Patent application number | Description | Published |
20090093371 | MEMBRANE ARRAYS AND METHODS OF MANUFACTURE - The invention relates to G protein-coupled receptor (GPCR) microarrays on porous substrates for structural or functional analyses of GPCRs, and methods of preparing porous substrate surfaces for receiving membranes that comprise GPCRs. In one embodiment, a GPCR microarray of the invention comprises a membrane adhered to an upper surface of a porous substrate, the membrane spanning across a plurality of pores on the porous substrate to form a plurality of cavities having sufficient geometry to permit entry of assay reagents into each cavity, thereby allowing access of assay reagents to both sides of GPCR in the membrane. | 04-09-2009 |
20090131263 | Normalization methods for G-protein coupled receptor membrane array - Reference membrane components are either pre-labeled or labeled during assays for purposes of normalizing signals associated with binding or functional assays employing G-protein coupled receptor microarrays. A reference component may be included in a membrane in which the target GPCR is embedded or may be present in another membrane printed in conjunction with the target membrane on a microspot. Or, a GPCR microarray may be pre-labeled by incorporating a label on an exposed substrate in a defect in the printed microspot. | 05-21-2009 |
20120083428 | Method and Device for Protein Delivery into Cells - Methods for performing surface-mediated protein delivery into living cells, and fabricating protein-transfected cell cluster arrays are provided. The method comprises providing a protein-containing mixture; depositing said protein-containing mixture onto a surface at defined locations; affixing the protein-containing mixture to the surface as microspots; and plating cells onto the surface in sufficient density and under conditions for the proteins to be delivered into the cells. The protein-containing mixture comprises any suitable amino acid sequence, including peptides, proteins, protein-domains, antibodies, or protein-nucleic acid conjugates, etc., with a carrier reagent. Protein-transfected cell arrays may be used for rapid and direct, screening of protein or enzymatic functions or any given intracellular protein interaction in the natural environment of a living cell, as well as for high-throughput screening of other biological and chemical analytes, which affect the functions of these proteins. | 04-05-2012 |
20120088695 | Method and Device for Protein Delivery into Cells - Methods for performing surface-mediated protein delivery into living cells, and fabricating protein-transfected cell cluster arrays are provided. The method comprises providing a protein-containing mixture; depositing said protein-containing mixture onto a surface at defined locations; affixing the protein-containing mixture to the surface as microspots; and plating cells onto the surface in sufficient density and under conditions for the proteins to be delivered into the cells. The protein-containing mixture comprises any suitable amino acid sequence, including peptides, proteins, protein-domains, antibodies, or protein-nucleic acid conjugates, etc., with a carrier reagent. Protein-transfected cell arrays may be used for rapid and direct, screening of protein or enzymatic functions or any given intracellular protein interaction in the natural environment of a living cell, as well as for high-throughput screening of other biological and chemical analytes, which affect the functions of these proteins. | 04-12-2012 |
20120244568 | LABEL-FREE RIGID CELL ASSAY METHOD - A label-free cell assay method including:
| 09-27-2012 |
Patent application number | Description | Published |
20080218531 | SYSTEM AND METHOD FOR VISUALIZATION AND INTERACTION WITH SPATIAL OBJECTS - A computer program product including machine readable instructions stored on machine readable media, the product for assembling and providing a visual interface for a user to interact with spatial information, the product including: a build subsystem for assembling spatial information by converting drawings including the spatial information into scalable vector graphic (SVG) files; the build sub-system further including instructions for merging graphic data of the spatial information and annotating resources represented within the graphic data; and a run-time subsystem for interpreting assembled spatial information and providing the visual interface; wherein the run-time subsystem includes instructions for display and event management control to provide interaction between the user and the spatial information. | 09-11-2008 |
20090044169 | METHOD, FRAMEWORK, AND PROGRAM PRODUCT FOR FORMATTING AND SERVING WEB CONTENT - The present invention provides an approach and corresponding framework that separates data from its formatting/view by generating the dynamic JavaScript (data) as a set (e.g., at least one) of JavaScript (data) objects, without any HTML formatting. Then, a set of JavaScript functions can be created that takes the set of JavaScript objects as a parameter, and outputs all or a subset of this data object in a format determined by this JavaScript function. In general, these formatting functions can be static, rather than dynamic, JavaScript. This approach has the advantage of providing a much greater degree of formatting flexibility, without the need for each new format to establish a connection with the back-end system providing the data. | 02-12-2009 |
