Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Lee, MA

Aaron Lee, Jamaica Plain, MA US

Patent application numberDescriptionPublished
20100106356Control and systems for autonomously driven vehicles - A navigation and control system including one or more position sensors configured to generate position signals indicative of the location and heading of a vehicle. The system includes one or more operation control mechanisms having inputs and producing outputs which control an operation of the vehicle and includes a self-contained autonomous controller disposed remote from the operation control mechanisms. The autonomous controller includes a processor configured to receive the position signals from the position sensors and to generate operation control signals defining an updated travel path for the vehicle, and a programmable interface providing communication among the position sensors, the operation control mechanisms, and the processor. The programmable interface is configured to normalize inputs to the processor from the position sensors and to generate compatible operation control signals applied as the inputs to the operation control mechanisms, whereby the self-contained autonomous controller is configurable for operation with a variety of different sensors and different operation control mechanisms.04-29-2010

Ann-Hwee Lee, Chestnut Hill, MA US

Patent application numberDescriptionPublished
20090232738Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity - The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal transduction pathway involving XBP-1 to treat dyslipidemias and steatosis disorders. The present invention also pertains to methods for identifying compounds that modulate the expression, processing, post-translational modification, and/or activity of XBP-1 protein or a molecule in a signal transduction pathway involving XBP-1.09-17-2009
20110052669METHODS FOR MODULATING DE NOVO HEPATIC LIPOGENESIS BY MODULATING XBP-1 ACTIVITY - The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal transduction pathway involving XBP-I to treat dyslipidemias and steatosis disorders. The present invention also pertains to methods for identifying compounds that modulate the expression, processing, post-translational modification, and/or activity of XBP-I protein or a molecule in a signal transduction pathway involving XBP-1.03-03-2011

Ben Lee, Hudson, MA US

Patent application numberDescriptionPublished
20100299195SYSTEMS AND METHODS FOR IMPLEMENTING FINANCIAL TRANSACTIONS - A payment processing system to provide merchant-specific accounts to consumers that are accessed by payment instruments. In one embodiment, the payment processing system can create and provide a variety of payment methodologies for purchases, such as pay-as-you-go, virtual prepaid, virtual subscription, and post-paid purchases. The merchant may, in some embodiments provide consumers with merchant rewards accounts and an opportunity to earn reward points or other loyalty-based currencies through qualifying purchase transactions. The consumer may access their merchant-specific accounts for purchase payment using a preferred payment instrument, such as a credit or debit card.11-25-2010

Brian Seungwhan Lee, Boston, MA US

Patent application numberDescriptionPublished
20110194337Non-Volatile Memory Cell With Precessional Switching - A method and apparatus for writing data to a non-volatile memory cell, such as a spin-torque transfer random access memory (STRAM) memory cell. In some embodiments, a selected resistive state is written to a magnetic tunneling structure by applying a succession of indeterminate write pulses thereto until the selected resistive state is verified.08-11-2011

Bryant Christopher Lee, Cambridge, MA US

Patent application numberDescriptionPublished
20110191317Method for Human Editing of Information in Search Results - A search engine may perform a search for a user search query. Result items may be returned as a result of the search. The user may enter new human edited information for some of the result items. The new human edited information may be displayed when other users search and view some of the result items at a later time.08-04-2011
20110191327Method for Human Ranking of Search Results - A search engine may perform a search for a user search query. A rankings of result items may be returned as a result of the search. The user may enter new suggested rankings for some of the items. The new suggested rankings may change the rankings of result items when other users search for the same search query at a later time.08-04-2011
20120079267Securing Locally Stored Web-based Database Data - The present invention extends to methods, systems, and computer program products for locally storing Web-based database data in a secure manner. Embodiments of the present invention permit Web-based database data to be locally stored at a computer system to increase the efficiency of rendering the Web-based database data within a Web browser at the computer system. Web-based database data can be sandboxed per domain to mitigate (and possibly eliminate) the exposure of the Web-based database data to malicious computer systems. A web server may be required to authenticate itself before it may present database data to be locally stored at a computer system. A web server may be required to authenticate itself before being allowed to access database data stored locally at a computer system.03-29-2012

Calvin Lee, Needham, MA US

Patent application numberDescriptionPublished
20110290944Concentric Peripheral Canopy Parachute - A concentric peripheral canopy parachute having a canopy system including a number of peripheral, stacked, concentric, canopies, each superior canopy centered and spaced above the inferior canopy and having its skirt connected to the vent of the inferior canopy for generating an increased low pressure disturbance behind the canopy system for producing higher fluid drag.12-01-2011

Cameron Lee, Cambridge, MA US

Patent application numberDescriptionPublished
20110200582LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM - Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I).08-18-2011

Chao Young Lee, Weston, MA US

Patent application numberDescriptionPublished
20110307276Context Management Systems and Methods in a Mobile Computing Framework For Enterprise Applications - A framework for a handheld computing device comprising a user interface that: (1) controls the display, selection and launching of program modules; (2) controls patient context within the program modules; and (3) provides for messaging and sharing of databases between and among program modules. In various embodiments, databases are shared between the program modules by the publishing of XML and metadata identifying the structure of the databases.12-15-2011

Charles Lee, Marlborough, MA US

Patent application numberDescriptionPublished
20110034677RECURRENT GENE FUSIONS IN PROSTATE CANCER - Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.02-10-2011
20110110923FISH ASSAY FOR EML4 AND ALK FUSION IN LUNG CANCER - Methods and compositions provided relate to conducting a FISH assay for detecting a chromosomal inversion between EML4 and ALK. The FISH assay described herein is useful for diagnostic and prognostic purposes, as well as for determination of therapeutic strategies.05-12-2011

