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| 20080209607 | Protective Glove With Independent Pads - A protective glove having an elastic substrate, a first pad segment attached to the elastic substrate, and a second pad segment attached to the elastic substrate independently from the first pad segment. The elastic substrate can be disposed over an area intended to substantially cover a forearm, a wrist, a back of a hand, a finger, and/or a thumb of a user wearing the glove. The elastic substrate can be stretchable in different directions and to different degrees in the areas around each pad segment, thereby enabling independent movement of the individually attached pad segments to accommodate any number of contours and flex points. Other embodiments provide methods for manufacturing a protective glove having independent pads. | 09-04-2008 |
| 20110078847 | PROTECTIVE EYEWEAR - A protective eyewear apparatus including a base substantially oval in shape, an upper bar connected to the base, a lower bar connected to the base, and a main support bar connected to the upper bar and the lower bar. Another embodiment includes two eyepieces attached by a flexible bridge member, in which an eyepiece comprises a base generally oval in shape and defining an opening, and an upper and lower bar spanning the opening and connected to the base. | 04-07-2011 |
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| 20090075339 | AUTOPHILIC ANTIBODIES - Autophilic antibodies including an immunoglobulin component and an autophilic peptide fused thereto are provided according to embodiments of the present invention. Particular autophilic antibodies described herein include a chimeric gamma immunoglobulin heavy chain and autophilic peptide expressed as a fusion protein. Preferably the autophilic peptide is expressed at the C-terminus of the immunoglobulin component. Expression vectors according to embodiments of the present invention for use in generating autophilic antibodies are provided which include a first nucleic acid sequence encoding an autophilic peptide, operably linked to a transcription promoter. In particular embodiments, a second nucleic acid sequence encoding a chimeric heavy chain of an immunoglobulin operably linked to the transcription promoter and connected to the first nucleic acid sequence such that expression of the first and second nucleic acid sequences produces a fusion protein of the chimeric heavy chain and the autophilic peptide. | 03-19-2009 |
| 20090208418 | SUPERANTIBODY SYNTHESIS AND USE IN DETECTION, PREVENTION AND TREATMENT OF DISEASE - Superantibodies having enhanced autophilic, catalytic, and/or membrane-penetrating properties are prepared by affinity-based conjugation of a photoactivatable organic molecule to a target immunoglobulin. The photoactivatable organic molecule bears a chromophoric aromatic hydrocarbon moiety, which has affinity for the immunoglobulin. Upon photolysis, the organic molecule is covalently linked to the immunoglobulin. A preferred organic molecule is a peptide and a preferred aromatic hydrocarbon moiety is a tryptophan residue. The photoactivatable organic molecule need not bear a purine, pyrimidine or azido group to effect binding to the immunoglobulin and/or photoactivation. The superantibodies can enhance the potency and expand the targeting range of target antibodies. Autophilic superantibodies can promote apoptosis of target cells and/or enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Exemplary of such diseases are atherosclerosis and cardiovascular disease. Membrane-penetrating superantibodies can prevent apoptosis by binding to intracellular anti-caspase signal proteins. Compositions containing the superantibodies, as well as methods of making and using them, are disclosed. | 08-20-2009 |
| 20090274710 | TRANS-MEMBRANE-ANTIBODY INDUCED INHIBITION OF APOPTOSIS - Cell suicide (apoptosis) is associated with pathogenesis, for example, it is the major cause for the loss of neurons in Alzheimer's disease. Caspase-3 is critically involved in the pathway of apoptosis. Superantibody (SAT)-trans-membrane technology has been used to produce antibodies against the caspase enzyme in an effort to inhibit apoptosis in living cells. The advantage of using trans-membrane antibodies as apoptosis inhibitors is their specific target recognition in the cell and their lower toxicity compared to conventional apoptosis inhibitors. It is shown that a MTS-transport-peptide modified monoclonal anti-caspase-3 antibody reduces actinomycin D-induced apoptosis and cleavage of spectrin in living cells. These results indicate that antibodies conjugated to a membrane transporter peptide have a therapeutic potential to inhibit apoptosis in a variety of diseases. | 11-05-2009 |
| 20090317379 | AUTOPHILIC ANTIBODIES AND METHOD OF MAKING THE SAME - Antibodies having noncovalent, autophilic properties are disclosed. The autophilic antibodies are derived from antibodies conjugated with an autophilic peptide. Such autophilic antibodies can promote apoptosis of target cells and enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Compositions containing the antibodies, and methods of making and using the antibodies are also disclosed. | 12-24-2009 |
