, sea salts, distilled water, hot water, hot steam, saline/brine products, and brine photobiological cultures for production of advanced biofuels and bioproducts, in addition to solar electricity. | 05-26-2011 |
| 20110177571 | DESIGNER CALVIN-CYCLE-CHANNELED PRODUCTION OF BUTANOL AND RELATED HIGHER ALCOHOLS - Designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathways, the associated designer genes and designer transgenic photosynthetic organisms for photobiological production of butanol and related higher alcohols from carbon dioxide and water are provided. The butanol and related higher alcohols include 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer photosynthetic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathway gene(s) and biosafety-guarding technology for enhanced photobiological production of butanol and related higher alcohols from carbon dioxide and water. | 07-21-2011 |
| 20110256613 | Designer proton-channel transgenic algae for photobiological hydrogen production - A designer proton-channel transgenic alga for photobiological hydrogen production that is specifically designed for production of molecular hydrogen (H | 10-20-2011 |
Jerry S.h. Lee, Bethesda, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100317537 | BIOPHYSICAL PARAMETERS FOR SYSTEMS BIOLOGY - The invention relates to apparatus and methods for studying intracellular rheology. The invention further relates to use of such apparatus and methods to screen for potentially therapeutic molecules that give rise to rheological effects within a cell. As one example, the disclosed ballistic intracellular nanorheology (BIN) apparatus and methods may be employed in a high-throughput screen to identify mediators or inhibitors of the cytoskeletal modifications involved in cancer metastasis. | 12-16-2010 |
Jia-Hai Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100262436 | MEDICAL INFORMATION SYSTEM FOR COST-EFFECTIVE MANAGEMENT OF HEALTH CARE - The invention is to solve the high cost problems in the current health care system and to increase efficiency and quality of medical care service by using an integrated medical information management system. The invention allows users or patients to manage their own medical information worldwide in a portable device to enhance medication adherence and self-management of personalized health care. A multi-functional medical information center is developed to manage medical information received from various resources to satisfy stakeholders by improving the efficacy, accuracy, and quality of health care information, but simultaneously operated at a cost-effective manner for stakeholders. In addition, the quality control of medical data management will be guarded by a side-by-side comparison technology to warn inconsistent information in medical billing history to prevent medical insurance fraudulent claims. The invention also makes the medical billing system more transparent and patients can find their desired medical doctors, preferred insurance policy, and price comparison of medical products at ease. | 10-14-2010 |
Jihun Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110224404 | METHOD FOR DEVELOPMENT OF A PEPTIDE BUILDING BLOCK USEFUL FOR DE NOVO PROTEIN DESIGN - The present invention relates to a top-down symmetric deconstruction approach which provides a novel alternative means to successfully identify a useful polypeptide “building block” for subsequent “bottom-up” de novo design of target protein architecture. The present invention also pertains to a novel peptides isolated by top-down symmetric deconstruction which may be useful for design or directed evolution of novel proteins with novel functionalities. | 09-15-2011 |
Kang Taek Lee, Greenbelt, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110200910 | ADVANCED MATERIALS AND DESIGN FOR LOW TEMPERATURE SOFCS - Embodiments of the invention are directed to SOFC with a multilayer structure comprising a porous ceramic cathode, optionally a cathodic triple phase boundary layer, a bilayer electrolyte comprising a cerium oxide comprising layer and a bismuth oxide comprising layer, an anion functional layer, and a porous ceramic anode with electrical interconnects, wherein the SOFC displays a very high power density at temperatures below 700° C. with hydrogen or hydrocarbon fuels. The low temperature conversion of chemical energy to electrical energy allows the fabrication of the fuel cells using stainless steel or other metal alloys rather than ceramic conductive oxides as the interconnects. | 08-18-2011 |
Kwan Hee Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080226611 | Gene Therapy Using TGF-beta - The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF-β cDNA expression vectors into fibroblasts (NIH 3T3-TGF-β1), the cells were injected into rabbit achilles tendon and knee joints with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to simulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen. | 09-18-2008 |
| 20080279832 | OSTEOGENIC DIFFERENTIATION OF PREOSTEOBLASTIC CELLS - The application discloses a method for making bone at a bone defect site which includes generating a member of a transforming growth factor superfamily of proteins; generating a population of cultured connective tissue cells that may contain a vector encoding a gene, or a population of cultured connective tissue cells that do not contain any vector encoding a gene; and transferring the protein and the connective tissue cells of to the bone defect site, and allowing the bone defect site to make the bone. | 11-13-2008 |