Charles Ching Lee, Ashland, MA US

Patent application numberDescriptionPublished
20080229415SYSTEMS AND METHODS FOR PROCESSING DATA FLOWS - A flow processing facility, which uses a set of artificial neurons for pattern recognition, such as a self-organizing map, in order to provide security and protection to a computer or computer system supports unified threat management based at least in part on patterns relevant to a variety of types of threats that relate to computer systems, including computer networks. Flow processing for switching, security, and other network applications, including a facility that processes a data flow to address patterns relevant to a variety of conditions are directed at internal network security, virtualization, and web connection security. A flow processing facility for inspecting payloads of network traffic packets detects security threats and intrusions across accessible layers of the IP-stack by applying content matching and behavioral anomaly detection techniques based on regular expression matching and self-organizing maps. Exposing threats and intrusions within packet payload at or near real-time rates enhances network security from both external and internal sources while ensuring security policy is rigorously applied to data and system resources. Intrusion Detection and Protection (IDP) is provided by a flow processing facility that processes a data flow to address patterns relevant to a variety of types of network and data integrity threats that relate to computer systems, including computer networks.09-18-2008
20080262990SYSTEMS AND METHODS FOR PROCESSING DATA FLOWS - A flow processing facility, which uses a set of artificial neurons for pattern recognition, such as a self-organizing map, in order to provide security and protection to a computer or computer system supports unified threat management based at least in part on patterns relevant to a variety of types of threats that relate to computer systems, including computer networks. Flow processing for switching, security, and other network applications, including a facility that processes a data flow to address patterns relevant to a variety of conditions are directed at internal network security, virtualization, and web connection security. A flow processing facility for inspecting payloads of network traffic packets detects security threats and intrusions across accessible layers of the IP-stack by applying content matching and behavioral anomaly detection techniques based on regular expression matching and self-organizing maps. Exposing threats and intrusions within packet payload at or near real-time rates enhances network security from both external and internal sources while ensuring security policy is rigorously applied to data and system resources. Intrusion Detection and Protection (IDP) is provided by a flow processing facility that processes a data flow to address patterns relevant to a variety of types of network and data integrity threats that relate to computer systems, including computer networks.10-23-2008
20080262991SYSTEMS AND METHODS FOR PROCESSING DATA FLOWS - A flow processing facility, which uses a set of artificial neurons for pattern recognition, such as a self-organizing map, in order to provide security and protection to a computer or computer system supports unified threat management based at least in part on patterns relevant to a variety of types of threats that relate to computer systems, including computer networks. Flow processing for switching, security, and other network applications, including a facility that processes a data flow to address patterns relevant to a variety of conditions are directed at internal network security, virtualization, and web connection security. A flow processing facility for inspecting payloads of network traffic packets detects security threats and intrusions across accessible layers of the IP-stack by applying content matching and behavioral anomaly detection techniques based on regular expression matching and self-organizing maps. Exposing threats and intrusions within packet payload at or near real-time rates enhances network security from both external and internal sources while ensuring security policy is rigorously applied to data and system resources. Intrusion Detection and Protection (IDP) is provided by a flow processing facility that processes a data flow to address patterns relevant to a variety of types of network and data integrity threats that relate to computer systems, including computer networks.10-23-2008
20120017262SYSTEMS AND METHODS FOR PROCESSING DATA FLOWS - A flow processing facility, which uses a set of artificial neurons for pattern recognition, such as a self-organizing map, in order to provide security and protection to a computer or computer system supports unified threat management based at least in part on patterns relevant to a variety of types of threats that relate to computer systems, including computer networks. Flow processing for switching, security, and other network applications, including a facility that processes a data flow to address patterns relevant to a variety of conditions are directed at internal network security, virtualization, and web connection security. A flow processing facility for inspecting payloads of network traffic packets detects security threats and intrusions across accessible layers of the IP-stack by applying content matching and behavioral anomaly detection techniques based on regular expression matching and self-organizing maps. Exposing threats and intrusions within packet payload at or near real-time rates enhances network security from both external and internal sources while ensuring security policy is rigorously applied to data and system resources. Intrusion Detection and Protection (IDP) is provided by a flow processing facility that processes a data flow to address patterns relevant to a variety of types of network and data integrity threats that relate to computer systems, including computer networks.01-19-2012

Patent applications by Charles Ching Lee, Ashland, MA US

Chee-Seng Lee, Somerville, MA US

Patent application numberDescriptionPublished
20110152235Aminopyrimidine Kinase Inhibitors - Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.06-23-2011

Chi-Wan Lee, Grafton, MA US

Patent application numberDescriptionPublished
20100298331TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS - The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.11-25-2010
20110009397TRIAZONE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.01-13-2011
20110105749TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.05-05-2011

Patent applications by Chi-Wan Lee, Grafton, MA US

Chunghsin Lee, Lynnfield, MA US

Patent application numberDescriptionPublished
20110053368Arrangement for solder bump formation on wafers - An apparatus and a process for the manufacture of a solder-bump adhered wafer substrate for use in the semiconductor industry, comprising one or more of the following steps including: arranging a first compressive member and a second compressive member in an opposed, compressibly displaceable, spaced-apart relationship, with a pattern plate disposed therebetween with the pattern plate having a plurality of aligned through-holes arranged thereon; filling the through-holes with a molten solder; compressing the solder and the pattern plate between the first and second opposed compressive members to compact the solder therein and cleans the pattern plate of excess solder; chilling the pattern plate to solidify the molten solder in the through-holes; and removing the pattern plate from the spaced-apart compressive members to produce a wafer with solder bumps thereon.03-03-2011
20110215483Flux-free chip to substrate joint serial linear thermal processor arrangement - A linear, serial chip/substrate assembly processing machine for stepwise advancing a pre-assembled chip/die substrate on a support plate through a series of sealable chambers beginning at a loading station and ending up at an unloading station after various melting and vacuuming of chip/substrate components has been stepwise indexed through those various chambers to the final joining thereof.09-08-2011

Patent applications by Chunghsin Lee, Lynnfield, MA US

Cynthia K. Lee, Needham, MA US

Patent application numberDescriptionPublished
20110287519HIGH YIELD YELLOW FEVER VIRUS STRAIN WITH INCREASED PROPAGATION IN CELLS - The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.11-24-2011

Daeyeon Lee, Lexington, MA US

Patent application numberDescriptionPublished
20110116993Virus/Nanowire Encapsulation within Polymer Microgels for 2D and 3D Devices for Energy and Electronics - Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices.05-19-2011

Daeyeon Lee, Somerville, MA US

Patent application numberDescriptionPublished
20100239824Metal Oxide Coating On Surfaces - The present invention provides a method for coating metal oxide on a PDMS surface. The method includes preparing a mixture that contains a sol-gel precursor, reacting the mixture to form a preconverted sol-gel precursor, where the preconverted sol-gel precursor does not diffuse into PDMS and is not in the form of a gel, forming a reactive PDMS surface, applying the preconverted sol-gel precursor onto the reactive PDMS surface, binding the preconverted sol-gel precursor to the re-active PDMS surface, and converting the bound preconverted sol-gel precursor to a metal oxide to form a metal oxide coating on the PDMS surface. The present invention also provides a PDMS microfluidic device where one or more channels of the microfluidic device is provided with a metal oxide coating covalently bound only on the surface of the one or more channels.09-23-2010