| 20100017898 | THERAPEUTIC APPLICATIONS OF NONCOVALENT DIMERIZING ANTIBODIES - Compositions and methods for providing antibodies having noncovalent, self-binding properties are disclosed. Such autophilic antibodies can bind cellular receptors to promote apoptosis of target cells and enhance therapeutic efficacies in the treatment of patients with debilitating or life-threatening diseases. Representative diseases targeted by the autophilic antibodies are lymphomas, breast cancers, colon cancers, and melanomas. Autoimmune disorders, Alzheimer's disease, and other neuro-degenerative conditions, as well as graft or transplant rejection, are among other treatable conditions. | 01-21-2010 |
| 20120064593 | SUPERANTIBODY SYNTHESIS AND USE IN DETECTION, PREVENTION AND TREATMENT OF DISEASE - Superantibodies having enhanced autophilic, catalytic, and/or membrane-penetrating properties are prepared by affinity-based conjugation of a photoactivatable organic molecule to a target immunoglobulin. The photoactivatable organic molecule bears a chromophoric aromatic hydrocarbon moiety, which has affinity for the immunoglobulin. Upon photolysis, the organic molecule is covalently linked to the immunoglobulin. A preferred organic molecule is a peptide and a preferred aromatic hydrocarbon moiety is a tryptophan residue. The photoactivatable organic molecule need not bear a purine, pyrimidine or azido group to effect binding to the immunoglobulin and/or photoactivation. Autophilic superantibodies can promote apoptosis of target cells and/or enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Exemplary of such diseases are atherosclerosis and cardiovascular disease. Membrane-penetrating superantibodies can prevent apoptosis by binding to intracellular anti-caspase signal proteins. Compositions containing the superantibodies, as well as methods of making and using them, are disclosed. | 03-15-2012 |
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| 20080317940 | Method for Producing Corrugated Cardboard - A method of applying adhesive to flutes of a corrugated sheet includes the steps of applying a layer of adhesive on an outer surface of an applicator roll, rotating the applicator roll, and rotating a web positioning roll adjacent the applicator roll. The web positioning roll and the applicator roll each have rotational axes and define a gap between respective outer surfaces thereof. The corrugated sheet is moved along a path adjacent the outer surface of the applicator roll to apply adhesive to the flutes from the layer of adhesive. A control system is utilized to automatically maintain the rotational axes substantially parallel to one another. In other examples, the control system can automatically maintain a desired width of the gap, maintain a desired pressure to be applied to the flute crests, and/or automatically determine flute height. | 12-25-2008 |
| 20100181015 | METHOD FOR MOISTURE AND TEMPERATURE CONTROL IN CORRUGATING OPERATION - A method of producing a corrugated product comprises the steps of providing at least one medium conditioning apparatus upstream of at least one of a corrugating labyrinth, single-facer, and/or double-backer. The moisture content in at least one of a web of medium material, first face-sheet, and/or second face-sheet is adjusted to be in the range of 6-9 wt. % moisture by applying a substantially continuous thin film of liquid thereto using the at least one medium conditioning apparatus. In one example, at least one heating arrangement is arranged downstream from the at least one medium conditioning apparatus to heat at least one of the web of medium material, first-face sheet, and/or second face-sheet. | 07-22-2010 |
| 20100331160 | APPARATUS FOR PRODUCING CORRUGATED BOARD - An apparatus is provided for producing longitudinally corrugated product. The apparatus includes a guide roll for guiding a web of medium material, wherein at least a portion of the guide roll is adapted to be arranged at an angle relative to another portion of the guide roll. The apparatus further includes a plurality of flute forming bars oriented generally along a longitudinal axis of the web to define a first corrugating labyrinth effective to longitudinally corrugate the web to an intermediate geometry. The apparatus further includes a pair of corrugating rollers that cooperate to define, at a nip therebetween, a second corrugating labyrinth effective to longitudinally corrugate the web to a substantially final geometry. The apparatus further includes a web travel pathway for the web that follows a path around a portion of the guide roll, through the first corrugating labyrinth, and through the second corrugating labyrinth. | 12-30-2010 |
