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Lamb, MA

Albert A. Lamb, Somerville, MA US

Patent application numberDescriptionPublished
20090289114PRICE GUARANTEE TRACKING SERVICE - Price guarantee tracking services are an automated method for acquiring price guarantee terms and conditions from retailers and subsequently viewing them. A system for tracking a price guarantee includes a processor; memory operably connected to the processor; a find price guarantee program loaded into the memory and operable by the processor; a parse price guarantee program loaded into the memory and operable by the processor; and a list of price guarantee terms loaded into the memory and operable by the processor.11-26-2009
20110023110Interactive Video Captcha - Provided is a Captcha Access Control System (CACS) for generating an improved captcha that are based, in one described embodiment, upon a command in one format and a response in a different format, one or both of which are rendered in a format that is difficult for an automated system to interpret. A computer system or program to which a user is requesting access generates a textual or audible command. A video device captures the user's response and transmits the response to a response evaluation device. Based upon an analysis of the transmitted video and a comparison between the analyzed video and the command, the computer or program either enables access or denies access.01-27-2011
20110238828REDIRECTING WEB CONTENT - A peer group can be established for sharing Web cache data among a set of computing devices through a peer-to-peer network. The Web cache data can be used by each of the computing devices to respond to requests issued over a client-server network from a Web browser running on that computing device. Web cache data can be exchanged among the peers of the peer group via the peer-to-peer network. A client request issued from a Web browser of one of the computing devices can be satisfied using Web cache data obtained from a different one of the computing devices in the peer group. The client request can be a request to one of the Web servers for Web content. The server associated with the request may never provide the Web content responsive to the client request, which is obtained instead from the different one of the computing devices.09-29-2011

Albert Andrus Lamb, Somerville, MA US

Patent application numberDescriptionPublished
20100023615REDIRECTING WEB DOWNLOADS - One or more downloads of web content from one or more web content servers are monitored. A swarm is defined including one or more previous downloaders of the web content from the one or more web content servers. The one or more previous downloaders of the web content include one or more web content caches including at least a portion of the web content. Stored web content within the one or more web content caches of the swarm is tracked. A new downloader of the one or more web content servers is redirected to the one or more web content caches of the swarm.01-28-2010

Andrew Lamb, Arlington, MA US

Patent application numberDescriptionPublished
20100131490MODULAR QUERY OPTIMIZER - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for modular query optimizer. In one aspect, a method includes selecting one or more projections from a set of projections for each table in a database query wherein each of the selected projections for the table has leads to an estimated lower execution cost for the query as compared to non-selected projections; generating join orders for the query based on data distribution of one or more of the selected projections among sites in a computer network wherein the join orders reflect different combinations of data distribution operations applied to the output of one or more of the query's joins; and selecting a join order from the join orders based on evaluation of the join orders using a cost model.05-27-2010
20120246147MODULAR QUERY OPTIMIZER - Computer programs encoded on a computer storage medium provide for a modular query optimizer. In one aspect, a computer program product includes selecting one or more projections from a set of projections for each table in a database query wherein each of the selected projections for the table has leads to an estimated lower execution cost for the query as compared to non-selected projections; generating join orders for the query based on data distribution of one or more of the selected projections among sites in a computer network wherein the join orders reflect different combinations of data distribution operations applied to the output of one or more of the query's joins; and selecting a join order from the join orders based on evaluation of the join orders using a cost model.09-27-2012

