Lawrence, MA
Carolyn Lawrence, Boston, MA US
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20120135486 | Methods and Compositions for the Extracellular Transport of Biosynthetic Hydrocarbons and Other Molecules - The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into hydrocarbons, e.g., n-alkanes and n-alkenes, wherein the n-alkanes are secreted into the culture medium via recombinantly expressed transporter proteins. In particular, the use of such organisms for the commercial production of n-alkanes and related molecules is contemplated. | 05-31-2012 |
20140093923 | Methods and Compositions for the Extracellular Transport of Biosynthetic Hydrocarbons and Other Molecules - The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into hydrocarbons, e.g., n-alkanes and n-alkenes, wherein the n-alkanes are secreted into the culture medium via recombinantly expressed transporter proteins. In particular, the use of such organisms for the commercial production of n-alkanes and related molecules is contemplated. | 04-03-2014 |
Christian Lawrence, Plympton, MA US
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20130036983 | Method and System for Mass Production of Fish Embryos - A method and system for producing large quantities of aquatic animal embryos includes providing a water filled spawning tank adapted for holding the male and female aquatic animals in various configurations. The system can include a spawning platform which includes a porous or perforated element that allows the embryos but not the aquatic animal to pass through and a separator which includes a porous or perforated element that can be used to separate the male aquatic animals from the female aquatic animals during a priming phase. In operation, the spawning platform can be placed in the bottom of the tank in order to provide a bottom collection area where the embryos can be collected and the aquatic animals cannot eat or otherwise harm the embryos. The female aquatic animals can be placed in tank above the spawning platform. The separator can be placed in the tank above the female aquatic animals and the male aquatic animals can be placed in the tank above, remaining separated from the female aquatic animals, beginning the priming phase. When embryos are desired, the separator can be removed allowing the male aquatic animals to mingle with the female aquatic animals and the height of the water above the porous or perforated element of the spawning platform can be changed, by raising the spawning platform or lowering the water level, in the spawning phase. The porous or perforated element of the spawning platform can be undulating or angled with respect to horizontal to create areas of varying depth over the surface of the porous or perforated element of the spawning platform to improve embryo production. | 02-14-2013 |
Christine Lawrence, Waltham, MA US
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20100268691 | Universal Visualization Platform - The invention relates to a framework system and methods for connecting a plurality of tools. The system comprises a plug-in mechanism configured to dynamically load the plurality of tools, a data pool having storage space configured to store data sets associated with the plurality of tools, a linking mechanism configured to establish communications links between the loaded plurality of tools to enable coordinated operation of the loaded plurality of tools, a session component configured to record the process history of the operations of the loaded plurality of tool and the system states corresponding to the process history of the operations and an annotation module configured to associate user-provided data corresponding to one or more of the stored data sets. | 10-21-2010 |
Doug Lawrence, Framingham, MA US
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20150065991 | VIAL DOSING SYSTEMS AND METHODS - Vial dosing systems and methods are disclosed. A vial dosing device includes a connecting body coupleable to a vial, a cannulated plunger having a proximal end coupled to the connecting body, a dose chamber adapted to slidably receive a distal end of the cannulated plunger and to expel medicament through a distal end of the dose chamber, and a plunger tip check valve coupled to the cannulated plunger and adapted for fluid flow from the cannulated plunger through the plunger tip check valve into the dose chamber. | 03-05-2015 |
Douglas W. Lawrence, Southborough, MA US
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20100152646 | Intravitreal injection device and method - A coordinated cutting and spreading mechanism within a syringe dilator sub-assembly is applied to an eye surface during an intravitreal injection to provide an access window free of the conjunctival layer and through which an injection needle can be inserted. The system and method comprises a dilator sub-assembly including both the cutting and spreading mechanism and the intravitreal injection needle, for use with a conventional syringe. The dilator sub-assembly includes a number of projections to secure points of the surface of the conjunctival layer, a cutting member to incise the conjunctival layer, and at least one deflectable projection to move during the intravitreal injection, spreading the incision, and creating a window opening in the conjunctival layer through which the intravitreal injection needle then enters. Upon removal of the device from the injection site, the deflectable projection is released and the window opening in the conjunctival layer is closed. | 06-17-2010 |
Gregory M. Lawrence, West Boylston, MA US
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20150241424 | MULTI-ANALYTE ASSAY - The present invention is directed to devices and methods using pan-generic antibodies to detect bacteria in a sample. | 08-27-2015 |
Jimmy Lawrence, Amherst, MA US
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20120137764 | Detecting Gas Compounds For Downhole Fluid Analysis - A gas separation and detection tool for performing in situ analysis of borehole fluid is described. The tool comprises a sampling chamber for a downhole fluid. The sample chamber comprises a detector cell with an opening. The tool also comprises a gas separation module for taking a gas from the downhole fluid. The gas separation module comprises a membrane located in the opening, a support for holding the membrane, and a sealant applied between the housing and the membrane or support. Moreover, the tool comprises a gas detector for sensing the gas. | 06-07-2012 |