David S. Lee, Wenham, MA US

Patent application numberDescriptionPublished
20100125000GOLF CLUB HEAD OR OTHER BALL STRIKING DEVICE HAVING MULTI-PIECE CONSTRUCTION - A ball striking device has a head that includes a metal face configured for striking a ball, a rearwardly extending metal band, a top piece, and a bottom piece. The metal band has a first end extending from one side of the face, a second end extending from the opposite side of the face, and a rear portion extending between the first and second ends and defining at least a portion of the rear periphery of the head. The top piece and the bottom piece are non-metallic or substantially non-metallic. The top piece is connected to the top side of the metal band and forms at least a portion of a top side of the head, and the bottom piece is connected to the bottom side of the metal band and forms at least a portion of a bottom side of the head. The top piece and the bottom piece are separated by the metal band.05-20-2010
20100248852Golf Club Head and Head Cover Combination Providing Enhanced Functionality - A golf club head has structure for assisting a golfer, and a head cover has structure for supporting the golfer-assisting structure. In one aspect, the golfer-assisting structure provides a visual indicator, such as an alignment marker, a ball impact indicator, a temperature indicator, or the like. In another aspect, the golfer-assisting structure includes sensor(s) and/or other electronic components for measuring swing characteristics, course conditions, global position, or the like. The supporting structure may provide a source of energy, such as a power source, a light source, or a heat source. In some aspects, the supporting structure may include a processor for receiving data from the golfer-assisting structure, and may transmit data to a display on the head cover and/or to an external source.09-30-2010
20100261538Golf Club Having Hydrophobic And Hydrophilic Portions - A golf club or component thereof has a surface, wherein at least one area of the surface has a level of hydrophilicity which is less than the level of hydrophilicity in at least one surrounding portion, causing moisture to be preferentially attracted to the surrounding portion. In one aspect, the surface is a striking face and the surrounding portion is one or more grooves formed in the striking face. In another aspect, the surface is a grip and the surrounding portion is one or more channels formed in the grip. In some examples, hydrophobic or superhydrophobic surfaces on golf club components repel water and, in some instances, also offer self-cleaning functionality.10-14-2010
20110263350Golf Club Head or Other Ball Striking Device Having Multi-Piece Construction and Method for Manufacturing - A ball striking device has a head that includes a metal face configured for striking a ball, a rearwardly extending metal band, a top piece, and a bottom piece. The metal band has a first end extending from one side of the face, a second end extending from the opposite side of the face, and a rear portion extending between the first and second ends and defining at least a portion of the rear periphery of the head. The top piece and the bottom piece are non-metallic or substantially non-metallic. The top piece is connected to the top side of the metal band and forms at least a portion of a top side of the head, and the bottom piece is connected to the bottom side of the metal band and forms at least a portion of a bottom side of the head. The top piece and the bottom piece are separated by the metal band.10-27-2011

David Yue-Wei Lee, Cambrigde, MA US

Patent application numberDescriptionPublished
20100324131Salvinorin Derivatives and Uses Thereof - The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.12-23-2010

Ditte S. Lee, Cambridge, MA US

Patent application numberDescriptionPublished
20110111393PNA Probes, Mixtures, Methods And Kits Pertaining To The Determination Of Mycoplasma and related Mollicutes - This invention is related to PNA probes, probe sets, mixtures, methods and kits pertaining to the determination of 05-12-2011

Doug Hyun Lee, Amherst, MA US

Patent application numberDescriptionPublished
20100075116SELF-ASSEMBLY OF BLOCK COPOLYMERS ON TOPOGRAPHICALLY PATTERNED POLYMERIC SUBSTRATES - Highly-ordered block copolymer films are prepared by a method that includes forming a polymeric replica of a topographically patterned crystalline surface, forming a block copolymer film on the topographically patterned surface of the polymeric replica, and annealing the block copolymer film. The resulting structures can be used in a variety of different applications, including the fabrication of high density data storage media. The ability to use flexible polymers to form the polymeric replica facilitates industrial-scale processes utilizing the highly-ordered block copolymer films.03-25-2010

Elaine Chungmin Lee, Cambridge, MA US

Patent application numberDescriptionPublished
20110124869Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.05-26-2011
20110251253SOLID FORMS OF (R)-1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6- -FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL) CYCLOPROPANECARBOXAMIDE - The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.10-13-2011

Hae-Seung Lee, Bedford, MA US

Patent application numberDescriptionPublished
20080278358REFERENCE CIRCUITS FOR SAMPLED-DATA CIRCUITS - A switched capacitor circuit includes a first level-crossing detector to generate a level-crossing detection signal when an input signal crosses a first predetermined level. A first waveform generator generates a first predetermined waveform and a second waveform generator generates a second predetermined waveform. A second level-crossing detector generates a second level-crossing detection signal when said second predetermined waveform crosses a voltage reference level a second time. A second switch is coupled to the second level-crossing detector, and a third switch is coupled to the first level-crossing detector. The second switch turns OFF when the second level-crossing detection signal indicates the second predetermined waveform crossed the voltage reference level a second time. The third switch turns OFF when the first level-crossing detection signal indicates the input signal crossed the first predetermined level.11-13-2008
20090267650PASSIVE OFFSET AND OVERSHOOT CANCELLATION FOR SAMPLED-DATA CIRCUITS - A zero-crossing detector with effective offset cancellation includes a set of series connected capacitors and an amplifier having an input terminal. An offset capacitor is operatively connected between the amplifier and the set of series connected capacitors. A switch is operatively connected to the input terminal, and an offset sampling capacitor is operatively connected to the switch. The switch connects the offset sampling capacitor to the input terminal of the amplifier during a charge transfer phase.10-29-2009
20090309635CONSTANT SLOPE RAMP CIRCUITS FOR SAMPLED-DATA CIRCUITS - A circuit includes a level-crossing detector to generate a level-crossing detection signal when an input signal crosses a predetermined voltage level. A first stage set of capacitors is operatively coupled to the level-crossing detector. A ramp circuit is operatively coupled to the set of series-connected capacitors. A second stage set of capacitors is operatively coupled to the first stage set of capacitors and the ramp circuit. The ramp circuit includes a feedback capacitor and a preset switch to provide a linear ramp output.12-17-2009
20110032003OFFSET CANCELLATION FOR SAMPLED-DATA CITCUITS - A comparator based circuit with effective offset cancellation includes first and second amplifiers and an offset capacitor operatively connected to the first and second amplifiers. An offset voltage source generates an offset voltage. A first switch connects the offset voltage source to ground during a first time period. The first amplifier generates an output voltage in response to the first switch connecting the offset voltage source to ground during the first time period. A second switch connects the offset capacitor to ground during a second time period. The first switch disconnects the offset voltage source from ground during a third time period, and the second switch disconnects the offset capacitor from ground during the third time period.02-10-2011

Patent applications by Hae-Seung Lee, Bedford, MA US

Hae-Seung Lee, Lexington, MA US

Patent application numberDescriptionPublished
201101693402-PHASE THRESHOLD DETECTOR BASED CIRCUITS - A switched capacitor circuit includes a threshold detector to generate a threshold detection signal when a difference between first and second input signals crosses a predetermined level. A variable current source produces a varying amount of current in response to the difference between the input signals. A voltage measurement means produce a measurement signal in response to the difference between the input signals. A correction means produces a correction signal in response to the measurement signal to produce an optimum coarse phase overshoot. A timing comparison means produces a timing signal in response to the difference between the input signals. A correction means produces a correction signal in response to the timing signal to produce an optimum coarse phase overshoot.07-14-2011

Hong Myung Lee, Cambridge, MA US

Patent application numberDescriptionPublished
20110190323CORTISTATIN ANALOGUES AND SYNTHESES THEREOF - The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R08-04-2011

Hsin H. Lee, Marlborough, MA US

Patent application numberDescriptionPublished
20120030174DISTRIBUTED SNAPSHOT PROCESS - Systems and methods for providing an efficient partitioned resource server are disclosed. The partitioned resource server includes a plurality of individual servers, and the individual servers support a storage service. The systems and methods provide archiving processes for partitioned resources. To this end, the systems and process include a snapshot process operating on a server and capable of coordinating with other snapshot processes operating on the other servers for generating state information representative of the state of the partitioned resources.02-02-2012

