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Leach, GB

Anthony Leach, Cheshire GB

Patent application number	Description	Published
20090037900	METHOD FOR OPTIMIZING MEMORY MODULES FOR USER-SPECIFIC ENVIRONMENTS - A method for altering and preferably optimizing the performance of system memory of a computer system. The method includes identifying the motherboard and the memory module of the computer system, and then searching multiple SPD update files associated with multiple motherboards and containing data corresponding to physical and operational characteristics of multiple memory modules. From these SPD update files, a compatible SPD update file is identified that is compatible with the motherboard and contains data corresponding to physical and operational characteristics of the memory module. Thereafter, a software utility is used to erase pre-existing SPD data stored on the SPD circuit device and then write and verify installation of the data of the compatible SPD update file on the SPD circuit device. New SPD settings for the memory module are then enabled based on the data of the compatible SPD update file.	02-05-2009
20110053429	CONNECTOR ASSEMBLY AND METHOD FOR SATA DRIVES - A connector assembly and method suitable for making data and power connections with mass storage devices that use the SATA interface standard. The connector assembly includes a connector having a pair of oppositely-disposed surfaces, a face between the surfaces, and data and power connector portions disposed in the face. The data and power connector portions are adapted to establish data and power connections between the connector and a SATA interface of a mass storage device. The connector assembly further has data and power cables for transmitting, respectively, data and power through the data and power connector portions of the connector. Opposing clips protrude from the oppositely-disposed surfaces of the connector and project beyond the face of the connector. The clips engage opposing sides of the mass storage device and mechanically stabilize the data and power connections between the connector and the SATA interface of the mass storage device.	03-03-2011
20110138113	RAID STORAGE SYSTEMS HAVING ARRAYS OF SOLID-STATE DRIVES AND METHODS OF OPERATION - RAID storage systems and methods adapted to enable the use of NAND flash-based solid-state drives. The RAID storage system includes an array of solid-state drives and a controller operating to combine the solid-state drives into a logical unit. The controller utilizes data striping to form data stripe sets comprising data (stripe) blocks that are written to individual drives of the array, utilizes distributed parity to write parity data of the data stripe sets to individual drives of the array, and writes the data blocks and the parity data to different individual drives of the array. The RAID storage system detects the number of data blocks of at least one of the data stripe sets and then, depending on the number of data blocks detected, may invert bit values of the parity data or add a dummy data value of “1” to the parity value.	06-09-2011

Anthony Leach, Stockport GB

Patent application number	Description	Published
20110119462	METHOD FOR RESTORING AND MAINTAINING SOLID-STATE DRIVE PERFORMANCE - A method of maintaining a solid-state drive so that free space within memory blocks of the drive becomes free usable space to the drive. The drive comprises cells organized in pages that are organized in memory blocks in which at least user files are stored. A defragmentation utility is executed to cause at least some of the memory blocks that are partially filled with data and contain file fragments to be combined or aligned and to cause at least some of the memory blocks that contain only invalid data to be combined or aligned. A block consolidation utility is then executed to eliminate at least some of the partially-filled blocks by consolidating the file fragments into a fewer number of the memory blocks. The consolidation utility also increases the number of memory blocks that contain only invalid memory. All of the memory blocks containing only invalid data are then erased.	05-19-2011

Chris Leach, Inverness GB

Patent application number	Description	Published
20110144915	FILL SUFFICIENCY METHOD AND SYSTEM - Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.	06-16-2011