| 20090238806 | TREATMENT OF INTERVERTEBRAL DISC DEGENERATION - The present application discloses a method for preventing or retarding degeneration of intervertebral disc at an intervertebral disc defect site, which includes injecting a mammalian connective tissue cell into the intervertebral disc defect site. | 09-24-2009 |
| 20100316612 | PRIMED CELL THERAPY - The subject invention is directed to a composition comprising primed connective tissue cells and a pharmaceutically acceptable carrier thereof. | 12-16-2010 |
| 20110229445 | METHOD FOR HEALING BONE FRACTURE USING TRANSFECTED CHONDROCYTES - The application discloses a method for making bone at a bone defect site for a person suffering from low bone mass which includes inserting a gene encoding a protein having bone regenerating function into a connective tissue cell operably linked to a promoter, and transplanting the mammalian cell into the bone defect site, and allowing the bone defect site to make the bone. | 09-22-2011 |
Kwan Hee Lee, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100055080 | BIOADHESIVE DIRECTED SOMATIC CELL THERAPY - The subject invention is related to a cell-mediated gene therapy treatment using a cell composition that includes bioadhesive material. The bioadhesive material allows targeted and localized delivery of therapeutic somatic cells to the site of interest. | 03-04-2010 |
| 20100330053 | MIXED-CELL GENE THERAPY - The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a gene that is sought to be expressed, and a second population of mammalian cells that have not been transfected or transduced with the gene, wherein endogenously existing forms of the second population of mammalian cells are decreased at the target site, and wherein generation of the therapeutic protein by the first population of mammalian cells at the target site stimulates the second population cells to induce a therapeutic effect. | 12-30-2010 |
Kwan Hyi Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120100560 | DEVICE FOR CAPTURE, ENUMERATION, AND PROFILING OF CIRCULATING TUMOR CELLS - Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. The present invention, in one embodiment, utilizes quantitative profiling, spatial mapping, and multiplexing of cancer biomarkers using functionalized quantum dots. This approach provides highly selective targeting molecular markers for pancreatic cancer with extremely low levels of non-specific binding and provides quantitative spatial information of biomarker distribution on a single cell, which is important since tumors cell populations are inherently heterogeneous. The quantitative measurements (number of molecules per square micron) is validated using flow cytometry and demonstrated using multiplexed quantitative profiling using color-coded quantum dots. | 04-26-2012 |
Kyung S. Lee, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110076693 | METHOD FOR DETECTION AND QUANTIFICATION OF PLK1 EXPRESSION AND ACTIVITY - Isolated peptide substrates of Plk1 and nucleic acids encoding these peptides are disclosed. The peptides include two to ten repeats of the amino acid sequence set forth as X | 03-31-2011 |
| 20120065146 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE - Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plk1. Further provided herein are methods for use of the compounds for the treatment of hyperproliferative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament. | 03-15-2012 |
Lynn Lee, Edgewater, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110071873 | Method and apparatus for mitigating aviation risk by analyzing and modeling air crew fatigue - Apparatus and method for analyzing and managing fatigue primarily in aviation occupations. The invention is adaptable to other occupations where assuring crew rest is critical. Air crew specific graphical user interfaces (GUIs) allow for the insertion of sleep into crew work schedules. Alternative sleep models are used for different modes of sleep. The invention produces as an output work/sleep schedules with an associated effectiveness determination. | 03-24-2011 |
| 20120029971 | Method and apparatus for risk identification and mitigation in shift work fatigue - Method and apparatus for shift work scheduling based upon an optimization of analyzing and managing fatigue primarily in but not limited to aviation occupations. The invention matches workers to shifts in a manner that minimizes fatigue while on shift and maximizes shift worker effectiveness. The invention is adaptable to other occupations where assuring shift work crew rest is critical. Graphical user interfaces (GUIs) allow for the insertion of sleep into crew shift work schedules. Alternative sleep models are used for different modes of sleep. The invention produces as an output an optimized shift work/sleep schedules with an associated effectiveness determination. | 02-02-2012 |