20100268681 | Increasing Knowledge Sharing Success Rates Using Real Time Match Making - A method of knowledge sharing using a computer system is provided. The method includes: receiving a question electronically submitted by a user; forwarding the question and at least one response option to at least one expert using a first computer interface; monitoring selected response options from the at least one expert; and selectively presenting the selected response options to the user using a second computer interface. | 10-21-2010 |
20110029472 | Method and Apparatus for Run-Time User Control of System-Generated Content - Methods and apparatus are provided for run-time user control of system-generated content. A user is presented with the system-generated content and can configure one or more rules at run-time. The rules identify one or more automated actions to perform upon the system-generated content when one or more conditions are satisfied. The automated actions are executed upon the system-generated content when the one or more conditions are satisfied. The exemplary automated actions may comprise transform, retrieve, update and alert. The conditions can specify, for example, when to perform the automated actions. Active tags may optionally be attached to or embedded directly in the system-generated content or in a document containing the system-generated content. Tools are optionally provided to allow a user to manage active tags. | 02-03-2011 |
20110111384 | METHOD AND SYSTEM FOR CONTROLLING SKILL ACQUISITION INTERFACES - A method and system for capturing expert behavior that the expert is not even necessarily conscious of, such as gaze patterns, that are tied to positive outcomes, and to create a catalog (e.g. database) of these behaviors. The system compares the current behavior of a person, for example a novice, against this catalog of expert behaviors. If the current behavior is significantly different, the system would adapt various aspects of the interface to bring the current behavior closer in line to that of the expert. | 05-12-2011 |
20120106925 | AUTOMATIC STATIC VIDEO SUMMARIZATION - Techniques are disclosed for automatic static summarization of videos. For example, a method of creating a static summary of a video comprises the following steps. Shots in the video are detected, wherein the detected shots are frames of the video having a correlation. The detected shots are clustered into clusters based on similarity. The clusters of shots are ranked. At least a portion of the shots are selected based on cluster ranking for inclusion in the static summary. The static summary is generated by combining thumbnail images of the selected shots. Prior to the ranking step, the method may further comprise detecting a presence of slides in any of the shots, and the ranking of a given shot is based in part on whether the shot is a slide. By way of example, such static summaries can be shared in emails and in calendar applications. | 05-03-2012 |
20120209871 | Automated Contextual Information Retrieval Based on Multi-Tiered User Modeling and Dynamic Retrieval Strategy - Automated contextual information retrieval techniques are provided based on multi-tiered user modeling and a dynamic retrieval strategy. Content relevant to a current message is presented by initially obtaining a multi-tiered user model containing a multi-tiered representation of interactions of a first user with each contact, wherein the multi-tiered representation includes a plurality of topic models each corresponding to interactions between the first user and one contact. The topic models contain a set of topics, each containing topic keywords. Context information is extracted based on content of the current message, a sender and/or a recipient of the current message, and the multi-tiered user model. A retrieval strategy is determined based on the extracted context information. Contextual queries are generated to search the information repositories selected based on the determined retrieval strategy. Content relevant to the current message is presented based on search results from the selected information repositories. | 08-16-2012 |
20120303717 | INCREASING KNOWLEDGE SHARING SUCCESS RATES USING REAL TIME MATCH MAKING - An embodiment provides for knowledge sharing using a computer system. An aspect of the invention includes receiving a question electronically submitted by a user. The question is forwarded and at least one response option to at least one expert using a first computer interface. The selected response options from the at least one expert are monitored. The selected response options are selectively presented to the user using a second computer interface. | 11-29-2012 |
20120311186 | METHOD, FRAMEWORK, AND PROGRAM PRODUCT FOR FORMATTING AND SERVING WEB CONTENT - The present invention provides an approach and corresponding framework that separates data from its formatting/view by generating the dynamic JavaScript (data) as a set (e.g., at least one) of JavaScript (data) objects, without any HTML formatting. Then, a set of JavaScript functions can be created that takes the set of JavaScript objects as a parameter, and outputs all or a subset of this data object in a format determined by this JavaScript function. In general, these formatting functions can be static, rather than dynamic, JavaScript. This approach has the advantage of providing a much greater degree of formatting flexibility, without the need for each new format to establish a connection with the back-end system providing the data. | 12-06-2012 |
