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Lai, San Diego
Andiliy G. Lai, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100048890 | CONJUGATED SMALL MOLECULES - Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnostic, separation, and therapeutic applications. | 02-25-2010 |
| 20100173917 | UREA DERIVATIVES AS ABL MODULATORS - The invention provides methods and compositions for treating conditions mediated by Bcr-Abl. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects. | 07-08-2010 |
| 20110118245 | RAF KINASE MODULATOR COMPOUNDS AND METHODS OF USE THEREOF - Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate of hydrate thereof, wherein X is O or S(O) | 05-19-2011 |
Benjamin Lai, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080261295 | Cell Sorting System and Methods - Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching. | 10-23-2008 |
Jing-Yu Lai, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080262249 | Psorospermin and Analogues - Methods of making chiral psorospermin or its analogues and/or intermediates thereof are provided. | 10-23-2008 |
| 20100003267 | ANTI-ANGIOGENIC COMPOUNDS - The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis. | 01-07-2010 |
| 20110087010 | ANTI-ANGIOGENIC COMPOUNDS - The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis. | 04-14-2011 |
King-Chuang Lai, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100080459 | CONTENT ADAPTIVE HISTOGRAM ENHANCEMENT - This disclosure describes techniques for performing content adaptive histogram enhancement. In accordance with the content adaptive histogram enhancement techniques of this disclosure, a frame of digital image data, e.g., digital video data or digital still image data, is classified into one of a plurality of content classes based on histogram of pixel intensity values of the frame. The content classes may represent various levels of brightness, contrast, or the like. To classify the frame into the corresponding content class, a shape of the histogram may be analyzed using various histogram statistics. Based on the content class of the frame, the pixel intensity values of the frame are mapped to new pixel intensity values. | 04-01-2010 |
King-Chung Lai, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090028458 | SCALING FILTER FOR VIDEO SHARPENING - A device has a single scaling filter to filter a video signal once to perform both sharpening and scaling. A memory stores original scaling filter coefficients for the scaling filter. An integrated circuit calculates new sharpening-scaling filter coefficients derived from the original scaling filter coefficients and one of sharpening filter coefficients for a sharpening filter and a sharpening strength and applies the new sharpening-scaling filter coefficients to the single scaling filter. | 01-29-2009 |
| 20100054621 | DUAL LOOKUP TABLE DESIGN FOR EDGE-DIRECTED IMAGE SCALING - In general, the disclosure describes various techniques for providing edge-directed scaling filters that may be used to scale image data. An example device includes a storage medium configured to store a first lookup table and a second lookup table, and one or more processors configured to obtain one or more gradient values that each indicates a gradient between values of at least two pixels in a source image. The one or more processors are also configured to generate one or more inverse gradient values from a first lookup table based on the gradient values, and to generate one or more edge-directed scaling filter coefficients from a second lookup table based on the inverse gradient values. The one or more processors may be further configured to generate an edge-directed filter based on the coefficients, and to apply the filter to the at least two pixels to generate an interpolated pixel. | 03-04-2010 |
Yuping Lai, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100166708 | ANTIMICROBIAL AND ANTI-INFLAMMATORY THERAPIES AND COMPOSITIONS - The disclosure provides methods and compositions useful for treating microbial and viral infections. In certain aspects, the compositions and methods relate to the use of an effective amount of a delta-haemolysin and/or phenol soluble modulin-delta or functional variant thereof. In other aspects, the compositions and methods relate to the use of an effective amount of | 07-01-2010 |