Hyomin Lee, Cambridge, MA US

Patent application numberDescriptionPublished
20120058355Coatings - A hydrophilic coating can be applied to virtually any surface to produce a long-lasting, durable antifog effect. The coating can be biocompatible. The coating includes a molecular-level blend of hydrophilic polymers. The coating can be assembled using a layer-by-layer assembly process.03-08-2012

Jaekyoo Lee, North Andover, MA US

Patent application numberDescriptionPublished
20110269739KINASE INHIBITORS - The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.11-03-2011
20110281841Kinase Inhibitors - The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.11-17-2011

Jae Kyoo Lee, North Andover, MA US

Patent application numberDescriptionPublished
20080260834VITAMIN D3 ANALOG LOADED POLYMER FORMULATIONS FOR CANCER AND NEURODEGENERATIVE DISORDERS - Localized delivery of 1,25 D10-23-2008

James M. Lee, Northborough, MA US

Patent application numberDescriptionPublished
20090240462System and Method for Capturing an Event in MEMS Inertial Sensors - A method of capturing an event in a MEMS accelerometer stores acceleration data in memory, detects a trigger event based on the acceleration data, and modifies a configuration of the memory so that a specified amount of the acceleration data is saved. A MEMS event capturing system includes an inertial sensor having sensor circuitry and event capturing circuitry implemented with the sensor circuitry. The event capturing circuitry includes memory capable of storing acceleration data received from the inertial sensor and a detection module operatively coupled with the memory that detects a trigger event. The event capturing circuitry also includes a management module operatively coupled with the memory and the detection module that modifies the memory's storage configuration when the trigger event is detected.09-24-2009
20090240463Activity Detection in MEMS Accelerometers - A method of detecting activity in a MEMS accelerometer captures an acceleration bias, measures acceleration at a predetermined time, calculates a change in acceleration using the measured acceleration and the acceleration bias, and compares the change in acceleration to a threshold to detect activity. A method of detecting inactivity uses a similar technique along with a timer. The method of detecting inactivity in a MEMS accelerometer captures an acceleration bias, measures acceleration at a predetermined time, calculates a change in acceleration using the measured acceleration and the acceleration bias, and compares the change in acceleration to a threshold to detect inactivity. The method further determines if the change in acceleration is less than the threshold and, if so, determines if a predetermined period of time has elapsed to detect inactivity.09-24-2009
20090293615Management System for MEMS Inertial Sensors - A MEMS system includes an inertial sensor having sensor circuitry and management circuitry implemented with the sensor circuitry. The management circuitry includes a detection module that detects a condition of the system and a management module that coordinates the functionality of the inertial sensor and the detection module based on the detected condition.12-03-2009
20110087454Tap Detection - Methodology and circuitry for determining if a device, such as a cellular phone or personal digital assistant has been tapped is disclosed. The device includes an accelerometer and in response to an acceleration, the accelerometer outputs an acceleration signal. The accelerometer may continuously output an acceleration signal even if no acceleration occurs. A tap detection device receives the temporally sampled acceleration signal and takes the first derivative of the temporally sampled acceleration signal producing one or more derivative values. The tap detection system compares each derivative value to a threshold value and if the derivative value exceeds the threshold a tap is detected. By taking the derivative of the acceleration signal, the noise floor for the acceleration signal is reduced leading to more accurate results with less false positives and less positive negatives.04-14-2011

Janette H. Lee, Everett, MA US

Patent application numberDescriptionPublished
20080239920Wireless transmission of temperature data - An identification input device and a temperature detector that detects body temperature data. The identification input device may be an optical touch pen. The infrared touch pen may be affixed to the temperature detector using a hook and connector or a snap fit connector. In use, the temperature detector computes body temperature data and the identification input device determines an identifier. The identifier is unique to a user. After obtaining the body temperature data and identifier, a transmitter may transmit body temperature data and the identifier over a wireless communications path to a processing unit. By transmitting data over a wireless communications path, an individual's data or a large group of data may be analyzed and viewed via a display unit.10-02-2008
20080262782Wireless transmission of temperature data for a geographic area - A user obtains an individual's body temperature data and transmits the data to a medical monitor (e.g., a medical device) for display. Additional data includes a timestamp and location of the body temperature data. Once the data is transmitted, a user may view the medical monitor for a temperature reading. For example, a doctor may take a patient's temperature and the temperature reading is displayed on a medical monitor. The body temperature data of each patient is detected using a preferred temperature detector, such as a temporal artery thermometer using an arterial heat balance approach. After collecting an individual's body temperature data, the body temperature data can be transferred to a processor. By sending body temperature data for many individuals for a geographic region, the processor can identify a pattern (e.g., a pandemic) in the body temperature data.10-23-2008

Je Kyun Lee, Brookline, MA US

Patent application numberDescriptionPublished
20100160472POLYOLEFIN AEROGELS AND COMPOSITES - The present invention relates to cross-linked polyolefin aerogels in simple and fiber-reinforced composite form. Of particular interest are polybutadiene aerogels. Especially aerogels derived from polybutadienes functionalized with anhydrides, amines, hydroxyls, thiols, epoxies, isocyanates or combinations thereof.06-24-2010

Patent applications by Je Kyun Lee, Brookline, MA US

John J. Lee, Somerville, MA US

Patent application numberDescriptionPublished
20080221077Ansamycin formulations and methods of use thereof - Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”).09-11-2008
20090062528Ansamycin formulations and methods of use thereof - Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”).03-05-2009
20090069281Ansamycin formulations and methods of use thereof - Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”).03-12-2009

John J. Lee, Arlington, MA US

Patent application numberDescriptionPublished
20110135739Oral Formulations of a Hedgehog Pathway Inhibitor - Oral formulations of the drug product IPI-926 are described. Pharmaceutical formulations (e.g., solid dosage forms) that are useful for the oral administration of a compound of formula (I), or a pharmaceutically acceptable salt thereof (e.g., IPI-926), to a human or animal subject are disclosed.06-09-2011

John W. Lee, Waltham, MA US

Patent application numberDescriptionPublished
20100152219PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES - Compounds of formula (I): and their use in the inhibition of Trk activity are described.06-17-2010

Jong-Suk Lee, Lexington, MA US

Patent application numberDescriptionPublished
20110216595NAND FLASH MEMORY OF USING COMMON P-WELL AND METHOD OF OPERATING THE SAME - A flash memory using hot carrier injection and a method of operating the same are provided. A plurality of strings constituting a page are formed on a single p-well and share the p-well. During a program operation, a string selection transistor is turned off, and electrons are accumulated in a source or drain region in response to a bias voltage applied to the p-well. Thereafter, the accumulated electrons are trapped in a charge trap layer of a memory cell in response to a program voltage applied through a word line. Also, during an erase operation, holes accumulated in response to a bias voltage applied to the p-well are trapped in the charge trap layer in response to an erase voltage. The flash memory performs NAND-type program and erase operations using hot carrier injection.09-08-2011

