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Ledeboer

Adrianus Marinus Ledeboer, Vlaardingen NL

Patent application numberDescriptionPublished
20080206233Heavy Chain And Single Domain Antibodies - The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.08-28-2008
20090035288EDIBLE PRODUCT CONTAINING BENEFICIAL BACTERIA - The present invention provides a method of preparing an edible product comprising non-viable bacteria providing a health benefit, the method comprising subjecting viable bacteria to at least two sub-lethal treatments to obtain the non-viable bacteria providing a health benefit, each sub-lethal treatment on its own not being sufficient to render the bacteria non-viable. The method porvides non-viable bacteria providing health benefits but which can conveniently be incorporated into a range of edible products.02-05-2009
20090123608Edible product containing beneficial moulds and/or yeasts - The present invention provides a method of preparing an edible product comprising non-viable moulds and/or yeasts that are substantially structurally intact and which provide a health benefit, the method comprising subjecting viable moulds and/or yeasts to at least two sub-lethal treatments to obtain the non-viable moulds and/or yeasts providing a health benefit, each sub-lethal treatment on its own not being sufficient to render the moulds and/or yeasts non-viable.05-14-2009
20090226418Food Products Comprising Probiotic Micro-Organisms and Antibodies - The present invention relates to food products or pharmaceutical preparations comprising antibodies or antibody fragments which are active in the gut and probiotic micro-organisms independent from the antibodies or antibody fragments. In particular, the invention relates to a method for preparing food products and pharmaceutical preparations comprising the antibodies or antibody fragments and probiotic micro-organisms and the use of these products to deliver health benefits to humans.09-10-2009
20090269307Edible Product Containing Ginseng Polysaccharides and Beneficial Bacteria - One aspect of the present invention relates to an edible product containing: • probiotic bacteria in an amount of at least 1010-29-2009

Patent applications by Adrianus Marinus Ledeboer, Vlaardingen NL

Annemarie Ledeboer, Alameda, CA US

Patent application numberDescriptionPublished
20110039873SUBSTITUTED PYRAZOLO[1,5-a] PYRIDINE COMPOUNDS HAVING MULTI-TARGET ACTIVITY - The substituted pyrazolo[1,5-a]pyridine compounds in accordance with Formula 1 are strong inhibitors of phosphodiesterase and c-Jun N-terminal kinase activity.02-17-2011

Fred Ledeboer, Aurora, OR US

Patent application numberDescriptionPublished
20090178164Spreading Ryegrass - Perennial ryegrass plants with a spreading habit are provided. The perennial ryegrass plants of the present invention display a growth habit with intertwining tillers that form a very dense sward of 10,000 tillers or more per square foot within one growing season. The ryegrass plants of the present invention also display secondary tillers, something not seen in currently available commercial perennial ryegrass varieties. The spreading growth habit of the plants of the present invention makes a very attractive turfgrass when grown for turf and also provides high seed production.07-09-2009

Mark Ledeboer, Acton, MA US

Patent application numberDescriptionPublished
20090088445Deazapurines useful as inhibitors of Janus kinases - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.04-02-2009
20100160287COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASES - The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.06-24-2010
20110118255PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JAK2 INHIBITORS - The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.05-19-2011
20110135603INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.06-09-2011

Patent applications by Mark Ledeboer, Acton, MA US

Mark Willem Ledeboer, Acton, MA US

Patent application numberDescriptionPublished
20120039849TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE - The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.02-16-2012