20140074524 | Method and System for Business Outcome-Based Personalized Ranking of Information Objects - Business outcome-based personalized ranking of information objects is provided. Information objects in outcome-based business processes are ranked by recording information objects generated during a creation of the outcome-based business processes. At least one business process comprises an outcome attribute, and at least one business process comprises in-process information objects. A composite graph is generated of the information objects and business processes. Each node in the graph corresponds to an information object or a business process. Links between two information object nodes have a strength based on a content similarity and a social network distance. The in-process information object node connects to a corresponding business process node, and two business process nodes have a link if they are indicated as related in the business process information system. The information objects are ranked based on the link strengths. | 03-13-2014 |
20140074525 | Method and System for Business Outcome-Based Personalized Ranking of Information Objects - Methods and apparatus are provided for business outcome-based personalized ranking of information objects. Information objects in outcome-based business processes are ranked by recording information objects generated during a creation of the outcome-based business processes. At least one business process comprises an outcome attribute, and at least one business process comprises in-process information objects. A composite graph is generated of the information objects and business processes. Each node in the graph corresponds to an information object or a business process. Links between two of the information object nodes have a strength based on a content similarity and a social network distance. The in-process information object node connects to a corresponding business process node, and two business process nodes have a link if they are indicated as related in the business process information system. The information objects are ranked based on the link strengths (for example, in response to a query for a given user and a given business process). | 03-13-2014 |
20150134736 | METHOD, FRAMEWORK, AND PROGRAM PRODUCT FOR FORMATTING AND SERVING WEB CONTENT - The present invention provides an approach and corresponding framework that separates data from its formatting/view by generating the dynamic JavaScript (data) as a set (e.g., at least one) of JavaScript (data) objects, without any HTML formatting. Then, a set of JavaScript functions can be created that takes the set of JavaScript objects as a parameter, and outputs all or a subset of this data object in a format determined by this JavaScript function. In general, these formatting functions can be static, rather than dynamic, JavaScript. This approach has the advantage of providing a much greater degree of formatting flexibility, without the need for each new format to establish a connection with the back-end system providing the data. | 05-14-2015 |
Patent application number | Description | Published |
20110041196 | miRNA-Regulated Differentiation-Dependent Self-Deleting Cassette - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 02-17-2011 |
20110041197 | Promoter-Regulated Differentiation-Dependent Self-Deleting Cassette - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 02-17-2011 |
20130095565 | miRNA-Regulated Differentiation-Dependent Self-Deleting Cassette - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 04-18-2013 |
20130312128 | PROMOTER-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 11-21-2013 |
20130312129 | PROMOTER-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 11-21-2013 |
20140075586 | Parental Cell Lines for Making Cassette-Free F1 Progeny - Non-human totipotent or pluripotent cells are provided comprising at a genomic locus a self-excisable, recombinase expression cassette flanked with recombination recognition sites, wherein a recombinase gene is operably linked to a promoter that is active in a post-meiotic spermatid stage when cytoplasmic bridging occurs between spermatids. Compositions and methods are provided for making cassette-deleted F1 non-human animals, wherein the methods comprise employing totipotent or pluripotent cells containing a self-excisable, recombinase expression cassette. | 03-13-2014 |
20140189900 | miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 07-03-2014 |
20140199761 | PROMOTER-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 07-17-2014 |
20140221734 | CLONED NON-HUMAN ANIMALS FREE OF SELECTIVE MARKERS - Genetically modified somatic cells of a non-human animal are provided that are engineered to contain a self-excisable, recombinase expression cassette comprising a site-specific recombinase gene operably linked to an ES cell-specific promoter. Compositions and methods for producing a genetically modified, cloned non-human animal that is free of a selective marker gene and a recombinase gene are provided, wherein a targeting construct comprising a self-excisable recombinase gene operably linked to an ES cell-specific promoter is introduced into differentiated somatic cells. The genetically modified genome of the somatic cells is transferred into an enucleated host oocyte. The artificially created zygote is then cultured in vitro until the blastocyst embryonic stage and subsequently implanted into a uterus of a surrogate mother to form a genetically modified, cloned non-human animal free of selective marker and recombinase genes. | 08-07-2014 |