Kar Yue Lee, Burlington, MA US

Patent application numberDescriptionPublished
20100027100Display with controlled formation of bubbles - The invention relates to a display apparatus including a first substrate supporting an array of light modulators, a second substrate separated from the first substrate by a gap, a fluid substantially filling the gap, sealing material joining the first substrate to the second substrate, and a bubble trapping region within a space enclosed by the sealing material for substantially constraining a location of a bubble trapped within the gap. In some embodiments, the bubble trapping region extends along a majority of a side of at least one of the substrates. In some embodiments, the fluid has a viscosity less than 70 centipoise.02-04-2010

Kevin Fun Lee, Raynham, MA US

Patent application numberDescriptionPublished
20100114174Systems and Methods for Delivering Bone Cement to a Bone Anchor - A system for delivering bone cement to a bone anchor includes an anchor connection instrument for releasably connecting to a proximal end of the bone anchor. The anchor connection instrument includes a first member coupled to an opposed second member. The first member and the second member have a distal end configured to releasably connect to the proximal end of the bone anchor. The first member is movable between a release position to facilitate release of the anchor connection instrument from the proximal end of the bone anchor and a connect position in which the first member and the second member connect to the proximal end of the bone anchor. A cement delivery tube is positionable in the passage between the first member and the second member of the anchor connection instrument. A bone cement delivery system is coupled to the tube.05-06-2010

Kwangho Lee, Waltham, MA US

Patent application numberDescriptionPublished
20110269244LIGAND-DIRECTED COVALENT MODIFICATION OF PROTEIN - The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.11-03-2011

Kyongbum Lee, Winchester, MA US

Patent application numberDescriptionPublished
20110158980METHODS TO TREAT AND SCREEN FOR AGENTS TO TREAT OBESITY - Described herein are methods for treating obesity or promoting weight loss using agents that alter pyruvate flux in an adipocyte. Methods are provided for administering an agent or combination of agents to an obese individual to alter the flux of pyruvate in an adipocyte. Also described herein is a method for modifying triglyceride storage in an adipocyte by contacting an adipocyte with an agent or combination of agents that alter pyruvate flux.06-30-2011

Peter Jeng Jong Lee, Westborough, MA US

Patent application numberDescriptionPublished
20090139323NOVEL ION EXCHANGE POROUS RESINS FOR SOLID PHASE EXTRACTION AND CHROMATOGRAPHY - Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit superior wetting and ion exchange performance.06-04-2009
20100324159NOVEL ION EXCHANGE POROUS RESINS FOR SOLID PHASE EXTRACTION AND CHROMATOGRAPHY - Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit superior wetting and ion exchange performance.12-23-2010

Patent applications by Peter Jeng Jong Lee, Westborough, MA US

Po-Shun Lee, Brookline, MA US

Patent application numberDescriptionPublished
20090258830DIAGNOSTIC AND THERAPEUTIC USES OF GELSOLIN IN RENAL FAILURE - The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).10-15-2009
20100021428Use Of Gelsolin To Treat Multiple Sclerosis And To Diagnose Neurologic Disease (Stossel) - The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.01-28-2010

Robert M. Lee, Magnolia, MA US

Patent application numberDescriptionPublished
20090293276ROTOR ASSEMBLY SYSTEM AND METHOD - A method and system are disclosed for use in assembling a plurality of rotatable elements in the assembly of a turbine engine. The system and method include an initialization unit, a measurement unit, and a processing unit. The initialization unit receives and stores initialization data in a computer datastore. The initialization data includes a first set of initialization data that is representative of characteristics of a first rotatable element, and a second set of initialization data that is representative of characteristics of a second rotatable element. The measurement unit receives measured data including a first set of measured data characteristic of measured features of the first rotatable element, and a second set of measured data characteristic of measured features of the second rotatable element. The processor unit determines an optimal order and rotational arrangement of the first and second rotatable elements with respect to one another responsive to the first and second sets of initialization data and the first and second sets of measured data.12-03-2009
20090320309SYSTEM FOR OPTIMAL ALIGNMENT OF A BEARING SEAL ON A SHAFT OF A GAS TURBINE - A method for substantially aligning a bearing seal on a shaft of a turbine engine. The method including measuring characteristics of the subject shaft, measuring characteristics of a plurality of bearing seal components and determining and outputting alignment information of the plurality of bearing seal components with the shaft based on the measured characteristics. The alignment information can be outputted for either substantially perpendicular alignment for an axial seal or substantially parallel alignment for a radial seal.12-31-2009
20100198553ABSOLUTE DIAMETER MEASUREMENT ARM - A measurement apparatus calibrated to measure an absolute diameter of a part in a shop floor environment. The measurement apparatus includes a calibration that includes compensation factors for thermal expansion, shifting of measurement parts (arm, support tower, and related laser), and variances of these parts. The resulting measurements report an absolute diameter of a part to a higher degree of accuracy than previously possible. Also, the calculated compensation factor eliminate the need for an isolated, climate-controlled measurement room.08-05-2010

Patent applications by Robert M. Lee, Magnolia, MA US

Seoung Bum Lee, Arlington, MA US

Patent application numberDescriptionPublished
20120026877High performance data transport system and method - System and method for providing data transport Quality of Service (QoS) assurances in homogeneous and heterogeneous communication networks consisting of one or more communication interface types. The system includes Subnet Managers for managing the resources of nodes within the subnets and Flow Managers for managing the communication flows between the nodes. A Real-time Reservation Transport Protocol (RRTP) establishes the resource reservations and QoS transport services for the communication flow payload over the reserved paths. The communication flows are protected against topological variations in the network, such as from node mobility. QoS assurances are also provided to secure communication flows through interoperation with security protocols, such as Internet Protocol Security (IPsec), or encryption devices, such as High Assurance Internet Protocol Encryptor (HAIPE).02-02-2012

Seung-Wuk Lee, Lexington, MA US

Patent application numberDescriptionPublished
20120003629Biological control of nanoparticle nucleation, shape and crystal phase - The present invention includes compositions and methods for selective binding of amino acid oligomers to semiconductor and elemental carbon-containing materials. One form of the present invention is a method for controlling the particle size of the semiconductor or elemental carbon-containing material by interacting an amino acid oligomer that specifically binds the material with solutions that can result in the formation of the material. The same method can be used to control the aspect ratio of the nanocrystal particles of the semiconductor material. Another form of the present invention is a method to create nanowires from the semiconductor or elemental carbon-containing material. Yet another form of the present invention is a biologic scaffold comprising a substrate capable of binding one or more biologic materials, one or more biologic materials attached to the substrate, and one or more elemental carbon-containing molecules attached to one or more biologic materials. 01-05-2012

