Lee, Boston
Alan W. Lee, Boston, MA US
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20100002739 | LENS COUPLED QUANTUM CASCADE LASER - Terahertz quantum cascade (QC) devices are disclosed that can operate, e.g., in a range of about 1 THz to about 10 THz. In some embodiments, QC lasers are disclosed in which an optical element (e.g., a lens) is coupled to an output facet of the laser's active region to enhance coupling of the lasing radiation from the active region to an external environment. In other embodiments, terahertz amplifier and tunable terahertz QC lasers are disclosed. | 01-07-2010 |
Brian S. Lee, Boston, MA US
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20100103717 | TUNING A VARIABLE RESISTANCE OF A RESISTIVE SENSE ELEMENT - Method and apparatus for tuning a variable resistance resistive sense element of an electronic device. In some embodiments, a value indicative of a selected number of consecutive pulses is stored in a memory location and a resistive sense element (RSE) is set to a baseline RSE resistance. A tuning operation is performed by applying the selected number of consecutive pulses to the RSE to tune the baseline RSE resistance to a final adjusted resistance. | 04-29-2010 |
Chih-Hao Lee, Boston, MA US
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20140315781 | METHODS OF TREATING FATTY LIVER DISEASE WITH HELMINTH-DERIVED GLYCAN-CONTAINING COMPOUNDS - The present invention provides a compound comprising a helminth-derived glycan and/or glycoconjugate thereof (e.g., a compound comprising a Lewis | 10-23-2014 |
20150018396 | PREVENTION AND TREATMENT OF RESPIRATORY INFECTION WITH PEROXISOME PROLIFERATOR ACTIVATOR RECEPTOR DELTA AGONIST - The present disclosure is related generally to a method for prevention and/or treatment of infections, e.g., respiratory infections, in a subject before or after the onset of a disease state associated with the infection. | 01-15-2015 |
Hangjin Lee, Boston, MA US
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20140065240 | METHODS AND COMPOSITIONS RELATING TO MESENCHYMAL STEM CELL EXOSOMES - The invention provides compositions comprising mesenchymal stem cell (MSC) derived exosomes, and methods of their use in subjects having certain lung diseases including inflammatory lung disease. | 03-06-2014 |
Harry Lee, Boston, MA US
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20080299539 | Parallel integrated bioreactor device and method - In one embodiment, the present invention introduces integrated fluid injection and mixing devices to enable pH control in a miniature parallel integrated bioreactor array system. In another embodiment, the environmental conditions of the growth chamber is enabled through fluidic injections in a miniature parallel cell culture system. In still another embodiment, the present invention utilizes gas switches to control oxygen concentration within a miniature parallel integrated bioreactor array. | 12-04-2008 |
20090038417 | FLUID INJECTION PORT - Fluid injection port. An elastomeric injection nipple is supported within a compression fitting and the injection nipple includes a slit. A first via is provided that connects the slit in the nipple to a flow channel leading into a fluid reservoir. A venting channel is provided in fluid communication with the fluid reservoir and also in fluid communication with a second via. When a pipette is inserted into the slit in the injection nipple, the nipple deforms allowing the second via to be in fluid communication with space on either side of the pipette tip whereby air can be discharged. | 02-12-2009 |
20090220935 | APPARATUS AND METHOD FOR DISSOLVED OXYGEN CONTROL IN PARALLEL INTEGRATED BIOREACTOR ARRAY - Parallel, integrated bioreactor. The bioreactor includes a plurality of growth chambers, each growth chamber associated with a peristaltic oxygenating mixer and separated therefrom by a porous membrane. Each oxygenating mixture has a gas inlet and a gas outlet with the gas inlet in fluid communication with a gas reservoir. A gas mixer switch is provided for controlling oxygen concentration in the reservoir. The apparatus and methods disclosed in the application allow precise control over dissolved oxygen concentration with a quick response time. | 09-03-2009 |