20140235933 | GENETIC MODIFICATION OF RATS - Compositions and methods are provided for making rat pluripotent and totipotent cells, including rat embryonic stem (ES) cells. Compositions and methods for improving efficiency or frequency of germline transmission of genetic modifications in rats are provided. Such methods and compositions comprise an in vitro culture comprising a feeder cell layer and a population of rat ES cells or a rat ES cell line, wherein the in vitro culture conditions maintain pluripotency of the ES cell and comprises a media having mouse leukemia inhibitor factor (LIF) or an active variant or fragment thereof. Various methods of establishing such rat ES cell lines are further provided. Methods of selecting genetically modified rat ES cells are also provided, along with various methods to generate a transgenic rat from the genetically modified rat ES cells provided herein. Various kits and articles of manufacture are further provided. | 08-21-2014 |
20140309487 | TARGETED MODIFICATION OF RAT GENOME - Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline. | 10-16-2014 |
20140310828 | TARGETED MODIFICATION OF RAT GENOME - Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline. | 10-16-2014 |
20150047062 | lincRNA-DEFICIENT NON-HUMAN ANIMALS - Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more lncRNAs. | 02-12-2015 |
20150099296 | PROMOTER-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 04-09-2015 |
20150106961 | Humanized IL-15 Animals - Genetically modified non-human animals comprising a humanized interleukin-15 (IL-15) gene. Cells, embryos, and non-human animals comprising a human IL-15 gene. Rodents that express humanized or human IL-15 protein. | 04-16-2015 |
20150159174 | Methods and Compositions for the Targeted Modification of a Genome - Compositions and methods are provided for modifying a genomic locus of interest in a eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Further methods combine the use of the LTVEC with a CRISPR/Cas system. Compositions and methods for generating a genetically modified non-human animal comprising one or more targeted genetic modifications in their germline are also provided. | 06-11-2015 |
20150159175 | METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME - Compositions and methods are provided for modifying a genomic locus of interest in a eukaryotic cell, a mammalian cell, a human cell or a non-human mammalian cell using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Further methods combine the use of the LTVEC with a CRISPR/Cas system. Compositions and methods for generating a genetically modified non-human animal comprising one or more targeted genetic modifications in their germline are also provided. | 06-11-2015 |
20150291978 | miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE - Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell. Promoters include Blimp1, Prm1, Gata6, Gata4, Igf2, Lhx2, Lhx5, and Pax3. Targeting constructs with a cassette flanked on both sides by recombinase sites can be removed using a recombinase gene operably linked to a 3′-UTR that comprises a recognition site for an miRNA that is transcribed in undifferentiated cells but not in differentiated cells. The constructs may be included in targeting vectors, and can be used to automatically modify or excise a selection cassette from an ES cell, a non-human embryo, or a non-human animal. | 10-15-2015 |
Patent application number | Description | Published |
20120134188 | Systems and Apparatus for Reducing Electromagnetic Interference and Methods of Assembling the Same - An electric machine drive system is described. The system includes an inverter, an electric machine coupled to the inverter by at least one output conductor and including a ground connection, and an active common mode current reducing device coupled between the ground connection of the electric machine and the inverter. | 05-31-2012 |
20120249145 | GRADIENT AMPLIFIER SYSTEM - A gradient amplifier system is presented. An embodiment of a gradient amplifier system that includes a power stage having a plurality of bridge amplifiers, where each of the plurality of bridge amplifiers operates at a first switching frequency. The gradient amplifier system further includes a gradient coil coupled to an output terminal of the power stage and configured to produce a magnetic field proportional to a coil current signal supplied by the power stage. In addition, the gradient amplifier system includes a controller stage coupled to an input terminal of the power stage and configured to generate a pulse width modulated gate signal based on the coil current signal and a reference current signal, where the pulse width modulated gate signal is generated at a second switching frequency upon occurrence of a slew rate associated with the reference current signal is below a determined threshold rate and an amplitude level associated with the reference current signal is above a determined level. Further, the controller stage is configured to apply the generated pulse width modulated gate signal to the power stage for changing an operating frequency of each of the plurality of bridge amplifiers from the first switching frequency to the second switching frequency. | 10-04-2012 |