| 20110011522 | Method and apparatus for producing a corrugated product - A method and apparatus are useful to produce a corrugated product. They can be used to produce a corrugated product at low temperature, such as room temperature. A zero-contact roll is used to support a web of medium material on a cushion of air at a location prior to the web entering the corrugating labyrinth. The web is free to move toward or away from the surface of the zero-contact roll, on the cushion of air, in response to small oscillatory changes in downstream tension demand based on the fluting frequency in the corrugating labyrinth. A mechanism is also provided to precisely control the mean tension in the web prior to entering the corrugating labyrinth at a low value. Thus, mean web tension is precisely controlled and is low, tension oscillations can be damped, and low temperature corrugating can be achieved without significant fracturing in the corrugated web. A single-facer useful to apply a high-solids content adhesive, also desirable for low-temperature corrugating, is also provided. | 01-20-2011 |
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| 20100036670 | Premises Enabled Mobile Kiosk, Using Customers' Mobile Communication Device - A contact center is provided that can service customers on premises via a mobile kiosk. The mobile kiosk may be carried by the customer or by an on-site customer service representative. The mobile kiosk may be enqueued in the contact center contact queue such that enhanced customer service can be provided through interfacing with the enterprise database, vendor databases, as well as assigning an appropriately skilled contact center agent to the customer contact. | 02-11-2010 |
| 20100121672 | System and method for identifying and managing customer needs - The system monitors the activity of customers, agents, and industry-experts in a network for new topics relevant to a business and the interests in those topics. A determination is made automatically if there is enough interest to warrant adding a skill. If there is not enough interest, the system continues to monitor for topics and interests. If there is enough interest, the system automatically projects a resource needed for a skill. The system monitors internal resources and the network to determine if the resource needed for the skill exists in an internal resource. If the resource needed for the skill exists in an internal resource, the internal resource is reallocated. If the resource needed for the skill does exist in the internal resource, the system monitors the network for an external resource that has the skill. | 05-13-2010 |
| 20100296646 | INSTANT MESSAGE CONTACT MANAGEMENT IN A CONTACT CENTER - The present invention is directed to a method for servicing a transaction in a contact center. When an instant message communication associated with a transaction is suspended prematurely, special treatment may be provided to the transaction initiator. The special treatment includes: (a) maintaining the assigned service priority for the transaction for assignment to a subsequent communication; (b) scheduling a subsequent outbound instant message to an external endpoint associated with the transaction initiator; (c) assigning to the transaction initiator a favored service priority when the subsequent inbound instant message is received by the contact center; and (d) maintaining previously selected item(s) in memory and providing the item(s) to the transaction initiator in a subsequent communication. | 11-25-2010 |
| 20120084111 | SYSTEM AND METHOD FOR ADAPTIVE MULTIPLE CONTACT ASSIGNMENT - Embodiments of the present invention generally relate to a system and method for adaptively assigning multiple contacts to an agent determined by that agent's current metrics data or effectiveness measure. In one embodiment, there is provided a method for adaptively assigning multiple contacts to an agent in a contact center, comprising providing a reporting engine containing an agent's metrics; providing an assignment engine for assigning multiple contacts to the agent based upon the agent's metrics received from the reporting engine; storing each contact being served by the agent with at least one agent metrics element to be measured by the reporting engine; updating the agent's metrics in the reporting engine based upon the measured at least one metrics element; comparing the agent's updated metrics with stored target metrics; and assigning multiple contacts to the agent when the agent's metrics is within the target metrics. | 04-05-2012 |
| 20120084217 | SYSTEM AND METHOD FOR RESPONDING TO CHANGING CONDITIONS IN CONTACT CENTERS - Embodiments of the present invention relate to a business continuity system and method where conditional profiles and processes can be set for multiple contact centers with a set of object types while each contact center object is capable of responding uniquely to a changed condition. In accordance with one embodiment, there is provided a contact center management system for managing conditions in a contact center, the system comprising a computer system database for storing conditional profiles, each conditional profile corresponding to a set of varying types of objects associated with a contact center; a condition monitoring unit for receiving condition notifications from the contact center; and a response unit for responding to a received condition notification with a corresponding conditional profile having the set of objects associated with that conditional profile, wherein multiple object types in the set of objects are capable of uniquely responding to the received condition. | 04-05-2012 |
