Patent application number | Description | Published |
20100240736 | Novel Compounds for the Treatment or Alleviation of Edema, and Methods for their Use - Isolated and substantially purified oligonucleotide compounds have been shown to be effective in reducing swelling and edema. Novel methods and substances are presented for the prevention, alleviation or treatment of edema of various aetiology. | 09-23-2010 |
20100285477 | Method for Predicting the Response to a Therapy - The invention concerns an in vitro method for selecting the therapy for a steroid resistant patient, wherein the method comprises isolating cells from a sample taken from said patient; cultivating said isolated cells in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof; determining an expression level of at least one marker gene in said isolated cells; and comparing said expression level of said at least one marker gene to a value obtained from the cultivation of cells from a healthy person in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof, or to a normalized value obtained from a healthy population. Examples of marker genes are CD163, Tsp1, IL1-R2, TLR2, TLR4, MKP-1 and TXK. | 11-11-2010 |
20110183337 | Method and Kit for Use in the Differentiation of IBD and IBS and Further Distinction Between Disease Types of IBD - A quantification of the expression levels of a number of specific genes and their corresponding proteins can be utilized in accurately determining, using samples from faeces or blood, whether the patient is suffering from irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD), and in a follow up analysis using a biopsy, determine if the same patient is afflicted with ulcerative colitis (UC) or Crohn's disease (CD). The method also has utility in determining the severity of the disease, as well as observing a patient's response to treatment. | 07-28-2011 |
20110280934 | Increased Expression of Specific Antigens - The response of immunotherapy in the treatment of cancer is enhanced by use of an oligonucleotide in a dose effective to induce at least one of endogenous production of cytokines, and the regulation of the expression of one or more of the cell surface antigens (FIG. | 11-17-2011 |
20140030723 | Method for Predicting the Response to a Therapy - A test kit for selecting a therapy for a steroid resistant patient presenting inflammatory symptoms comprises primer pairs or antibodies specific for at least one marker gene or protein translated from at least one marker gene, and instructions for use. The primer pairs or antibodies enable analysis of expression level of the at least one marker gene or translated protein from the at least one marker gene. | 01-30-2014 |
Patent application number | Description | Published |
20110182880 | Combination Therapies Against Cancer - Specific oligonucleotide sequences, when given subcutaneously and in particular when administered on a mucous membrane, e.g. intranasally, intravaginally, or rectally, have a profound effect on various human cancer forms as confirmed in vivo, in animal studies, and in vitro, in human PBMCs collected from blood from healthy subjects and from patients suffering from CLL. The compounds are also preferably used in combination with a cancer therapy chosen among radiation treatment, hormone treatment, surgical intervention, chemotherapy, immunological therapies, photodynamic therapy, laser therapy, hyperthermia, cryotherapy, angiogenesis inhibition, or a combination of any of these, and most preferably an immunological treatment comprising the administration of an antibody to the patient. | 07-28-2011 |
Patent application number | Description | Published |
20080210545 | Method and Apparatus for Producing Electric Discharges - In producing discharges in a load element such as a magnetron sputtering device, electric pulses are provided from different electric pulse sources, e.g. three or more electric pulse sources. The pulse sources are controlled by a control and monitoring unit to give the element electric pulses different heights and start and end times. The element electric pulses are summed, such as by connecting the pulse sources in parallel to the load, to form resulting, relatively long electric pulses. Each of the resulting electric pulses can have a portion that has a substantially constant level and then the substantially constant level is formed from at least two element electric pulses having the same pulse height. The resulting electric pulses are applied to electrodes in the load. The element electric pulses can have the same polarity such as being half a period of a sinusoid oscillation of a single frequency. Then the time intervals between starts of successive element electric pulses are relatively short such as not being not larger than one third of the period of the sinusoid. For example, the resulting electric pulses can have a substantially rectangular shape, a shape including two different substantially constant levels or have a substantially triangular shape. | 09-04-2008 |
20090057133 | Method and Apparatus for Reactive Solid-Gas Plasma Deposition - A device for magnetically enhanced sputtering and plasma deposition includes a plasma source unit and a work piece processing unit in which an anode space and a processing chamber are located in direct communication with each other. Sputtering and reactive gases are provided through an inlet of the processing chamber holding the work piece. Pulsed electric discharges are produced between the magnetron sputtering cathode and the anode, including walls of the anode space. A stationary magnetic mirror trap is provided in the combined vessel by an anode coil surrounding the anode space and another coil mounted at the processing chamber remote from the cathode. A plasma can then flow into the processing chamber suitable for reactive deposition on three-dimensional and large work pieces. A chemisorption filter including filter plates is arranged in the anode space for preventing penetration of the reactive gas into the region at the cathode. The other coil can be included in a plasma source similar to the first one, both plasma sources connected to the same work piece processing unit. | 03-05-2009 |
20110008576 | Method, Material and Apparatus for Enhancing Dynamic Stiffness - A composite, carbon based material that can be used for enhancing the dynamic stiffness of objects, in the case where it for instance is applied as a coating, comprises at least one layer of substantially parallel carbon pillars. The pillars extend from the bottom surface up to the top surface of the layer, substantially perpendicularly to said surfaces, have substantially hexagonal or pentagonal cross-sections and a relatively weak conical shape, their cross-section widening from their bottom ends to their top ends. The carbon based pillars can typically have a cross-sectional dimension in the range of 50-200 μm such as about 100 μm and have heights in the range of 50 μm-2 mm. The pillars can be seen as built from macro-sized aggregates that have at least one dimension in the nano range, e.g. in the range of 10-800 run, and include carbon, oxygen and hydrogen and in most cases also nitrogen. The material can be produced using PECVD, PEPVD methods and plasma generation by electric discharges with closed electron drift. | 01-13-2011 |
20110081477 | Plasma Activated Chemical Vapour Deposition Method and Apparatus Therefor - In plasma activated chemical vapour deposition a plasma decomposition unit is used that is arranged in or connected to a vacuum vessel having a relatively low pressure or vacuum, to which an operating gas is provided. Periodically repeated voltage pulses are applied between the anode and the cathode of the plasma decomposition unit in such a manner that pulsed electric discharges are produced between the cathode and the surrounding anode of the plasma decomposition unit. The anode is arranged in a special way so that at least a portion thereof will obtain only an electrically conductive coating or substantially no coating when operating the unit. For that purpose, the anode includes a portion located in the direct vicinity of the free surface of the cathode. The portion is a flange or edge portion which is located or extends over margins of the free surface of the cathode. In that way, the anode will include a portion that is shielded for direct coating with particles from the plasma formed and that hence will obtain e.g. substantially no dielectric coating at all. | 04-07-2011 |
20130062198 | APPARATUS FOR PROCESSING WORK PIECE BY PULSED ELECTRIC DISCHARGES IN SOLID-GAS PLASMA - Work piece processing is performed by pulsed discharges between an anode ( | 03-14-2013 |
20140291140 | METHOD AND APPARATUS FOR PLASMA GENERATION - In a simple method and device for producing plasma flows of a metal and/or a gas electric discharges are periodically produced between the anode and a metal magnetron sputtering cathode in crossed electric and magnetic fields in a chamber having a low pressure of a gas. The discharges are produced so that each discharge comprises a first period with a low electrical current passing between the anode and cathode for producing a metal vapor by magnetron sputtering, and a second period with a high electrical current passing between the anode and cathode for producing an ionization of gas and the produced metal vapor. Instead of the first period a constant current discharge can be used. Intensive gas or metal plasma flows can be produced without forming contracted arc discharges. The selfsputtering phenomenon can be used. | 10-02-2014 |