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Lai, MA

Alan Lai, Westborough, MA US

Patent application numberDescriptionPublished
20090283410COATED ARTICLES AND RELATED METHODS - Coated articles and related methods are described. In some cases, the coated articles may exhibit high strength, hardness, brightness, abrasion resistance, corrosion resistance, and other desirable structural and functional properties. In some embodiments, the coatings may include an alloy, such as a nickel-tungsten alloy and/or metal oxides.11-19-2009
20090286103COATED ARTICLES AND RELATED METHODS - Coated articles and related methods are described. In some cases, the coated articles may exhibit high strength, hardness, brightness, abrasion resistance, corrosion resistance, and other desirable structural and functional properties. In some embodiments, the coatings may include an alloy, such as a nickel-tungsten alloy and/or metal oxides.11-19-2009

Chao Qiang Lai, Belmont, MA US

Patent application numberDescriptionPublished
20090100536Transgenic plants with enhanced agronomic traits - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.04-16-2009
20110258734GENE SEQUENCES AND USES THEREOF IN PLANTS - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.10-20-2011

Patent applications by Chao Qiang Lai, Belmont, MA US

Chengjung Lai, Belmont, MA US

Patent application numberDescriptionPublished
20120088764PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY - The instant application relates to deazapurines, thienopyrimidines and furopyrimidines with zinc-binding moiety based derivatives and their use in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.04-12-2012

Cheng-Jung Lai, Belmont, MA US

Patent application numberDescriptionPublished
20100222343PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY - The instant application relates to deazapurines, thienopyrimidines and furopyrimidines with zinc-binding moiety based derivatives and their use in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.09-02-2010

Chien-Jen Lai, Cambridge, MA US

Patent application numberDescriptionPublished
20110140009Efficient High-Harmonic-Generation-Based EUV Source Driven by Short Wavelength Light - Extreme ultraviolet radiation is generated based on high-order harmonic generation. First, a driver pulse is generated from a drive laser. Second, the infrared driver pulse is passed through a second harmonic generator with an output wavelength in the range from 400 to 700 nm. Third, the pulse is then passed through a gas medium, which can be inside a resonant cavity, to generate a high-order harmonic in the form of extreme ultraviolet radiation.06-16-2011

Jan-Ji Lai, Westborough, MA US

Patent application numberDescriptionPublished
20090197799METHODS FOR PREPARING PURIFIED LIPOTIDES - The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.08-06-2009
20100041589METHODS FOR PREPARING PURIFIED LIPOPEPTIDES - The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions. 02-18-2010
20110207658High Purity Lipopeptides - The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of 08-25-2011

Patent applications by Jan-Ji Lai, Westborough, MA US

Jonathan R. Lai, Roxbury, MA US

Patent application numberDescriptionPublished
20100048422Methods of Producing Modified Assembly Lines and Related Compositions - The present invention provides a method producing a modified assembly line, such as those that produce non-ribosomal peptides and polyketides. The modified assembly lines of the invention can be used to produce novel compounds with therapeutic activities. The invention also provides organisms containing modified assembly lines and libraries of modified assembly lines.02-25-2010

Justin Y. Lai, Cambridge, MA US

Patent application numberDescriptionPublished
20110037488FLEXURAL MECHANISM FOR PASSIVE ANGLE ALIGNMENT AND LOCKING - A passive alignment structure is provided that includes at least one rigid post being coupled to a top surface and a bottom surface. At least one in-plane clamp is associated with a respective at least one rigid post. The at least one in-plane clamp receives a clamping force to lock the respective at least one rigid post. A plurality of pins allows the top surface to align to the bottom surface.02-17-2011

Katherine Jane Lai, Cambridge, MA US

Patent application numberDescriptionPublished
20100077098System and Method for Enabling Website Owners to Manage Crawl Rate in a Website Indexing System - Web crawlers crawl websites to access documents of the website for purposes of indexing the documents for search engines. The web crawlers crawl a specified website at a crawl rate that is based on multiple factors. One of the factors is a pre-set crawl rate limit. According to certain embodiments, an owner for a specified website is enabled to modify the crawl rate limit for the specified website when one or more pre-set criteria are met.03-25-2010
20120023091System and Method for Enabling Website Owner to Manage Crawl Rate in a Website Indexing System - Web crawlers crawl websites to access documents of the website for purposes of indexing the documents for search engines. The web crawlers crawl a specified website at a crawl rate that is based on multiple factors. One of the factors is a pre-set crawl rate limit. According to certain embodiments, an owner for a specified website is enabled to modify the crawl rate limit for the specified website when one or more pre-set criteria are met.01-26-2012

