Patent application number | Description | Published |
20090048286 | Inhibitors of Protein Tyrosine Phosphatase 1B - Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes. | 02-19-2009 |
20100029648 | 11-Beta HSD1 Inhibitors - This invention relates to inhibiting 11βHSD1. | 02-04-2010 |
20100152099 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA - The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma. | 06-17-2010 |
20110263532 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF - The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications. | 10-27-2011 |
20130252919 | URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS - This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 09-26-2013 |
20140066613 | URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS - This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 03-06-2014 |
20140162972 | URIDINE DIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS - This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 06-12-2014 |
20140371167 | URIDINE NUCLEOSIDE DERIVATIVES, COMPOSITIONS AND METHODS OF USE - This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 12-18-2014 |
20150045319 | URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS - This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 02-12-2015 |
Patent application number | Description | Published |
20080284837 | METHODS AND SYSTEMS FOR THERMA-BASED LASER PROCESSING A MULTI-MATERIAL DEVICE - A method and system for locally processing a predetermined microstructure formed on a substrate without causing undesirable changes in electrical or physical characteristics of the substrate or other structures formed on the substrate are provided. The method includes providing information based on a model of laser pulse interactions with the predetermined microstructure, the substrate and the other structures. At least one characteristic of at least one pulse is determined based on the information. A pulsed laser beam is generated including the at least one pulse. The method further includes irradiating the at least one pulse having the at least one determined characteristic into a spot on the predetermined microstructure. The at least one determined characteristic and other characteristics of the at least one pulse are sufficient to locally process the predetermined microstructure without causing the undesirable changes. | 11-20-2008 |
20090016388 | LASER PROCESSING OF CONDUCTIVE LINKS - A laser system for processing conductive link structures includes a seed laser generating a seed laser beam. The seed laser is sliced by a modulator into a user configurable series of pulses and the pulses are optically amplified and applied to a conductive link structure. Preferably, the bandwidth of the seed laser is less than 1 nm with an IR center frequency, and the frequency of the laser light of the pulses is doubled or quadrupled prior to application to the conductive structure. Preferably, the pulses are about 1-18 second pulsewidth and are separated by 100-400 ns. | 01-15-2009 |
20110062127 | LASER-BASED METHOD AND SYSTEM FOR REMOVING ONE OR MORE TARGET LINK STRUCTURES - Laser-based methods and systems for removing one or more target link structures of a circuit fabricated on a substrate includes generating a pulsed laser output at a predetermined wavelength less than an absorption edge of the substrate are provided. The laser output includes at least one pulse having a pulse duration in the range of about 10 picoseconds to less than 1 nanosecond, the pulse duration being within a thermal laser processing range. The method also includes delivering and focusing the laser output onto the target link structure. The focused laser output has sufficient power density at a location within the target link structure to reduce the reflectivity of the target link structure and efficiently couple the focused laser output into the target link structure to remove the target link structure without damaging the substrate. | 03-17-2011 |
20120195331 | LASER PROCESSING OF CONDUCTIVE LINKS - A laser system for processing conductive link structures includes a seed laser generating a seed laser beam. The seed laser is sliced by a modulator into a user configurable series of pulses and the pulses are optically amplified and applied to a conductive link structure. Preferably, the bandwidth of the seed laser is less than 1 nm with an IR center frequency, and the frequency of the laser light of the pulses is doubled or quadrupled prior to application to the conductive structure. Preferably, the pulses are about 1-18 nanosecond pulsewidth and are separated by 100-400 nanoseconds. | 08-02-2012 |
20120276754 | METHODS AND SYSTEMS FOR THERMAL-BASED LASER PROCESSING A MULTI-MATERIAL DEVICE - A method and system for locally processing a predetermined microstructure formed on a substrate without causing undesirable changes in electrical or physical characteristics of the substrate or other structures formed on the substrate are provided. The method includes providing information based on a model of laser pulse interactions with the predetermined microstructure, the substrate and the other structures. At least one characteristic of at least one pulse is determined based on the information. A pulsed laser beam is generated including the at least one pulse. The method further includes irradiating the at least one pulse having the at least one determined characteristic into a spot on the predetermined microstructure. The at least one determined characteristic and other characteristics of the at least one pulse are sufficient to locally process the predetermined microstructure without causing the undesirable changes. | 11-01-2012 |
Patent application number | Description | Published |
20100301747 | LAMP WITH APPEARANCE DIFFERENTIATED FROM ITS MAIN ILLUMINATION - A lamp including a two-sided source plate, a plurality of light sources, a lens, a diffuser plate, and a driver insulator is disclosed. One set of the light sources generates white light and is attached to one side of the source plate. Another set of the light sources generates colored light and is attached to the source plate's other side. The lens encapsulates the white light-generating set, and redirects that white light. The driver insulator and the diffuser plate are each in contact with the source plate's other side. The driver insulator, diffuser plate, and that side of the source plate define a light box region that contains the colored light-generating set of light sources. The driver insulator acts as a reflector, and the diffuser plate acts as a diffuser, such that colored light is dispersed from the light box region through the diffuser plate. | 12-02-2010 |
20110317413 | OPTICAL ILLUMINATION SYSTEM PRODUCING AN ASYMMETRIC BEAM PATTERN - A light fixture, such as for an overhead street light, is disclosed. A light redirection device ( | 12-29-2011 |
20130335961 | LAMP WITH APPEARANCE DIFFERENTIATED FROM ITS MAIN ILLUMINATION - A lamp including a two-sided source plate, a plurality of light sources, a lens, a diffuser plate, and a driver insulator is disclosed. One set of the light sources generates white light and is attached to one side of the source plate. Another set of the light sources generates colored light and is attached to the source plate's other side. The lens encapsulates the white light-generating set, and redirects that white light. The driver insulator and the diffuser plate are each in contact with the source plate's other side. The driver insulator, diffuser plate, and that side of the source plate define a light box region that contains the colored light-generating set of light sources. The driver insulator acts as a reflector, and the diffuser plate acts as a diffuser, such that colored light is dispersed from the light box region through the diffuser plate. | 12-19-2013 |