S. Kevin Lee, Cambridge, MA US

Patent application numberDescriptionPublished
20110195260METHOD OF HYDROLYTICALLY STABLE BONDING OF ELASTOMERS TO SUBSTRATES - Active devices such as pumps and mixers have been fabricated in plastic-PDMS hybrid devices. By utilizing functionalized bis-silane primers, bond strength between Polycarbonate or PMMA and PDMS improved in dry and aqueous environments. Plastic-primer-PDMS layers exposed to acid and base solutions at 70° C. for 2 hours showed no signs of delamination at 30 psi for pH −1 to 15 and 60 psi for pH 0 to 15. A peristaltic pump fabricated in polycarbonate achieved consistent flow rates up to peristaltic cycle frequencies of 10 Hz in water, 1OM HCl, and 1OM NaOH solutions.08-11-2011

Stacey Lee, Southborough, MA US

Patent application numberDescriptionPublished
20120084990HAND SIZING TOOL - A hand sizing tool includes a base platform and a secondary platform affixed to and raised above the base platform. The platforms include a palm heel indicia on the base platform and an index finger tip indicia on the secondary platform. Each of an index finger guide, an index finger measurement slider, and a palm width measurement slider extends out of the secondary platform, these elements being adapted for measuring the hand size.04-12-2012

Stanley Y. Lee, Framingham, MA US

Patent application numberDescriptionPublished
20090276664METHOD AND APPARATUS FOR MONITORING BIT-ERROR RATE - A test set for evaluating network performance is described, and which may include an output device, a processor, a power supply, a memory unit, and a control terminal. The test set may be configured to receive a user-entered selection of one of a plurality of different bit-error rate profiles and generate a test signal exhibiting the selected bit-error rate profile. The test set may also supply the test signal exhibiting the selected bit-error rate profile to a network under test. In addition, the test set may receive as an input, an output from the network under test. The output may include the test signal exhibiting the selected bit-error rate. The test set may evaluate the received test signal and determine the performance of the network in response to the received test signal exhibiting the bit-error rate. The test set may then output the results of the evaluation.11-05-2009

Stephanie Yat-Lin Lee, Needham, MA US

Patent application numberDescriptionPublished
20080205733Quantitative tract-of-interest metrics for white matter integrity based on diffusion tensor MRI data - The exemplary embodiments of this invention relate at least in part to a method, apparatus and system to characterize white matter, such as for detecting a presence of a white matter impairment. An exemplary method to characterize white matter includes identifying at least one tract of interest (TOI) in the brain of a subject of interest, the tract of interest having a set of streamtubes representing white matter fibers; determining a set of quantitative tractography metrics associated with the tract of interest, the set of quantitative tractography metrics having a plurality of members; and comparing at least one member of the determined set of quantitative tractography metrics to a corresponding member of a reference set of quantitative tractography metrics, or comparison of one TOI in a single subject or group of subjects and other TOI in the same subject(s).08-28-2008

Steve Hsing Lee, Tewksbury, MA US

Patent application numberDescriptionPublished
20110271180Initiating Font Subsets - A computer-implemented method includes analyzing content of a received electronic document in an autonomous manner to identify each unique character of one or more fonts included in the content of the electronic document. The method also includes initiating a request for a subset of one or more of the fonts included in the content of the electronic document, wherein the request includes each identified unique character of the respective one or more fonts.11-03-2011

Steven Lee, Arlington, MA US

Patent application numberDescriptionPublished
20110125573METHODS AND APPARATUS FOR OPTIMIZING ADVERTISEMENT ALLOCATION - In some embodiments, an apparatus includes a weight module, a performance module and an allocator module. The weight module calculates a weight for each segment from a set of segments of potential advertisement placements matching a criterion. The weight for a segment is based at least partially on (1) a budget score for an advertisement campaign and (2) a number of potential placements for the segment. The performance module calculates a performance score for the advertisement campaign at each segment from the set of segments. The performance score of the segment is based on a success metric for an advertisement at the segment and a number of impressions for the segment. The allocator module presents the advertisement at a placement associated with the segment if the weight for the segment is greater than a first threshold and the performance score for the segment is greater than a second threshold.05-26-2011

Sue S. Lee, Framingham, MA US

Patent application numberDescriptionPublished
20110033825DENTAL IMPLANT - A dental implant system for supporting a cosmetic tooth prosthesis includes an elongated body adapted to be disposed in a jaw bone of a patient. The elongated body includes a distal end and a proximal end and extends along a longitudinal axis. The elongated body includes a tapered outer surface that tapers along the longitudinal axis distally from the proximal end of the elongated body. The outer surface of the tapered elongated body includes a plurality of barbs for securing the elongated body in the jaw bone of the patient.02-10-2011

Sugjoon Lee, Westborough, MA US

Patent application numberDescriptionPublished
20090061221COMPOSITE TACK FILM FOR ASPHALTIC PAVING, METHOD OF PAVING, AND PROCESS FOR MAKING A COMPOSITE TACK FILM FOR ASPHALTIC PAVING - A tack film material comprises a carrier substrate comprising a polymer film having first and second major surfaces. A surface layer on the first and second major surfaces comprises a resinous non-asphaltic material or a material including about 50% or more resinous non-asphaltic component and about 50% or less of asphaltic component. The surface layer is capable of forming a bond with an adjacent layer of asphaltic paving material, when the surface layer is heated to a temperature of about 120° C. or more under a pressure that is applied to the tack film material by an overlying layer of the asphaltic paving material having a thickness of about 3.8 cm (1.5 inch) or more laid. The surface layer is not tacky at a temperature of about 20° C. and a pressure of about one atmosphere.03-05-2009
20090097917REINFORCEMENT FOR ASPHALTIC PAVING, METHOD OF PAVING, AND PROCESS FOR MAKING A GRID WITH THE COATING FOR ASPHALTIC PAVING - A composite material comprises: an open grid comprising at least two sets of strands. Each set of strands has openings between adjacent strands. The sets are oriented at a substantial angle to one another. A tack film is laminated to the open grid. The tack film has first and second major surfaces, such that a material of the tack film at its first and second major surfaces is a material including about 50% or more of resinous non-asphaltic component and about 50% or less of asphaltic component.04-16-2009
20090098330COMPOSITE GRID WITH TACK FILM FOR ASPHALTIC PAVING, METHOD OF PAVING, AND PROCESS FOR MAKING A COMPOSITE GRID WITH TACK FILM FOR ASPHALTIC PAVING - A composite material comprises: an open grid comprising at least two sets of strands. Each set of strands has openings between adjacent strands. The sets are oriented at a substantial angle to one another. A tack film is laminated to the open grid. The tack film has first and second major surfaces, such that a material of the tack film at its first and second major surfaces includes about 50% or more of resinous non-asphaltic component and about 50% or less of asphaltic component.04-16-2009
20120003889REINFORCEMENT FOR ASPHALTIC PAVING, METHOD OF PAVING, AND PROCESS FOR MAKING A GRID WITH THE COATING FOR ASPHALTIC PAVING - A composite material comprises: an open grid comprising at least two sets of strands. Each set of strands has openings between adjacent strands. The sets are oriented at a substantial angle to one another. A tack film is laminated to the open grid. The tack film has first and second major surfaces, such that a material of the tack film at its first and second major surfaces is a material including about 50% or more of resinous non-asphaltic component and about 50% or less of asphaltic component.01-05-2012

