Lechler
Andreas Lechler, Vaihingen/enz DE
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20110215270 | Solenoid Valve for Controlling a Fluid - A solenoid valve for controlling a fluid includes an armature having a base region, a lateral region and a head region. The solenoid valve includes a valve member connected to the armature. The solenoid valve further includes an armature casing component in which the armature is positioned. A flow path is formed between the armature and the armature casing component, the flow path extending from a lower armature space to an upper armature space and back to the lower armature space. A junction region is arranged between the head region and the lateral region. The junction region has at least one groove formed therein to facilitate an overflow between the lateral region and the head region. | 09-08-2011 |
20120161047 | Solenoid Valve - A solenoid valve includes a housing which extends in the axial direction and has at least one axial section which is embodied as a circular hollow cylinder, and a solenoid armature which is removably guided in the housing along a cylinder inner wall in an axial direction along the longitudinal axis of said housing and the solenoid armature having a solenoid armature casing wall. At least one axial flow duct for a medium is located in the housing and is provided to permit a flow around the solenoid armature. The flow duct has a first and a second duct wall region, and the first duct wall region is formed by a section of the cylinder inner wall and the second duct wall region is formed by a section of the solenoid armature casing wall. The second duct wall region is embodied as a planar second duct wall region. | 06-28-2012 |
20120211691 | Valve for Controlling a Fluid - A valve for controlling a fluid includes a closing body and a valve seat. The closing body opens and closes a passage at the valve seat along a sealing line. The valve seat and the closing body have a rotationally symmetrical region where the sealing line between the valve seat and closing body is formed. The valve seat and/or the closing body also has a nonrotationally symmetrical region, which adjoins the rotationally symmetrical region in a throughflow direction of the valve. | 08-23-2012 |
20120313029 | VALVE FOR CONTROLLING A FLUID - A valve for controlling a fluid includes a valve seat and a closing body which has a spherical-cap-shaped end region and which is configured to open up and close off a passage at the valve seat. The closing body is rotatably mounted on a bearing and has at least one contouring formed on a surface of the closing body. The contouring is configured to set the closing body in rotation. | 12-13-2012 |
Gerald Lechler, Berlin DE
Gerhard Lechler, Berlin DE
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20110121513 | SEALING RING AND DEVICE AND METHOD FOR INSTALLING A SEALING RING - (EN) The invention relates to an installation device ( | 05-26-2011 |
Markus Lechler, Schorndorf DE
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20120240878 | Internal combustion engine with fan system - In an internal combustion engine cooling system, wherein a fan with an adjustable cooling performance is provided with a fan wheel having a hub with radial fan blades pivotally supported on the hub, a control piston is disposed in the hub and connected to the blades for the pivot position adjustment thereof over a range from a suction position to a blowing position including a neutral position in which the blades are oriented in a plane including the axis of rotation of the fan wheel under the control of a control unit causing movement of the piston for pivoting the blades to a position for a cooling performance adjusted to the engine requirements. The system is simple, safe and efficient and permits counter flow operation of the fan for cleaning purposes. | 09-27-2012 |
Robert Lechler, London GB
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20130143223 | METHOD OF DETERMINING KIDNEY TRANSPLANTATION TOLERANCE - The present invention relates to a method of determining an individual's transplantation tolerance by determining the level of a number of biomarkers. The present invention also relates to a kit comprising reagents for detecting the levels of the biomarkers. The present invention also relates to a sensor for detecting the expression levels of a plurality of genes that can be used to determine an individual's transplantation tolerance. | 06-06-2013 |
Robert Ian Lechler US
