Patent application number | Description | Published |
20090124583 | 7-N-substituted phenyl tetracycline compounds - 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described. | 05-14-2009 |
20090258842 | 7-Phenyl-Substituted Tetracycline Compounds - 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. | 10-15-2009 |
20090306022 | 7-SUBSTITUTED TETRACYCLINE COMPOUNDS - The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression. | 12-10-2009 |
Patent application number | Description | Published |
20110118215 | 7,8 And 9-Substituted Tetracycline Compounds - 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described. | 05-19-2011 |
20110257421 | 7-N-Substituted Phenyl Tetracycline Compounds - 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described. | 10-20-2011 |
20120283201 | 9-SUBSTITUTED MINOCYCLINE COMPOUNDS - The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression. | 11-08-2012 |
20130029943 | Methods of Preparing Substituted Tetracyclines with Transition Metal-Based Chemistries - The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed. Such compounds may optionally act as intermediates for making other compounds, e.g., hydrogenation of unsaturated groups on the substituent. | 01-31-2013 |
Patent application number | Description | Published |
20120194967 | SIGNAL-PROCESSING DEVICES HAVING ONE OR MORE MEMRISTORS - Signal-processing devices having memristors are described for performing frequency-discrimination functions, amplitude-discrimination functions, and time-oriented functions. In each case, the time-domain behavior of the memristors described herein enables these functions to be performed. In one embodiment, memristance of an arrangement of memristors of a device is, after an initial transitional period, predominantly at a first level if frequency of an input signal of the device is less than a first frequency and predominantly at a second level if the frequency of the input signal is greater than a second frequency. | 08-02-2012 |
20140361851 | SIGNAL-PROCESSING DEVICES HAVING ONE OR MORE MEMRISTORS - Signal-processing devices having memristors are described for performing frequency-discrimination functions, amplitude-discrimination functions, and time-oriented functions. In each case, the time-domain behavior of the memristors described herein enables these functions to be performed. In one embodiment, memristance of an arrangement of memristors of a device is, after an initial transitional period, predominantly at a first level if frequency of an input signal of the device is less than a first frequency and predominantly at a second level if the frequency of the input signal is greater than a second frequency. | 12-11-2014 |
Patent application number | Description | Published |
20100278634 | ROTARY MACHINE BALANCE WEIGHTS - In a one embodiment, a balance weight includes a base, a rotational axis extending from the base, and a circumference having opposite cam surfaces about the rotational axis. The opposite cam surfaces are at least partially angled toward one another in a direction away from the base along the rotational axis. The balance weight is designed to mount in a groove of a rotary component of a turbine engine. | 11-04-2010 |
20110164957 | Method and Apparatus for Double Flow Turbine First Stage Cooling - A cooling path is defined through a double-flow steam turbine. The steam turbine includes a generator end and a turbine end and a double-flow tub diaphragm disposed axially between the generator end and the turbine end. A first stage of the steam turbine includes a plurality of first stage nozzles and a plurality of first stage buckets, and a steam path is defined from an inlet region, through the turbine end, to a steam outlet. The cooling path includes cooling holes in the tub diaphragm and root radial seals permitting steam flow beneath the tub diaphragm and around the first stage nozzles and back into the steam path before the first stage buckets. | 07-07-2011 |
20130195644 | STEAM TURBINE WITH SINGLE SHELL CASING, DRUM ROTOR, AND INDIVIDUAL NOZZLE RINGS - A steam turbine with a drum rotor utilizing individual nozzle ring assemblies in the IP section incased by a single shell. In one embodiment, a steam turbine has a high pressure (HP) section with a double shell drum and an intermediate pressure (IP) section with a single shell drum, with the IP section including a plurality of individual nozzle ring assemblies axially spaced along the single shell casing, such that each nozzle ring assembly surrounds the drum rotor. In other embodiments, a low pressure section (LP) of the steam turbine can have a single-flow or dual-flow connection to a condenser, and the condenser can be positioned to the side, vertically below, or axially aligned with the LP section. | 08-01-2013 |
20140119910 | TURBINE EXHAUST HOOD AND RELATED METHOD - A turbine exhaust hood and related method of installation is disclosed. In one embodiment, the turbine exhaust hood includes: a housing having an end wall, the end wall including a first portion of a releasable coupling, and a first radially inner steam guide structure disposed within the housing, the first radially inner steam guide structure including a second portion of the releasable coupling, integral with a first end of the first radially inner steam guide structure. The first portion and the second portion of the releasable coupling releasably couple the first radially inner steam guide structure to the end wall. | 05-01-2014 |
Patent application number | Description | Published |
20140279907 | Reducing Reading Of Database Logs By Persisting Long-Running Transaction Data - According to one embodiment of the present invention, a system reduces re-reading of database logs by persisting long running transaction data. The system processes the database log records of the database transaction log; generates a snapshot of the database log records at periodic intervals, wherein each snapshot includes database log records for pending transactions; and in response to an interruption in processing of the database log records, utilizes a snapshot to restore database log records for the pending transactions and resume processing of the database transaction log from a position succeeding the database log records of the selected snapshot. | 09-18-2014 |
20140379663 | REDUCING READING OF DATABASE LOGS BY PERSISTING LONG-RUNNING TRANSACTION DATA - According to one embodiment of the present invention, a system reduces re-reading of database logs by persisting long running transaction data. The system processes the database log records of the database transaction log; generates a snapshot of the database log records at periodic intervals, wherein each snapshot includes database log records for pending transactions; and in response to an interruption in processing of the database log records, utilizes a snapshot to restore database log records for the pending transactions and resume processing of the database transaction log from a position succeeding the database log records of the selected snapshot. | 12-25-2014 |
20150268998 | RESOURCE MANAGEMENT VIA ITERATIVE NEGOTIATION - A system and method manages resources within a process by identifying a first resource threshold associated with available resources. The method receives a resource request from a resource requesting participant requiring the available resources. The method determines that an estimated resource usage, associated with the resource request, approaches the first resource threshold. The method negotiates with at least one resource consuming participant to voluntarily release resources until the estimated resource usage approaches a second resource threshold associated with the available resources within the process. | 09-24-2015 |
Patent application number | Description | Published |
20150204824 | MATERIALS FOR HYDROPHILIC INTERACTION CHROMATOGRAPHY AND PROCESSES FOR PREPARATION AND USE THEREOF FOR ANALYSIS OF GLYCOPROTEINS AND GLYCOPEPTIDES - The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances. | 07-23-2015 |
20150316515 | MATERIALS FOR HYDROPHILIC INTERACTION CHROMATOGRAPHY AND PROCESSES FOR PREPARATION AND USE THEREOF FOR ANALYSIS OF GLYCOPROTEINS AND GLYCOPEPTIDES - The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances. | 11-05-2015 |