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Kuipers, NL
Anneke Kuipers, Haule NL
| Patent application number | Description | Published |
|---|---|---|
| 20090042246 | Methods For The Production And Secretion Of Modified Peptides - The invention relates to the production of heterologous polypeptides in a recombinant host cell. More specifically, it relates to the production and secretion of peptides, such as biologically active peptides, that are modified by one or more lantibiotic-synthesizing enzymes. Provided is a nucleic acid construct encoding a polypeptide comprising 1) a non-lantibiotic export signal that is recognized by a non-lantibiotic export system; 2) a lantibiotic leader peptide that is recognized by at least a lantibiotic dehydratase such as LanB and, C-terminally of said export signal and said leader peptide, 3) a peptide of interest containing one or more serine or threonine residue(s) which can be posttranslationally dehydrated by said dehydratase. Also provided is a method for producing a polypeptide in a host cell, comprising providing a host cell with a nucleic acid construct according to the invention and allowing expression and secretion of the encoded polypeptide by said host cell, wherein said host cell comprises at least a dehydratase capable of modifying said encoded polypeptide and a non-lantibiotic export system capable of secreting said modified polypeptide. | 02-12-2009 |
| 20100055146 | CYCLIC ANGIOTENSIN ANALOGS - The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(1-8) agonistic or antagonistic activity and to cyclised Ang(1-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyr | 03-04-2010 |
Christiaan Kuipers, Eindhoven NL
| Patent application number | Description | Published |
|---|---|---|
| 20110083020 | SECURING A SMART CARD - The invention provides a method for securing a smart card ( | 04-07-2011 |
Frans Kuipers, Veenendaal NL
| Patent application number | Description | Published |
|---|---|---|
| 20110288361 | REAL TIME RADIATION TREATMENT PLANNING SYSTEM - The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions. | 11-24-2011 |
Herman Pieter Charles Eduard Kuipers, Amsterdam NL
| Patent application number | Description | Published |
|---|---|---|
| 20080255257 | PROCESS FOR MAKING AN EGG SHELL FT CATALYST - A process for preparing a Fischer-Tropsch catalyst comprising the steps of a) providing a particle having a size of at least 1 mm and having a catalytically active metal homogenously distributed therein, wherein at least 50 wt % of the catalytically active metal is present as divalent oxide or divalent hydroxide; b) treating the particle with formic acid, acetic acid, propionic acid, butyric acid, n-pentanoic acid, hexanoic acid, citric acid, and/or benzoic acid an organic acid for more than 5 minutes; c) washing the catalyst particle; and d) drying the catalyst particle and/or heating the particle to a temperature in the range of 200 to 400° C. | 10-16-2008 |
| 20110138851 | PROCESS FOR PRODUCING PURIFIED NATURAL GAS FROM NATURAL GAS COMPRISING WATER AND CARBON DIOXIDE - The invention provides a process for producing purified natural gas from feed natural gas comprising water and carbon dioxide, the process comprising the steps of: (a) removing water from the feed natural gas to obtain natural gas depleted in water and comprising carbon dioxide; (b) contacting the natural gas obtained in step (a) with solid sorbent comprising a metal organic framework to remove at least part of the carbon dioxide, thereby obtaining the purified natural gas. | 06-16-2011 |
Johannes Kuipers, Hantum NL
| Patent application number | Description | Published |
|---|---|---|
| 20100181252 | METHOD AND SYSTEM FOR PURIFYING A LIQUID COMPRISING CRYSTAL INHIBITOR RECOVERY - The present invention relates to a method for purifying a liquid, comprising the steps of:—supplying a flow of liquid for purifying;—adding a crystal growth inhibitor;—purifying the flow;—separating the flow into a purified flow and a return flow; and—concentrating the crystal growth inhibitor, present in the return flow, in a crystallizer | 07-22-2010 |
| 20100243570 | METHOD, INSTALLATION AND SYSTEM FOR MEASURING AND/OR TREATING CONTAMINATING COMPOUNDS DISSOLVED IN A LIQUID - The present invention relates to a method, device and system for measuring and/or treating contaminating components dissolved in a liquid in a liquid flow, such as in a water treatment, the method comprising the steps of: —carrying at least a part of the liquid from the liquid flow with contaminating components present therein into a container or a conduit; —causing precipitation of at least a part of the dissolved contaminating components, wherein solid particles are formed, and/or treating the quantity of process liquid; optionally followed by: —measuring the presence and/or the quantity of solid particles formed. | 09-30-2010 |
Oscar Paul Kuipers, Groningen NL
| Patent application number | Description | Published |
|---|---|---|
| 20090042246 | Methods For The Production And Secretion Of Modified Peptides - The invention relates to the production of heterologous polypeptides in a recombinant host cell. More specifically, it relates to the production and secretion of peptides, such as biologically active peptides, that are modified by one or more lantibiotic-synthesizing enzymes. Provided is a nucleic acid construct encoding a polypeptide comprising 1) a non-lantibiotic export signal that is recognized by a non-lantibiotic export system; 2) a lantibiotic leader peptide that is recognized by at least a lantibiotic dehydratase such as LanB and, C-terminally of said export signal and said leader peptide, 3) a peptide of interest containing one or more serine or threonine residue(s) which can be posttranslationally dehydrated by said dehydratase. Also provided is a method for producing a polypeptide in a host cell, comprising providing a host cell with a nucleic acid construct according to the invention and allowing expression and secretion of the encoded polypeptide by said host cell, wherein said host cell comprises at least a dehydratase capable of modifying said encoded polypeptide and a non-lantibiotic export system capable of secreting said modified polypeptide. | 02-12-2009 |
| 20090209007 | Method of Expression Cloning in a Host Cell - The invention relates to a promoter DNA sequence highly suited in an improved expression cloning method for isolation of DNA sequences comprising a DNA sequence encoding a protein of interest in a host cell and to the improved expression cloning method wherein use is made of this promoter. The isolated DNA sequences are useful in processes for producing a protein of interest. | 08-20-2009 |
| 20090239264 | Immunization with bacterial ghost-based vaccines - Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a protein, lipoteichoic acid or carbohydrate from the cell-wall material and contacting the proteinaceous substance with the cell-wall material. | 09-24-2009 |
| 20100183596 | Virulence Factors of Streptoccus Pnuemoniae - The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of | 07-22-2010 |
Robertus Adolphus Maria Kuipers, Helmond NL
| Patent application number | Description | Published |
|---|---|---|
| 20110007288 | HEAT TRANSFER ASSEMBLY, LITHOGRAPHIC APPARATUS AND MANUFACTURING METHOD - A lithographic apparatus includes a heat transfer assembly configured to temperature control at least a portion of the lithographic apparatus. The heat transfer assembly includes a printed circuit board, and a plurality of heat transfer elements. The printed circuit board and the plurality of heat transfer elements are configured to be attached to the portion of the lithographic apparatus. The plurality of heat transfer elements are separate from and are electrically coupled to the printed circuit board. | 01-13-2011 |