Andrew Allinson Lamb, Boston, MA US

Patent application numberDescriptionPublished
20120290559JOIN ORDER RESTRICTIONS - A query that is submitted to a database is analyzed so as to determine a join order restriction. The join order restriction is associated with a join between two tables of a plurality of tables of the database that participate in the query. The join order restriction constrains its associated join to be executed prior to another join of the query. At least one join plan is generated, the join plan being constrained by the join order restriction. Different join plans include different join orders. A join plan is selected from among the join plans for execution of the query.11-15-2012
20120290590CONSTRUCTING A PROJECTION FOR STORING DATA - A method for constructing a projection for storing data on a storage device may include causing a processor to extract characteristics of expected output of a query on the data, and to construct a projection for the data based on the extracted characteristics.11-15-2012
20120290615SWITCHING ALGORITHMS DURING A RUN TIME COMPUTATION - A system and method for switching algorithms during a run time computation, the method including configuring hardware of a networked cluster of processing elements, each processing element with a memory hierarchy, to perform a first-tier algorithm on input data, the input data having cardinality and stored on one or a plurality of nodes in the networked cluster. Performing at least a portion of a second-tier algorithm and determining whether to complete the second-tier algorithm and perform a third or subsequent tier algorithm, the determination dependent on cardinality. Automatically passing data to an output if the cardinality of the second-tier algorithm is greater than a threshold cardinality, and passing the data back to the second-tier algorithm or to one or a plurality of subsequent algorithms, in response to the cardinality being less than the threshold, and automatically passing the data to an output at the completion of the data processing.11-15-2012

David Lamb, Medford, MA US

Patent application numberDescriptionPublished
20120246210METHOD AND APPARATUS FOR ADAPTIVE CONTROL OF THE DECIMATION RATIO IN ASYNCHRONOUS SAMPLE RATE CONVERTERS - An asynchronous sample rate converter prevents the folding back of a signal in the passband of an input sample rate into the passband of the output sample by adaptively controlling the decimation rate. The ASRC includes an adaptive decimation rate controller that selectably controls a decimation filter based on the ratio of the input sampling rate to the output sampling rate. By adaptively controlling the decimation rate in the ASRC, a significant amount of area and power is saved.09-27-2012

Justin Lamb, Cambridge, MA US

Patent application numberDescriptionPublished
20110015080Solution-based methods for RNA expression profiling - The present invention is directed to novel high-throughput, low-cost, and flexible solution-based methods for RNA expression profiling, including expression of microRNAs and mRNAs.01-20-2011
20110223171Methods and Compositions for the Diagnosis and Treatment of Cyclin A-1 Associated Conditions - The present invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for inhibiting cancer metastasis by inhibiting cyclin A1.09-15-2011
20110263693CELASTROL, GEDUNIN, AND DERIVATIVES THEREOF AS HSP90 INHIBITORS - Based on the discovery that celastrol and gedunin are Hsp90 inhibitors, the present invention provides novel inhibitors of Hsp90. and pharmaceutically acceptable salts, derivatives, and compositions thereof. The invention provides two classes of compounds. One class includes celastrol and its derivatives. The other class includes gedunin and its derivatives. The present invention further provides methods for treating disorders wherein Hsρ90 inhibition is desired (e.g., proliferative diseases, cancer, inflammatory diseases, fungal infections, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. Celastrol, gedunin, and derivatives thereof are particularly useful in the treatment of prostate cancer, breast cancer, ovarian cancer, lung cancer, and leukemia.10-27-2011

Patent applications by Justin Lamb, Cambridge, MA US

Michelle Lamb, Waltham, MA US

Patent application numberDescriptionPublished
20100204231AMINO-THIAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER - The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.08-12-2010
201002042465-AMINOPYRAZOL-3-YL-3H-IMIDAZO (4,5-B) PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER - The present invention relates to compounds of Formula (I) and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.08-12-2010
201003240409-(PYRAZOL-3-YL)-9H-PURINE-2-AMINE AND 3-(PYRAZOL-3-YL) -3H-IMIDAZO[4,5-B] PYRIDIN-5- AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER - The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.12-23-2010
20110218182CHEMICAL COMPOUNDS 251 - The invention relates to chemical compounds of formula (I), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of PIM-1 and/or PIM-2, and/or PIM-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of PIM kinase related conditions and diseases, preferably cancer.09-08-2011
20120122892CHEMICAL COMPOUNDS - This invention relates to novel compounds having the formula (I):05-17-2012

Patent applications by Michelle Lamb, Waltham, MA US

Michelle Lamb, Belmont, MA US

Patent application numberDescriptionPublished
20090137624Chemical Compounds - This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.05-28-2009