| 20120065893 | Method and apparatus for mitigating aviation risk by determining cognitive effectiveness from sleep history - Method and apparatus for analyzing and managing fatigue primarily in but not limited to aviation occupations. The invention is adaptable to other occupations where assuring crew rest is critical. Graphical user interfaces (GUIs) allow for the insertion of sleep quantity, quality, and sleep interruptions over a number of days. The invention produces as an output the user's cognitive effectiveness ranging from high levels to critically low levels over a period of days. | 03-15-2012 |
Martin N. Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120197232 | METHODS AND DEVICES FOR AUTOFLUSH SYRINGES - Described herein are syringe devices, systems and methods. In general, the syringe may include a first chamber and a cartridge movable within the first chamber. The cartridge may include a cartridge chamber and a valve in fluid communication with the cartridge chamber and the first chamber and having an open configuration and a closed configuration. The valve may allow movement of a liquid out of the cartridge chamber while in a open configuration. The cartridge may also include a second end, movable within the cartridge chamber, and a locking mechanism having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration. | 08-02-2012 |
Min-Jung Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100041617 | Modulating mxa expression - The invention provides compositions and methods for inhibiting cell motility, metastatic cancer and viral infections in a mammal that involve increasing the activity or expression of MxA. | 02-18-2010 |
Norman H. Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080317754 | Human Osteoclast Derived Cathepsin - Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases. | 12-25-2008 |
Peng Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110033059 | METHOD AND SYSTEM FOR REDUCING ECHO AND NOISE IN A VEHICLE PASSENGER COMPARTMENT ENVIRONMENT - An echo cancelling algorithm in a communication device initializes a step size value used in an adaptive echo filter based on a background noise signal power level relative to a power level of a received signal and a power level of an echo estimate relative to an output of an echo canceller. The algorithm then adjusts the step size value. One aspect adjusts the step size based on the detection of large fast fourier transform values at one, or more, disturbing-signal frequencies. Another aspect estimates residual echo energy to adjust an estimated echo energy, which then is used to set a double talk flag if a transmit signal has much more power than the estimated echo signal. Another aspect compares transmit signal power to a decimated version of the transmit signal power and sets the double talk flag if the former exceeds the latter by a predetermined amount. | 02-10-2011 |
Reiko Takasaka Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110077386 | NOVEL LIVER-TARGETING AGENTS AND THEIR SYNTHESIS - This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in N | 03-31-2011 |
| 20110097264 | RADIOLABELING METHOD USING MULTIVALENT GLYCOLIGANDS AS HEPATIC RECEPTOR IMAGING AGENT - A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent is provided. The multivalent glycoligand-DTPA derivatives (In-111-DTPA-hexa lactoside and In-111-DTPA-tri-galactosamine glycoside) labeled with In-111 are used as hepatic receptor imaging agent. The effects of imaging of a hepatic receptor in different species are evaluated, the lowest specific radioactivity values of hepatic receptor imaging required in different species are discovered. Since the specificity of the human ASGPR closely resembles that of the mouse. This kind of radiolabelling method, agent and related study about specific radioactivity could be used in clinical trial in the future. | 04-28-2011 |
| 20110097265 | QUANTIFICATION METHOD FOR REMAINING LIVER FUNCTION AND NOVEL LIVER RECEPTOR IMAGING AGENT - A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed. | 04-28-2011 |
Ross A. Lee, Chesapeake City, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080220192 | MULTILAYER STRUCTURES OF POLY(1,3 PROPYLENE 2,6-NAPHTHALATE) AND POLY(ETHYLENE TEREPHTHALATE) - Multilayer shaped articles, including films, preforms and containers, and method for forming the same, having at least one layer of poly(l, 3-propylene 2,6-naphthalate) and at least one layer of poly(ethylene terephthalate). Poly(1,3-propylene 2,6-naphthalate) can be co-stretched with poly(ethylene terephthalate) to form oriented multilayer structures which have superior barrier properties. The poly(l,3-propylene 2,6-naphthalate) and poly(ethylene terephthalate) layers have good adhesion and do not require an adhesive tie layer. | 09-11-2008 |
Sang Bok Lee, Clarksville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090108252 | Lateral two-terminal nanotube devices and method for their formation - An apparatus, system, and method are provided for a lateral two-terminal nanotube device configured to capture and generate energy, to store electrical energy, and to integrate these functions with power management circuitry. The lateral nanotube device can include a substrate, an anodic oxide material disposed on the substrate, and a column disposed in the anodic oxide material extending from one distal end of the anodic oxide material to another end of the anodic oxide material. The lateral nanotube device further can include a first material disposed within the column, and a second material disposed within the column. The first material fills a distal end of the column and gradiently decreases towards another distal end of the column along inner walls of the column. The second material fills the another distal end of the column and gradiently decreases towards the distal end of the column within the first material. | 04-30-2009 |
