| Patent application number | Description | Published |
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| 20100325264 | MEDIA RESOURCE STORAGE AND MANAGEMENT - Provided are computer-implemented methods and systems for performing media resource storage and management. The computer-implemented method and system implemented as a request manager is capable of monitoring requests for media resources in a content delivery network. For each monitored request, the request manager determines whether to generate a multifile for the requested media resource. For example, the request manager can first determine whether the media resource is eligible for multifile generation. If eligible, the request manager then determines whether the media resource has reached a popularity threshold. If the media resource has reached the popularity threshold, the request manager initiates generation of the multifile for the requested media resource. Generally, the generated multifile is stored in a storage system associated with the content delivery network. | 12-23-2010 |
| 20100332664 | LOAD-BALANCING CLUSTER - A load-balancing cluster includes a switch having a plurality of ports; and a plurality of servers connected to at least some of the plurality of ports of the switch. Each server is addressable by the same virtual Internet Protocol (VIP) address. Each server in the cluster has a mechanism constructed and adapted to respond to connection requests at the VIP by selecting one of the plurality of servers to handle that connection, wherein the selecting is based, at least in part, on a given function of information used to request the connection; and a firewall mechanism constructed and adapted to accept all requests for the VIP address for a particular connection only on the server that has been selected to handle that particular connection. The selected server determines whether it is responsible for the request and may hand it off to another cluster member. | 12-30-2010 |
| 20110145386 | Policy-Based Content Delivery Network Selection - In a framework wherein resources of a content provider may be delivered to clients from different domains, a method distributes the requests based on content-provider policies. In some cases, the domains include at least two distinct content delivery network (CDN) domains. The domains may include a content provider domain. Responsive to a request, either the content provider domain or one of the two CDN domains is selected, the selection being based at least in part on one or more policies set by the content provider. | 06-16-2011 |
| Patent application number | Description | Published |
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| 20090175529 | METHOD AND APPARATUS FOR SELECTIVELY TARGETING SPECIFIC CELLS WITHIN A CELL POPULATION - This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially affecting non-targeted cells within the mixture. | 07-09-2009 |
| 20090191619 | METHOD AND DEVICE FOR SELECTIVELY TARGETING CELLS WITHIN A THREE-DIMENSIONAL SPECIMEN - The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen. The apparatus includes (a) a stage capable of supporting the specimen; (b) a detector including at least one camera, wherein the detector is capable of resolving a particle of interest within the specimen; (c) a means for locating the particle of interest in three dimensions; (d) a means for focusing electromagnetic radiation to a focal volume within the specimen; and (e) a means for adjusting the relative positions of the stage and electromagnetic radiation focusing means, thereby positioning the particle of interest within the focal volume. | 07-30-2009 |
| 20100086984 | OPTOINJECTION METHODS - Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse of radiation. | 04-08-2010 |
| 20100136683 | METHODS FOR ISOLATING CELLS BASED ON PRODUCT SECRETION - The invention provides methods for purifying one or more cells based on the level of one or more products secreted by the cells. In one embodiment, the method involves (a) contacting a plurality of cells immobilized in proximity to a capture matrix, the capture matrix capable of localizing a product secreted by one or more of the cells, with an agent that selectively binds to the product, the agent capable of generating a signal detectable as a property of light; (b) illuminating a population of the cells, the population contained in a frame; (c) detecting two or more properties of light directed from the frame, wherein a first property of light identifies substantially all cells of the population, and the second property of light identifies product localized to the capture matrix; (d) locating (i) substantially all cells of the population with reference to the detected first property of light, and (ii) one or more selected cells with reference to the detected second property of light, and (e) irradiating the non-selected cells, wherein each non-selected cell receives a substantially lethal dose of radiation, whereby one or more selected cells having a desired product secretion profile are purified. | 06-03-2010 |
| 20110201075 | OPTOINJECTION METHODS - Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse of radiation. | 08-18-2011 |
