Koichi Yamazaki
Koichi Yamazaki, Tokyo JP
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20090054474 | Novel pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same - A compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: | 02-26-2009 |
20090062306 | NOVEL PYRIMIDINE COMPOUNDS HAVING BENZYL (HETEROCYCLIC METHYL) AMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME - A compound represented by the following general formula (I), wherein R | 03-05-2009 |
20090082352 | NOVEL PYRIMIDINE COMPOUND HAVING DIBENZYLAMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME - A compound represented by the following general formula (I), wherein R | 03-26-2009 |
20090247587 | 1,3-DIHYDROISOBENZOFURAN DERIVATIVES - The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate. | 10-01-2009 |
20090286780 | 2-OXOCHROMENE DERIVATIVES - To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. | 11-19-2009 |
20100249148 | NOVEL PYRIMIDINE COMPOUNDS HAVING BENZYL (HETEROCYCLIC METHYL) AMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME - A compound represented by the following general formula (I), wherein R | 09-30-2010 |
20110079605 | ARTICLE ADVANCING DEVICE AND ARTICLE ARRANGEMENT SHELF - Provided are an article advancing device and an article arrangement shelf, wherein the article advancing device has a flexible sheet on which articles can be arranged at a condition where the sheet is extended, a roller to which one end of the sheet is fixed and which winds the sheet in the reverse extension direction, a drive means which rotates the roller in the winding direction of the sheet, and a wall member with which the articles in the first row of the articles arranged on the sheet come into contact. When the articles are arranged on the sheet, the article advancing device stops the winding operation of the sheet by the drive means by the contact of the articles in the first row with the wall member. The article advancing device has a simple article advancing function which employs a horizontally extending shelf basically having no incline and which does not require energy, such as electric power, and can be used regardless of the packaging state of the articles. | 04-07-2011 |
20110127287 | ARTICLE ADVANCING DEVICE AND ARTICLE ARRANGEMENT SHELF - An object is to provide an article advancing device and an article arrangement shelf that can be securely operated with a simple structure while not requiring electric power. An article advancing device of the present invention includes: an elongated drawer member | 06-02-2011 |
20110166351 | METHOD FOR PREPARING 5-[2-(METHYLTHIO)ETHOXY]PYRIMIDINE-2-AMINE - A novel method for preparing 5-[2-(methylthio)ethoxy]pyrimidin-2-amine useful as a regent or raw material for manufacture of medicaments, agricultural chemicals, and industrial products, which comprises alkanoylating the amino group of a 2-amino-4-alkoxypyrimidine, then converting the resultant into a 4-hydroxypyrimidine compound by a treatment with anhydrous aluminum chloride, further etherifying the 4-hydroxypyrimidine compound by a reaction with a 2-haloethyl methyl sulfide in the presence of a base, and removing the alkanoyl group to obtain 5-[2-(methylthio)ethoxy]pyrimidin-2-amine. | 07-07-2011 |
20110288328 | METHOD FOR PREPARING TRANS-ACETIC ACID ESTER - A method for preparing a trans-{4-[(alkylamino)methyl]cyclohexyl}acetic acid, which is useful as a raw material compound for manufacture of medicaments and the like, comprising the step of reducing amide group of a compound represented by the following general formula (6) (R | 11-24-2011 |
20130190540 | METHOD FOR PREPARING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANE - A method for preparing optically active 1-bromo-1-[3,5-bis(trifluoromethyl)-phenyl]ethane having a high optical purity, which comprises the step of brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl]ethanol by using, as a brominating agent, (a) a combination of a phosphorus halide and hydrogen bromide, (b) a combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and an organic phosphorous compound represented by the general formula (I): P(R | 07-25-2013 |
20130225814 | OPTICALLY ACTIVE DIBENZYLAMINE DERIVATIVE, AND METHOD FOR PREPARING THEREOF - Substantially optically pure (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, or a salt thereof, or a solvate thereof, which has actions of reducing amount of PCSK9 protein and increasing amount of LDL receptor. | 08-29-2013 |
Koichi Yamazaki, Yamanashi-Ken JP
