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Lakshmi

Lakshmi Amaravadi, Natick, MA US

Patent application numberDescriptionPublished
20090176256Methods and Products for Evaluating an Immune Response to a Therapeutic Protein - The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. A first aspect of the invention relates to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab). A second aspect of the invention concerns the chronological details of sample collection for determining the titre of antibodies against the therapeutic protein, e.g. the collection of at least two samples at two different time points. A third aspect of the invention relates to the selection of the critical threshold level, which corresponds to the antibody titre of untreated patients increased by the double of the standard deviation of this control antibody titre.07-09-2009

Lakshmi Ananthaneni, Andhra Pradesh IN

Patent application numberDescriptionPublished
20100298351NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS - The invention relates to substituted pyrazolo[3,4-d]pyrimidine derivatives of the Formula-(I), or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted pyrazolo[3,4-d]pyrimidine derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti-proliferative effect in a warm-blooded animal such as man.11-25-2010

Lakshmi Anathaneni, Andhra Pradesh IN

Patent application numberDescriptionPublished
20100261740NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT - The invention relates to substituted 4-(tetrazol-5-yl)-quinazoline derivatives of the formula-I, or pharmaceutically-acceptable salts thereof, which possess anti-proliferative activity such as anti-cancer activity and are accordingly useful in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of substituted 4-(tetrazol-5-yl)-quinazoline derivatives, to pharmaceutical compositions containing the compound and to its use in the manufacture of medicaments for the production of an anti-proliferative effect in a warm-blooded animal such as man.10-14-2010

Lakshmi Arunachalan, Menlo Park, CA US

Patent application numberDescriptionPublished
20110161202Method and apparatus for enabling real-time bi-directional transactions on a network - The present invention provides a method and apparatus for providing real-time, two-way transactional capabilities on the Web. Specifically, one embodiment of the present invention discloses a method for enabling object routing, the method comprising the steps of creating a virtual information store containing information entries and attributes associating each of the information entries and the attributes with an object identity, and assigning a unique network address to each of the object identities. A method is also disclosed for enabling service management of the value-added network service, to perform OAM&P functions on the services network06-30-2011

Lakshmi Balagopalan, Bethesda, MD US

Patent application numberDescriptionPublished
20120114700LAT ADAPTER MOLECULE FOR ENHANCED T-CELL SIGNALING AND METHOD OF USE - LAT (Linker for Activation of T-cells) is a protein involved in signaling through the T-cell receptor (TCR). The invention provides a LAT protein including mutations at ubiquitylation sites that result in an increase in stability of LAT in stimulated and unstimulated cells, and enhanced signaling through the TCR. The invention further provides use for a LAT protein including mutations at ubiquitylation sites for therapeutic and laboratory methods.05-10-2012

Lakshmi Chakarapani, Irving, TX US

Patent application numberDescriptionPublished
20110052146SYSTEMS AND METHODS FOR ENHANCING UTILIZATION OF RECORDED MEDIA CONTENT PROGRAMS - Exemplary systems and methods for enhancing utilization of recorded media content programs are disclosed. An exemplary method includes a media content processing system maintaining data representative of a recorded media content program in a data storage facility, accessing program highlights data for the recorded media content program, the program highlights data specifying a set of one or more select segments of the recorded media content program, and utilizing the program highlights data to access and play back the set of one or more select segments of the recorded media content program for experiencing by a user. In some examples, the end user has control of selection and playback of the set of one or more select segments of the recorded media content program. Corresponding systems and methods are also disclosed.03-03-2011