20130162250 | SYSTEM AND METHOD TO REDUCE POWER LOSS IN A GRADIENT AMPLIFIER - A gradient amplifier system, includes: a power stage comprising a plurality of bridge amplifiers, each operates at a first switching frequency; a gradient coil coupled to the power stage and configured to produce a magnetic field proportional to a coil current signal supplied by the power stage; a controller stage coupled to an input terminal of the power stage and configured to: generate a pulse width modulated gate signal based on the coil current signal and a reference current signal, wherein the pulse width modulated gate signal is generated at a second switching frequency when a slew rate associated with the reference current signal is below a threshold rate for at least a first time period; and apply the pulse width modulated gate signal to the power stage for changing an operating frequency of each of the plurality of bridge amplifiers from the first to the second switching frequency. | 06-27-2013 |
20130162370 | SYSTEMS AND METHODS FOR PROVIDING AN ELECTRIC CHOKE - Systems and methods for an electric choke are provided. The choke may be provided as part of a power transmission arrangement that includes a cable for electrically coupling a power source and a powered device having a ground node and a wire separate from the cable providing a path for a common-mode current through the ground node. The power transmission arrangement also includes an unbalanced choke coupled between the power source and the powered device, wherein a number of turns of the cable in the choke is different than a number of turns of the wire in the choke. | 06-27-2013 |
20140077812 | SYSTEM AND METHOD FOR MAINTAINING SOFT SWITCHING CONDITION IN A GRADIENT COIL DRIVER CIRCUIT - In one embodiment, a system includes a gradient coil driver configured to supply electrical signals to a gradient coil of a magnetic resonance imaging system. The gradient coil driver includes an electronic circuit. The electronic circuit includes a first H-bridge circuit electrically coupled to a power source. The first H-bridge includes a plurality of metal-oxide-semiconductor field-effect transistor (MOSFET) switches; and a plurality of diodes electrically coupled in parallel with each MOSFET switch. Each diode of the plurality of diodes is configured to conduct current to cause zero voltage potential across a source and a drain of one of the plurality of MOSFET switches. The first H-bridge also includes a load configured to regulate currents flowing through each of the plurality of diodes and each MOSFET switch of the plurality of MOSFET switches. | 03-20-2014 |
20140092660 | MULTILEVEL CONVERTER SYSTEM - A power converter includes at least one leg with a first string including a plurality of controllable semiconductor switches, a first connecting node, and a second connecting node, wherein the first string is operatively coupled across a first bus and a second bus. The at least one leg also includes a second string operatively coupled to the first string via the first connecting node and the second connecting node, wherein the second string includes a plurality of switching units. The first string includes a first branch and a second branch, wherein the second branch is operatively coupled to the first branch via a third connecting node and the third connecting node is coupled to a ground connection. | 04-03-2014 |
20140233277 | DIRECT CURRENT POWER DELIVERY SYSTEM AND METHOD - A power transmission system includes a first unit for carrying out the steps of receiving high voltage direct current (HVDC) power from an HVDC power line, generating an alternating current (AC) component indicative of a status of the first unit, and adding the AC component to the HVDC power line. Further, the power transmission system includes a second unit for carrying out the steps of generating a direct current (DC) voltage to transfer the HVDC power on the HVDC power line, wherein the HVDC power line is coupled between the first unit and the second unit, detecting a presence or an absence of the added AC component in the HVDC power line, and determining the status of the first unit based on the added AC component. | 08-21-2014 |
20150015066 | METHOD AND SYSTEM FOR CONTROL AND PROTECTION OF DIRECT CURRENT SUBSEA POWER SYSTEMS - A method and a high-voltage DC (HVDC) power system are provided. The system includes a plurality of sending-end (SE) modules coupled in electrical series and divided into at least two groups that each operate independently with respect to an electrical ground and a plurality of receiving-end (RE) power converter modules electrically coupled to the plurality of SE modules, the plurality of RE power converter modules including a fast ground-fault detection and control device, the plurality of RE power converter modules including a receiving-end front-end DC-DC converter controller, and an output current damping control. | 01-15-2015 |