Marc R. Lai, Dover, MA US

Patent application numberDescriptionPublished
20100076288Method and System for Transferring Analyte Test Data - A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD.03-25-2010
20100082266Method and System for Transferring Analyte Test Data - A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD.04-01-2010
20100121168Method and System for Transferring Analyte Test Data - A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD.05-13-2010
20100309001Method and System for Transferring Analyte Test Data - A system for transferring data includes an analyte test instrument (ATI) adapted to store data, a wirelessly enabled data management device (DMD) for comprehensively analyzing data, and an adaptor removably connected to the ATI for transferring data stored on the ATI to the DMD. The adaptor includes a data communication device capable of removable connection with the ATI, a microprocessor electrically connected to the data communication device, a wireless controller electrically connected to the microprocessor and a wireless transceiver electrically connected to the wireless controller. In use, data transfer is executed between the ATI and the DMD by electrically and mechanically connecting the adaptor to the ATI. Data stored on the ATI is then automatically downloaded into adaptor memory. Upon completion of the download, the user activates an externally accessible input device on the adaptor which, in turn, wirelessly transmits data from the adaptor memory to the DMD.12-09-2010

Nelson Lai, Cambridge, MA US

Patent application numberDescriptionPublished
20090254861DUAL DISPLAY CONTENT COMPANION - A method includes displaying a listing of content items in a first display area and displaying supplemental content items related to at least one of the content items in a second display area that is separate from the first display area. The listing of content items may represent content items that are available for rendering on a content rendering device. The listing of content items and the supplemental content items may be displayed simultaneously. One of the displayed content items may be selected and in response, the displayed listing of content items may be swapped to the second display area and the displayed supplemental content items may be swapped to the first display area.10-08-2009

Peter Lai, Cambridge, MA US

Patent application numberDescriptionPublished
20080201320SYSTEM AND METHOD FOR SEARCHING ANNOTATED DOCUMENT COLLECTIONS - Methods, apparatus and articles of manufacture therefor, are disclosed sharing and searching annotated document collections. In one embodiment, the method may be performed by: transforming a plurality of document identifiers and their associated set of tags into a set of URL/TAG pairs; constructing a bigraph using the set of URL/TAG pairs; using the bigraph to compute tag profiles and document profiles using spreading activation for document identifiers and tags in the set of URL/TAG pairs; for a selected tag or document, identifying a tag profile or a document profile associated with the selected tag or document, respectively; arranging by relevance those tags or documents in the identified tag profile or document profile associated with the selected tag or document, respectively.08-21-2008

Shih-Hao Lai, Stoneham, MA US

Patent application numberDescriptionPublished
20120058226BEVERAGE CARTRIDGE - A method, system and cartridge for forming a beverage includes a cartridge having a container defining an interior space, a lid, a filter, and a beverage medium contained in the interior space. The filter may be attached to the lid only, and extend into the interior space to separate first and second chambers of the cartridge. The filter may hold the beverage medium and be arranged so that, when the lid is removed from the container, e.g., by peeling the lid from the container, the filter and beverage medium are removed together with the lid.03-08-2012

Wei Lai, Cambridge, MA US

Patent application numberDescriptionPublished
20090035664BATTERIES AND ELECTRODES FOR USE THEREOF - The present invention generally relates to batteries or other electrochemical devices, and systems and materials for use in these, including novel electrode materials and designs. In some embodiments, the present invention relates to small-scale batteries or microbatteries. For example, in one aspect of the invention, a battery may have a volume of no more than about 5 mm02-05-2009
20090202903BATTERIES AND ELECTRODES FOR USE THEREOF - The present invention generally relates to batteries or other electrochemical devices, and systems and materials for use in these, including novel electrode materials and designs. In some embodiments, the present invention relates to small-scale batteries or microbatteries. For example, in one aspect of the invention, a battery may have a volume of no more than about 5 mm08-13-2009
20110097623SMALL-SCALE BATTERIES AND ELECTRODES FOR USE THEREOF - The present invention generally relates to batteries or other electrochemical devices. In some embodiments, the present invention relates to small-scale batteries or microbatteries. For example, in one aspect of the invention, a battery may have a volume of no more than about 5 mm3, while having an energy density of at least about 400 Wh/l. Other aspect of the invention is directed to techniques of packaging such batteries.04-28-2011