Lakshmi C.s., Balmain AU

Patent application numberDescriptionPublished
20090066742PRINTHEAD WITH INCREASING DRIVE PULSE TO COUNTER HEATER OXIDE GROWTH - An inkjet printer that has a printhead with an array of ejection devices for ejecting drops of liquid onto a media substrate. Each of the ejection devices having a chamber for holding liquid, a nozzle in fluid communication with the chamber and a heater positioned in the chamber for contact with the liquid such that resistive heating of the heater generates a vapour bubble that ejects a drop of the liquid through the nozzle. The printer also has a controller for receiving print data and generating drive pulses to energize the heaters in accordance with the print data. The controller increases the drive pulse energy during the printhead lifetime.03-12-2009
20090078674Reactive Ion Etching Process for Etching Metals - A method of etching a metal by a reactive ion etching process is provided. The etchant gas chemistry for the reactive ion etching process consists essentially of NH03-26-2009
20090078675METHOD OF REMOVING PHOTORESIST - A method of photoresist removal is provided. The method employs a plasma formed from a gas chemistry comprising NH03-26-2009
20100097429INKJET PRINTHEAD WITH TITANIUM ALUMINIUM ALLOY HEATER - An inkjet printhead with a resistive heaters for vaporizing ink to eject drops through respective nozzles. The heater is formed from a TiAlX alloy where Ti contributes more than 40% by weight, Al contributes more than 40% by weight and X contributes less than 5% by weight and comprises zero or more of Ag, Cr, Mo, Nb, Si, Ta and W.04-22-2010
20110122183PRINTHEAD INCORPORATING PRESSURE PULSE DIFFUSING STRUCTURES BETWEEN INK CHAMBERS SUPPLIED BY SAME INK INLET - An inkjet printer includes a printhead having a plurality of ink chambers fed be an ink inlet, each ink chamber having a heater element for ejecting drops of ink from a nozzle aperture of each chamber; a plurality of pressure pulse diffusing structure positioned between the plurality of ink chambers fed by the ink inlet, the plurality of pressure pulse diffusing structures for retarding a propagation of pressure waves generated by each ink chamber to adjacent ink chambers; and a controller for receiving print data and generating drive pulses to energize the heater elements in accordance with the print data. The controller increases the drive pulse energy during the printhead lifetime such that the drive pulse energy is never less than that of a preceding drive pulse.05-26-2011
20110228010PRINTHEAD WITH BUBBLE VENTS - An inkjet printhead includes a plurality of ink chambers fed by a common ink inlet, the plurality of ink chambers sharing a common roof structure; a plurality of heater elements respectively allocated to each of ink chambers; a plurality of nozzle apertures defined through the common roof structure and respectively aligned with the heater element of each ink chamber; and a bubble vent defined in the common roof of the ink chambers and aligned with the common ink inlet, the bubble vent sized to allow ink surface tension to restrict an egress of ink, and permit egress of gas bubbles therefrom.09-22-2011

Patent applications by Lakshmi C.s., Balmain AU

Lakshmi Khandke, Nanuet, NY US

Patent application numberDescriptionPublished
20090016946PROCESS FOR PRODUCING ALUMINUM PHOSPHATE - The present invention provides improved methods for producing the aluminum adjuvant AlPO01-15-2009
20110172393NOVEL FORMULATIONS WHICH STABILIZE AND INHIBIT PRECIPITATION OF IMMUNOGENIC COMPOSITIONS - The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.07-14-2011

Patent applications by Lakshmi Khandke, Nanuet, NY US

Lakshmi Manickavasagam, Lucknow IN

Patent application numberDescriptionPublished
20110112042NOVEL FLAVONOL COMPOUNDS, A BIOACTIVE EXTRACT/FRACTION FROM ULMUS WALLICHIANA AND ITS COMPOUNDS FOR PREVENTION FOR TREATMENT OF OSTEO-HEALTH RELATED DISORDERS - The present invention provides a flavonol compound and a bioactive extract/fraction from 05-12-2011
20120003273SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS - The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R01-05-2012

Lakshmi Narayanan V., Farmington, MI US

Patent application numberDescriptionPublished
20100018813LEVER ASSEMBLY FEATURING BLIND CABLE ASSEMBLY - The present invention is predicated upon improved vehicle brake assemblies, parking brake assemblies, parking brake actuating mechanisms, or combinations thereof, having simplified attachment features and for assembling a brake cable within the parking assembly with substantially limited or no visual access therein.01-28-2010
20110100772CABLE END RETENTION CLIP ASSEMBLY AND METHOD - The present invention is premised upon a clip and housing plate assembly capable of (“to accommodate”) loading, unloading and retaining a cable end within the housing plate assembly. Of particular interest is the clip and housing plate assembly used in a drum brake assembly and where the cable end is part of a cable assembly for a parking brake. The clip and housing plate assembly having clip member and a housing plate member and wherein the clip member is generally disposed outside an outer surface (or inside an inside surface) of the of the housing plate member and rotatably connected thereto.05-05-2011
20120043168BRAKE SYSTEMS, CALIPER ASSEMBLIES AND PADS INCORPORATING DIFFERENTIAL ABUTMENTS - The present invention is directed to a unique solution for caliper assemblies, brake pads utilized in such caliper assemblies, support structures utilized in caliper assemblies and disc brake systems containing such caliper assemblies which utilize push pull or pull push abutment designs.02-23-2012
20120085597CALIPER ASSEMBLY FOR DISC BRAKE SYSTEM - A caliper assembly comprising: a brake pad comprising a carrier plate having two opposing faces and a top edge a bottom edge and two opposing side edges, wherein on one face is friction material and on the opposing face is a projection adapted to seat in a matched hole or recess in a caliper body, the two opposing side edges each having an ear which is adapted to seat in pad locator indentations in a support structure; a support structure comprising a recess for housing at least one brake pad and at least two pad locator indentations adapted for receiving the ears located on the two opposing sides of the brake pad and at least two caliper body locator indentations for seating two ears defined by the caliper body; and a caliper body having a hole or recess adapted for seating the projection on the opposing face of the brake pad and having two ears on each opposing side which are adapted to seat in the caliper body locator indentations of the support structure; wherein the ears of the brake pad are seated in the pad locator indentations of the support structure, the projection on the opposing face of the brake pad is seated in the hole or recess located in the caliper body, and a clip which engages the opposing face of the brake pad and the caliper body and holds the brake pad in position with respect to the caliper body and the ears of the caliper body are seated in the caliper body locator indentations in the support structure.04-12-2012