| 20100266897 | High-Powered Electrochemical Energy Storage Devices and Methods for Their Fabrication - The present invention relates to electrochemical storage devices, such as supercapacitors, batteries, etc., and more particularly to such devices that comprise an electrochemically active coaxial nanowire. The invention particularly concerns such devices in which the coaxial nanowire comprises an inner core of a transition metal oxide and an axially surrounding outer shell composed of an electroconductive organic polymer, such as poly(3,4-ethylenedioxythiophene) (PEDOT). The invention particularly relates to a facile method for achieving the self-assembly of such coaxial nanowires. | 10-21-2010 |
| 20110073827 | NANODEVICE ARRAYS FOR ELECTRICAL ENERGY STORAGE, CAPTURE AND MANAGEMENT AND METHOD FOR THEIR FORMATION - An apparatus, system, and method are provided for a vertical two-terminal nanotube device configured to capture and generate energy, to store electrical energy, and to integrate these functions with power management circuitry. The vertical nanotube device can include a column disposed in an anodic oxide material extending from a first distal end of the anodic oxide material to a second distal end of the anodic oxide material. Further, the vertical nanotube device can include a first material disposed within the column, a second material disposed within the column, and a third material disposed between the first material and the second material. The first material fills the first distal end of the column and extends to the second distal end of the column along inner walls of the column. The second material fills the first distal end of the column and extends to the second distal end of the column within the first material. Both the first material and the second material are exposed at the first distal end of the column. | 03-31-2011 |
Sang Bong Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100254899 | RADIOLABELED AFFIBODY MOLECULES - The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from | 10-07-2010 |
Sean Lee, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090320069 | METHOD AND SYSTEM FOR ELECTRONIC PROGRAM GUIDE TEMPORAL CONTENT ORGANIZATION - A method and system which temporally sorts data such as program guide data for example, to ensure that near-term data (i.e. most likely to be used, or “now data”) is always available for rapid access from a physical memory location such as a high-speed temporal cache. The method incorporates two low-priority background processes or algorithms, termed “event horizons” into the storage and manipulation of the data so that applications using the data may be run without having to always access a mass storage device. The method and system are highly applicable to all set top boxes (STBs) used in various communication systems such as satellite communication, Cable-TV and DVB systems. The method and system are economical in that superior STB and/or system performance may be obtained with the inclusion of lesser amounts of expensive high-speed RAM. | 12-24-2009 |
Sean S. Lee, Potomac, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120192237 | METHOD AND APPARATUS FOR PROVIDING PREAUTHORIZATION FOR A MOBILE RECEIVING DEVICE TO ACCESS WIRELESS NETWORKS - A mobile wireless system includes a transmitter such as a satellite that broadcasts wireless signals such as boundaries for wireless networks to a mobile receiving device. Mobile receiving device may include an antenna. A locating receiver is used to generate locating signals so that a determination may be made to the location of the mobile receiving device. Preauthorizations may be obtained to allow the mobile receiving device to communicate back to business controller to enable functions such as pay-per-view or on-demand, interactive television, gaming, and the like. The preauthorizations enable access to various wireless networks as the mobile receiving device moves. | 07-26-2012 |
Sung Lee, College Park, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100023755 | METHOD AND APPARATUS FOR SECURE INFORMATION TRANSFER TO SUPPORT MIGRATION - A system and method are disclosed for providing and maintaining a high level of security during migration of data from one platform to another. The disclosed system combines user and equipment authentication with equipment environment authorization guaranteed by a security module such as supported by a trusted platform module (TPM) in parallel, for secure information transfer to support migration between platforms. | 01-28-2010 |
Sunmin Lee, Boyds, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100041617 | Modulating mxa expression - The invention provides compositions and methods for inhibiting cell motility, metastatic cancer and viral infections in a mammal that involve increasing the activity or expression of MxA. | 02-18-2010 |