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20120017288 | Anticoagulant Fusion Protein Anchored to Cell Membrane - The invention relates to the inhibition of blood coagulation, especially during organ rejection, and in particular the inhibition of delayed vascular rejection. The invention provides anticoagulant proteins which are anchored to cell membranes. The anticoagulant function is preferably provided by heparin, antithrombin, hirudin, TFPI, tick anticoagulant peptide, or a snake venom factor. These anticoagulant proteins are preferably prevented from being constitutively expressed at the cell surface. In particular, expression at the cell surface is regulated according to cell activation, for instance by targeting the protein to a suitable secretory granule. Expression of these proteins renders cells, tissues and organs less vulnerable to rejection after transplantation (e.g. after xenotransplantation). | 01-19-2012 |
Robert Ian Lechler, London GB
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20100146648 | Immunosuppression by blocking T cell co-stimulation signal 2 (B7/CD28 interaction) - The invention provides means and methods for inhibiting T-cell mediated rejection of a xenotransplanted organ by blocking the delivery of co-stimulatory signal 2 (the B7/CD28 interaction) in order to prevent the activation of xenoreactive T-cells in the recipient. In a first aspect, co-stimulation is prevented by administration to the organ recipient of a soluble form of CTLA-4 from the xenogeneic donor organism. This preferentially binds B7 on the xenograft and blocks the interaction between B7 on the xenogeneic donor cells and CD28 on recipient T-cells. In a second aspect, co-stimulation is antagonised by expressing a ligand for CTLA-4 on the xenogeneic donor cells. This ligand binds to CTLA-4 on activated T-cells of the recipient and antagonises signal 2. In a third aspect, co-stimulation is prevented by expressing recipient organism MHC class II on the surface of the cells of the xenogeneic donor organ. The donor cells are thus able to present xenoantigens to a recipient T-cell in the context of self-MHC class II. If the donor cells do not express B7, or if B7 is blocked, the xenoreactive recipient T-cell becomes anergic. | 06-10-2010 |
20130078266 | Immunosuppression By Blocking T Cell Co-Stimulation Signal 2 (B7/CD28 Interaction) - The invention provides methods for inhibiting T-cell mediated rejection of a xenotransplanted organ by blocking the delivery of co-stimulatory signal 2 (the B7/CD28 interaction) prevent the activation of xenoreactive T-cells in the recipient. In a first aspect, co-stimulation is prevented by administration to the organ recipient of a soluble form of CTLA-4 from the xenogeneic donor organism. In a second aspect, co-stimulation is antagonised by expressing a ligand for CTLA-4 on the xenogeneic donor cells. In a third aspect, co-stimulation is prevented by expressing recipient organism MHC class II on the surface of the cells of the xenogeneic donor organ. | 03-28-2013 |
William M. Lechler, Virginia Beach, VA US
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20080251452 | "In-situ" ballast water treatment system and method - A method and system for ballast water treatment are provided. Living organisms are added into a vessel's ballast water tank (e.g., via an existing vent) to consume (i) oxygen dissolved in ballast water contained in the ballast water tank, and (ii) food sources for selected organisms contained in the ballast water. | 10-16-2008 |
20090101006 | In-line deaerating system for aquatic species control - A water deaerating system and method are provided. The first end of an open-ended conduit is placed beneath the surface of a body of oxygen-rich water. The conduit extends into a housing and where the second end of the conduit resides at a location in the housing that is above the surface of the body of oxygen-rich water. A vacuum is applied to a spatial region defined within the housing above the location of the second end of the conduit. The oxygen-rich water is pumped through the conduit and exits the second end of the conduit to enter the spatial region of the housing. The oxygen-rich water descends through the housing due to gravity. The oxygen-rich water's descension is interrupted and the vacuum operates to remove oxygen from the oxygen-rich water so-descending to generate oxygen-depleted water. | 04-23-2009 |
20140076803 | "IN-SITU" BALLAST WATER TREATMENT METHOD AND SYSTEM - A method and system for ballast water treatment is provided for a vessel with a ballast water tank system that pumps water from a local environment through a conduit into at least one tank on the vessel. The water contains aerobic micro-organisms from the local environment. Oxygen-containing gas is introduced into the water as it is pumped through the conduit. Living organisms are added into the water with the oxygen-containing gas introduced therein. As a result, the tank receives a mixture of the water with the oxygen-containing gas introduced therein and the living organisms added thereto. The living organisms are selected to consume (i) the aerobic micro-organisms, (ii) oxygen dissolved in the water, and (iii) food sources for the aerobic micro-organisms contained in the water. A vacuum is applied to the tank's ullage space at a point in time after the mixture is received in the tank. | 03-20-2014 |