Patent applications by Lakshmi Narayanan V., Farmington, MI US

Lakshmi Nrusimhan N.v., Tamil Nadu IN

Patent application numberDescriptionPublished
20110154078METHOD AND APPARATUS FOR MONITORING, ASSESSING, AND MANAGING POWER SOURCE PERFORMANCE - An approach is provided for monitoring, assessing, and managing power source performance. Depletion of a power source of a mobile device caused by executing a plurality of activities is determined. A duration value is determined for executing each of the activities. The duration values are attributed to the depletion. Statistical data corresponding to performance of the power source is generated.06-23-2011
20110154444METHOD AND APPARATUS FOR PROVIDING USER AUTHENTICATION BASED ON USER ACTIONS - An approach is provided for authenticating using user actions. A prompt is initiated on a display for an input to authenticate a user. The input is received as a sequence of user actions on the display. A predetermined sequence associated with the user is retrieved. The received sequence is compared with the predetermined sequence to determine a match. The user is declared to be authenticated based on the comparison.06-23-2011
20110161123METHOD AND SYSTEM FOR ACCURATELY DETERMINING SERVICE PROVIDER ASSETS - An approach for automatically generating system asset inventory discrepancies and matches and for identifying system asset accuracy information based on comparison of asset data in subsystems thereof, and for providing a list of actual assets based on comparison of trouble ticket information and a cumulative matching data set.06-30-2011
20110320961METHOD AND APPARATUS FOR SHARING VIRTUAL WORKSPACES - An approach is provided for sharing the virtual workspaces of a plurality of user devices. One of the plurality of devices is designated as the only active device. The active device submits an update of the virtual workspace of the active device. Then an update of the virtual workspaces of the other devices is initiated that includes the workspace of the active device. A request from one of the other devices to become active is granted and the previously active device is undesignated as active.12-29-2011
20120008761System and Method for Ring Delay on a User Agent - A system and method for ring delay on a user agent. A destination user agent may receive a request from an origination user agent to establish a session between the two user agents. The destination user agent may delay ringing according to a ring delay parameter. If the request has not been terminated by the time the ring delay parameter is met, the destination user agent may ring and a session may occur between the origination user agent and destination user agent. If the request is terminated before the ring delay parameter is met, the destination user agent may never ring. The ring delay parameter may be a ring delay time period. The ring delay parameter may be received as part of the request from the origination user agent, set by the destination user agent, or set by a service provider for the destination user agent.01-12-2012

Lakshmi Nrusimhan N V, Channai IN

Patent application numberDescriptionPublished
20110099549METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR A REMINDER MANAGER FOR PROJECT DEVELOPMENT - This disclosure details the implementation of apparatuses, methods and systems of a reminder manager for project development (hereinafter, “R-Manager”). In one embodiment, a R-Manager system may implement a daemon application to monitor a plurality of code development entities, maintain a list of reminders and associated tasks and send reminders to users. In one embodiment, the R-Manager allows a user to directly write a reminder in a segment of source code, and then locate and add the embedded reminder to the system by automatically scanning the body of the source file. The R-Manager system can also enforce the completion of a task if the reminder of the task has expired and the task has not been marked as completed.04-28-2011