Taeyong Lee, Frederick, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120078773 | Method and System for Calculating an Intraday Indicative Value of Leveraged Bullish and Bearish Exchange Traded Funds - A computer implemented method, system, and software for calculating and using an intraday indicative value of a leveraged Bullish or Bearish exchange traded fund (“ETF”) for arbitrage purposes, includes calculating an intraday current value of all the equity securities in the ETF (applicable only to Bullish ETFs), calculating mark to market gains or losses of at least one derivative product, and retrieving an accumulated loss or gain of the at least one derivative product and other cash equivalent amounts. The intraday indicative value of the ETF is determined by combining the calculated intraday current value of all the equity securities (applicable only to Bullish ETFs), the accumulated loss or gain, the mark to market gains of the at least one derivative product and other cash equivalent amounts. The determined intraday value of the ETF is used, by a party, for arbitrage purposes. | 03-29-2012 |
| 20120078774 | Method and System for Calculating an Intraday Indicative Value of Leveraged Bullish and Bearish Exchange Traded Funds - A computer implemented method, system, and software for calculating and using an intraday indicative value of a leveraged Bullish or Bearish exchange traded fund (“ETF”) for arbitrage purposes, includes calculating an intraday current value of all the equity securities in the ETF (applicable only to Bullish ETFs), calculating mark to market gains or losses of at least one derivative product, and retrieving an accumulated loss or gain of the at least one derivative product and other cash equivalent amounts. The intraday indicative value of the ETF is determined by combining the calculated intraday current value of all the equity securities (applicable only to Bullish ETFs), the accumulated loss or gain, the mark to market gains of the at least one derivative product and other cash equivalent amounts. The determined intraday value of the ETF is used, by a party, for arbitrage purposes. | 03-29-2012 |
William Jeremy Lee, Crownsville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100124330 | Secure transmission over satellite phone network - A reach back secure communications terminal includes a modem to satellite interconnect board that captures DTMF tones, demodulates encrypted modem information, and converts both into an ASCII string for presentation to a data port of a satellite phone, allowing out-of-band control of a non-secure satellite system (e.g., AT command control of a data port) by a user on a secure side of an encryption device, by including the ability to interpret control signals and control the satellite system appropriately. A false dial tone is presented to the encryption device, and the data stream coming from the encryption device is monitored for the presence of dual-tone, multi-frequency (DTMF) tones representing control signals, the DTMF tones are converted to ASCII characters, which are in turn received as control signals by the satellite phone, allowing control of the functions of the satellite system directly from the secure side of the encryption device. | 05-20-2010 |
| 20110237247 | Secure transmission over satellite phone network - A reach back secure communications terminal includes a modem to satellite interconnect board that captures DTMF tones, demodulates encrypted modem information, and converts both into an ASCII string for presentation to a data port of a satellite phone, allowing out-of-band control of a non-secure satellite system (e.g., AT command control of a data port) by a user on a secure side of an encryption device, by including the ability to interpret control signals and control the satellite system appropriately. A false dial tone is presented to the encryption device, and the data stream coming from the encryption device is monitored for the presence of dual-tone, multi-frequency (DTMF) tones representing control signals, the DTMF tones are converted to ASCII characters, which are in turn received as control signals by the satellite phone, allowing control of the functions of the satellite system directly from the secure side of the encryption device. | 09-29-2011 |
Yikloon Lee, Leonardtown, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110196906 | Simple and Fast Method to Find Inside Points - A commonly recurring computational geometry problem in many diverse science and engineering disciplines is to determine if a point is inside an enclosed body. Usually this needs to be solved for a very large set of points. Many algorithms for different applications have been proposed. But fundamentally, they are all based on the same underlying strategy of focusing solely on the 2D body surface as the defining boundary. For a general solution, these traditional algorithms remain very complex and computationally costly. A new concept for a simple and efficient approach not specifically tied to any application is described here. | 08-11-2011 |
Young B. Lee, Clarksburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20090030021 | Quinazoline Derivatives and Therapeutic Use Thereof - Quinazoline derivatives represented by the general formula | 01-29-2009 |