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| 20090236252 | Blanks And Methods For Forming A Beverage Carrier From The Blanks - A beverage carrier including at least two cartons and a tray having a retractable handle for holding the cartons is provided. The cartons and the tray are each formed from blanks of sheet material. Each carton includes a first and second side wall, a top panel, a bottom panel, and first and second end walls, wherein the side walls, the top panel, the bottom panel and the end walls are interconnected to form the carton. The tray includes a first and second side panel, a first and second bottom panel, a first and second divider panel, and a first and second end panel. The tray includes an$ opening through which a retractable handle is placed. The retractable handle is configured to move between a recessed position and an extended position. The tray is configured to hold at least two cartons for easy transport and storage. | 09-24-2009 |
| 20100308104 | Carton With Display Header - More than one embodiment of a blank and carton are provided. In one embodiment, a blank forms a carton with an opening flap that forms a display header for the carton. The opening flap is defined along a tear line pattern in a side panel and an overlapped and adhered end flap configuration, with the overlapped portion defined along a fold line. The opening flap is foldable along the fold line to dispose interior surfaces of the overlapped end flaps in facing relationship with one another. A portion of the opening flap extends into the carton interior, and can be received into two tuck-in flaps formed in another side panel. A display header is formed of the exposed portion of the opening flap when the opening flap is oriented in a display configuration. In another embodiment, only one tuck-in flap is included. | 12-09-2010 |
| 20110315750 | CARTON WITH REINFORCED CORNER - A carton for containing a plurality of articles. The carton comprises a bottom panel, a first side panel foldably, and a second side panel. At least one end flap comprises a first portion foldably connected to the one of the first side panel and the second side panel, a second portion foldably connected to the first portion, and a third portion foldably connected to the second portion. The carton has at least one reinforced corner that comprises a reinforced end panel and a reinforced portion of one of the first side panel and the second side panel. The reinforced end panel comprises the second portion and the third portion of the at least one end flap. The reinforced portion comprises the third portion of the at least one end flap and a portion of the one of the first side panel and the second side panel. | 12-29-2011 |
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| 20100084052 | Compositions of corrosion-resistant Fe-based amorphous metals suitable for producing thermal spray coatings - A method of coating a surface comprising providing a source of amorphous metal that contains manganese (1 to 3 atomic %), yttrium (0.1 to 10 atomic %), and silicon (0.3 to 3.1 atomic %) in the range of composition given in parentheses; and that contains the following elements in the specified range of composition given in parentheses: chromium (15 to 20 atomic %), molybdenum (2 to 15 atomic %), tungsten (1 to 3 atomic %), boron (5 to 16 atomic %), carbon (3 to 16 atomic %), and the balance iron; and applying said amorphous metal to the surface by a spray. | 04-08-2010 |
| 20110165348 | Compositions of Corrosion-resistant Fe-Based Amorphous Metals Suitable for Producing Thermal Spray Coatings - A method of coating a surface comprising providing a source of amorphous metal that contains manganese (1 to 3 atomic %), yttrium (0.1 to 10 atomic %), and silicon (0.3 to 3.1 atomic %) in the range of composition given in parentheses; and that contains the following elements in the specified range of composition given in parentheses: chromium (15 to 20 atomic %), molybdenum (2 to 15 atomic %), tungsten (1 to 3 atomic %), boron (5 to 16 atomic %), carbon (3 to 16 atomic %), and the balance iron; and applying said amorphous metal to the surface by a spray. | 07-07-2011 |
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| 20090306691 | CUTTING AND CORING ATHERECTOMY DEVICE AND METHOD - The invention provides a rotational and/or axially translatable atherectomy system, device and method comprising a flexible, elongated drive shaft or catheter comprising an expandable and collapsible conical coil with a cutting edge on the coil's large diameter proximal end. When retracted, the coil's sections are collapsed around each other, held together in the retracted position by a sheath that, when distally retracted, allows the coil to automatically expand. The coil is expanded at a point distal to the occlusion, then pulled proximally to cut the occluding material near the lumen wall. The proximal pulling force may be combined with low-speed rotation and/or translation and/or axial vibration at low to ultrasonic frequency. | 12-10-2009 |