Lakshmi Nrusimhan N. V., Chennai IN

Patent application numberDescriptionPublished
20110145340SYSTEM FOR AND METHOD OF PROVIDING REMOTE ACCESS TO AN EMAIL PLATFORM - A system for and method of providing remote access to an email platform. The system and method may include receiving, from a user system, authentication data that comprises an authentication code that is associated with a user of the user system via a network, receiving, from the user system, mail mimic message data that indicates at least one mail service operation to be performed by an email system, and outputting, to the email system, one or more command signals that initiate the performance of the mail service operation.06-16-2011
20110150197SYSTEM AND METHOD FOR PROVIDING AUTOMATIC GENERATION OF A LOCAL SERVICE REQUEST - A system and method for providing automatic generation of a local service request is disclosed. The system may comprise a front-end module configured to receive data associated with an order for a telecommunications service. A request generation interface may be provided to determine at least a service provider and a telecommunications service associated with the order. The request generation interface may also be configured to find a one or more matching templates in a list of templates stored in at least one data storage unit, apply the one or more matching templates to the order, and generate a local service request. A template module may be provided to generate at least one template based on the determination and match at the request generation interface. A business rules module may be provided to apply one or more business rules when generating the local service request. A back-end module may be provided to transmit the local service request to the service provider for ordering the telecommunications service.06-23-2011
20110153443SYSTEM AND METHOD FOR PROVIDING AUTOMATIC GENERATION OF AN ACCESS SERVICE REQUEST - A system and method for providing automatic generation of a access service request is disclosed. The system may comprise a front-end module configured to receive data associated with an order for a telecommunications service. A request generation interface may be provided to determine at least a service provider and a telecommunications service associated with the order. The request generation interface may also be configured to find a one or more matching templates in a list of templates stored in at least one data storage unit, apply the one or more matching templates to the order, and generate a access service request. A template module may be provided to generate at least one template based on the determination and match at the request generation interface. A business rules module may be provided to apply one or more business rules when generating the access service request. A back-end module may be provided to transmit the access service request to the service provider for ordering the telecommunications service.06-23-2011

Lakshmi Potluri, Scottsdale, AZ US

Patent application numberDescriptionPublished
20080220798MECHANISM TO FACILITATE CUSTOMIZATION OF REAL TIME MESSAGING USING MOBILE DEVICES - A customized messaging system facilitates customization of text messaging using mobile devices. The customized messaging system converts user-defined, customized shortcuts into full text equivalents for sending and receiving messages. The present system allows a user to enter a message using key entry shortcuts for character strings or phrases that may have meaning only to the user while sending a full text version of the message to a message recipient. A user may modify the presentation of the message depending on the recipient; i.e., a business colleague or employer can receive a more formal, full text message while a friend or family member receives a more casual message with some of the shortcuts replaced. The customized message system modifies text in an incoming message, selecting shortcuts for text equivalents according to a pre-defined profile supplied by the user. The incoming message viewed by the user thus uses shortcuts defined by the user.09-11-2008

Lakshmi Rambhatla, Redwood City, CA US

Patent application numberDescriptionPublished
20090136955Protocols for making hepatocytes from embryonic stem cells - This disclosure provides a newly developed strategy and particular options for differentiating pluripotent stem cells into cells of the hepatocyte lineage. Many of the protocols are based on a strategy in which the cells are first differentiated into early germ layer cells, then into hepatocyte precursors, and then into mature cells. The cells obtained have morphological features and phenotypic markers characteristic of human adult hepatocytes. They also show evidence of cytochrome p450 enzyme activity, validating their utility for commercial applications such as drug screening, or use in the manufacture of medicaments and medical devices for clinical therapy.05-28-2009

Lakshmi Sangameswaran, San Jose, CA US

Patent application numberDescriptionPublished
20100234470Instillation Administration of Capsaicinoids for the Treatment of Pain - This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical composition. In certain embodiments of the invention, the capsaicinoid is capsaicin.09-16-2010

Patent applications by Lakshmi Sangameswaran, San Jose, CA US

Lakshmi Supriva, Arlington, MA US

Patent application numberDescriptionPublished
20100155923Microball assembly methods, and packages using maskless microball assemblies - A method of forming a microball grid array includes adhering a microball precursor material to a transfer medium under conditions to reflect a selective charge pattern. The method includes transferring the microball precursor material from the transfer medium across a gap and to an integrated circuit substrate under conditions to reflect the selective charge pattern. The method includes achieving the microball grid array without the aid of a mask.06-24-2010