Sze-Ming Lee, Westford, MA US

Patent application numberDescriptionPublished
20080249217Inkjet ink compositions comprising multiple modified pigments - The present invention relates to dispersions and inkjet ink compositions comprising a liquid vehicle and at least two modified pigments. The first modified pigment comprises a first pigment having attached at least one non-polymeric group, and the second modified pigment comprises a second pigment having attached at least one polymeric group.10-09-2008
20100160536Method of preparing polymer modified pigments - The present invention relates to a method of preparing a polymer modified pigment comprising the steps of, combining, in any order, a modified pigment comprising a pigment having attached at least one reactive group, a polymer comprising at least one functional group, and a non-reactive diluent, to form a reaction mixture, reacting the polymer and the modified pigment in the reaction mixture to form a mixture comprising the polymer modified pigment and the non-reactive diluent; and removing the non-reactive diluent from the mixture to form the polymer modified pigment. Also disclosed are the resulting polymer modified pigments and inkjet ink compositions comprising them.06-24-2010

Patent applications by Sze-Ming Lee, Westford, MA US

Taesik Lee, Cambridge, MA US

Patent application numberDescriptionPublished
20110247937Method and apparatus for permeating flow desalination - A water desalination system and method in accordance with the principles of the present invention employs capacitive deionization to remove ions from source water to produce deionzed and waste water. The process employs charged electrodes to attract ions of opposite polarity from the source water. The process of discharging the electrodes employs solvent drag10-13-2011

Thomas Lee, Lexington, MA US

Patent application numberDescriptionPublished
20110130578STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS - A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′)06-02-2011

Thomas Wai-Ho Lee, Lexington, MA US

Patent application numberDescriptionPublished
20110230521Pyrazole Compounds As CCR1 Antagonists - Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.09-22-2011

Tom W. Lee, Wilmington, MA US

Tzuo-Chang Lee, Shrewsbury, MA US

Patent application numberDescriptionPublished
20100074090STORAGE SYSTEM AND OPTICAL PICK-UP UNIT - Disclosed herein are aspects of optical tape technology, tape manufacturing, and tape usage. Methods and systems of tape technology disclose optical tape media including: configurations, formulations, markings, and structure; optical tape manufacturing methods, systems, and apparatus methods and systems including: curing processes, coating methods, embossing, drums, testing, tracking alignment stamper strip; optical tape methods and systems including: pick up head adapted for the disclosed optical tape; and optical tape uses including optical storage media devices for multimedia applications03-25-2010

W. D. Lee, Brookline, MA US

Patent application numberDescriptionPublished
20110104071METHODS AND SYSTEMS FOR SPATIALLY IDENTIFYING ABNORMAL CELLS - The present invention provides compositions and methods for imaging tumor resections.05-05-2011

W. Davis Lee, Newburyport, MA US

Patent application numberDescriptionPublished
20110171817Aromatic Molecular Carbon Implantation Processes - Methods for implanting an aromatic carbon molecule or a selected ionized lower mass byproduct into a workpiece generally includes vaporizing and ionizing aromatic carbon molecule in an ion source to create a plasma and produce aromatic carbon molecules and its ionized lower mass byproducts. The ionized aromatic carbon molecules and lower mass byproducts within the plasma are then extracted to form an ion beam. The ion beam is mass analyzed with a mass analyzer magnet to permit selected ionized aromatic carbon molecules or selected ionized lower mass byproducts to pass therethrough and implant into a workpiece.07-14-2011

William D. Lee, Newburyport, MA US

Patent application numberDescriptionPublished
20100110603WAFER GROUNDING METHOD FOR ELECTROSTATIC CLAMPS - An electrostatic chuck and method for clamping and de-clamping a workpiece is provided. The ESC comprises a clamping plate having a clamping surface, and one or more electrodes. An electric potential applied to the one or more electrodes selectively clamps the workpiece to the clamping surface. An arc pin operably coupled to the clamping plate and a power source provides an arc for penetrating an insulating layer of the workpiece. The arc pin is selectively connected to an electrical ground, wherein upon removal of the insulative layer of the workpiece, the arc pin provides an electrical ground connection to the workpiece.05-06-2010
20100110604ELECTROSTATIC CHUCK GROUND PUNCH - An electrostatic chuck and method for clamping a workpiece is provided. The ESC comprises a clamping plate having a clamping surface, and one or more electrodes. An electric potential applied to the one or more electrodes selectively clamps the workpiece to the clamping surface. A punch is operably coupled to the clamping plate and an electrical ground, wherein the punch comprises a trigger mechanism and a punch tip. The punch tip translates between extended and retracted positions, wherein a point of the punch tip is proud of the clamping surface when the punch tip is in the extended position. The punch tip is configured to translate toward the clamping surface upon clamping the workpiece to the clamping plate. Upon reaching the retracted position, the trigger mechanism imparts an impact force to the punch tip, forcing the punch tip into the workpiece and providing an electrical ground connection to the workpiece.05-06-2010
20100142113DE-CLAMPING WAFERS FROM AN ELECTROSTATIC CHUCK - One embodiment of the present invention relates to a method for declamping a semiconductor wafer that is electrically adhered to a surface of an electrostatic chuck by a clamping voltage. In this method, the clamping voltage is deactivated. For a time following the deactivation, a first region of the wafer is lifted an first distance from the surface of the electrostatic chuck while a second region of the wafer remains adhered to the surface of the electrostatic chuck. A predetermined condition is monitored during the time. The second region is lifted from the surface of the electrostatic chuck when the predetermined condition is met.06-10-2010
20100142114ELECTROSTATIC CHUCK WITH COMPLIANT COAT - The present invention is directed to an electrostatic chuck (ESC) with a compliant layer formed from TT-Kote® and a method of forming a clamping plate for an ESC. The ESC comprises a compliant layer having a low friction surface for reducing or eliminating particulates generated from thermal expansion. The method comprises forming a clamping member for a substrate comprising a ceramic material and a ceramic surface, and coating the ceramic surface with a compliant layer comprising an organic silicide or TT-Kote®.06-10-2010
20100171044Vapor Compression Refridgeration Chuck for Ion Implanters - Aspects of the present invention relate to ion implantation systems that make use of a vapor compression cooling system. In one embodiment, a thermal controller in the vapor compression system sends refrigeration fluid though a compressor and a condenser according to an ideal vapor compression cycle to help limit or prevent undesired heating of a workpiece during implantation, or to actively cool the workpiece.07-08-2010
20100187447NON-CONDENSING THERMOS CHUCK - The present invention is directed to an apparatus and method of forming a thermos layer surrounding a chuck for holding a wafer during ion implantation. The thermos layer is located below a clamping surface, and comprises a vacuum gap and an outer casing encapsulating the vacuum gap. The thermos layer provides a barrier blocking condensation to the outside of the chuck within a process chamber by substantially preventing heat transfer between the chuck when it is cooled and the warmer environment within the process chamber.07-29-2010
20110291022Post Implant Wafer Heating Using Light - An ion implantation system, method, and apparatus for abating condensation in a cold ion implant is provided. An ion implantation apparatus is configured to provide ions to a workpiece positioned in a process chamber. A sub-ambient temperature chuck supports the workpiece during an exposure of the workpiece to the plurality of ions. The sub-ambient temperature chuck is further configured to cool the workpiece to a processing temperature, wherein the process temperature is below a dew point of an external environment. A load lock chamber isolates a process environment of the process chamber from the external environment. A light source provides a predetermined wavelength of electromagnetic radiation to the workpiece concurrent with the workpiece residing within the load lock chamber, wherein the predetermined wavelength or range of wavelengths is associated with a maximum radiant energy absorption range of the workpiece, wherein the light source is configured to selectively heat the workpiece.12-01-2011
20110291023HEATED ROTARY SEAL AND BEARING FOR CHILLED ION IMPLANTATION SYSTEM - A workpiece scanning system is provided having a scan arm that rotates about a first axis and a chilled end effector rotatably coupled to the scan arm about a second axis for selectively securing a workpiece. The chilled end effector has a clamping plate and one or more cooling mechanisms for cooling the clamping plate. A bearing is positioned along the second axis and rotatably couples the end effector to the scan arm, and a seal is positioned along the second axis to provide a pressure barrier between an external environment and an internal environment. One or more of the bearing and seal can have a ferrofluid associated therewith. A heater assembly is positioned proximate to the bearing and seal, wherein the heater assembly selectively provides a predetermined amount of heat to the bearing and seal, therein increasing a propensity of the end effector to rotate about the second axis.12-01-2011
20110291030ACTIVE DEW POINT SENSING AND LOAD LOCK VENTING TO PREVENT CONDENSATION ON WORKPIECES - A system, apparatus, and method is provided for preventing condensation on a workpiece in an end station of an ion implantation system. A workpiece is cooled in a first environment, and is transferred to a load lock chamber that is in selective fluid communication with the end station and a second environment, respectively. A workpiece temperature monitoring device is configured to measure a temperature of the workpiece in the load lock chamber. An external monitoring device measures a temperature and relative humidity in the second environment, and a controller is configured to determine a temperature of the workpiece at which condensation will not form on the workpiece when the workpiece is transferred from the load lock chamber to the second environment.12-01-2011
20110292562MATCHED COEFFICIENT OF THERMAL EXPANSION FOR AN ELECTROSTATIC CHUCK - An apparatus and method are provided for selecting materials for forming an electrostatic clamp. The electrostatic clamp has a backing plate having a first coefficient of thermal expansion, wherein the backing plate provides structural support and rigidity to the electrostatic clamp. The electrostatic clamp further has a clamping plate having a clamping surface associated with contact with a workpiece, wherein the clamping plate has a second coefficient of thermal expansion associated therewith. The clamping plate is bonded, attached or grown to the backing plate, wherein minimal deflection of the clamping plate is evident across a predetermined temperature range. The first coefficient of thermal expansion and second coefficient of thermal expansion, for example, are substantially similar, and vary by no greater than a factor of three.12-01-2011

