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Kohlhoff
Kai J. Kohlhoff, Cambridge GB
| Patent application number | Description | Published |
|---|---|---|
| 20100160602 | METHOD FOR PREDICTING PROTEIN AGGREGATION AND DESIGNING AGGREGATION INHIBITORS - The present invention provides methods of predicting protein aggregation and designing aggregation inhibitors. One such method for predicting potential protein aggregation inhibiting peptide sequences, includes the steps of: a) identifying a peptide sequence forming at least part of an aggregation region in a target protein; b) testing whether said peptide sequence forms part of a β-sheet; c) if a positive result is achieved in step b), extracting the adjacent strands of that sheet; d) identifying residues in the adjacent strands to said peptide sequence whose side chains interact with said peptide sequence, those residues forming a potential protein aggregation inhibiting peptide sequence. The present invention also provides methods of designing compounds using the residues identified in the above method; compounds produced by the methods and computer programs for carrying out the above methods. | 06-24-2010 |
Markus Kohlhoff, Belo Horizonte BR
| Patent application number | Description | Published |
|---|---|---|
| 20100310633 | CHITINOSANASE - A chitinosanase obtainable from the fungus | 12-09-2010 |
Stephan Kohlhoff, Brooklyn, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100167335 | METHODS FOR DIAGNOSING AND TREATING ALLERGIES - The present invention relates to methods of screening actives for the treatment of allergic reactions and providing treatment therefor. In particular, the invention relates to the screening of various antibacterial actives for treatment of asthma and other related symptoms. | 07-01-2010 |
Stephan Kohlhoff, Wiesbaden DE
| Patent application number | Description | Published |
|---|---|---|
| 20120130521 | Visual Assembly Tool - An assembly model is identified including a plurality of part models. Each part model is a predefined, selectable model corresponding to at least one part in a plurality of assembly parts. The assembly model is presented and a sequence of user selections identifying part models in the assembly model are received through a user interface. User selections can correspond to designations of parts to be removed from the modeled assembly during a disassembly of the assembly. Selected part models are removed from the displayed presentation in response to corresponding user selections. A disassembly order is generated including an ordered grouping of disassembly steps, each disassembly step corresponding to a user selection of a part model in the sequence of user selections. The disassembly steps are ordered based on an order of selection of the corresponding part models. The order of the disassembly order is reversed and an assembly order is generated for the assembly from the reversed disassembly order. | 05-24-2012 |