Christopher Philip Leach, Inverness GB

Patent application number	Description	Published
20100206727	TEST STRIP COMPRISING PATTERNED ELECTRODES - Described herein is an analyte test strip and method for making the test strip. The test strip utilizes isolated conductive areas to define electrode whiskers. The method utilizes laser ablation to define electrode patterns.	08-19-2010
20110005941	METHODS FOR DETERMINING AN ANALYTE CONCENTRATION USING SIGNAL PROCESSING ALGORITHMS - A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.	01-13-2011
20110048972	MULTI-ANALYTE TEST STRIP WITH SHARED COUNTER/REFERENCE ELECTRODE AND INLINE ELECTRODE CONFIGURATION - A multi-analyte test strip includes a first insulating layer and an electrically conductive layer disposed on the first insulating layer. The electrically conductive layer has a first working electrode with a first analyte contact pad, a shared counter/reference electrode with a counter/reference electrode contact pad, and a second working electrode with a second analyte contact pad. The multi-analyte test strip also includes a second insulating layer disposed above the first insulating layer and a patterned spacer layer positioned between the first insulating layer and the first electrically conductive layer with the patterned spacer layer defining a bodily fluid sample-receiving chamber that overlies the first working electrode, the shared counter/reference electrode and the second working electrode. The multi-analyte test strip further includes a mediator reagent layer disposed over the first working electrode, the shared counter/reference electrode and the second working electrode; a first analyte reagent layer disposed over the first working electrode and mediator reagent layer; and a second analyte reagent layer disposed over the second working electrode and mediator reagent layer. Furthermore, the first analyte electrode, shared counter/reference electrode and second analyte electrode of the multi-analyte test strip are disposed on the first insulating layer in a planar inline configuration.	03-03-2011
20110094882	TEST METER FOR USE WITH A DUAL CHAMBER, MULTI-ANALYTE TEST STRIP WITH OPPOSING ELECTRODES - A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip. The signal processing module is configured to receive a first signal via the first electrical connector and the third electrical connector and employ the first signal for the determination of a first analyte (such as glucose) in a bodily fluid sample (for example, whole blood sample) applied to the dual-chamber, multi-analyte test strip. Moreover, the signal processing module is also configured to receive a second signal via the second electrical connector and fourth electrical connector and employ the second signal for the determination of a second analyte (e.g., a ketone analyte) in the bodily fluid sample applied to the dual-chamber, multi-analyte test strip. Furthermore, the third and fourth electrical contacts provide contact in an opposing manner.	04-28-2011
20110094896	DUAL CHAMBER, MULTI-ANALYTE TEST STRIP WITH OPPOSING ELECTRODES - A dual chamber, multi-analyte test strip has a first insulating layer, a first electrically conductive layer, with a first working electrode, disposed on the first insulating layer and a first patterned spacer layer positioned above the first electrically conductive layer. The first patterned spacer layer has a first sample-receiving chamber, with first and second end openings, defined therein that overlies the first working electrode. The test strip also includes a first counter/reference electrode layer that is exposed to the first sample receiving chamber and is in an opposing relationship to the first working electrode. The test strip further includes a counter/reference insulating layer disposed over the first counter/reference electrode layer and a second counter/reference electrode layer disposed on the counter/reference substrate. Also included in the test strip is a second patterned spacer layer that is positioned above the second counter/reference electrode layer. The second patterned spacer layer has a second sample-receiving chamber, with first and second end openings, defined therein. The test strip additionally has a second electrically conductive layer, with a second working electrode, disposed above the second patterned spacer layer, a second insulating layer disposed above the second electrically conductive layer, a first analyte reagent layer disposed on the first working electrode within the first sample-receiving chamber; and a second analyte reagent layer disposed on the second working electrode within the second sample-receiving chamber. The second counter/reference electrode layer is exposed to the second sample receiving chamber and is in an opposing relationship to the second working electrode.	04-28-2011
20110162978	SYSTEMS AND METHODS FOR DETERMINING A SUBSTANTIALLY HEMATOCRIT INDEPENDENT ANALYTE CONCENTRATION - A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.	07-07-2011

Christopher Philip Leach, Inverness-Shire GB

Patent application number	Description	Published
20090280551	A REAGENT FORMULATION USING RUTHENIUM HEXAMINE AS A MEDIATOR FOR ELECTROCHEMICAL TEST STRIPS - Described herein are various embodiments of a test strip, which may be capable of measuring an analyte. The test strip may include a working electrode and a reference electrode where the reagent formulation is disposed on the working electrode. The reagent formulation may be coated onto the test strip. The reagent formulation includes an enzyme, a ruthenium hexamine mediator, and a solution for dissolving the enzyme and the ruthenium hexamine mediator. The reagent formulation may be coated onto the test strip. The reagent formulation includes an enzyme, a ruthenium hexamine mediator, and a solution for dissolving the enzyme and the ruthenium hexamine mediator. The ruthenium hexamine has a concentration range from about 15% to about 20% (weight of mediator/volume) of solution. The enzyme may be either glucose oxidase and glucose dehydrogenase.	11-12-2009
20100219084	METHOD FOR DETERMINING HEMATOCRIT CORRECTED ANALYTE CONCENTRATIONS - Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator. The method can be achieved by: providing a test strip comprising a reference electrode and a working electrode formed with a plurality of microelectrodes and coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.	09-02-2010

Colin Andrew Leach, Harlow GB

Patent application number	Description	Published
20090118313	Novel Compounds - Pyrimidone compounds of formula (I):	05-07-2009
20090170877	5,6-Trimethylenepyrimidin-4-one compounds - Pyrimidone compounds of formula (I):	07-02-2009
20100144765	5,6-TRIMETHYLENEPYRIMIDIN-4-ONE COMPOUNDS - Pyrimidone compounds of formula (I):	06-10-2010

Graham R. Leach, Swindon GB

Patent application number	Description	Published
20110243290	PHASE-LOCKED LOOP - A PLL circuit (	10-06-2011