William Davis Lee, Newburyport, MA US

Patent application numberDescriptionPublished
20110260047SILABORANE IMPLANTATION PROCESSES - Methods for implanting an silaborane molecule or a selected ionized lower mass byproduct into a workpiece generally includes vaporizing and ionizing silaborane molecule in an ion source to create a plasma and produce silaborane molecules and its ionized lower mass byproducts. The ionized silaborane molecules and lower mass byproducts within the plasma are then extracted to form an ion beam. The ion beam is mass analyzed with a mass analyzer magnet to permit selected ionized silaborane molecules or selected ionized lower mass byproducts to pass therethrough and implant into a workpiece.10-27-2011
20110297845EFFECTIVE ALGORITHM FOR WARMING A TWIST AXIS FOR COLD ION IMPLANTATIONS - A method for warming a rotational interface in an ion implantation environment provides a scan arm configured to rotate about a first axis and an end effector coupled to the scan arm via a motor to selectively secure a workpiece. The end effector is configured to rotate about a second axis having a bearing and a seal associated with the second axis and motor. The motor is activated, and the rotation of motor is reversed after a predetermined time or when the motor faults due to a rotation the end effector about the second axis. A determination is made as to whether the rotation of the end effector about the second axis is acceptable, and the scan arm is reciprocated about the first axis when the rotation of the end effector is unacceptable, wherein inertia of the end effector causes a rotation of the end effector about the second axis.12-08-2011
20110299217HEATED ELECTROSTATIC CHUCK INCLUDING MECHANICAL CLAMP CAPABILITY AT HIGH TEMPERATURE - An electrostatic clamp is provided, having a clamping plate, wherein a clamping surface of the clamping plate is configured to contact the workpiece. A voltage applied to one or more electrodes selectively electrostatically attracts the workpiece to the clamping surface. One or more auxiliary clamping members are further provided wherein the one or more auxiliary clamping members are configured to selectively secure at least a portion of the workpiece to the clamping surface. A temperature monitoring device configured to determine a temperature of the workpiece is provided, and a controller is configured to selectively clamp the workpiece to the clamping surface via a control of the voltage to the one or more electrodes and the one or more auxiliary clamping members, based, at least in part, on the temperature of the workpiece.12-08-2011
20110299218HEATED ANNULUS CHUCK - A clamping device and method is provided for securing first and second workpieces having different sizes to a clamping device and providing thermal conditioning thereto. An electrostatic clamping plate having a diameter associated with the first workpiece surrounds a central portion of the clamp. A non-electrostatic central portion provides a heater within the annulus, wherein the central portion has a diameter associated with the second workpiece. A workpiece carrier is provided, wherein the workpiece carrier is configured to hold the second workpiece above the heater, and wherein a diameter of the workpiece carrier is associated with the electrostatic clamping plate annulus. The annulus selectively electrostatically clamps the workpiece carrier or a circumferential portion of the first workpiece to its clamping surface, therein selectively maintaining a position of the first or second workpiece with respect to the annulus or non-electrostatic central portion.12-08-2011

Yongwoo Lee, Waltham, MA US

Patent application numberDescriptionPublished
20110124079Sorption reinforced catalytic coating system and method for the degradation of threat agents - Sorption reinforced catalytic coating system for the degradation of threat agents including a synzyme coating about a material configured for the degradation of the threat agents, the synzyme coating including bucket-shaped molecules configured for the sorption of the threat agents A binding agent is configured for synzyme immobilization to maximize loading and retention of the synzyme coating on the material.05-26-2011

Yuchun Lee, Sudbury, MA US

Patent application numberDescriptionPublished
20110113026Scalable Computation of Data - Techniques for producing a cross tabulation are described. The techniques involve issuing a plurality of queries to a database. The queries are for each of at least one sublevel of data for each of at least one dimension of data associated with records in the database. The queries provide sublists of sorted identifiers for each one of the queries. The technique determines occurrences of intersections of levels of one dimension with levels of another dimension of the data associated with records in the database by traversing the sublists to detect intersections of the dimensions.05-12-2011

Patent applications by Yuchun Lee, Sudbury, MA US