Patent application number | Description | Published |
20100217269 | Discectomy Instrument - The present invention provides a discectomy instrument that is capable of removing portions of the spinal disc between adjacent vertebrae in a controlled manner that is efficient and easy to use. In an exemplary embodiment, the discectomy instrument includes a handle, a rotary scraper, a barrel, a drive shaft, an outer sleeve and a retaining clip. | 08-26-2010 |
20130282013 | Discectomy Instrument - The present invention provides a discectomy instrument that is capable of removing portions of the spinal disc between adjacent vertebrae in a controlled manner that is efficient and easy to use. In an exemplary embodiment, the discectomy instrument includes a handle, a rotary scraper, a barrel, a drive shaft, an outer sleeve and a retaining clip. | 10-24-2013 |
20150073418 | DISCECTOMY INSTRUMENT - A discectomy instrument capable of removing portions of the spinal disc between adjacent vertebrae in a controlled manner that is efficient and easy to use. The discectomy instrument may include a handle, a rotary scraper, a barrel, a drive shaft, an outer sleeve and a retaining clip. | 03-12-2015 |
20160030059 | DISCECTOMY INSTRUMENT - A discectomy instrument capable of removing portions of the spinal disc between adjacent vertebrae in a controlled manner that is efficient and easy to use. The discectomy instrument may include a handle, a rotary scraper, a barrel, a drive shaft, an outer sleeve and a retaining clip. | 02-04-2016 |
Patent application number | Description | Published |
20110243948 | Monoclonal Antibodies Against ANGPTL3 - Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided. | 10-06-2011 |
20120201827 | ANTI-CD38 ANTIBODIES - Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies. | 08-09-2012 |
20130171154 | ANTI-CD38 ANTIBODIES - Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies. | 07-04-2013 |
20140155584 | CONJUGATED ANTI-CD38 ANTIBODIES - Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies. | 06-05-2014 |
20150203587 | ANTI-CD38 ANTIBODIES - Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies. | 07-23-2015 |
20150291702 | CONJUGATED ANTI-CD38 ANTIBODIES - Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies. | 10-15-2015 |
Patent application number | Description | Published |
20120245812 | System and Method for Automatically Downshifting an Automatic Transmission with Alternate Forward Launch Gear - An electronic control system for an automatic transmission having an alternate forward start gear, a lower forward start gear and a lower forward start gear lock our feature, in which the electronic control system can sense from various conditions when more power to the drive train is needed and cause the automatic transmission to automatically downshift to the lower forward start gear. | 09-27-2012 |
20140249729 | Hill Start in a Vehicle - A hill brake system in a vehicle uses a controller to determine when a number of conditions, such as being stopped on an incline, are met and then automatically applies a braking force at least equal to a calculated grade load, that is, gravitational force. Using drive train measurements and known drivetrain characteristics, a rimpull force is calculated after release of an operator-controlled brake and the automatically applied braking force is reduced corresponding to the rimpull force generated by the drivetrain. The automatically applied braking force is released when any of several conditions are met including uphill motion of the vehicle or expiration of a timeout timer. | 09-04-2014 |
20140257656 | RETARDING DOWNSHIFT MANAGEMENT - A retarding unit in a vehicle is automatically controlled based on conditions including a current setting of the retarding control, downhill grade, speed, current gear, and impending gear change. With the retarder control set in the high position, when the vehicle is operating at a downhill angle greater than the low angle threshold and less than the high angle threshold, and the pending gear is a large step downshift, automatically setting a retarder level to a low retarder level. When the vehicle is operating on level ground and the pending gear is a large step downshift or the current gear is first or second gear, automatically setting the retarder level to off. When the vehicle is operating on flat ground and the deceleration is above a trigger level, automatically setting the retarder level to a low retarder level. | 09-11-2014 |
Patent application number | Description | Published |
20090031699 | DRIVE LINE TORQUE PERTURBATION FOR PTO MODE SHIFTING - A method of controlling a machine drive having a driveline PTO establishes a driveline torque perturbation via conversion of internal inertia through two transmission neutral conditions. In an example, when a request is received, e.g., from an operator, to shift the driveline PTO from a first mode to a second mode, the transmission is automatically modulated between its first neutral condition and its second neutral condition while the driveline PTO is shifted from the first mode to the second mode, thus minimizing torque lock and facilitating mode changes. | 02-05-2009 |