20120273203 | DOWNHOLE MIXING DEVICE FOR MIXING A FIRST FLUID WITH A SECOND FLUID - Methods and devices for mixing a first fluid with a second fluid downhole include a chamber having a first end, a second end and an opening for fluid to flow there through. A top surface of a perforated piston is capable of contacting the second end and a top surface of a piston is capable of contacting a bottom surface of the perforated piston. The perforated piston is located at a first position within the chamber based upon characteristics of a first fluid. A first fluid delivery system supplies the first fluid and a second fluid delivery system supplies a second fluid to the chamber, wherein the second fluid is at a pressure that moves the piston approximate to the first end. An actuating device applies a force against the bottom surface of the piston to inject the fluids through channels of the perforated piston to produce spray droplets. | 11-01-2012 |
20120276648 | ELECTROSTATICALLY STABILIZED METAL SULFIDE NANOPARTICLES FOR COLORIMETRIC MEASUREMENT OF HYDROGEN SULFIDE - Methods and related apparatuses and mixtures are described for spectroscopic detection of hydrogen sulfide in a fluid, for example a formation fluid downhole. A reagent mixture is combined with the fluid. The reagent mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and a solvent that stabilizes the metal sulfide nanoparticles and assist in preventing precipitation by electrostatic stabilization. The solvent includes a property having a density above 1 kg/l. Further, dissolving the metal ions into the solvent to create the reagent mixture, and mixing the reagent mixture with the hydrogen sulfide sample in a formation. So, the metal ions of the reagent mixture react with the hydrogen sulfide sample to form the metal sulfide nanoparticles, resulting in the metal sulfide nanoparticles having properties with a density from 1 kg/l to about 8 kg/l. | 11-01-2012 |
20130075093 | SYSTEM AND METHOD FOR FLUID PROCESSING WITH VARIABLE DELIVERY FOR DOWNHOLE FLUID ANALYSIS - Described herein are variable-volume reservoir (e.g., syringe pump) based processes and systems usable to characterize samples of reservoir fluids, without having to first transport the fluids to the surface. Variable-volume reservoirs are used, for example, for one or more of storing reactants, controlling mixing ratios and storing used chemicals. The processes and systems can be used in various modes, such as continuous mixing mode, flow injection analysis, and titrations. A fluid interrogator, such as a spectrometer, can be used to detect a change in a physical property of the mixture, which is indicative of an analyte within the mixture. In at least some embodiments, a concentration of the analyte solution can be determined from the detected physical property. | 03-28-2013 |
Mark Gregory Lawrence, Westfield, MA US
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20140272318 | COMPOSITES AND ARTICLES MADE FROM NONWOVEN STRUCTURES - The present invention generally relates to composites and articles made from nonwoven structures. One aspect of the invention is generally directed to nonwoven structures which are heated and/or pressed to form a substantially rigid article. In some cases, the nonwoven structure may be heated to temperatures greater than the glass transition temperature but less than the melting temperature of a polymer within the nonwoven structure. Such articles may exhibit creep of the polymer around other fibers in the nonwoven structure, but without any evidence of melting and/or flow. In addition, in some embodiments, such articles may have relatively large void volumes, or exhibit properties such as low flammability, smoke resistance, or acoustic insulation. Other aspects of the present invention are generally directed to systems and methods for making such articles, methods of use of such articles, kits comprising such articles, etc. | 09-18-2014 |
20140273705 | COMPOSITES COMPRISING NONWOVEN STRUCTURES AND FOAM - The present invention generally relates to nonwoven structures and composites comprising such nonwoven structures, particularly structures incorporating foam, and methods of making and use thereof. One aspect of the invention is generally directed to composites comprising a nonwoven structure immobilized to foam, e.g., using adhesive, needling, or other techniques. The nonwoven structure may comprise any of a variety of fibers. In certain embodiments, the composite may be substantially thermally insulating and/or acoustic insulating. Other aspects of the present invention are generally directed to systems and methods for making such composites, methods of use of such composites, kits comprising such composites, and the like. | 09-18-2014 |
Michael Lawrence, Cambridge, MA US
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20150178445 | DETECTING VARIANTS IN SEQUENCING DATA AND BENCHMARKING - A system, method, and computer program product for detecting variants from sequencing data. Aligned sequencing data can be provided and filters can be applied to the aligned sequencing data. The filtered data can be used as input, and a first classifier can be applied to determine if any alteration is present beyond an expected threshold due to a sequencing error and candidate variants can be identified. The identified candidate variants can be passed through additional filters to remove false positives. A somatic status of the filtered candidate variants can be determined using a second classifier. The related apparatus, systems, techniques and articles are also described. | 06-25-2015 |
Nathan Lawrence, South Easton, MA US
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20090286301 | EXTRACTION OF BIOMOLECULAR COMPLEXES ASSISTED BY ALTERNATING HYDROSTATIC PRESSURE - Extraction methods that allow a molecular complex (e.g., an organelle) to be extracted from a sample by employing pressure cycling are described. | 11-19-2009 |