Gregory Matthew Leach, Chester GB

Patent application number	Description	Published
20090145392	FUEL FORMULATIONS - A diesel fuel formulation is disclosed containing a water-in-fuel emulsion of (a) a Fischer-Tropsch derived gas oil, optionally in combination with conventional diesel, (b) a fatty acid alkyl ester in an amount of at least 1% v/v and (c) water. An emulsifier may be present.	06-11-2009

Gwendoline Leach, London GB

Patent application number	Description	Published
20110226267	Transgenic Plants - The invention provides transgenic plants, specifically tobacco plants, which accumulate the amino acid threonine in their leaves. The biosynthetic pathway leading to production of threonine is tightly regulated, and previous attempts to achieve a transgenic plant which overproduces threonine has compromised the fitness of the plants. This invention has overcome these difficulties and found a method of increasing the level of threonine in plant leaves above the corresponding wild type level without compromising plant fitness, comprising altering plant metabolism to achieve increased production of threonine after the initiation of leaf senescence. This invention involves a genetic construct comprising a senescence specific promoter operably linked to a coding sequence encoding a polypeptide having threonine insensitive aspartate kinase activity.	09-22-2011

Martin Leach, Cambridge GB

Patent application number	Description	Published
20090232263	Timing Errors - A method of analysing a sampled signal that is supplied for decimation, wherein the decimation process produces a decimated version of the signal and wherein the method comprises determining an adjustment, if any is required, to the sampling instant of the signal prior to decimation that will cause the frequency responses of the decimated signal and of a main alias to combine constructively at a given frequency.	09-17-2009
20100014614	Digital Radio Systems - Apparatus comprising a pre-filter rake architecture with various features designed to, in at least some circumstances, to lessen the data processing burden associated with the architecture. In one embodiment, the pre-filter aspect can be disabled.	01-21-2010
20100054380	Refinement of Channel Estimation With a Bank of Filters - A receiver for acquiring a signal through a propagation channel, the receiver comprising channel estimating means (	03-04-2010

Martin Geoffrey Leach, Cambridge GB

Patent application number	Description	Published
20080212694	Signal decoding systems - We describe a method of decoding a DCM (dual carrier modulation) modulated OFDM signal, the method comprising: inputting first received signal data representing modulation of a multibit data symbol onto a first carrier of said OFDM signal using a first constellation; inputting second received signal data representing modulation of said multibit data symbol onto a second, different carrier of said OFDM signal using a second, different constellation; determining a combined representation of said first and second received signal data, said combined representation representing a combination of a distance of a point representing a bit value of said multibit data from a constellation point in each of said different constellations; and determining a decoded value of a data bit of said multibit data using said combined representation.	09-04-2008

Martin Osmund Leach, Sussex GB

Patent application number	Description	Published
20090046914	TIME-SEQUENTIAL VOLUME RENDERING - There is disclosed a method and apparatus for generating data for a two-dimensional image which identifies different classes of property of an imaged subject, this being done by separately rendering volumetric data classified into those different classes and, from all of those separate renderings, choosing one datum for use in the two-dimensional image as an image pixel. This being repeatable for each datum to be used in the two-dimensional image—thereby, for example, to selectively build-up the data for whole of the two-dimensional image as a mixture/combination of different classes of data. The data for the two-dimensional image may be colour coded for visually distinguishing data of different classes. Thus when applied to the image enhancement of tissues subjected to contrast agent uptake in patients kinetic information may be incorporated into the volume renderings to enable tissues of different enhancement and kinetic characteristics to be identified as such.	02-19-2009

Michael Leach, Kent GB

Patent application number	Description	Published
20090291954	Medical Use of Triazine Derivatives - Compounds of formula (I) especially where R	11-26-2009
20110009413	CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS - Compounds of general structure in which X and Y are each N or C with at least one of X and Y being N; Z is a single bond or an optionally substituted linking group R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when RI is hydrogen or ═NH when R1 is a substituent group; or N* is a group NRaRb where Ra and Rb are independently H or an alkyl group; or N* is an optionally substituted piperazinyl ring; and A is an optionally substituted heterocyclic or carbocyclic ring system which may be linked to the triazo/diazo ring through R2 to form a fused multicyclic ring; are indicated as suitable for treatment of disorders in mammals that are susceptible to sodium channel blockers and antifolates, and particularly disorders such epilepsy, multiple sclerosis, glaucoma and uevitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety and cognitive disorders, schizophrenia and trigeminal autonomic cephalalgias; for treatment of mammalian cancers; and for treatment of malaria.	01-13-2011

