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Kool, US
Eric Kool, Stanford, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110312529 | CONFORMATIONAL PROBES AND METHODS FOR SEQUENCING NUCLEIC ACIDS - This disclosure provides a method of determining a sequence of nucleotides for a nucleic acid template. The method can include the steps of contacting the nucleic acid template with a conformationally labeled polymerase and at least four different nucleotide species under conditions wherein the conformationally labeled polymerase catalyzes sequential addition of the nucleotide species to form a nucleic acid complement of the nucleic acid template, wherein the sequential addition of each different nucleotide species produces a conformational signal change from the conformationally labeled polymerase and wherein the rate or time duration for the conformational signal change is distinguishable for each different nucleotide species; detecting a series of changes in the signal from the conformationally labeled polymerase under the conditions; and determining the rates or time durations for the changes in the signal, thereby determining the sequence of nucleotides for the nucleic acid template. | 12-22-2011 |
Eric T. Kool, Stanford, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080227160 | Circular DNA vectors for synthesis of RNA and DNA - The present invention provides methods for synthesis and therapeutic use of DNA and RNA oligonucleotides and analogs. RNA oligonucleotides are synthesized using a small, circular DNA template which lacks an RNA polymerase promoter sequence. The RNA synthesis is performed by combining a circular single-stranded oligonucleotide template with an effective RNA polymerase and at least two types of ribonucleotide triphosphate to form an RNA oligonucleotide multimer comprising multiple copies of the desired RNA oligonucleotide sequence. Preferably, the RNA oligonucleotide multimer is cleaved to produce RNA oligonucleotides having well-defined ends. Preferred RNA oligonucleotide multimers contain ribozymes capable of both cis (autolytic) and trans cleavage. | 09-18-2008 |
| 20100190839 | Telomere-Encoding Synthetic DNA Nanocircles, and Their Use for the Elongation of Telomere Repeats - Telomere-encoding nucleic acid nanocircles, methods for their preparation, and methods for their use are disclosed. The nanocircles can be constructed containing multiple repeats of the complement of telomere repeat sequences. The telomere-encoding nanocircles are useful for extending telomeres both in vitro and in vivo, for treating macular degeneration, the effects of skin aging, liver degeneration, and cancer. The nanocircles are further useful for treating cell cultures to produce long-lived non-cancerous cell populations. This use has wide applicability in scientific research, tissue engineering, and transplantation. | 07-29-2010 |
Eric Todd Kool, Stanford, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100129820 | STRONGLY QUENCHING OLIGOMERIC EXCIMER/QUENCHER PAIRS FOR DETECTION SCHEMES - Compositions and systems are provided for the high efficiency quenching small water-soluble oligomers, or oligofluors, of from about 1-10 kd in size, where the oligofluors comprise multiple excimeric or exciplex forming fluorophores arranged on a scaffold, which are efficiently quenched by a quencher entity linked to the oligomer through a cleavable moiety. Fluorophores of interest include, without limitation, aromatic fluorophores such as pyrenes, e.g. benzopyrene, perylene, pyrene, etc. In some embodiments the oligofluor/quencher combination provides for a Stern-Vollmer constant (K | 05-27-2010 |
Lawrence B. Kool, Clifton Park, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080223819 | Method and etchant for removing glass-coating from metal wires - An etchant for and method of removing a glass coating on a metallic wire is provided. The etchant comprises an acid solution having metal ions contained therein. The metal ions prevent the acid solution from pitting or damaging the metallic wire, while allowing the acid solution to effectively etch and remove the glass coating. In one embodiment, a fluorine-based acid solution can be used. In another embodiment, a glass coated, metal alloy microwire is etched and the metal ions added to the etchant are chosen to be the same as the majority constituent element in the metal alloy. The glass coating can be either removed in full or only partially removed. | 09-18-2008 |
| 20090132175 | REPLENISHMENT METHOD FOR AN ADVANCED COATING REMOVAL STRIPPING SOLUTION - A method for calculating the amount of solution components to add to an advanced coating removal (ACR) stripping solution in a coating removal stripping bath to replenish and recover stripping potential. The stripping effectiveness may be restored by the addition of only the primary acid of the composition of acids of the stripping bath and fresh water, in an amount necessary to restore the stripping solution to its original density. | 05-21-2009 |
| 20110030270 | Methods for removing impurities from coal including neutralization of a leaching solution - A method for removing at least one impurity from coal is provided. The method comprises providing coal having a plurality of impurities and contacting the coal with a first leaching solution. The first leaching solution reacts with at least one of the impurities to produce one or more first products soluble in the first leaching solution. The method further comprises adding a neutralizing composition to the first leaching solution. The neutralizing composition reacts with the first leaching solution to form a precipitate. The method further comprises separating at least a portion of the first leaching solution from the coal and the precipitate and contacting the coal and the precipitate with a second leaching solution. The second leaching solution reacts with at least one of the impurities and the precipitate to form one or more second products and one or more third products, respectively, the second products and the third products being soluble in the second leaching solution. The method further comprises separating at least a portion of the second leaching solution from the coal. | 02-10-2011 |
| 20110030271 | Method for removing impurities from coal in a reaction chamber - A method for removing at least one impurity from coal is described herein. The method includes providing coal comprising a plurality of impurities and contacting the coal with an acid solution in a reaction chamber. At least one of the impurities reacts with the acid solution to produce one or more first products soluble in the acid solution. The method further includes removing at least a portion of the acid solution including at least a portion of the first products from the reaction chamber and adding a nitrate composition to the reaction chamber to form a nitrate solution. At least one of the impurities, at least one of the first products, or combinations thereof react with the nitrate composition to produce one or more second products soluble in the nitrate solution. The method still further includes removing at least a portion of the nitrate solution including at least a portion of the second products from the reaction chamber. | 02-10-2011 |
Lawrence Bernard Kool, Niskayuna, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20110088720 | METHODS FOR CLEANING SUBSTRATES - A method for removing sand particles from a substrate is described. The method includes the step of treating the substrate with an acid solution comprising H | 04-21-2011 |