20100159507 | SHREDDER FOR MECHANICAL DISRUPTION BY GENTLE CONTROLLED COMPRESSIVE ROTATION - The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures. | 06-24-2010 |
Nathan P. Lawrence, South Easton, MA US
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20150232917 | Materials and Methods for Achieving Differential Lysis of Mixtures with the Aid of Alkaline Lysis and Pressure Cycling Technology (PCT) - The subject invention provides a two-step protocol using pressure cycling technology (PCT) and alkaline lysis for differential extraction of mixtures. In a preferred embodiment the procedure is used in forensic DNA applications such as, for example, DNA testing in the case of rape. | 08-20-2015 |
Philip Lawrence, Bolton, MA US
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20110118554 | DEVICE-ASSISTED SOCIAL NETWORKING FOR HEALTH MANAGEMENT - Device-assisted social networking for health management, in one aspect, collects health related information associated with one or more users, performs analysis and publishes data resulting from the analyzing to a social networking website associated with one or more users, wherein the data may be shared among the users in a group for peer encouragement in habits that would improve the users' health conditions. | 05-19-2011 |
Sandra B. Lawrence, Brookline, MA US
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20090128613 | High Speed Photo-Printing Apparatus - A thermal printer is disclosed which includes a plurality of thermal print heads, each of the plurality of thermal print heads being operable to print a distinct one of a plurality of colors. The plurality of thermal print heads may print output at a plurality of spatial resolutions. The thermal printer may include dot size varying means for varying perceived levels of color printed by the thermal printer by varying sizes of dots printed by the plurality of thermal print heads. The printer may perform various image processing steps on an image to be printed, such as tone scale adjustment, thermal history control, and common mode voltage correction, to improve the perceived quality of the printed image. The thermal printer may be incorporated into a digital photo-printing vending machine for printing images provided by a customer. | 05-21-2009 |
Stephen D. Lawrence, Ayer, MA US
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20130191046 | Integrated, portable sample analysis system and method - An integrated, portable sample analysis system and method. A viscometer subsystem receives a first portion of a sample. A spectrometer subsystem receives a second portion of the sample. A syringe pump subsystem receives a third portion of the sample and is configured to urge the third portion of the sample through a filter which collects particles in the sample thereon. An x-ray analysis subsystem is configured to x-ray the particles. The x-ray analysis subsystem also receives a fourth portion of the sample in order to determine the composition of any dissolved material in the sample. A processing subsystem provides a report concerning the sample and its viscosity, physical properties, particulate count and size distribution, and the composition of particulate and dissolved elements in the sample. | 07-25-2013 |
20130333449 | FILTRATION PARTICLE QUANTIFIER - A particle quantifier includes a filter with a predetermined number of pores of a first predetermined size, a pump, and a fluid path from the pump to the filter. A pressure sensor is responsive to fluid pressure in the fluid path, and a processing module is responsive to the pressure sensor. The pressure increase of a sample fluid in the fluid path is determined as it is pumped through the filter and particles in the fluid are trapped by the filter. This pressure increase is compared with calibration data and an estimate is made concerning the concentration of particles greater than a second predetermined size present in the sample. | 12-19-2013 |
Tyson Lawrence, Cambridge, MA US
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20100106163 | Uterine Manipulator Assemblies and Related Components and Methods - A uterine manipulator includes an elongate shaft and a tip hub. The elongate shaft has a proximal end and a distal end. The distal end is configured to be inserted into a vagina. The tip hub is disposed at the distal end and is configured to releasably receive and support a tip mount for engaging a uterus. The elongate shaft includes one or more channels extending between the distal and proximal ends. The channels are configured to releasably receive catheter tubing. | 04-29-2010 |
20120150123 | INFUSION SET - A single package infusion set is provided, including one or more of the following inserters: pushbutton-type, squeeze-type, contact-type, skin pinching-type, folding retraction-type, or multistage-type inserter having at least one reusable stage. The infusion set further includes adhesion means with user-selectable degrees of adhesion strength, self-sealing tube connection means, a lens feature to view, a site beneath the set, exemplary tube management and connection elements, insulin supply, adhesion concealment means, finger loops on the inserter and site preparation wipes or sprays, optionally provided as part of the inserter. The system further includes a package which may hold a number of easily released sets, retrievable by an inserter, an exemplary insertion needle handle and shroud, an exemplary squeeze-type latch between an upper portion and a lower portion of the set, and/or a tool removable upper portion of the set. | 06-14-2012 |
20130345714 | Uterine Manipulator Assemblies and Related Components and Methods - A uterine manipulator includes an elongate shaft and a tip hub. The elongate shaft has a proximal end and a distal end. The distal end is configured to be inserted into a vagina. The tip hub is disposed at the distal end and is configured to releasably receive and support a tip mount for engaging a uterus. The elongate shaft includes one or more channels extending between the distal and proximal ends. The channels are configured to releasably receive catheter tubing. | 12-26-2013 |
20150211579 | LINER-AS-SEAL BEARINGS - Disclosed are bearing assemblies including a compliant layer within a mounting socket for reducing wear of the bearing. | 07-30-2015 |