20110137381 | Treatment of neurological disorders via electrical stimulation, and methods related thereto - Disclosed are medical devices for the prevention and/or treatment of neurological disorders via electrical stimulation, and methods related thereto. The devices may also be utilized to detect disorders before the prevention or treatment of a neurological disorder. These devices are minimally or non-invasive. The present medical devices comprise various components, which include electrodes and control electronics. The electrodes are targeting electrodes constructed from ring type structures or virtually connected disc type arrays. The electrodes are located entirely outside the skull. The present medical devices also comprise one or more subsystems, a control system, a battery unit, and wires connecting the one or more subsystems. These devices may also be used for acute seizure control. | 06-09-2011 |
20110195260 | METHOD OF HYDROLYTICALLY STABLE BONDING OF ELASTOMERS TO SUBSTRATES - Active devices such as pumps and mixers have been fabricated in plastic-PDMS hybrid devices. By utilizing functionalized bis-silane primers, bond strength between Polycarbonate or PMMA and PDMS improved in dry and aqueous environments. Plastic-primer-PDMS layers exposed to acid and base solutions at 70° C. for 2 hours showed no signs of delamination at 30 psi for pH −1 to 15 and 60 psi for pH 0 to 15. A peristaltic pump fabricated in polycarbonate achieved consistent flow rates up to peristaltic cycle frequencies of 10 Hz in water, 1OM HCl, and 1OM NaOH solutions. | 08-11-2011 |
20130194575 | Apparatus and methods to measure optical density - The present invention provides apparatus and methods for measuring the optical density of a fluid by measuring the light transmission through a reconfigurable optical path. The optical path is reconfigured by the deflection of an elastic membrane wherein the optical path length through the fluid is determined by the position of the membrane relative to a fixed surface. The optical density can be determined from two measurements with different optical path lengths through the fluid. | 08-01-2013 |
20130196276 | Apparatus and methods to operate a microreactor - The present invention provides apparatus and methods to operate microreactor devices through the controlled delivery of pressurized fluids. A heated reservoir, a heated manifold, and a heater for the microreactor device provides for the delivery of a pressurized gas while minimizing evaporation and condensation; and a fluid interface and pressure interlock provides for the delivery of aseptic fluids while minimizing contamination and fluid loss. | 08-01-2013 |
Helen Lee, Boston, MA US
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20150093328 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING - The present invention relates to a novel composition useful in targeted diagnostic and/or therapy of a target site, such as cancerous tissue. The composition and methods disclosed herein find particular use in diagnosing and imaging cancerous tissue. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique. | 04-02-2015 |
Jeannie T. Lee, Boston, MA US
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20140142160 | Polycomb-associated Non-Coding RNAs - This invention relates to long non-coding RNAs (lncRNAs), libraries of those ncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2, inhibitory nucleic acids and methods and compositions for targeting lncRNAs. | 05-22-2014 |
20140213460 | RNA-YY1 Interactions - Methods relating to obtaining libraries of YY1-binding long non-coding RNAs, libraries obtained thereby, and methods of use thereof. | 07-31-2014 |
Jeongwon Lee, Boston, MA US
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20140126602 | CONTINUOUS-WAVE ORGANIC DYE LASERS AND METHODS - An organic dye laser produces a continuous-wave (cw) output without any moving parts (e.g., without using flowing dye streams or spinning discs of solid-state dye media to prevent photobleaching) and with a pump beam that is stationary with respect to the organic dye medium. The laser's resonant cavity, organic dye medium, and pump beam are configured to excite a lasing transition over a time scale longer than the associated decay lifetimes in the organic dye medium without photobleaching the organic dye medium. Because the organic dye medium does not photobleach when operating in this manner, it may be pumped continuously so as to emit a cw output beam. In some examples, operation in this manner lowers the lasing threshold (e.g., to only a few Watts per square centimeter), thereby facilitating electrical pumping for cw operation. | 05-08-2014 |
