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Kuslich, US

Christine Kuslich, Gilbert, AZ US

Patent application numberDescriptionPublished
20100113290METHODS FOR ASSESSING RNA PATTERNS - Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.05-06-2010
20100184046Methods and systems of using exosomes for determining phenotypes - Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.07-22-2010
20100203529Methods and systems of using exosomes for determining phenotypes - Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.08-12-2010
20110151460METHODS AND SYSTEMS OF USING EXOSOMES FOR DETERMINING PHENOTYPES - Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.06-23-2011
20110237450METHODS AND SYSTEMS OF USING EXOSOMES FOR DETERMINING PHENOTYPES - Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.09-29-2011

John E. Kuslich, Phoenix, AZ US

Patent application numberDescriptionPublished
20100152855EXPANDABLE POROUS MESH BAG DEVICE AND METHODS OF USE FOR REDUCTION, FILLING, FIXATION AND SUPPORTING OF BONE - A method of treating a compression fracture in a bone comprising the steps of forming a transverse cavity within said bone defined by at least one substantially flat surface lying substantially in a transverse plane formed by and communicating with said transverse cavity, the transverse cavity having a substantially uniform transverse extent and a maximum height, the maximum height being less than said transverse extent and applying a force within said transverse cavity generally normal to said surface to displace said surface and restore said bone to its substantially normal anatomic position.06-17-2010
20100268231EXPANDABLE POROUS MESH BAG DEVICE AND METHODS OF USE FOR REDUCTION, FILLING, FIXATION AND SUPPORTING OF BONE - A method of treating a compression fracture in a bone comprising the steps of forming a transverse cavity within said bone defined by at least one substantially flat surface lying substantially in a transverse plane formed by and communicating with said transverse cavity, the transverse cavity having a substantially uniform transverse extent and a maximum height, the maximum height being less than said transverse extent and applying a force within said transverse cavity generally normal to said surface to displace said surface and restore said bone to its substantially normal anatomic position.10-21-2010
20100286702METHOD KIT FOR TREATING BONY DEFECTS - The present invention is a kit and a method of using a kit for treating bone including a fill material mixture made of osteoconductive material, osteoinductive material and a lubricating carrier, a porous container to receive the fill material mixture and a tool that flowably introduces the fill material mixture into the porous container.11-11-2010

Patent applications by John E. Kuslich, Phoenix, AZ US

Patricia K. Kuslich, Stillwater, MN US

Patent application numberDescriptionPublished
20110213463ANNULUS-REINFORCING BAND - A pliable band or hoop that is flexible to normal handling, but cannot stretch circumferentially once it has reached the limits of its circumferential length. The band may have a structural portal to be used for filling, or it may simply be constructed of a fabric-like material that allows a fill tube to perforate its walls to allow for filling. In the latter case, the perforated wall tends to self-seal once the fill tube is withdrawn. The band may be flat or tubular in cross-section. However, unlike a balloon, the band does not require either a bottom or a top, as we found that a top and bottom are unnecessary when using a band or hoop to enclose material injected into a reamed out intervertebral space.09-01-2011

Patricia K. Kuslich US

Patent application numberDescriptionPublished
20120116514SEMI-BIOLOGICAL INTERVERTEBRAL DISC REPLACEMENT SYSTEM - Disclosed is a system and method for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth. The fibro-cartilaginous tissue05-10-2012

Patricia Kocian Kuslich, Stillwater, MN US

Patent application numberDescriptionPublished
20100049251METHOD AND DEVICE FOR INTERSPINOUS PROCESS FUSION - The device of the invention includes a flexible container that may be filled with fill material either before or after placement at the insertion site. It is one object of the present invention to provide a flexible container filled with morselized cortico-cancellous bone graft. According to one aspect of the present invention, a filled flexible container may be placed at the insertion site and then molded to the local anatomy. In an embodiment, a filled flexible container may be placed between two spinous processes.02-25-2010
20110245924Annulus-Reinforcing Band - A method and device for supporting bone graft including a porous enclosure having a first collapsed state and a second expanded state wherein the second expanded state is sized to conform to the excavated intervertebral cavity upon insertion of bone graft into the enclosure.10-06-2011

