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Lattuada
Luciano Lattuada, Bussero IT
| Patent application number | Description | Published |
|---|---|---|
| 20100202967 | FIBRIN BINDING PEPETIDE CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors. | 08-12-2010 |
| 20100331567 | PROCESS FOR THE IODINATION OF AROMATIC COMPOUNDS - The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2,4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3,5-disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7). | 12-30-2010 |
| 20110052491 | GASTRIN RELEASING PEPTIDE COMPOUNDS - New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided. | 03-03-2011 |
| 20110082280 | Methods Of Coupling Multidentate AZA Ligands To Targeting Molecules - Methods of coupling targeting molecules to multidentate aza ligands of general formula (I): | 04-07-2011 |
Luciano Lattuada, Bussero (mi) IT
| Patent application number | Description | Published |
|---|---|---|
| 20080247946 | Gastrin Releasing Peptide Compounds - New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided. | 10-09-2008 |
| 20090175786 | Gastrin Releasing Peptide Compounds - New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: | 07-09-2009 |
Luciano Lattuada, Milan IT
| Patent application number | Description | Published |
|---|---|---|
| 20080317668 | Integrin Targeted Synthetic Ligands for Diagnostic and Therapeutic Applications - The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors. | 12-25-2008 |
Luciano Lattuada, Colleretto Giacosa (to) IT
| Patent application number | Description | Published |
|---|---|---|
| 20110250133 | GASTRIN RELEASING PEPTIDE COMPOUNDS - Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means. | 10-13-2011 |
Luciano Lattuada, Milano IT
| Patent application number | Description | Published |
|---|---|---|
| 20110256067 | Contrast agents endowed with high relaxivity - The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity. | 10-20-2011 |
Luciano Lattuada, Ivrea IT
| Patent application number | Description | Published |
|---|---|---|
| 20110275850 | Process For The Preparation Of Triiodinated Carboxylic Aromatic Derivatives - The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is iopamidol. The said process comprises reacting suitable N-sulfinyl intermediate compounds with a commercially available α-hydroxyacid or a salt thereof. | 11-10-2011 |