20140230884 | EXCITATION ENHANCEMENT AND EXTRACTION ENHANCEMENT WITH PHOTONIC CRYSTALS - Disclosed herein is a system for stimulating an emission from at least one emitter, such as a quantum dot or organic molecule, on the surface of a photonic crystal comprising a patterned dielectric substrate. Embodiments of this system include a laser or other source that illuminates the emitter and the photonic crystal, which is characterized by an energy band structure exhibiting a Fano resonance, from a first angle so as to stimulate the emission from the emitter at a second angle. The coupling between the photonic crystal and the emitter may result in spectral and angular enhancement of the emission through excitation and extraction enhancement. These enhancement mechanisms also reduce the emitter's lasing threshold. For instance, these enhancement mechanisms enable lasing of a 100 nm thick layer of diluted organic molecules solution with reduced threshold intensity. This reduction in lasing threshold enables more efficient organic light emitting devices and more sensitive molecular sensing. | 08-21-2014 |
Jonghwan Lee, Boston, MA US
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20140073915 | APPARATUS AND METHOD FOR VOLUMETRIC IMAGING OF BLOOD FLOW PROPERTIES - Apparatus, method and computer accessible medium can be provided for determining presence of individual scattering objects in at least one blood vessel. For example, with at least one detector arrangement, it is possible to detect interferometric radiation from at least one portion of the blood vessel(s), and provide data associated therewith. The interferometric radiation can be based on a first radiation provided from the portion at a second radiation provided from a reference. Further, with a computer arrangement, it is possible to determine the presence of the individual scattering objects in the portion of the blood vessel(s) based on the data. It is also possible to identify individual passage of the scattering objects and/or measure at least one characteristic of the passage. | 03-13-2014 |
Kimberly A. Lee, Boston, MA US
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20130266965 | Identification of Non-Small Cell Lung Carcinoma (NSCLC) Tumors Expressing PDGFR-ALPHA - The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFRα-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFRα is expressed, and for determining whether a compound inhibits the progression of a PDGFRα-expressing mammalian NSCLC tumor. | 10-10-2013 |
Po-Shun Lee, Boston, MA US
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20080261260 | USE OF GELSOLIN TO TREAT INFECTIONS - The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression. | 10-23-2008 |
Seonkyong Lee, Boston, MA US
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20120209125 | Singlet Oxygen Production and Dosimetry for Photodynamic Therapy - An apparatus for photodynamic therapy (PDT) includes a light source configured to provide excitation light for a photosensitizer, an optical system configured to direct the excitation light to a target region and receive light emitted by the photosensitizer and/or singlet oxygen generated in the target region, and a detection system configured to receive the light emitted by the photosensitizer and/or the singlet oxygen. The apparatus also includes a filter system configured to spectrally discriminate between emission from the photosensitizer and the singlet oxygen and a processor configured to determine concentrations of the singlet oxygen and/or the photosensitizer based on an emission signal measured by the detection system. | 08-16-2012 |
Seonkyung Lee, Boston, MA US
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20090323743 | High-Power, High-Throughput Microwave Discharge Singlet Oxygen Generator for Advanced Electrical Oxygen-Iodine Lasers - A laser device includes an optical resonator, a microwave driven discharge device, and a source for a second gas. The microwave driven discharge device is disposed relative to the optical resonator. The microwave driven discharge device operates at a discharge power and gas flow rate to produce a selected amount of energetic singlet oxygen metastables flowing in the direction of the optical resonator. The second source for the second gas is disposed between the optical resonator and the microwave driven discharge device. The second gas reacts with the selected amount of energetic singlet oxygen metastables to form an excited species in an amount sufficient to support lasing of the excited species in the optical resonator. | 12-31-2009 |