20090111652 | Vehicle speed limiting via engine control commands issued by electronic transmission controller - A machine includes a drive train with an electronically controlled transmission in communication with an electronic engine controller. The machine ground speed is limited by executing a vehicle speed limit algorithm in the electronic transmission controller. This algorithm generates an engine control message that is communicated to the electronic engine controller. The power output of the engine is reduced responsive to the engine control message. The machine responds by not exceeding a prescribed speed limit programmed into the electronic transmission controller. This vehicle speed limiting strategy is particularly applicable to machines without a vehicle speed limiting algorithm resident in the electronic engine controller. | 04-30-2009 |
20100121543 | Method for controlling gear ratio changes in an automatic transmission - A method of controlling an automatic transmission of a machine includes a step of identifying an upcoming gear ratio change from a current gear ratio to a proposed gear ratio. An estimated power output value, based on the proposed gear ratio and a current engine speed, is determined. The estimated power output value is adjusted based on a derated operating condition. If the estimated power output value is greater than or equal to a current power output value, a gear evaluation identifier is set to a first value. If the estimated power output value is less than the current power output value, the gear evaluation identifier is set to a second value. | 05-13-2010 |
20120215378 | WORKSITE MANAGEMENT SYSTEM IMPLEMENTING REMOTE MACHINE RECONFIGURATION - A worksite management system for use with a mobile machine is disclosed. The worksite management system may have a control module located onboard the mobile machine and configured to store a least one operational relationship, and an offboard controller located at a worksite of the mobile machine in communication with the control module. The offboard controller may be configured to generate an analysis of machine performance at the worksite. The offboard controller may be further configured to cause remote reconfiguration of the at least one operational relationship based on the analysis to positively affect performance of the mobile machine. | 08-23-2012 |
20120215379 | WORKSITE MANAGEMENT SYSTEM IMPLEMENTING ANTICIPATORY MACHINE CONTROL - A worksite management system for use with a mobile machine is disclosed. The worksite management system may have a control module located onboard the mobile machine and configured to control operations of the mobile machine, and a controller in communication with the control module. The controller may be configured to anticipate a non-failure machine performance irregularity, and determine an adjustment to an operation of the mobile machine that positively affects the machine performance irregularity. The controller may also be configured to cause implementation of the adjustment before the machine performance irregularity occurs. | 08-23-2012 |
20140172256 | Grade and Payload Based Transmission Gear Selection Strategy - A method is described for controlling an automatic transmission of a vehicle during deceleration arising from a force resisting forward movement arising from an incline grade and a vehicle mass. The force of resistance to forward movement is determined at least based upon the incline grade. A destination gear is calculated based upon a set of gear-specific output curves and the force of resistance. The destination gear is compared to a current gear within which the machine is operating. The programmed controller executes an early downshift schedule when the destination gear is at least two positions lower than the current gear, thereby initiating a series of downshifts of the automatic transmission from the current gear to the destination gear. During each gear shift performed according to the early downshift schedule, shifting occurs at a cross-over point between output curves of current and next lower gears. | 06-19-2014 |
20140324302 | Method of Estimating Mass of a Payload in a Hauling Machine - A method implemented by a programmable controller to estimate the payload mass in a bed of a moving hauling machine. The method includes determining whether the machine is at a steady acceleration and grade, estimating transmission torque, calculating axle torque at at least one of the ground engaging elements, calculating force at said ground engaging element, determining the acceleration of the machine, calculating mass of the machine with the payload, adjusting the calculated mass of the machine with the payload based upon an estimated machine mass and rolling resistance, and providing an estimate of the mass of the payload. | 10-30-2014 |