| 20100121361 | DIRECTIONAL ROTATIONAL ATHERECTOMY DEVICE WITH OFFSET SPINNING ABRASIVE ELEMENT - The invention provides a rotational atherectomy system, device and method comprising a flexible, elongated, rotatable drive shaft with a pre-curved abrasive section disposed within a catheter that deforms the abrasive section to a substantially straight profile and, when the abrasive section is moved distally out of the catheter, the abrasive section resumes its pre-curved profile. Directional ablation is achieved by rotation of the drive shaft along its pre-curved axis as the abrasive section is urged against a portion of the lumen wall. | 05-13-2010 |
| 20100145343 | APPARATUS AND METHOD FOR SCULPTING THE SURFACE OF A JOINT - Methods and devices for sculpting bones, particularly in preparation for implanting prosthetic devices to replace articulating bone joint surfaces. Improved bone removal devices including burr mills driven by gears and loop drives are provided. Reciprocating cutters and belt cutters are also provided. Some devices have either integral or removable expandable portions to vary the force and bone resection depth. Devices can have irrigation ports and plenums to remove bone fragments. Some cutters are dual cutters, adapted to remove bone in two or more regions, such as the knee joint, simultaneously. | 06-10-2010 |
| 20110270258 | METHOD FOR SCULPTING THE SURFACE OF A JOINT - Methods and devices for sculpting bones, particularly in preparation for implanting prosthetic devices to replace articulating bone joint surfaces. Improved bone removal devices including burr mills driven by gears and loop drives are provided. Reciprocating cutters and belt cutters are also provided. Some devices have either integral or removable expandable portions to vary the force and bone resection depth. Devices can have irrigation ports and plenums to remove bone fragments. Some cutters are dual cutters, adapted to remove bone in two or more regions, such as the knee joint, simultaneously. | 11-03-2011 |
| 20120046600 | HIGH-SPEED ROTATIONAL ATHERECTOMY SYSTEM, DEVICE AND METHOD FOR LOCALIZED APPLICATION OF THERAPEUTIC AGENTS TO A BIOLOGICAL CONDUIT - The invention provides a system, device and method for localized application of therapeutic agents within a biological conduit. A preferred biological conduit comprises a blood vessel. A preferred device comprises a high-speed rotational atherectomy device having, in various embodiments, a flexible, elongate non-rotatable therapeutic agent delivery sheath having a lumen therethrough and a flexible, elongated, rotatable, drive shaft with at least one flexible eccentric enlarged abrading head disposed within lumen of the delivery sheath. The operator may actuate a controlled amount or dose of one or more therapeutic agents to release from the distal end of the delivery sheath lumen during high-speed rotation of the drive shaft. The therapeutic agent(s) is thus released into a turbulent fluidic environment resulting from high-speed rotation and orbital motion of the eccentric abrading head, which aids to drivingly urge the therapeutic agent(s) radially through the boundary layer of fluid flow in the conduit and into the target region of the conduit wall. | 02-23-2012 |
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| 20100100546 | Context-aware semantic virtual community for communication, information and knowledge management - A method for creation of a semantic information management environment, said method comprised of steps of: providing said semantic information environment consisting of an architecture partitioned according to the classification of the use of natural language by information scale, dynamical properties, or semantic classifications; detection, classification, and storage of semantic and contextual information detected and stored by recording of observed contextual parameters associated with events in said semantic information management environment; said interactions including the use of information management or electronic communication applications embedded or linked to said architecture, or separate from said architecture; said observations including the use of natural language as parameters that have specific semantic properties; detection, classification and storage of use of natural language in said semantic information environment; representation of semantic processes containing said detected, classified, and stored contextual information and natural language use in said semantic information environment; said representations of semantic processes used to link and associate natural language use with objects, entities, facts, communication, information, and digital files in said semantic information environment; providing said users of said semantic information environment with information and knowledge management tools, reports, representations, and interfaces that utilize said semantic process representations. | 04-22-2010 |