| 20090270358 | PHARMACEUTICAL FORMULATION OF CLAVULANIC ACID - The present invention generally relates to stable pharmaceutical compositions, and methods of making and administering such compositions. In one aspect, the invention features stabilized pharmaceutical compositions that include pharmaceutically active ingredients such as potassium clavulanate or Clavitesse™, preferably in an immediate-release solid dosage form or an extended-release solid dosage form. Also provided are methods for making and using such immediate-release and stabilized compositions or extended-release and stabilized compositions. | 10-29-2009 |
| 20100099644 | HPMA - DOCETAXEL OR GEMCITABINE CONJUGATES AND USES THEREFORE - Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer. | 04-22-2010 |
| 20100255099 | CLAVULANATE FORMULATION FOR NEUROPROTECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS - The present invention generally relates to use of a stable solid pharmaceutical compositions that includes a clavulanate as the pharmaceutically active ingredients in an immediate-release or an extended-release solid dosage form. The composition can be used in a method of treating a neurodegenerative disease, providing neuroprotection, or preventing neuronal cell loss or death. Exemplary neurodegenerative diseases include Parkinson's disease, Alzheimer's disease and multiple sclerosis. | 10-07-2010 |
| 20110086111 | POLYMERIC SYSTEMS FOR THE DELIVERY OF ANTICANCER DRUGS - The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer units derived from one or more of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(2-aminopropyl)methacrylamide (2-APMA) and/or N-(3-aminopropyl)methacrylamide (3-APMA) are also included. Anticancer agents in compositions can be attached to said polymeric carrier by side-chains which can be susceptible to hydrolysis by lysosomal enzymes intracellularly. Compositions can also include a targeting ligand attached to the polymeric carrier, optionally through a second linker. | 04-14-2011 |
Young B. Lee, Clarksville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20120029012 | 5, 6, or 7-SUBSTITUTED -3-(HETERO) ARYLISOQUINOLINAMINE DERIVATIVES AND THERAPEUTIC USE THEREOF - The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included. | 02-02-2012 |
Young Bok Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080318963 | 1-[6,7-Substituted Alkoxyquinoxalinyl) Aminocarbonyl]-4-(Hetero) Arylpiperazine Derivatives - The present invention relates to novel quinoxaline-piperazine compounds, 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives and their pharmaceutically acceptable salts, a process for their preparation thereof, and compositions containing such compounds. Therapeutic methods for the treatment of hyperproliferative disorders, including cancers, by administering quinoxalin-piperazine compounds are also included. | 12-25-2008 |
Young Jong Lee, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20100110426 | METHOD FOR NRB-FREE NONLINEAR VIBRATIONAL SPECTROSCOPY AND MISCROSCOPY - Methods and systems are described for suppressing nonresonant background in broadband coherent anti-Stokes Raman scattering (CARS) microscopy and spectroscopy. The methods and systems improve sensitivity and signal to noise ratio in CARS. | 05-06-2010 |
Yuan C. Lee, Timonium, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110229931 | Engineering intracellular sialylation pathways - Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bioinformatics to identify gene sequences for critical processing enzymes. The compositions comprise cells of interest producing sialylated glycoproteins. The methods and compositions are useful for heterologous expression of glycoproteins. | 09-22-2011 |
Yuan C. Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080207532 | Use of Nordihydroguaiaretic Acid Derivatives in the Treatment of Drug Resistant Cancer, Viral and Microbial Infection - Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections. | 08-28-2008 |
Yuan-Chuan Lee, Baltimore, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110077386 | NOVEL LIVER-TARGETING AGENTS AND THEIR SYNTHESIS - This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in N | 03-31-2011 |
| 20110097264 | RADIOLABELING METHOD USING MULTIVALENT GLYCOLIGANDS AS HEPATIC RECEPTOR IMAGING AGENT - A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent is provided. The multivalent glycoligand-DTPA derivatives (In-111-DTPA-hexa lactoside and In-111-DTPA-tri-galactosamine glycoside) labeled with In-111 are used as hepatic receptor imaging agent. The effects of imaging of a hepatic receptor in different species are evaluated, the lowest specific radioactivity values of hepatic receptor imaging required in different species are discovered. Since the specificity of the human ASGPR closely resembles that of the mouse. This kind of radiolabelling method, agent and related study about specific radioactivity could be used in clinical trial in the future. | 04-28-2011 |
| 20110097265 | QUANTIFICATION METHOD FOR REMAINING LIVER FUNCTION AND NOVEL LIVER RECEPTOR IMAGING AGENT - A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed. | 04-28-2011 |
Yun-Han Lee, Rockville, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110178155 | SILENCING OF CSN5 GENE EXPRESSION USING INTERFERING RNA - The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles. | 07-21-2011 |