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Lee, Lexington

Chul J. Lee, Lexington, MA US

Patent application numberDescriptionPublished
20090040096Method and apparatus for interleaved gridding in distributed multiple computing for real-time RCS prediction - Apparatus and method for real-time determination of radar cross sections is disclosed using interleaved gridding. Radar cross section calculations are amenable to an implementation on parallel processors wherein the shooting window is subdivided into smaller areal units that are assigned to the parallel processors in an alternating fashion, such that the calculations performed by a single processor are not localized to a single area of the shooting window.02-12-2009
20090040098RCS signature generation for closely spaced multiple objects using N-point models - A method and system for analyzing the RCS of an object using N Point signature prediction models is provided. N-point signature prediction models are created for each object in a scenario and stored in lookup tables. Shooting and Bounce trace back techniques are used to determine RCS signatures of multiple objects in modeled scenarios to account for blockage by and coupling phenomena of a scattered field.02-12-2009
20100066592PARALLEL PROCESSING TO GENERATE RADAR SIGNATURES FOR MULTIPLE OBJECTS - In one aspect, a system to generate a radar signature of an object includes electromagnetic processing modules that include a first module including at least one processing unit to perform a shooting and bouncing (SBR) technique to solve for physical optics and multi-bounce characteristics of the object, a second module including a processing unit to perform a physical theory (PTD) technique to solve for material edges of the object and a third module including a processing unit to perform an incremental length diffraction coefficient (ILDC) to solve for material boss/channel. Results from the first, second and third modules are coherently integrated by frequency to generate radar cross section (RCS) values of the object in real-time. Performance of the system is scalable by adding processing units to at least one of the first, second or third modules.03-18-2010
20100066595ELECTROMAGNETIC (EM) SOLVER USING A SHOOTING BOUNCING RAY (SBR) TECHNIQUE - In one aspect, a system to generate radar signatures for multiple objects in real-time includes a first module including at least one processor to perform a shooting and bouncing (SBR) technique to solve for physical optics and multi-bounce characteristics of the objects. The at least one processor includes a central processing unit to perform dynamic ray tracing and a graphics processing unit (GPU) to perform far field calculations. The GPU includes a hit point database to store entries associated with rays that intersect an object.03-18-2010

Kwangho Lee, Lexington, MA US

Patent application numberDescriptionPublished
20090062537N-Formyl Hydrozyamine Compounds - Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.03-05-2009
20090325948INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE - The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these compounds for treating bacterial disease, such as bacterial infection.12-31-2009
20100063278N-Formyl Hydroxylamines compounds - Novel N-formyl hydroxylamine compounds and their derivatives are discloses. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.03-11-2010

Patent applications by Kwangho Lee, Lexington, MA US

Wen-Cherng Lee, Lexington, MA US

Patent application numberDescriptionPublished
20100035918Imidazolone Compounds and Methods of Making and Using the Same - In one aspect, the invention features a compound of the general Formula (I). Compounds of Formula (I) possess high affinity for Alk 5 and/or AIk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.02-11-2010
20100056505Substituted Pyrazalones - The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable.03-04-2010
20100105714Furanone Compounds and Methods of Making and Using The Same - The invention features compounds of the general Formula (I): (formula should be inserted here) Compounds of Formula (I) possess unexpectedly high affinity for Alk5 and/or Alk4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders.04-29-2010
20100144730PYRIDINONYL PDK1 INHIBITORS - The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.06-10-2010
20100160258Bicyclic aryl sphingosine 1-phosphate analogs - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.06-24-2010
20100160357Heterobicyclic sphingosine 1-phosphate analogs - Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.06-24-2010
20100166819Transforming Growth Factor Modulators - The invention is related to compounds of formula (I) that can be used as antagonists of the TGFβ family type I receptors, Alk5 and/or Alk4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable.07-01-2010

Patent applications by Wen-Cherng Lee, Lexington, MA US