20150022975 | METHOD AND SYSTEM FOR AN IMMERSION BOILING HEAT SINK - A method and system for cooling a heat-generating component are provided. The system includes a heat generating electronic component including a heat conductive face, a heat sink device including at least one open face pin fin array surface directly coupled to the conductive face, each fin including a distal end including an outwardly facing contact area, the contact areas covering only a portion of the conductive face, the contact areas configured to carry electrical current therethrough, and an immersion of dielectric fluid contained in a vessel, the vessel including a heat-conductive hull at least partially submerged in a heat sink fluid. | 01-22-2015 |
20150062991 | METHOD AND SYSTEM FOR POWER CONVERSION - A power converter includes at least one leg including a first string that includes controllable semiconductor switches, a first connecting node, and a second connecting node and that is operatively coupled across a first bus and a second bus. A second string is operatively coupled to the first string via the first connecting node and the second connecting node. The second string includes a plurality of switching modules wherein each of the plurality of switching modules includes a plurality of fully controllable semiconductor switches and at least one energy storage device. The power converter includes a system controller to control activation of the controllable semiconductor switches and switching modules such that a controlled electrical variable is maintained at a first predetermined reference voltage value and the average internal stored energy of the energy storage devices is maintained at a second predetermined reference value. | 03-05-2015 |
20150070802 | METHOD AND SYSTEM FOR ARCHITECTURE, CONTROL, AND PROTECTION SYSTEMS OF MODULAR STACKED DIRECT CURRENT SUBSEA POWER SYSTEM - A high-voltage DC (HVDC) power system and a method of controlling and protecting the HVDC power system includes a plurality of sending-end (SE) modules coupled in electrical series and a plurality of receiving-end (RE) power converter modules electrically coupled to said plurality of SE modules, the RE modules coupled in a switchyard configuration, the switchyard configuration including a plurality of load branches coupled together in electrical series, each load branch including a branch bypass switch configured to bypass load current around an associated load branch, and a branch protection system. | 03-12-2015 |
20150091488 | METHOD AND SYSTEM FOR DRIVING ELECTRIC MACHINES - A system for driving an electric machine is provided. The system includes a power converter coupled to an input source and the electric machine. The power converter includes a leg that includes a first and second string. The first string includes plurality of controllable semiconductor switches, a first and second connecting node. The first string is operatively coupled across a first and second bus. The second string is operatively coupled to the first string via the first and second connecting node. The second string comprises plurality of switching modules. The switching modules include fully controllable semiconductor switches and energy storage devices. The system further includes a system controller configured to provide activation commands to the controllable semiconductor switches and the switching modules such that energy stored in the energy storage device is provided to the electric machine when the machine is switched on for operation. | 04-02-2015 |
20150102671 | DIRECT CURRENT POWER TRANSMISSION SYSTEM - A system for transmitting direct current (DC) power includes a system DC link for carrying power from a source to a plurality of loads and alternating current (AC) to DC power converter modules coupled in series to the system DC link on a supply side of the system DC link. At least one AC to DC power converter module is connected to the source via at least one controllable semiconductor switch such that when the controllable semiconductor switch is not conducting, the at least one AC to DC power converter module adds about zero voltage to a system DC link voltage and provides a path for a DC link current | 04-16-2015 |
20150108844 | HYBRID ENERGY STORAGE SYSTEM - A power converter is provided. The power converter includes a converter leg comprising a plurality of active power link modules coupled to each other. Each of the plurality of active power link module includes exactly two semiconductor switches comprising antiparallel diodes and wherein the antiparallel diodes are coupled in parallel to the respective switches, a filter inductor coupled to a node between the two semiconductor switches, a filter capacitor coupled in parallel across the at least two semiconductor switches and a power storage element directly coupled in parallel to the filter capacitor. | 04-23-2015 |
20150280605 | MULTILEVEL CONVERTER - A power converter is presented. The power converter includes at least one leg, the at least one leg includes a first string, where the first string includes a plurality of diodes, a first connecting node, and a second connecting node, and where the first string is operatively coupled across a first bus and a second bus. Furthermore, the at least one leg includes a second string operatively coupled to the first string via the first connecting node and the second connecting node, where the second string includes a plurality of switching units. | 10-01-2015 |