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20100175621 | Microwave Plasma Processing Apparatus - Disclosed is improvement of a quartz-glass top plate to be used as a microwave-transmitting window in a microwave plasma processing apparatus. The surface, facing a substrate W, of the top plate has surface roughness equal to or less than 0.2 μm in arithmetic mean surface roughness Ra. Thereby, generation of particles derived from the quartz glass material constituting the top plate is minimized, even when the top plate is exposed to a severe environment of high electron density and high electron temperature. | 07-15-2010 |
Koichi Yamazaki, Sapporo JP
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20110250229 | ALLOGENEIC CANCER CELL-BASED IMMUNOTHERAPY - Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g., gp96), depletion of B cells in the subject, or both. Antigen (e.g., epitope derived from neoantigen or tumor antigen of allogeneic or syngeneic cancer cells) may induce a specific immune response in the subject. For example, the epitope bound in an immunogenic complex with the secreted heat shock protein may be obtained from allogeneic cancer cells coexpressing both secreted gp96 and antigen, or from syngeneic cancer cells of the subject expressing only antigen. | 10-13-2011 |
Koichi Yamazaki, Chuo-Ku JP
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20130302376 | Allogeneic Cancer Cell-based Immunotherapy - Cell-based immunotherapy (e.g., immunization or vaccination) may be improved by frequent administration to a human subject of allogeneic cancer cells secreting a modified heat shock protein (e.g., gp96), depletion of B cells in the subject, or both. Antigen (e.g., epitope derived from neoantigen or tumor antigen of allogeneic or syngeneic cancer cells) may induce a specific immune response in the subject. For example, the epitope bound in an immunogenic complex with the secreted heat shock protein may be obtained from allogeneic cancer cells coexpressing both secreted gp96 and antigen, or from syngeneic cancer cells of the subject expressing only antigen. | 11-14-2013 |
Koichi Yamazaki US
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20140335086 | MODIFIED HEAT SHOCK PROTEIN-ANTIGENIC PEPTIDE COMPLEX - The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic peptides of cancer or infected cells. The claimed methods comprise the constructing of a nucleotide sequence encoding a secretable modified heat shock protein, expressing the sequence in an appropriate host cell, recovering the immunogenic complexes from the cell culture and the cells, and purifying the immunogenic complexes by affinity chromatography. Large amounts of such immunogenic complexes can be obtained by large-scale culturing of host cells containing the genetic sequence. The complexes can be used as a vaccine to elicit specific immune responses against cancer or infected cells, and to treat or prevent cancer or infectious diseases. | 11-13-2014 |
Koichi Yamazaki, Kanagawa JP
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20150023700 | DEVELOPING DEVICE, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE - A drawing-up magnetic pole and a control magnetic pole of a magnetic field generator that is disposed in a developer carrier are adjacent to each other and a prevention member is provided that secures, between the prevention member and an upper end of a side wall of a developer supply conveyance path, a supply path through which a developer in the developer supply conveyance path passes toward the developer carrier at least over the entire width of a developing area and that prevents a control retained developer, which is prevented by a developer control member from passing through a control gap, from moving toward the surface of the developer carrier along lines of the control magnetic force. The peak of the magnetic flux density of the drawing-up magnetic pole in the normal direction is disposed below the lower end of the supply path. | 01-22-2015 |
20150063875 | TONER SUPPLYING DEVICE AND IMAGE FORMING APPARATUS - A toner supplying device includes: a toner container that is tubular, includes a spiral groove at an outer circumferential face, a toner discharge opening at one end in a longitudinal direction, and a depression at the other end in the longitudinal direction, and is rotationally driven to convey toner contained in the toner container along the spiral groove in the longitudinal direction to discharge the toner from the toner discharge opening; a rotational driving unit that engages with the one end of the toner container to rotationally drive the toner container to cause the toner container to discharge the toner; and a projection provided at an interior portion at which the toner container is installed, and having an inclination in which a projection amount increases toward downstream in a rotational direction of the toner container. The projection is formed to fall in the depression of the toner container. | 03-05-2015 |