Stephen D. Kuslich, Grant Township, MN US

Patent application numberDescriptionPublished
20090125110SEMI-BIOLOGICAL INTERVERTEBRAL DISC REPLACEMENT SYSTEM - The present invention is a system for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth. The fibro-cartilaginous tissue05-14-2009
20110245924Annulus-Reinforcing Band - A method and device for supporting bone graft including a porous enclosure having a first collapsed state and a second expanded state wherein the second expanded state is sized to conform to the excavated intervertebral cavity upon insertion of bone graft into the enclosure.10-06-2011
20120116514SEMI-BIOLOGICAL INTERVERTEBRAL DISC REPLACEMENT SYSTEM - Disclosed is a system and method for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth. The fibro-cartilaginous tissue05-10-2012

Patent applications by Stephen D. Kuslich, Grant Township, MN US

Stephen D. Kuslich, Phoenix, AZ US

Patent application numberDescriptionPublished
20100286702METHOD KIT FOR TREATING BONY DEFECTS - The present invention is a kit and a method of using a kit for treating bone including a fill material mixture made of osteoconductive material, osteoinductive material and a lubricating carrier, a porous container to receive the fill material mixture and a tool that flowably introduces the fill material mixture into the porous container.11-11-2010

Stephen D. Kuslich, Stillwater, MN US

Patent application numberDescriptionPublished
20100049251METHOD AND DEVICE FOR INTERSPINOUS PROCESS FUSION - The device of the invention includes a flexible container that may be filled with fill material either before or after placement at the insertion site. It is one object of the present invention to provide a flexible container filled with morselized cortico-cancellous bone graft. According to one aspect of the present invention, a filled flexible container may be placed at the insertion site and then molded to the local anatomy. In an embodiment, a filled flexible container may be placed between two spinous processes.02-25-2010
20100152855EXPANDABLE POROUS MESH BAG DEVICE AND METHODS OF USE FOR REDUCTION, FILLING, FIXATION AND SUPPORTING OF BONE - A method of treating a compression fracture in a bone comprising the steps of forming a transverse cavity within said bone defined by at least one substantially flat surface lying substantially in a transverse plane formed by and communicating with said transverse cavity, the transverse cavity having a substantially uniform transverse extent and a maximum height, the maximum height being less than said transverse extent and applying a force within said transverse cavity generally normal to said surface to displace said surface and restore said bone to its substantially normal anatomic position.06-17-2010
20100268231EXPANDABLE POROUS MESH BAG DEVICE AND METHODS OF USE FOR REDUCTION, FILLING, FIXATION AND SUPPORTING OF BONE - A method of treating a compression fracture in a bone comprising the steps of forming a transverse cavity within said bone defined by at least one substantially flat surface lying substantially in a transverse plane formed by and communicating with said transverse cavity, the transverse cavity having a substantially uniform transverse extent and a maximum height, the maximum height being less than said transverse extent and applying a force within said transverse cavity generally normal to said surface to displace said surface and restore said bone to its substantially normal anatomic position.10-21-2010
20110213463ANNULUS-REINFORCING BAND - A pliable band or hoop that is flexible to normal handling, but cannot stretch circumferentially once it has reached the limits of its circumferential length. The band may have a structural portal to be used for filling, or it may simply be constructed of a fabric-like material that allows a fill tube to perforate its walls to allow for filling. In the latter case, the perforated wall tends to self-seal once the fill tube is withdrawn. The band may be flat or tubular in cross-section. However, unlike a balloon, the band does not require either a bottom or a top, as we found that a top and bottom are unnecessary when using a band or hoop to enclose material injected into a reamed out intervertebral space.09-01-2011

Patent applications by Stephen D. Kuslich, Stillwater, MN US