20140336889 | GRADE-BASED ANTI-HUNT TIMER - A system and method are provided for grade-based anti-hunt shift control of an automatic transmission powering a machine. A shift controller determines a recommended gear in which to operate the transmission and sets an anti-hunt timer upon recommending a shift from a first gear to a second gear. The anti-hunt timer prevents a subsequent shift back to the first gear while the anti-hunt timer is running. A grade-based controller is configured to track machine operation and to determine when the machine operational factors change such that an estimated steady state gear differs from the second gear. When such a change is encountered, the grade-based controller clears the anti-hunt timer and sets a secondary timer. The clearing of the anti-hunt timer allows a downshift to accommodate the detected grade while the setting of the secondary timer prevents a subsequent clearing of the anti-hunt timer while the secondary timer is running. | 11-13-2014 |
Patent application number | Description | Published |
20130040365 | POLYMERASE COMPOSITIONS, METHODS OF MAKING AND USING SAME - The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase. | 02-14-2013 |
20150094211 | POLYMERASE COMPOSITIONS, METHODS OF MAKING AND USING SAME - The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties. | 04-02-2015 |
20150368626 | Polymerase Compositions, Methods of Making and Using Same - The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragment thereof are provided that allow for nucleic acid amplification. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates for use in various downstream processes. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered catalytic properties. In some aspects, the disclosure provides modified polymerases having enhanced catalytic properties as compared to a reference polymerase. | 12-24-2015 |
Patent application number | Description | Published |
20130096739 | AUTOMATED TRACK SURVEYING AND BALLAST REPLACEMENT - A method of surveying a section of a railway to determine amounts of ballast to be replaced keyed to position coordinates of track locations includes moving a survey vehicle along the railway, optically scanning the track at selected intervals to obtain optical data points with associated position coordinates, recording images at the intervals with position coordinates, recording position coordinates of no-spread zones, processing the optical data points to derive ballast unit weights associated with locations along the track, detecting anomalous unit weights, accessing images associated with the locations of the anomalous unit weights, accessing the anomalous unit weights to adjust as necessary, and loading the adjusted data into a computer of a ballast train to control the application of replacement ballast along the track according to the detected position of the ballast train. | 04-18-2013 |
20130230212 | AUTOMATED TRACK SURVEYING AND DITCHING - A method of surveying a section of a railway to determine amounts of soil to be excavated or added at selected position coordinates of track locations includes moving a survey vehicle along the railway, optically scanning the track structure at selected intervals to obtain optical data points with position coordinates, recording images at the intervals with position coordinates, recording position coordinates of drainage points, processing the optical data points to derive ditch overlays formed by ditch profiles associated with locations along the track and ditch templates, detecting anomalous soil unit weights associated with track locations, reviewing images associated with the locations of the anomalous units, adjusting the ditch overlays as necessary, and loading the adjusted data into a computer of an excavator device for display to guide an excavator operator in reshaping the ditches along the track according to the detected position of the excavator device. | 09-05-2013 |
20140277863 | SYSTEM FOR MONITORING MOVEMENT OF RAILROAD TRACK - A system for monitoring movement of railroad track includes a plurality of data collection units secured to respective railroad ties in a curved section of railroad track. Each data collection unit includes a GPS receiver. The data collection units collect location data from the GPS receivers and transmit the location data to a base unit. The base unit collects the location data from the data collection units and periodically uploads the location data to a server. Software on the server reviews the data for any changes in location of the data collection units and reports the results to a user or users. | 09-18-2014 |
20140297069 | AUTOMATED TRACK SURVEYING AND BALLAST REPLACEMENT - A method of surveying a section of a railway to determine amounts of ballast to be replaced keyed to position coordinates of track locations includes moving a survey vehicle along the railway, optically scanning the track at selected intervals to obtain optical data points with associated position coordinates, recording images at the intervals with position coordinates, recording position coordinates of no-spread zones, processing the optical data points to derive ballast unit weights associated with locations along the track, detecting anomalous unit weights, accessing images associated with the locations of the anomalous unit weights, accessing the anomalous unit weights to adjust as necessary, and loading the adjusted data into a computer of a ballast train to control the application of replacement ballast along the track according to the detected position of the ballast train. | 10-02-2014 |