Michael J. Leach, London GB

Patent application number	Description	Published
20090036410	Structured Phospholipids - A method of treating a patient in need of therapy for a disease in which cyokines have become dysregulated, or are otherwise capable of modulation to provide therapeutic benefit, is provided comprising administering to that patient a therapeutically effective dose of a phospholipid comprising a phosphatidyl group esterifed with one or more fatty acyl groups, characterised in that the phospholipid has at least one fatty acyl group at the sn-1 and/or sn-2 position of the phosphatidyl group, the fatty acyl group being selected from the group consisting of γ-linolenoyl, dihomo-γ-linolenoyl acid and arachidonoyl.	02-05-2009
20100113595	Treatment of neurodegenerative conditions - A method is provided for treating a patient in need of therapy for a neurodegenerative disease comprising administering to that patient a therapeutically effective dose of a lipid glyceride comprising a glycerol moiety and a fatty acid moiety, the fatty acid moiety being selected from the group consisting of γ-linolenic acid, dihomo-γ-linolenic acid and arachidonic acid characterised in that the selected fatty acid moiety is attached to the glycerol moiety at its sn-2 position. Preferably the method is that wherein the lipid is administered for a duration and at a dose sufficient to maintain or elevate TGF-β1 levels in the patient to therapeutic levels.	05-06-2010
20100113810	Treatment of neurodegenerative conditions - A method is provided for treating a patient in need of therapy for a neurodegenerative disease comprising administering to that patient a therapeutically effective dose of a lipid glyceride comprising a glycerol moiety and a fatty acid moiety, the fatty acid moiety being selected from the group consisting of γ-linolenic acid, dihomo-γ-linolenic acid and arachidonic acid characterised in that the selected fatty acid moiety is attached to the glycerol moiety at its sn-2 position. Preferably the method is that wherein the lipid is administered for a duration and at a dose sufficient to maintain or elevate TGF-β1 levels in the patient to therapeutic levels.	05-06-2010

Michael J. Leach, Kent GB

Patent application number	Description	Published
20090023807	Treatment of Cytokine Dysregulation by Using Sn-2 Gamma-Linolenoyl, Gamma-Diho-Molinolenoyl or Arachidonoyl Patty Acid Glycerol Monoesters - A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a monoglyceride or metabolic precursor thereof of general formula (I), wherein R	01-22-2009
20090137660	Cytokine Modulators Using Cyclic Glycerides of Essential Polyunsaturated Fatty Acids - A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R	05-28-2009
20100297196	Cytokine modulators using cyclic glycerides of essential polyunsaturated fatty acids - A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R	11-25-2010
20110184063	Treatment of neurodegenerative conditions - A method is provided for treating a patient in need of therapy for a neurodegenerative disease comprising administering to that patient a therapeutically effective dose of a triglyceride oil containing both γ-linolenic acid and linoleic acid residues as triglyceride ester, the ratio of γ-linolenic acid to linoleic acid residues at the sn-2 position of the triglyceride being at least 0.8; the amount of γ-linolenic acid residues at the sn-2 position being at least 18%, wherein the oil is administered at a dose sufficient to maintain or elevate TGF-β1 levels in the patient at a therapeutic level. Preferably the method is that wherein the therapeutic level is such as to produce a TGF-β1/TNF-α ratio of at least 0.5 in blood of a patient, after 18 months of daily dosing. Preferred oils are Borage or Mucor oils having at least 35% of the sn-2 position fatty acid residues as γ-linolenic acid.	07-28-2011

Richard Leach, Middlesex GB

Patent application number	Description	Published
20110047661	MICROPROBE, MEASUREMENT SYSTEM AND METHOD - A microprobe, measurement system and method are disclosed. The microprobe includes a probe tip mounted at a meeting point of a plurality of flexures. The probe tip is moveable upon flexing of one or more of the flexures, each flexure further comprising one or more actuators controllable to flex the flexure and one or more sensors arranged to sense flexin of the flexure.	02-24-2011

Stephen Frederick Knight Leach, North Somerset GB

Patent application number	Description	Published
20120017068	PROCESSORS - A processing system comprises a plurality of processors (	01-19-2012

Thomas Robin Leach, Sheffield GB

Patent application number	Description	Published
20090295665	Electromagnetic Band-Gap Structure - An electromagnetic band gap structure is provided including a ground plane and a periodic planar arrangement of surface elements mounted parallel to and at a predetermined distance from the ground plane. Each of the surface elements is supported in the planar arrangement by at least one conducting support element extending from an edge of the surface element to the ground plane, avoiding back-to-back parallel support elements. This arrangement allows for the surface elements and their respective support elements to be folded from flat metal templates to greatly simplify manufacture. An antenna is also provided in which an antenna element is mounted in such a way as to use the electromagnetic band-gap structure as a ground plane. This allows for a low-profile antenna to be made as the antenna element may be mounted close to the plane of surface elements in the structure.	12-03-2009