20110170571 | High-Power, High-Throughput Microwave Discharge Singlet Oxygen Generator for Advanced Electrical Oxygen-Iodine Lasers - A laser device includes an optical resonator, a microwave driven discharge device, and a source for a second gas. The microwave driven discharge device is disposed relative to the optical resonator. The microwave driven discharge device operates at a discharge power and gas flow rate to produce a selected amount of energetic singlet oxygen metastables flowing in the direction of the optical resonator. The second source for the second gas is disposed between the optical resonator and the microwave driven discharge device. The second gas reacts with the selected amount of energetic singlet oxygen metastables to form an excited species in an amount sufficient to support lasing of the excited species in the optical resonator. | 07-14-2011 |
20130259769 | Catalytic Generation of Metastable Singlet Oxygen - Singlet oxygen metastables can be formed. A catalytic coating is formed on an interior surface of a flow reactor, and an oxygen containing species is flowed into the flow reactor to produce singlet oxygen metastables by a chemical reaction in the presence of the catalytic coating. | 10-03-2013 |
20140185642 | Catalytic Generation of Metastable Singlet Oxygen - Singlet oxygen metastables can be formed. A catalytic coating is formed on an interior surface of a flow reactor, and an oxygen containing species is flowed into the flow reactor to produce singlet oxygen metastables by a chemical reaction in the presence of the catalytic coating. | 07-03-2014 |
Seungwoo Lee, Boston, MA US
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20140357933 | MICROSCOPIC MAGNETIC STIMULATION OF NEURAL TISSUE - An implantable neural stimulation device includes a magnetic coil specifically dimensioned to be implantable inside the tissue and structured to generate, in the vicinity of the target tissue adjacent to which such coils is disposed in operation, magnetic field the strength of which is substantially the same as the strength of magnetic field generated in such tissue during the conventional TMS procedure. The modulation of orientation of microcoil modulates the activation of targeted neuronal tissue. | 12-04-2014 |
Soo-Kwan Lee, Boston, MA US
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20080242558 | FABRICATED BIOFILM STORAGE DEVICE - The present invention includes a method and composition of storing and preserving biofilms for input and output of high-density information. One form of the present invention is a fabricated biofilm storage device with a biologic material applied to a substrate to form, e.g., a dry thin film stable at room temperature for extended periods of time. Another form of the present invention is a method of fabricating a biofilm storage device in which a biologic material is applied to a substrate under conditions that promote alignment of the biologic material on the substrate. The composition, method, and kit of the present invention have universal application in biologics, magnetics, optics and microelectronics. | 10-02-2008 |
William David Lee, Boston, MA US
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20090273878 | GAS BEARING ELECTROSTATIC CHUCK - An electrostatic clamp is provided having a clamping plate, wherein the clamping plate has a central region and an annulus region. A plurality of gas supply orifices are defined in the central region of the clamping plate, wherein the plurality of gas supply orifices are in fluid communication with a pressurized gas supply, and wherein the pressurized gas supply is configured to provide a cushion of gas between the clamping surface and the workpiece in the central region of the clamping plate via the plurality of gas supply orifices. One or more gas return orifices defined in one or more of the central region and annulus region of the clamping plate, wherein the one or more gas return orifices are in fluid communication with a vacuum source, therein generally defining an exhaust path for the cushion of gas. A seal is disposed in the annulus region of the clamping plate, wherein the seal is configured to generally prevent a leakage of the cushion of gas from the central region to an environment external to the annulus region. One or more electrodes are further electrically connected to a first voltage potential to provide a first clamping force. | 11-05-2009 |
William W. Lee, Boston, MA US
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20080288917 | Smart generator - The Smart Generator of the present invention allows the designer/developer/user to model the EJB components in a natural way without being concerned with implementation-specific details. The developer models the business objects using a UML drawing tool and the Smart Generator creates a set of classes that implements these objects with reference to the Enterprise JavaBeans specification. That is, the Smart Generator automatically create access methods and handling containment of references from the UML diagram. | 11-20-2008 |